The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Sarcopenia: Current Concepts
Abstract
Sarcopenia, the loss of muscle mass and strength with age, is becoming recognized as a major cause of disability and morbidity in the elderly population. Sarcopenia is part of normal aging and does not require a disease to occur, although muscle wasting is accelerated by chronic diseases. Sarcopenia is thought to have multiple causes, although the relative importance of each is not clear. Neurological, metabolic, hormonal, nutritional, and physical-activity-related changes with age are likely to contribute to the loss of muscle mass. In this review, we discuss current concepts of the pathogenesis, treatment, and prevention of sarcopenia.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Changes in energy balance and body composition at menopause: a controlled longitudinal study.
Poehlman, E. T., Toth, M. J., & Gardner, A. W. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-123-9-199511010-00005 · Cited by 520 · cited 2×
“Acceleration of lean tissue loss is seen during the menopausal years in women (19,20).”
BackgroundRetractedEpidemiology of Sarcopenia among the Elderly in New Mexico
Baumgartner, R. N., Koehler, K. M., Gallagher, D., Romero, L., Heymsfield, S. B., Ross, R. R., Garry, P. J., & Lindeman, R. D. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009520 · Cited by 4,004
Exercise training and nutritional supplementation for physical frailty in very elderly people
Fiatarone, M. A., O'Neill, E. F., Ryan, N. D., Clements, K. M., Solares, G. R., Nelson, M. E., Roberts, S. B., Kehayias, J. J., Lipsitz, L. A., & Evans, W. J. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406233302501 · Cited by 2,857
High-Intensity Strength Training in Nonagenarians: Effects on Skeletal Muscle
Fiatarone, M. A. (1990) · JAMA · doi:10.1001/jama.1990.03440220053029 · Cited by 1,593
Aging of skeletal muscle: a 12-yr longitudinal study
Frontera, W. R., Hughes, V. A., Fielding, R. A., Fiatarone, M. A., Evans, W. J., & Roubenoff, R. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.4.1321 · Cited by 1,443
Self-citationLife and Death of Neurons in the Aging Brain
Morrison, J. H., & Hof, P. R. (1997) · Science · doi:10.1126/science.278.5337.412 · Cited by 1,344
Kern, P. A., Saghizadeh, M., Ong, J. M., Bosch, R. J., Deem, R., & Simsolo, R. B. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117899 · Cited by 1,305
Glucose Transporters and Insulin Action — Implications for Insulin Resistance and Diabetes Mellitus
Shepherd, P. R., & Kahn, B. B. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907223410406 · Cited by 1,295
Reduced Rate of Energy Expenditure as a Risk Factor for Body-Weight Gain
Ravussin, E., Lillioja, S., Knowler, W. C., Christin, L., Freymond, D., Abbott, W. G. H., Boyce, V., Howard, B. V., & Bogardus, C. (1988) · New England Journal of Medicine · doi:10.1056/nejm198802253180802 · Cited by 1,215
Appendicular skeletal muscle mass: effects of age, gender, and ethnicity
Gallagher, D., Visser, M., De Meersman, R. E., Sepúlveda, D., Baumgartner, R. N., Pierson, R. N., Harris, T., & Heymsfield, S. B. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.83.1.229 · Cited by 966
Predictors of skeletal muscle mass in elderly men and women
Baumgartner, R. N., Waters, D. L., Gallagher, D., Morley, J. E., & Garry, P. J. (1999) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00130-4 · Cited by 809 · cited 1×
“However, Baumgartner and colleagues (93), using the New Mexico data, recently performed a cross-sectional analysis evaluating the relative contributions of physical activity, dietary energy and protein, health status, serum testosterone, estrone, sex hormone-binding globulin, IGF-1 in 121 men and 180 women aged 65 to…”
BackgroundPhysical Fitness as a Predictor of Mortality among Healthy, Middle-Aged Norwegian Men
Sandvik, L., Erikssen, J., Thaulow, E., Erikssen, G., Mundal, R., & Rodahl, K. (1993) · New England Journal of Medicine · doi:10.1056/nejm199302253280803 · Cited by 788
Association of Muscle Power With Functional Status in Community-Dwelling Elderly Women
Foldvari, M., Clark, M., Laviolette, L. C., Bernstein, M. A., Kaliton, D., Castaneda, C., Pu, C. T., Hausdorff, J. M., Fielding, R. A., & Singh, M. A. F. (2000) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/55.4.m192 · Cited by 653
Monocyte Cytokine Production in an Elderly Population: Effect of Age and Inflammation
Roubenoff, R., Harris, T. B., Abad, L. W., Wilson, P. W. F., Dallal, G. E., & Dinarello, C. A. (1998) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/53a.1.m20 · Cited by 418 · cited 1×
“For example, Roubenoff and colleagues (90) found that production of IL-6 and IL-1Ra by peripheral blood mononuclear cells (PBMC) from ambulatory elderly participants (72–92 years old) in the Framingham Heart Study was significantly higher than from younger controls ( , 40 years old) (90).”
BackgroundSelf-citationAging, body composition, and lifestyle: the Fels Longitudinal Study
Guo, S. S., Zeller, C., Chumlea, W. C., & Siervogel, R. M. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.3.405 · Cited by 408
Skeletal muscle utilization of free fatty acids in women with visceral obesity.
Colberg, S. R., Simoneau, J. A., Thaete, F. L., & Kelley, D. E. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117864 · Cited by 320
Castaneda, C., Charnley, J., Evans, W., & Crim, M. (1995) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.1.30 · Cited by 290
Cornoni-Huntley, J. C., Harris, T. B., Everett, D. F., Albanes, D., Micozzi, M. S., Miles, T. P., & Feldman, J. J. (1991) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(91)90126-t · Cited by 276
Protein dynamics in whole body and in splanchnic and leg tissues in type I diabetic patients.
Nair, K. S., Ford, G. C., Ekberg, K., Fernqvist-Forbes, E., & Wahren, J. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118000 · Cited by 239
Diagnosis of Infective Endocarditis: Sensitivity of the Duke vs von Reyn Criteria
Heiro, M., Nikoskelainen, J., Hartiala, J. J., Saraste, M. K., & Kotilainen, P. M. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.1.18 · Cited by 62
Research works printed but not linked: 91
- Rosenberg, 1989, The American Journal of Clinical Nutrition, 50, 1231, 10.1093/ajcn/50.5.1231 · DOI · Paper page
- Pollock, 1997, Journal of Applied Physiology, 82, 1508, 10.1152/jappl.1997.82.5.1508 · DOI · Paper page
- 1979, J CLIN EXP GERONTOL, 1, 185
- Fleg, 1988, Journal of Applied Physiology, 65, 1147, 10.1152/jappl.1988.65.3.1147 · DOI · Paper page
- 1972, Journal of Gerontology, 27, 438, 10.1093/geronj/27.4.438 · DOI · Paper page
- Forbes, 1970, Metabolism: clinical and experimental, 19, 653, 10.1016/0026-0495(70)90062-4 · DOI · Paper page
- Frontera, 1991, Journal of Applied Physiology, 71, 644, 10.1152/jappl.1991.71.2.644 · DOI · Paper page
- 1990, Journals of Gerontology Series A: Biological and Medical Sciences, 45, M82
- 1980, American Journal of Physiology -- Legacy Content, 239, E524
- Kehayias, 1997, The American Journal of Clinical Nutrition, 66, 904, 10.1093/ajcn/66.4.904 · DOI
- 1990, Biological Trace Element Research, 2627, 385
- 1997, American Journal of Physiology -- Legacy Content, 272, E781
- Tracy, 1999, Journal of Applied Physiology, 86, 195, 10.1152/jappl.1999.86.1.195 · DOI · Paper page
- 2000, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 55, B152, 10.1093/gerona/55.3.B152 · DOI
- 2000, American Journal of Physiology -- Legacy Content, 279, C611
- Flynn, 1989, The American Journal of Clinical Nutrition, 50, 713, 10.1093/ajcn/50.4.713 · DOI
- Aloia, 1991, The American Journal of Clinical Nutrition, 53, 1378, 10.1093/ajcn/53.6.1378 · DOI
- Poehlman, 1995, Annals of Internal Medicine, 123, 673, 10.1059/0003-4819-123-9-199511010-00005 · DOI
- Siervogel, 1998, Arteriosclerosis, Thrombosis, and Vascular Biology, 18, 1759, 10.1161/01.ATV.18.11.1759 · DOI
- Marti, 1990, Journal of Applied Physiology, 69, 1451, 10.1152/jappl.1990.69.4.1451 · DOI
- Chien, 1975, Journal of Applied Physiology, 39, 825, 10.1152/jappl.1975.39.5.825 · DOI
- 1996, European journal of applied physiology, 72, 215, 10.1007/BF00838641 · DOI
- 1982, European journal of applied physiology, 49, 187, 10.1007/BF02334067 · DOI
- 1997, Scandinavian journal of social medicine, 53, 19
- Jackson, 1995, Medicine and Science in Sports and Exercise, 27, 113, 10.1249/00005768-199501000-00020 · DOI
- 1979, Journal of Gerontology, 34, 512, 10.1093/geronj/34.4.512 · DOI
- Sowers, 1996, Annals of human biology, 23, 253, 10.1080/03014469600004472 · DOI
- Jackson, 1996, Medicine and Science in Sports and Exercise, 28, 884, 10.1097/00005768-199607000-00016 · DOI
- Rooyackers, 1996, PNAS, 93, 15364, 10.1073/pnas.93.26.15364 · DOI · Paper page
- 1997, American Journal of Physiology -- Legacy Content, 273, E790
- Short, 2000, Current opinion in clinical nutrition and metabolic care, 3, 39, 10.1097/00075197-200001000-00007 · DOI
- Rall, 1996, Arthritis and rheumatism, 39, 1115, 10.1002/art.1780390707 · DOI
- 1989, American Journal of Physiology -- Legacy Content, 256, E829
- Launer, 1994, JAMA, 271, 1093, 10.1001/jama.1994.03510380049036 · DOI · Paper page
- H kkinen, 1996, Acta physiologica Scandinavica, 158, 77, 10.1046/j.1365-201X.1996.523293000.x · DOI
- 1994, Acta physiologica Scandinavica, 616, 5
- 1999, Medicine and Science in Sports and Exercise, 31, S377
- Jozsi, 1999, Journals of Gerontology Series A: Biological and Medical Sciences, 54, 591M, 10.1093/gerona/54.11.M591 · DOI · Paper page
- Brown, 1972, Journal of Neurology, Neurosurgery & Psychiatry, 35, 845, 10.1136/jnnp.35.6.845 · DOI · Paper page
- Sjobeck, 1999, Journals of Gerontology Series A: Biological and Medical Sciences, 54, 363B, 10.1093/gerona/54.9.B363 · DOI
- Grinspoon, 1997, Journal of Clinical Endocrinology & Metabolism, 82, 1332, 10.1210/jc.82.5.1332 · DOI
- Kaufman, 1997, Bailli re's clinical endocrinology and metabolism, 11, 289, 10.1016/S0950-351X(97)80302-3 · DOI · Paper page
- Morley, 1997, Metabolism: clinical and experimental, 46, 410, 10.1016/S0026-0495(97)90057-3 · DOI · Paper page
- Pottratz, 1994, Journal of Clinical Investigation, 93, 944, 10.1172/JCI117100 · DOI · Paper page
- Ralston, 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 9, 883, 10.1002/jbmr.5650090614 · DOI
- De, 1992, Developmental biology, 151, 297, 10.1016/0012-1606(92)90234-8 · DOI
- Roubenoff, 1998, Journal of Clinical Endocrinology & Metabolism, 83, 1502, 10.1210/jc.83.5.1502 · DOI
- Coutant, 1998, European Journal of Endocrinology, 139, 591, 10.1530/eje.0.1390591 · DOI
- 1999, Clinical endocrinology, 51, 556
- Cocchi, 1999, Journal of Endocrinology, 162, 95, 10.1677/joe.0.1620095 · DOI
- Roh, 1998, Neuroendocrinology, 68, 361, 10.1159/000054385 · DOI
- 1922, J METAB RES, 11, 767
- WALSH, 1976, QJM, 45, 295
- Charlton, 1997, Diabetes, 46, 1336, 10.2337/diabetes.46.8.1336 · DOI
- 1993, American Journal of Physiology -- Legacy Content, 264, E855
- Barzilai, 1999, Diabetes, 48, 94, 10.2337/diabetes.48.1.94 · DOI · Paper page
- Cox, 1999, Journal of Applied Physiology, 86, 2019, 10.1152/jappl.1999.86.6.2019 · DOI
- Hotamisligil, 1994, PNAS, 91, 4854, 10.1073/pnas.91.11.4854 · DOI · Paper page
- Williamson, 1993, Annals of Internal Medicine, 119, 646, 10.7326/0003-4819-119-7_Part_2-199310011-00004 · DOI · Paper page
- Rissanen, 1988, International journal of obesity, 12, 391
- Shimokata, 1989, International journal of obesity, 13, 455
- Rantanen, 1997, Journal of the American Geriatrics Society, 45, 1439, 10.1111/j.1532-5415.1997.tb03193.x · DOI · Paper page
- Kuta, 1970, Journal of Applied Physiology, 29, 168, 10.1152/jappl.1970.29.2.168 · DOI
- Hakim, 1998, New England Journal of Medicine, 338, 94, 10.1056/NEJM199801083380204 · DOI · Paper page
- Bamman, 1998, Journal of Applied Physiology, 84, 157, 10.1152/jappl.1998.84.1.157 · DOI · Paper page
- Hortobagyi, 2000, The Journal of Physiology, 524, 293, 10.1111/j.1469-7793.2000.00293.x · DOI · Paper page
- 1999, American Journal of Physiology -- Legacy Content, 276, R1739
- Uauy, 1978, The American Journal of Clinical Nutrition, 31, 779, 10.1093/ajcn/31.5.779 · DOI
- Cheng, 1978, The American Journal of Clinical Nutrition, 31, 12, 10.1093/ajcn/31.1.12 · DOI
- Zanni, 1979, The Journal of Nutrition, 109, 513, 10.1093/jn/109.3.513 · DOI
- Gersovitz, 1982, The American Journal of Clinical Nutrition, 35, 6, 10.1093/ajcn/35.1.6 · DOI
- Bunker, 1987, The British journal of nutrition, 57, 211, 10.1079/BJN19870027 · DOI
- 1999, The FASEB Journal, 13, A52
- Tilg, 1994, Blood, 83, 113, 10.1182/blood.V83.1.113.113 · DOI · Paper page
- Yeh, 1999, The American Journal of Clinical Nutrition, 70, 183, 10.1093/ajcn.70.2.183 · DOI
- Bhasin, 1996, New England Journal of Medicine, 335, 1, 10.1056/NEJM199607043350101 · DOI · Paper page
- 1995, American Journal of Physiology -- Legacy Content, 269, E820
- Sih, 1997, Journal of Clinical Endocrinology & Metabolism, 82, 1661, 10.1210/jc.82.6.1661 · DOI · Paper page
- Lieberman, 1997, Clinics in geriatric medicine, 13, 671, 10.1016/S0749-0690(18)30143-5 · DOI
- Vahl, 2000, Journal of Clinical Endocrinology & Metabolism, 85, 1874, 10.1210/jc.85.5.1874 · DOI
- Nelson, 1994, JAMA, 272, 1909, 10.1001/jama.1994.03520240037038 · DOI · Paper page
- Rall, 1996, Arthritis and rheumatism, 39, 415, 10.1002/art.1780390309 · DOI
- Beniamini, 1997, The American journal of cardiology, 80, 841, 10.1016/S0002-9149(97)00533-X · DOI
- Geliebter, 1997, The American Journal of Clinical Nutrition, 66, 557, 10.1093/ajcn/66.3.557 · DOI
- Ballor, 1988, The American Journal of Clinical Nutrition, 47, 19, 10.1093/ajcn/47.1.19 · DOI
- Pannemans, 1995, The American Journal of Clinical Nutrition, 61, 33, 10.1093/ajcn/61.1.33 · DOI
- Campbell, 1994, The American Journal of Clinical Nutrition, 60, 501, 10.1093/ajcn/60.4.501 · DOI · Paper page
- Rosenbaum, 1997, Journal of Clinical Endocrinology & Metabolism, 82, 3647, 10.1210/jc.82.11.3647 · DOI
- Roubenoff, 1996, Nutrition reviews, 54, S40
- Lee, 1999, The American Journal of Clinical Nutrition, 69, 373, 10.1093/ajcn/69.3.373 · DOI · Paper page
- Couillard, 1996, International journal of obesity, 20, 1081
Cited by
Goodpaster, B. H., Park, S. W., Harris, T. B., Kritchevsky, S. B., Nevitt, M., Schwartz, A. V., Simonsick, E. M., Tylavsky, F. A., Visser, M., Newman, A. B., et al. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.10.1059 · Cited by 3,083
Invited Review: Aging and sarcopenia
Doherty, T. J. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00347.2003 · Cited by 1,764
The healthcare costs of sarcopenia in the United States
Janssen, I., Shepard, D. S., Katzmarzyk, P. T., & Roubenoff, R. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52014.x · Cited by 1,546
Self-citationVisser, M., Goodpaster, B. H., Kritchevsky, S. B., Newman, A. B., Nevitt, M., Rubin, S. M., Simonsick, E. M., Harris, T. B., & Study, F. T. H. A. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.3.324 · Cited by 1,403
Mitchell, W. K., Williams, J., Atherton, P., Larvin, M., Lund, J., & Narici, M. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00260 · Cited by 1,377
Metadata
- Authors
- Roubenoff, R., & Hughes, V. A.
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-12-01
- Volume
- 55
- Issue
- 12
- Pages
- M716-M724
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- OpenAlex
- W2097971520
- Cited by
- 685
- References
- 20
- FWCI
- 11.34
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.