The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Markers of Human Skeletal Muscle Mitochondrial Biogenesis and Quality Control: Effects of Age and Aerobic Exercise Training
Open accessAbstract
Perturbations in mitochondrial health may foster age-related losses of aerobic capacity (VO2peak) and skeletal muscle size. However, limited data exist regarding mitochondrial dynamics in aging human skeletal muscle and the influence of exercise. The purpose of this study was to examine proteins regulating mitochondrial biogenesis and dynamics, VO2peak, and skeletal muscle size before and after aerobic exercise training in young men (20 ± 1 y) and older men (74 ± 3 y). Exercise-induced skeletal muscle hypertrophy occurred independent of age, whereas the improvement in VO2peak was more pronounced in young men. Aerobic exercise training increased proteins involved with mitochondrial biogenesis, fusion, and fission, independent of age. This is the first study to examine pathways of mitochondrial quality control in aging human skeletal muscle with aerobic exercise training. These data indicate normal aging does not influence proteins associated with mitochondrial health or the ability to respond to aerobic exercise training at the mitochondrial and skeletal muscle levels.
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In the citing paper
“Recent studies have investigated whether mitochondrial quality control is influenced by aging, but the results are not conclusive and remain to be elucidated (1,2,25,35,36).”
From Chronological Age Does not Influence Ex-vivo Mitochondrial Respiration and Quality Control in Skeletal Muscle (2016) · cites this paper as [25]
In the citing paper
“While Konopka et al. (25) and Bori et al. (36) have found no differences in mitochondrial fusion and fission between young and older subjects”
From Chronological Age Does not Influence Ex-vivo Mitochondrial Respiration and Quality Control in Skeletal Muscle (2016) · cites this paper as [25]
In the citing paper
“Studies that included an exercise intervention have also been performed and reported both similar and distinct quality control responses in young and older adults (25,35,36).”
From Chronological Age Does not Influence Ex-vivo Mitochondrial Respiration and Quality Control in Skeletal Muscle (2016) · cites this paper as [25]
In the citing paper
“Konopka et al. (25) have found an elevation of MFN1, MFN2, and FIS1 protein levels in both young and old subjects with aerobic exercise training (37).”
From Chronological Age Does not Influence Ex-vivo Mitochondrial Respiration and Quality Control in Skeletal Muscle (2016) · cites this paper as [37]
In the citing paper
“Konopka et al. (25) have found an elevation of MFN1, MFN2, and FIS1 protein levels in both young and old subjects with aerobic exercise training (37).”
From Chronological Age Does not Influence Ex-vivo Mitochondrial Respiration and Quality Control in Skeletal Muscle (2016) · cites this paper as [25]
In the citing paper
“In humans, while Mfn2 expression was decreased in aged skeletal muscle in one study [60], others have reported either similar [56,58,59,61] or even higher Mfn2 content in aged skeletal muscles [61].”
From Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging (2021) · cites this paper as [56]
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Metadata
- Authors
- Konopka, A. R., Suer, M. K., Wolff, C. A., & Harber, M. P.
- Affiliations
- Ball State University (US)
- Venue
- The Journals of Gerontology: Series A
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-07-20
- Volume
- 69
- Issue
- 4
- Pages
- 371-378
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- PMC
- PMC3968823
- OpenAlex
- W2144530325
- Cited by
- 187
- References
- 59
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 19 · 2023: 12 · 2022: 17 · 2021: 18 · 2020: 13 · 2019: 23 · 2018: 18 · 2017: 15 · 2016: 17 · 2015: 5 · 2014: 8 · 2013: 3
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG032127, R15AG032127)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- mitochondrial biogenesis, mitochondrial dynamics, mitochondrial quality control, skeletal muscle aging, aerobic exercise training, peak oxygen uptake, skeletal muscle hypertrophy, mitochondrial fusion, mitochondrial fission
- MeSH terms
- Aged, Aging, Humans, Male, Mitochondria, Muscle Proteins, Quality Control, Exercise, Muscle, Skeletal, Mitochondrial Proteins, Young Adult, Mitochondrial Turnover
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