Cited by 254Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular HealthNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 130 of the 131 references it cites were found in a registry or an index.

HDL and cholesterol handling in the brain

Vitali, C., Wellington, C. L., Calabresi, L.·2014·Cardiovascular Research

DOI 10.1093/cvr/cvu148

Open this paper in CoChat — free account

Abstract

Cholesterol is an essential component of both the peripheral nervous system and central nervous system (CNS) of mammals. Brain cholesterol is synthesized in situ by astrocytes and oligodendrocytes and is almost completely isolated from other pools of cholesterol in the body, but a small fraction can be taken up from the circulation as 27-hydroxycholesterol, or via the scavenger receptor class B type I. Glial cells synthesize native high-density lipoprotein (HDL)-like particles, which are remodelled by enzymes and lipid transfer proteins, presumably as it occurs in plasma. The major apolipoprotein constituent of HDL in the CNS is apolipoprotein E, which is produced by astrocytes and microglia. Apolipoprotein A-I, the major protein component of plasma HDL, is not synthesized in the CNS, but can enter and become a component of CNS lipoproteins. Low HDL-C levels have been shown to be associated with cognitive impairment and various neurodegenerative diseases. On the contrary, no clear association with brain disorders has been shown in genetic HDL defects, with the exception of Tangier disease. Mutations in a wide variety of lipid handling genes can result in human diseases, often with a neuronal phenotype caused by dysfunctional intracellular lipid trafficking.

Integrity signals

Registry

Crossref · 10.1093/cvr/cvu148

Cites

130 of 130 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,794
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Liu, C.-C., Kanekiyo, T., Xu, H., & Bu, G. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.263 · Cited by 3,459
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
Zlokovic, B. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.003 · Cited by 3,280
Huntington's disease
Walker, F. O. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60111-1 · Cited by 2,691
Antiinflammatory Properties of HDL
Barter, P. J., Nicholls, S., Rye, K.-A., Anantharamaiah, G. M., Navab, M., & Fogelman, A. M. (2004) · Circulation Research · doi:10.1161/01.res.0000146094.59640.13 · Cited by 1,394
Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.
Strittmatter, W. J., Weisgraber, K. H., Huang, D. Y., Dong, L. M., Salvesen, G. S., Pericak-Vance, M., Schmechel, D., Saunders, A. M., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.8098 · Cited by 1,363
Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies
Mazzulli, J. R., Xu, Y.-H., Sun, Y., Knight, A. L., McLean, P. J., Caldwell, G. A., Sidransky, E., Grabowski, G. A., & Krainc, D. (2011) · Cell · doi:10.1016/j.cell.2011.06.001 · Cited by 1,341
Human ApoE isoforms differentially regulate brain amyloid-β peptide clearance
Castellano, J. M., Kim, J., Stewart, F. R., Jiang, H., DeMattos, R. B., Patterson, B. W., Fagan, A. M., Morris, J. C., Mawuenyega, K. G., Cruchaga, C., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002156 · Cited by 1,242
Prevalence of Metabolic Syndrome and Metabolic Abnormalities in Schizophrenia and Related Disorders—A Systematic Review and Meta-Analysis
Mitchell, A. J., Vancampfort, D., Sweers, K., van Winkel, R., Yu, W., & Binder, M. D. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr148 · Cited by 1,120

Show all 131 references

Research works printed but not linked: 4

Frisoni, 1994, Dementia, 5, 240
2013, Biochimica et Biophysica Acta. Protein Structure and Molecular Enzymology, 1831, 263
2011, Journal of neurology, 258, 202
Yokoyama, 1993, Cell, 75, 187, 10.1016/0092-8674(93)90690-R · DOI

Sorted by citations

Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders
Mahley, R. W. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1427-y · Cited by 837
Parkinson’s Disease: Biomarkers, Treatment, and Risk Factors
Emamzadeh, F. N., & Surguchov, A. P. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00612 · Cited by 589
Central Nervous System Lipoproteins: ApoE and Regulation of Cholesterol Metabolism
Mahley, R. W. (2016) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.116.307023 · Cited by 516
APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases
Fernández-Calle, R., Konings, S. C., Frontiñán-Rubio, J., García-Revilla, J., Camprubí-Ferrer, L., Svensson, M., Martinson, I., Boza-Serrano, A., Venero, J. L., Nielsen, H. M., et al. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00566-4 · Cited by 278
Size-selective opening of the blood–brain barrier by targeting endothelial sphingosine 1–phosphate receptor 1
Yanagida, K., Liu, C. H., Faraco, G., Galvani, S., Smith, H. K., Burg, N. D., Anrather, J., Sánchez, T., Iadecola, C., & Hla, T. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1618659114 · Cited by 222
Circulating metabolites and general cognitive ability and dementia: evidence from 11 cohort studies
van der Lee, S. J., Teunissen, C. E., Pool, R., Shipley, M. J., Teumer, A., Chouraki, V., Melo van Lent, D., Tynkkynen, J., Fischer, K., Hernesniemi, J., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.11.012 · Cited by 197
Role of the Blood–Brain Barrier in the Nutrition of the Central Nervous System
Campos‐Bedolla, P., Walter, F. R., Veszelka, S., & Deli, M. A. (2014) · Archives of Medical Research · doi:10.1016/j.arcmed.2014.11.018 · Cited by 202
Cholesterol in myelin biogenesis and hypomyelinating disorders
Saher, G., & Stumpf, S. K. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2015.02.010 · Cited by 192
Steroid Transport, Local Synthesis, and Signaling within the Brain: Roles in Neurogenesis, Neuroprotection, and Sexual Behaviors
Diotel, N., Charlier, T. D., d’Hellencourt, C. L., Couret, D., Trudeau, V. L., Cano‐Nicolau, J., Meilhac, O., Kah, O., & Pellegrini, E. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00084 · Cited by 199
Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): From bench to bedside
Bao, X., Liang, Y., Chang, H., Cai, T., Feng, B., Gordon, K., Zhu, Y., Shi, H., He, Y., & Xie, L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01690-3 · Cited by 187
LXR Regulation of Brain Cholesterol: From Development to Disease
Courtney, R., & Landreth, G. E. (2016) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.03.018 · Cited by 190
Lipopolysaccharide enters the rat brain by a lipoprotein-mediated transport mechanism in physiological conditions
Vargas-Caraveo, A., Sayd, A., Maus, S. R., Caso, J. R., Madrigal, J. L. M., García‐Bueno, B., & Leza, J. C. (2017) · Scientific Reports · doi:10.1038/s41598-017-13302-6 · Cited by 181
Cholesterol metabolism in the brain and its association with Parkinson’s disease.
Jin, U., Park, S. J., & Park, S. M. (2019) · Experimental Neurobiology · doi:10.5607/en.2019.28.5.554 · Cited by 169
Mediterranean and Western diet effects on Alzheimer's disease biomarkers, cerebral perfusion, and cognition in mid‐life: A randomized trial
Hoscheidt, S. M., Sanderlin, A. H., Baker, L. D., Jung, Y., Lockhart, S. N., Kellar, D., Whitlow, C. T., Hanson, A. J., Friedman, S. D., Register, T. C., et al. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12421 · Cited by 176
ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes
Rawat, V., Wang, S., Sima, J., Bar, R., Liraz, O., Gundimeda, U., Parekh, T., Chan, J., Johansson, J. O., Tang, C., et al. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.1400-19.2019 · Cited by 165
The Role of the ATP-Binding Cassette A1 (ABCA1) in Human Disease
Jacobo‐Albavera, L., Domínguez‐Pérez, M., Medina-Leyte, D. J., González-Garrido, A., & Villarreal-Molina, M. T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041593 · Cited by 172
Role of Oxidative Stress in Blood–Brain Barrier Disruption and Neurodegenerative Diseases
Kim, S., Jung, U. J., & Kim, S. R. (2024) · Antioxidants · doi:10.3390/antiox13121462 · Cited by 189
Delivery of Biologics Across the Blood–Brain Barrier with Molecular Trojan Horse Technology
Pardridge, W. M. (2017) · BioDrugs · doi:10.1007/s40259-017-0248-z · Cited by 152
Lipid profile disturbances in antipsychotic-naive patients with first-episode non-affective psychosis: A systematic review and meta-analysis
Misiak, B., Stańczykiewicz, B., Łaczmański, Ł., & Frydecka, D. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.03.031 · Cited by 151
SR-BI Mediated Transcytosis of HDL in Brain Microvascular Endothelial Cells Is Independent of Caveolin, Clathrin, and PDZK1
Fung, K. Y., Wang, C., Nyegaard, S., Heit, B., Fairn, G. D., & Lee, W. L. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00841 · Cited by 129
Effect of dietary docosahexaenoic acid (DHA) in phospholipids or triglycerides on brain DHA uptake and accretion
Kitson, A. P., Metherel, A. H., Chen, C. T., Domenichiello, A. F., Trépanier, M., Berger, A., & Bazinet, R. P. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.02.009 · Cited by 112
Interactions of Lipids, Lipoproteins, and Apolipoproteins with the Blood-Brain Barrier
Rhea, E. M., & Banks, W. A. (2021) · Pharmaceutical Research · doi:10.1007/s11095-021-03098-6 · Cited by 104
Adiposity impacts cognitive function in Asian populations: an epidemiological and Mendelian Randomization study
Mina, T. H., Yew, Y. W., Ng, H. K., Sadhu, N., Wansaicheong, G. K. L., Dalan, R., Low, D. Y., Lam, B. C. C., Ríboli, E., Lee, E. S., et al. (2023) · The Lancet Regional Health - Western Pacific · doi:10.1016/j.lanwpc.2023.100710 · Cited by 100
Cholesterol homeostasis: Researching a dialogue between the brain and peripheral tissues
Gliozzi, M., Musolino, V., Bosco, F., Scicchitano, M., Scarano, F., Nucera, S., Zito, M. C., Ruga, S., Carresi, C., Macrì, R., et al. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105215 · Cited by 96
Role of LCAT in Atherosclerosis
Ossoli, A., Simonelli, S., Vitali, C., Franceschini, G., & Calabresi, L. (2015) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.32854 · Cited by 89
Self-citation
The role of high-density lipoprotein cholesterol, apolipoprotein A and paraoxonase-1 in the pathophysiology of neuroprogressive disorders
Morris, G., Puri, B. K., Bortolasci, C. C., Carvalho, A., Berk, M., Walder, K., Moreira, E. G., & Maes, M. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.037 · Cited by 84
Plasma high-density lipoprotein cholesterol and risk of dementia: observational and genetic studies
Kjeldsen, E. W., Thomassen, J. Q., Rasmussen, I. J., Nordestgaard, B. G., Tybjærg‐Hansen, A., & Frikke‐Schmidt, R. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab164 · Cited by 87
24S‐hydroxycholesterol: Cellular effects and variations in brain diseases
Sodero, A. O. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15228 · Cited by 84
The Complex Role of Apolipoprotein E in Alzheimer’s Disease: an Overview and Update
Mahoney‐Sanchez, L., Belaidi, A. A., Bush, A. I., & Ayton, S. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-016-0839-z · Cited by 84
Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine
Onderwater, G. L. J., Ligthart, L., Bot, M., Demirkan, A., Fu, J., Kallen, C., Vijfhuizen, L. S., Pool, R., Liu, J., Vanmolkot, F. H. M., et al. (2019) · Neurology · doi:10.1212/wnl.0000000000007313 · Cited by 74
Increased PCSK9 cerebrospinal fluid concentrations in Alzheimer’s disease
Zimetti, F., Caffarra, P., Ronda, N., Favari, E., Adorni, M. P., Zanotti, I., Bernini, F., Barocco, F., Spallazzi, M., Galimberti, D., et al. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-160411 · Cited by 75
ABCA1- and ABCG1-mediated cholesterol efflux capacity of cerebrospinal fluid is impaired in Alzheimer's disease
Marchi, C., Adorni, M. P., Caffarra, P., Ronda, N., Spallazzi, M., Barocco, F., Galimberti, D., Bernini, F., & Zimetti, F. (2019) · Journal of Lipid Research · doi:10.1194/jlr.p091033 · Cited by 64
APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain
Lefterov, I., Wolfe, C. M., Fitz, N. F., Nam, K. N., Letronne, F., Biedrzycki, R. J., Kofler, J., Han, X., Wang, J., Schug, J., et al. (2019) · Alzheimer's Research & Therapy · doi:10.1186/s13195-019-0558-0 · Cited by 74
DHA brain uptake and APOE4 status: a PET study with [1-11C]-DHA
Yassine, H. N., Croteau, É., Rawat, V., Hibbeln, J. R., Rapoport, S. I., Cunnane, S. C., & Umhau, J. C. (2017) · Alzheimer s Research & Therapy · doi:10.1186/s13195-017-0250-1 · Cited by 80
Metabolic syndrome biomarkers relate to rate of cognitive decline in MCI and dementia stages of Alzheimer’s disease
Pillai, J. A., Bena, J., Bekris, L. M., Kodur, N., Kasumov, T., Leverenz, J. B., Kashyap, S. R., & Initiative, O. B. O. T. A. D. N. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01203-y · Cited by 72
Clinical and pathophysiological evidence supporting the safety of extremely low LDL levels—The zero-LDL hypothesis
Masana, L., Girona, J., Ibarretxe, D., Rodríguez‐Calvo, R., Rosales, R., Vallvé, J.-C., Rodríguez-Borjabad, C., Guardiola, M., Rodríguez, M. M., Guaita‐Esteruelas, S., et al. (2018) · Journal of clinical lipidology · doi:10.1016/j.jacl.2017.12.018 · Cited by 71
Protective associations of HDL with blood-brain barrier injury in multiple sclerosis patients
Fellows, K., Uher, T., Browne, R. W., Weinstock‐Guttman, B., Horáková, D., Posová, H., Vaněčková, M., Seidl, Z., Krásenský, J., Týblová, M., et al. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m060970 · Cited by 68
Shedding light on thyroid hormone disorders and Parkinson disease pathology: mechanisms and risk factors
Mohammadi, S., Dolatshahi, M., & Rahmani, F. (2020) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01314-5 · Cited by 65
Peripheral versus central nervous system APOE in Alzheimer’s disease: Interplay across the blood-brain barrier
Chernick, D., Ortiz‐Valle, S., Jeong, A., Qu, W., & Li, L. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134306 · Cited by 64
Blood-brain barrier transporters: An overview of function, dysfunction in Alzheimer’s disease and strategies for treatment
Chaves, J. C. S., Dando, S. J., White, A. R., & Oikari, L. E. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166967 · Cited by 62
Neuronal extracellular microRNAs miR‐124 and miR‐9 mediate cell–cell communication between neurons and microglia
Veremeyko, T., Kuznetsova, I. S., Dukhinova, M., W. Y. Yung, A., Kopeikina, E., Barteneva, N. S., & Ponomarev, E. D. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24344 · Cited by 52
The Extent of Human Apolipoprotein A-I Lipidation Strongly Affects the β-Amyloid Efflux Across the Blood-Brain Barrier in vitro
Magro, R. D., Simonelli, S., Cox, A., Formicola, B., Corti, R., Cassina, V., Nardo, L., Mantegazza, F., Salerno, D., Grasso, G., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00419 · Cited by 58
Self-citation
HDL Proteome and Alzheimer’s Disease: Evidence of a Link
Marsillach, J., Adorni, M. P., Zimetti, F., Papotti, B., Zuliani, G., & Cervellati, C. (2020) · Antioxidants · doi:10.3390/antiox9121224 · Cited by 61
Brain Lipids and Lipid Droplet Dysregulation in Alzheimer’s Disease and Neuropsychiatric Disorders
Zhao, X., Zhang, S., Sanders, A. R., & Duan, J. (2023) · Complex Psychiatry · doi:10.1159/000535131 · Cited by 54
Role of Apolipoproteins and α-Synuclein in Parkinson’s Disease
Emamzadeh, F. N. (2017) · Journal of Molecular Neuroscience · doi:10.1007/s12031-017-0942-9 · Cited by 54
Interdependence of oxysterols with cholesterol profiles in multiple sclerosis
Mukhopadhyay, S., Fellows, K., Browne, R. W., Khare, P., Radhakrishnan, S. K., Hagemeier, J., Weinstock‐Guttman, B., Zivadinov, R., & Ramanathan, M. K. (2016) · Multiple Sclerosis Journal · doi:10.1177/1352458516666187 · Cited by 53
Metabolomics profiling of concussion in adolescent male hockey players: a novel diagnostic method
Daley, M., Dekaban, G. A., Bartha, R., Brown, A. M., Stewart, T. C., Doherty, T. J., Fischer, L. K., Holmes, J., Menon, R. S., Rupar, C. A., et al. (2016) · Metabolomics · doi:10.1007/s11306-016-1131-5 · Cited by 53
Dual Channel Microfluidics for Mimicking the Blood–Brain Barrier
Buchroithner, B., Mayr, S., Hauser, F., Priglinger, E., Stangl, H., Santa-Maria, A. R., Deli, M. A., Dér, A., Klar, T. A., Axmann, M., et al. (2021) · ACS Nano · doi:10.1021/acsnano.0c09263 · Cited by 54
HDL-cholesterol and apolipoproteins in relation to dementia
Koch, M., & Jensen, M. K. (2015) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000257 · Cited by 53
Brain‐derived neurotrophic factor modulates cholesterol homeostasis and Apolipoprotein E synthesis in human cell models of astrocytes and neurons
Spagnuolo, M. S., Donizetti, A., Iannotta, L., Aliperti, V., Cupidi, C., Bruni, A. C., & Cigliano, L. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26480 · Cited by 55
Connection between the Altered HDL Antioxidant and Anti-Inflammatory Properties and the Risk to Develop Alzheimer’s Disease: A Narrative Review
Zimetti, F., Adorni, M. P., Marsillach, J., Marchi, C., Trentini, A., Valacchi, G., & Cervellati, C. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6695796 · Cited by 49
Advances in high-density lipoprotein physiology: surprises, overturns, and promises
Constantinou, C., Karavia, E. A., Xepapadaki, E., Πετροπούλου, Π.-Ι., Παπακώστα, Ε., Karavyraki, M., Zvintzou, E., Theodoropoulos, V., Filou, S., Hatziri, A., et al. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00429.2015 · Cited by 48
Influence of metabolic syndrome on cerebral perfusion and cognition
Livingston, J. M., McDonald, M. W., Gagnon, T., Jeffers, M. S., Gomez-Smith, M., Antonescu, S., Cron, G. O., Boisvert, C., Lacoste, B., & Corbett, D. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104756 · Cited by 49
Phytosterols: Targeting Neuroinflammation in Neurodegeneration
Dash, R., Mitra, S., Ali, M. C., Oktaviani, D. F., Hannan, M. A., Choi, S. M., & Moon, I. S. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200628022812 · Cited by 47
Anti-Aging and Tissue Regeneration Ability of Policosanol Along with Lipid-Lowering Effect in Hyperlipidemic Zebrafish via Enhancement of High-Density Lipoprotein Functionality
Lee, E., Yoo, J., Lim, S.-M., & Cho, K. (2015) · Rejuvenation Research · doi:10.1089/rej.2015.1745 · Cited by 44
miRNA and cholesterol homeostasis
Jeon, T.-I., & Osborne, T. F. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.01.005 · Cited by 43
α-Synuclein Interacts with Lipoproteins in Plasma
Emamzadeh, F. N., & Allsop, D. (2017) · Journal of Molecular Neuroscience · doi:10.1007/s12031-017-0967-0 · Cited by 43
Emerging role of HDL in brain cholesterol metabolism and neurodegenerative disorders
Turri, M., Marchi, C., Adorni, M. P., Calabresi, L., & Zimetti, F. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2022.159123 · Cited by 54
Self-citation
HDL-like-Mediated Cell Cholesterol Trafficking in the Central Nervous System and Alzheimer’s Disease Pathogenesis
Borràs, C., Mercer, A., Sirisi, S., Alcolea, D., Escolà-Gil, J. C., Blanco-Vaca, F., & Tondo, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169356 · Cited by 39
PCSK9 affects astrocyte cholesterol metabolism and reduces neuron cholesterol supplying in vitro: potential implications in Alzheimer’s disease
Papotti, B., Adorni, M. P., Marchi, C., Zimetti, F., Ronda, N., Panighel, G., Lupo, M. G., Vilella, A., Giuliani, D., Ferri, N., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012192 · Cited by 41
Enhanced liver X receptor signalling reduces brain injury and promotes tissue regeneration following experimental intracerebral haemorrhage: roles of microglia/macrophages
Zhang, R., Dong, Y., Liu, Y., Moezzi, D., Ghorbani, S., Mirzaei, R., Lozinski, B. M., Dunn, J. F., Yong, V. W., & Xue, M. (2023) · Stroke and Vascular Neurology · doi:10.1136/svn-2023-002331 · Cited by 42
The effect of midlife cardiovascular risk factors on white matter hyperintensity volume and cognition two decades later in normal ageing women
Aljondi, R., Szoeke, C. E. I., Steward, C., Gorelik, A., & Desmond, P. M. (2018) · Brain Imaging and Behavior · doi:10.1007/s11682-018-9970-5 · Cited by 46
Fatty acids and beyond: Age and Alzheimer's disease related changes in lipids reveal the neuro-nutraceutical potential of lipids in cognition
Ooi, K.-L. M., Vacy, K., & Boon, W. C. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105143 · Cited by 42
Evaluating the link between Paraoxonase-1 levels and Alzheimer's disease development
Cervellati, C., Valacchi, G., Tisato, V., Zuliani, G., & Marsillach, J. (2019) · Minerva Medica · doi:10.23736/s0026-4806.18.05875-5 · Cited by 40
High-density lipoprotein in Alzheimer's disease: From potential biomarkers to therapeutics
Jin, Y., Chifodya, K., Han, G., Jiang, W., Chen, Y., Shi, Y., Xu, Q., Xi, Y., Wang, J., Zhou, J., et al. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.08.018 · Cited by 41
Inflammation as a Possible Link Between Dyslipidemia and Alzheimer’s Disease
Oliveira, B. C. D. L., Bellozi, P. M. Q., Reis, H. J., & de Oliveira, A. C. P. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.02.012 · Cited by 39
Reduction in Brain Heparan Sulfate with Systemic Administration of an IgG Trojan Horse–Sulfamidase Fusion Protein in the Mucopolysaccharidosis Type IIIA Mouse
Boado, R. J., Lu, J. Z., Hui, E. K., & Pardridge, W. M. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00958 · Cited by 38
Lipid efflux mechanisms, relation to disease and potential therapeutic aspects
Castaño, D., Rattanasopa, C., Monteiro-Cardoso, V. F., Corlianò, M., Liu, Y., Zhong, A., Rusu, M., Liehn, E. A., & Singaraja, R. R. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.04.013 · Cited by 37
Apolipoprotein E isoform-dependent effects on the processing of Alzheimer's amyloid-β
Chai, A. B., Lam, H. H. J., Kockx, M., & Gelissen, I. C. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.158980 · Cited by 41
Association of High-Density Lipoprotein Cholesterol Variability and the Risk of Developing Parkinson Disease
Park, J., Lee, C.-W., Nam, M. J., Kim, H., Kwon, D.-Y., Yoo, J. W., Lee, K. N., Han, K., Jung, J., Park, Y. G., et al. (2021) · Neurology · doi:10.1212/wnl.0000000000011553 · Cited by 35
Proprotein convertase subtilisin/kexin type 9 (PCSK9) in the central nervous system
Bell, A. S., Wagner, J., Rosoff, D. B., & Lohoff, F. W. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105155 · Cited by 36
Understanding the Exchange of Systemic HDL Particles Into the Brain and Vascular Cells Has Diagnostic and Therapeutic Implications for Neurodegenerative Diseases
Valkenburgh, J. S. V., Meuret, C. J., Martinez, A. E., Kodancha, V., Solomon, V. A., Chen, K., & Yassine, H. N. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.700847 · Cited by 38
Relation between plasma and brain lipids
Wellington, C. L., & Frikke-Schmidt, R. (2016) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000291 · Cited by 33
Self-citation
Lipids at the Nexus between Cerebrovascular Disease and Vascular Dementia: The Impact of HDL-Cholesterol and Ceramides
Sergi, D., Zauli, E., Tisato, V., Secchiero, P., Zauli, G., & Cervellati, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054403 · Cited by 32
Modulation of blood-brain barrier function by a heteroduplex oligonucleotide in vivo
Kuwahara, H., Song, J., Shimoura, T., Yoshida‐Tanaka, K., Mizuno, T., Mochizuki, T., Zeniya, S., Li, F., Nishina, K., Nagata, T., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-22577-2 · Cited by 30
Cholesterol Metabolism in Neurodegenerative Diseases
He, K., Zhao, Z., Zhang, J., Li, D., Wang, S., & Liu, Q. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2024.0674 · Cited by 30
Differential effects of apoE4 and activation of ABCA1 on brain and plasma lipoproteins
Boehm-Cagan, A., Bar, R., Harats, D., Shaish, A., Levkovitz, H., Bielicki, J. K., Johansson, J. O., & Michaelson, D. M. (2016) · PLOS ONE · doi:10.1371/journal.pone.0166195 · Cited by 29
Effect of the ABCA1 agonist CS-6253 on amyloid-β and lipoprotein metabolism in cynomolgus monkeys
Noveir, S. D., Kerman, B. E., Xian, H., Meuret, C. J., Smadi, S., Martinez, A. E., Johansson, J., Zetterberg, H., Parks, B. A., Kuklenyik, Z., et al. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-01028-1 · Cited by 30
Analogues of desferrioxamine B designed to attenuate iron-mediated neurodegeneration: synthesis, characterisation and activity in the MPTP-mouse model of Parkinson's disease
Gotsbacher, M. P., Telfer, T. J., Witting, P. K., Double, K. L., Finkelstein, D. I., & Codd, R. (2017) · Metallomics · doi:10.1039/c7mt00039a · Cited by 28
General intelligence is associated with subclinical inflammation in Nepalese children: A population-based plasma proteomics study
Lee, S. E., West, K. P., Cole, R. N., Schulze, K. J., Wu, L. S., Yager, J. D., Groopman, J. D., & Christian, P. S. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.03.023 · Cited by 28
Elevated OPRD1 promoter methylation in Alzheimer’s disease patients
Ji, H., Wang, Y., Liu, G., Chang, L. Y., Chen, Z., Zhou, D., Xu, X., Cui, W., Hong, Q., Jiang, L., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172335 · Cited by 27
A Novel Perspective on the ApoM-S1P Axis, Highlighting the Metabolism of ApoM and Its Role in Liver Fibrosis and Neuroinflammation
Hajny, S., & Christoffersen, C. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081636 · Cited by 28
Human cerebrospinal fluid contains diverse lipoprotein subspecies enriched in proteins implicated in central nervous system health
Merrill, N. J., Davidson, W. S., He, Y., Díaz Ludovico, I., Sarkar, S., Berger, M. R., McDermott, J. E., Van Eldik, L. J., Wilcock, D. M., Monroe, M. E., et al. (2023) · Science Advances · doi:10.1126/sciadv.adi5571 · Cited by 27
Genetic variation in clusterin and risk of dementia and ischemic vascular disease in the general population: cohort studies and meta-analyses of 362,338 individuals
Nordestgaard, L. T., Tybjærg‐Hansen, A., Rasmussen, K. L., Nordestgaard, B. G., & Frikke‐Schmidt, R. (2018) · BMC Medicine · doi:10.1186/s12916-018-1029-3 · Cited by 25
Identification of blood-based biomarkers for diagnosis and prognosis of Parkinson’s disease: A systematic review of proteomics studies
Chelliah, S. S., Bhuvanendran, S., Magalingam, K. B., Kamarudin, M. N. A., & Radhakrishnan, A. K. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101514 · Cited by 27
LXRβ controls glioblastoma cell growth, lipid balance, and immune modulation independently of ABCA1
Patel, D., Ahmad, F., Kambach, D. M., Sun, Q., Halim, A. S., Kramp, T. R., Camphausen, K. A., & Stommel, J. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-51865-8 · Cited by 27
Sterol and lipid analyses identifies hypolipidemia and apolipoprotein disorders in autism associated with adaptive functioning deficits
Tierney, E., Remaley, A. T., Thurm, A., Jager, L. R., Wassif, C. A., Kratz, L. E., Bailey-Wilson, J. E., Bukelis, I., Sarphare, G., Jung, E. S., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01580-8 · Cited by 26
Association of Circulating Apolipoprotein AI Levels in Patients With Alzheimer's Disease: A Systematic Review and Meta-Analysis
Tong, J., Gong, S., Zhang, Y.-S., Dong, J.-R., Zhong, X., Wei, M., & Liu, M. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.899175 · Cited by 28
Plasma and cerebrospinal fluid cholesterol esterification is hampered in Alzheimer’s disease
Turri, M., Conti, E., Pavanello, C., Gastoldi, F., Palumbo, M., Bernini, F., Aprea, V., Re, F., Barbiroli, A., Emide, D., et al. (2023) · Alzheimer's Research & Therapy · doi:10.1186/s13195-023-01241-6 · Cited by 27
Self-citation
Neurological aspects of SARS-CoV-2 infection: lipoproteins and exosomes as Trojan horses
Lam, S. M., Huang, X., & Shui, G. (2022) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2022.04.011 · Cited by 25
Suppression of brain cholesterol synthesis in male Mecp2-deficient mice is age dependent and not accompanied by a concurrent change in the rate of fatty acid synthesis
Lopez, A. M., Chuang, J.-C., Posey, K. S., & Turley, S. D. (2017) · Brain Research · doi:10.1016/j.brainres.2016.10.021 · Cited by 24
Schweinfurthins: Lipid Modulators with Promising Anticancer Activity
Koubek, E. J., Weissenrieder, J., Neighbors, J. D., & Hohl, R. J. (2018) · Lipids · doi:10.1002/lipd.12088 · Cited by 24
Apolipoprotein E3-mediated cellular uptake of reconstituted high-density lipoprotein bearing core 3, 10, or 17 nm hydrophobic gold nanoparticles
Chuang, S. T., Shon, Y., & Narayanaswami, V. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s145326 · Cited by 24
An innate immune response and altered nuclear receptor activation defines the spinal cord transcriptome during alpha-tocopherol deficiency in Ttpa-null mice
Finno, C. J., Bordbari, M. H., Gianino, G., Ming-Whitfield, B., Burns, E., Merkel, J., Britton, M., Durbin-Johnson, B. P., Sloma, E. A., McMackin, M. Z., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.02.037 · Cited by 22
Circadian Regulation of Apolipoproteins in the Brain: Implications in Lipid Metabolism and Disease
Lee, C., Murrell, C. E., Chu, A., & Pan, X. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417415 · Cited by 20
Emerging Lipid Targets in Glioblastoma
Darwish, A., Pammer, M., Gallyas, F., Vígh, L., Balogi, Z., & Juhász, K. (2024) · Cancers · doi:10.3390/cancers16020397 · Cited by 22
Spotlight on HDL biology: new insights in metabolism, function, and translation
Rader, D. J. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu164 · Cited by 21
Intra- and intercellular trafficking in sphingolipid metabolism in myelination
Wattenberg, B. W. (2018) · Advances in Biological Regulation · doi:10.1016/j.jbior.2018.11.002 · Cited by 21
A Human-Based Integrated Framework forAlzheimer’s Disease Research
Pistollato, F., Cavanaugh, S. E., & Chandrasekera, P. C. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150281 · Cited by 21
Cognitive impairments in HCV infection: From pathogenesis to neuroimaging
Amirsardari, Z., Rahmani, F., & Rezaei, N. (2019) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2019.1652728 · Cited by 20

Authors: Vitali, C., Wellington, C. L., & Calabresi, L.
Affiliations: University of Milan (IT)
University of British Columbia (CA)
Corresponding author: Calabresi, L.
ORCID: Vitali, C.
Wellington, C. L.
Calabresi, L.
Venue: Cardiovascular Research
Publisher: Oxford University Press (OUP)
Published: 2014-06-06
Volume: 103
Issue: 3
Pages: 405-413
ISSN: 0008-6363 (ISSN-L)
DOI: 10.1093/cvr/cvu148
OpenAlex: W2098990121
Cited by: 254
References: 131
Citations by year: 2026: 18 · 2025: 32 · 2024: 25 · 2023: 26 · 2022: 21 · 2021: 30 · 2020: 11 · 2019: 21 · 2018: 21 · 2017: 19 · 2016: 16 · 2015: 10 · 2014: 3
FWCI: 3.03
Type: journal article
Language: en
Open access: closed
Locations: Cardiovascular Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: high-density lipoprotein, brain cholesterol, cholesterol metabolism, apolipoprotein E, apolipoprotein A-I, astrocytes, oligodendrocytes, microglia, 27-hydroxycholesterol, scavenger receptor class B type I, lipid transfer proteins, cognitive impairment, neurodegenerative diseases, Tangier disease, lipid trafficking, genetic lipid disorders
MeSH terms: Animals, Apolipoproteins, Brain, Humans, Cholesterol, HDL, Phenotype, Risk Factors, Neurodegenerative Diseases, Genetic Predisposition to Disease

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

HDL and cholesterol handling in the brain

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks