Combined androgen excess and Western-style diet accelerates adipose tissue dysfunction in young adult, female nonhuman primates
Open accessAbstract
STUDY QUESTION: What are the separate and combined effects of mild hyperandrogenemia and consumption of a high-fat Western-style diet (WSD) on white adipose tissue (WAT) morphology and function in young adult female nonhuman primates? SUMMARY ANSWER: Combined exposure to mild hyperandrogenemia and WSD induces visceral omental (OM-WAT) but not subcutaneous (SC-WAT) adipocyte hypertrophy that is associated with increased uptake and reduced mobilization of free fatty acids. WHAT IS KNOWN ALREADY: Mild hyperandrogenemia in females, principally in the context of polycystic ovary syndrome, is often associated with adipocyte hypertrophy, but the mechanisms of associated WAT dysfunction and depot specificity remain poorly understood. STUDY DESIGN, SIZE AND DURATION: Female rhesus macaques were randomly assigned at 2.5 years of age (near menarche) to receive either cholesterol (C; n = 20) or testosterone (T; n = 20)-containing silastic implants to elevate T levels 5-fold above baseline. Half of each of these groups was then fed either a low-fat monkey chow diet or WSD, resulting in four treatment groups (C, control diet; T alone; WSD alone; T + WSD; n = 10/group) that were maintained until the current analyses were performed at 5.5 years of age (3 years of treatment, young adults). PARTICIPANTS/MATERIALS, SETTING AND METHODS: OM and SC-WAT biopsies were collected and analyzed longitudinally for in vivo changes in adipocyte area and blood vessel density, and ex vivo basal and insulin-stimulated fatty acid uptake and basal and isoproterenol-stimulated lipolysis. MAIN RESULTS AND THE ROLE OF CHANCE: In years 2 and 3 of treatment, the T + WSD group exhibited a significantly greater increase in OM adipocyte size compared to all other groups (P < 0.05), while the size of SC adipocytes measured at the end of the study was not significantly different between groups. In year 3, both WAT depots from the WSD and T + WSD groups displayed a significant reduction in local capillary length and vessel junction density (P < 0.05). In year 3, insulin-stimulated fatty acid uptake in OM-WAT was increased in the T + WSD group compared to year 2 (P < 0.05). In year 3, basal lipolysis was blunted in the T and T + WSD groups in both WAT depots (P < 0.01), while isoproterenol-stimulated lipolysis was significantly blunted in the T and T + WSD groups only in SC-WAT (P < 0.01). LIMITATIONS, REASONS FOR CAUTION: At this stage of the study, subjects were still relatively young adults, so that the effects of mild hyperandrogenemia and WSD may become more apparent with increasing age. WIDER IMPLICATIONS OF THE FINDINGS: The combination of mild hyperandrogenemia and WSD accelerates the development of WAT dysfunction through T-specific (suppression of lipolytic response by T), WSD-dependent (reduced capillary density) and combined T + WSD (increased fatty acid uptake) mechanisms. These data support the idea that combined hyperandrogenemia and WSD increases the risk of developing obesity in females. STUDY FUNDING/COMPETING INTEREST(S): Research reported in this publication was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health under award number P50 HD071836 to C.T.R. and award number OD 011092 from the Office of the Director, National Institutes of Health, for operation of the Oregon National Primate Research Center. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In rhesus monkeys, the combination of a high-fat diet and testosterone treatment accelerated development of white adipose tissue dysfunction.
“In a treatment paradigm comparing a high-fat diet with/or without testosterone treatment in rhesus monkeys, the combination of a high-fat diet and testosterone treatment accelerated development of white adipose tissue dysfunction [98].”
From Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls (2019) · cites this paper as [98]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481 · see citing works
Mechanisms of fatty acid-induced inhibition of glucose uptake.
Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,702 · see citing works
Azziz, R., Carmina, E., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H. F., Futterweit, W., Janssen, O. E., Legro, R. S., Norman, R. J., Taylor, A. E., et al. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.06.035 · Cited by 2,132 · see citing works
Diamanti-Kandarakis, E., & Dunaif, A. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1034 · Cited by 1,947 · see citing works
Legro, R. S. (1999) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.1.165 · Cited by 1,743 · see citing works
Rosenfield, R. L., & Ehrmann, D. A. (2016) · Endocrine Reviews · doi:10.1210/er.2015-1104 · Cited by 1,603 · see citing works
Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation
Hosogai, N., Fukuhara, A., Oshima, K., Miyata, Y., Tanaka, S., Segawa, K., Furukawa, S., Tochino, Y., Komuro, R., Matsuda, M., et al. (2007) · Diabetes · doi:10.2337/db06-0911 · Cited by 1,257 · cited 1× · see citing works
“Inadequate expansion of WAT capillary networks during diet-induced obesity is the principal factor responsible for the development of local hypoxia, inflammation and a major contributor to IR (Hosogai et al., 2007; Pasarica et al., 2009; Hodson et al., 2013; Rausch et al., 2008).”
BackgroundA Computational Tool for Quantitative Analysis of Vascular Networks
Zudaire, E., Gambardella, L., Kurcz, C., & Vermeren, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027385 · Cited by 1,074 · see citing works
Dumesic, D. A., Oberfield, S. E., Stener-Victorin, E., Marshall, J. C., Laven, J. S., & Legro, R. S. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1018 · Cited by 1,020 · see citing works
Pou, K. M., Massaro, J. M., Hoffmann, U., Vasan, R. S., Maurovich‐Horvat, P., Larson, M. G., Keaney, J. F., Meigs, J. B., Lipinska, I., Kathiresan, S., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.710509 · Cited by 898 · see citing works
Reduced Adipose Tissue Oxygenation in Human Obesity
Pasarica, M., Sereda, O. R., Redman, L. M., Albarado, D. C., Hymel, D. T., Roan, L. E., Rood, J. C., Burk, D. H., & Smith, S. R. (2009) · Diabetes · doi:10.2337/db08-1098 · Cited by 786 · see citing works
Rausch, M. E., Weisberg, S., Vardhana, P., & Tortoriello, D. V. (2008) · International Journal of Obesity · doi:10.1038/sj.ijo.0803744 · Cited by 585 · see citing works
Evidence for Distinctive and Intrinsic Defects in Insulin Action in Polycystic Ovary Syndrome
Dunaif, A. E., Segal, K. R., Shelley, D., Green, G., Dobrjansky, A., & Licholai, T. (1992) · Diabetes · doi:10.2337/diab.41.10.1257 · Cited by 544 · see citing works
The effect of obesity on polycystic ovary syndrome: a systematic review and meta‐analysis
Lim, S. S., Norman, R. J., Davies, M. J., & Moran, L. J. (2013) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01053.x · Cited by 539 · see citing works
Neeland, I. J., Ayers, C. R., Rohatgi, A. K., Turer, A. T., Berry, J. D., Das, S. R., Vega, G. L., Khera, A., McGuire, D. K., Grundy, S. M., et al. (2013) · Obesity · doi:10.1002/oby.20135 · Cited by 497 · see citing works
Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis
Zeng, W., Pirzgalska, R. M., Pereira, M. M. A., Kubasova, N., Barateiro, A., Seixas, E., Lu, Y.-H., Kozlova, A., Voss, H., Martins, G. G., et al. (2015) · Cell · doi:10.1016/j.cell.2015.08.055 · Cited by 490 · see citing works
Pasquali, R., Antenucci, D., Casimirri, F., Venturoli, S., Paradisi, R., Fabbri, R., Balestra, V., Melchionda, N., & Barbara, L. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-68-1-173 · Cited by 436 · see citing works
Holte, J., Bergh, T., Berne, C., Wide, L., & Lithell, H. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.9.7673399 · Cited by 435 · see citing works
Abdominal adiposity and the polycystic ovary syndrome
Escobar-Morreale, H. F., & Millán, J. L. S. (2007) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2007.07.003 · Cited by 386 · see citing works
Induction of insulin resistance by androgens and estrogens
Polderman, K. H., Gooren, L. J., Asscheman, H., Bakker, A., & Heine, R. J. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.1.8027240 · Cited by 382 · see citing works
Mannerås-Holm, L., Leonhardt, H., Kullberg, J., Jennische, E., Odén, A., Holm, G., Hellström, M., Lönn, L., Olivecrona, G., Stener-Victorin, E., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1290 · Cited by 369 · see citing works
Adipose tissue fibrosis, hypertrophy, and hyperplasia: Correlations with diabetes in human obesity
Muir, L. A., Neeley, C. K., Meyer, K. A., Baker, N. A., Brosius, A. M., Washabaugh, A. R., Varban, O. A., Finks, J. F., Zamarron, B. F., Flesher, C. G., et al. (2016) · Obesity · doi:10.1002/oby.21377 · Cited by 367 · see citing works
Caldwell, A. S. L., Middleton, L. J., Jimenez, M., Desai, R., McMahon, A. C., Allan, C. M., Handelsman, D. J., & Walters, K. A. (2014) · Endocrinology · doi:10.1210/en.2014-1196 · Cited by 338 · see citing works
Cellular mechanisms of insulin resistance in polycystic ovarian syndrome
Ciaraldi, T. P. (1992) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.75.2.577 · Cited by 336 · see citing works
Spritzer, P. M., Lecke, S. B., Satler, F., & Morsch, D. M. (2015) · Reproduction · doi:10.1530/rep-14-0435 · Cited by 330 · see citing works
Insulin Sensitivity, Insulin Secretion, and Abdominal Fat
Wagenknecht, L. E., Langefeld, C. D., Scherzinger, A. L., Norris, J. M., Haffner, S. M., Saad, M. F., & Bergman, R. N. (2003) · Diabetes · doi:10.2337/diabetes.52.10.2490 · Cited by 302 · see citing works
Chen, Y.-H., Heneidi, S. G., Lee, J.-M., Layman, L. C., Stepp, D. W., Gamboa, G. M., Chen, B.-S., Chazenbalk, G. D., & Azziz, R. (2013) · Diabetes · doi:10.2337/db12-0963 · Cited by 286 · see citing works
Thomson, R. L., Buckley, J. D., Noakes, M., Clifton, P. M., Norman, R. J., & Brinkworth, G. D. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0751 · Cited by 277 · see citing works
Robciuc, M. R., Kivelä, R., Williams, I. M., de Boer, J. F., van Dijk, T. H., Elamaa, H. P., Tigistu‐Sahle, F., Molotkov, D. A., Leppänen, V., Käkelä, R., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.03.004 · Cited by 234 · see citing works
THE EPIDEMIOLOGY OF POLYCYSTIC OVARY SYNDROME
Solomon, C. G. (1999) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70069-4 · Cited by 226 · see citing works
Sheep models of polycystic ovary syndrome phenotype
Padmanabhan, V., & Veiga‐Lopez, A. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.10.005 · Cited by 222 · see citing works
Dumesic, D. A., Akopians, A. L., Madrigal, V. K., Ramirez, E., Margolis, D. J., Sarma, M. K., Thomas, A. M., Grogan, T. R., Haykal, R., Schooler, T. A., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2586 · Cited by 222 · see citing works
Kauffman, A. S., Thackray, V. G., Ryan, G. E., Tolson, K. P., Glidewell-Kenney, C., Semaan, S. J., Poling, M. C., Iwata, N., Breen, K. M., Dulęba, A. J., et al. (2015) · Biology of Reproduction · doi:10.1095/biolreprod.115.131631 · Cited by 216 · see citing works
Gambineri, A., Pelusi, C., Genghini, S., Morselli‐Labate, A. M., Cacciari, M., Pagotto, U., & Pasquali, R. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.01973.x · Cited by 216 · see citing works
Grayson, B. E., Levasseur, P. R., Williams, S. M., Smith, M. S., Marks, D. L., & Grove, K. L. (2010) · Endocrinology · doi:10.1210/en.2009-1019 · Cited by 208 · see citing works
Regional Differences in Adipose Tissue Metabolism in Women
Tchernof, A., Bélanger, C., Morisset, A., Richard, C., Mailloux, J. R., Laberge, P. Y., & Dupont, P. (2006) · Diabetes · doi:10.2337/db05-1439 · Cited by 197 · see citing works
Diamanti‐Kandarakis, E., & Panidis, D. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02954.x · Cited by 183 · see citing works
Ek, I., Arner, P., Rydén, M., Holm, C., Thörne, A., Hoffstedt, J., & Wahrenberg, H. (2002) · Diabetes · doi:10.2337/diabetes.51.2.484 · Cited by 174 · see citing works
Neuroendocrine dysfunction in polycystic ovary syndrome
Burt Solorzano, C. M., Beller, J. P., Abshire, M. Y., Collins, J. S., McCartney, C. R., & Marshall, J. C. (2012) · Steroids · doi:10.1016/j.steroids.2011.12.007 · Cited by 173 · see citing works
Mehrabani, H. H., Salehpour, S., Amiri, Z., Farahani, S. J., Meyer, B. J., & Tahbaz, F. (2012) · Journal of the American College of Nutrition · doi:10.1080/07315724.2012.10720017 · Cited by 141 · see citing works
Metformin Treatment May Increase Omentin-1 Levels in Women With Polycystic Ovary Syndrome
Tan, B. K., Adya, R., Syed, F., Chen, J., Lehnert, H., & Randeva, H. S. (2010) · Diabetes · doi:10.2337/db10-0124 · Cited by 138 · see citing works
Rydén, M., Jocken, J. W. E., van Harmelen, V., Dicker, A., Hoffstedt, J., Wirén, M., Blomqvist, L., Mairal, A., Langin, D., Blaak, E. E., et al. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00040.2007 · Cited by 138 · see citing works
Subcutaneous adipose cell size and distribution: Relationship to insulin resistance and body fat
McLaughlin, T., Lamendola, C. A., Coghlan, N., Liu, T.-C., Lerner, K., Sherman, A., & Cushman, S. W. (2013) · Obesity · doi:10.1002/oby.20209 · Cited by 136 · see citing works
Metabolic Signatures of Human Adipose Tissue Hypoxia in Obesity
Hodson, L., Humphreys, S. M., Karpe, F., & Frayn, K. N. (2012) · Diabetes · doi:10.2337/db12-1032 · Cited by 134 · see citing works
Polycystic Ovary Syndrome Is Associated with Tissue-Specific Differences in Insulin Resistance
Ciaraldi, T. P., Aroda, V. R., Mudaliar, S. R. D., Chang, R. J., & Henry, R. R. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1492 · Cited by 128 · see citing works
Faulds, G., Rydén, M., Ek, I., Wahrenberg, H., & Arner, P. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021573 · Cited by 125 · see citing works
Mannerås, L., Jónsdóttir, I. H., Holmäng, A. B., Lönn, M., & Stener‐Victorin, E. (2008) · Endocrinology · doi:10.1210/en.2008-0053 · Cited by 122 · see citing works
Ek, I., Arner, P., Bergqvist, A., Carlström, K., & Wahrenberg, H. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.4.3899 · Cited by 116 · see citing works
Effects of Methyltestosterone on Insulin Secretion and Sensitivity In Women1
Diamond, M. P., Grainger, D. W., Connolly-Diamond, M., Sherwin, R. S., & DeFronzo, R. A. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.12.5333 · Cited by 107 · see citing works
Nonhuman primate models of polycystic ovary syndrome
Abbott, D. H., Nicol, L. E., Levine, J. E., Xu, N., Goodarzi, M. O., & Dumesic, D. A. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.01.013 · Cited by 105 · see citing works
Pietro, M. D., Parborell, F., Irusta, G., Pascuali, N., Bas, D., Bianchi, M. S., Tesone, M., & Abramovich, D. (2015) · Endocrinology · doi:10.1210/en.2014-1765 · Cited by 101 · see citing works
Zhu, Y., Gao, Y., Tao, C., Shao, M., Zhao, S., Huang, W., Yao, T., Johnson, J. A., Liu, T., Cypess, A. M., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.08.005 · Cited by 100 · see citing works
Michailidou, Z., Turban, S., Miller, E., Zou, X., Schrader, J., Ratcliffe, P. J., Hadoke, P. W. F., Walker, B. R., Iredale, J. P., Morton, N. M., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.259325 · Cited by 93 · see citing works
Chazenbalk, G. D., Chen, Y.-H., Heneidi, S. G., Lee, J.-M., Pall, M., Chen, Y. I., & Azziz, R. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2377 · Cited by 90 · see citing works
Adipocyte biology in polycystic ovary syndrome
Barber, T. M., & Franks, S. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.10.010 · Cited by 88 · see citing works
Nohara, K., Waraich, R. S., Liu, S., Ferron, M., Waget, A., Meyers, M. S., Karsenty, G., Burcelin, R., & Mauvais-Jarvis, F. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00620.2012 · Cited by 77 · see citing works
Effects of Methyltestosterone on Insulin Secretion and Sensitivity In Women
Diamond, M. P. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.12.4420 · Cited by 75 · see citing works
Ek, I. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.4.1147 · Cited by 75 · see citing works
Moro, C., Pasarica, M., Elkind-Hirsch, K. E., & Redman, L. M. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0051 · Cited by 74 · see citing works
Marsden, P. J., Murdoch, A. P., & Taylor, R. (1994) · Metabolism · doi:10.1016/0026-0495(94)90013-2 · Cited by 67 · see citing works
Veiga‐Lopez, A., Moeller, J., Patel, D., Ye, W., Pease, A. P., Kinns, J., & Padmanabhan, V. (2013) · Endocrinology · doi:10.1210/en.2012-2145 · Cited by 64 · see citing works
Keller, E., Chazenbalk, G. D., Aguilera, P., Madrigal, V., Grogan, T., Elashoff, D., Dumesic, D. A., & Abbott, D. H. (2014) · Endocrinology · doi:10.1210/en.2014-1050 · Cited by 60 · see citing works
McGee, W. K., Bishop, C. V., Pohl, C. R., Chang, R. J., Marshall, J. C., Pau, F. K.-Y., Stouffer, R. L., & Cameron, J. L. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00310.2013 · Cited by 51 · see citing works
Self-citationMichaud, A., Boulet, M. M., Veilleux, A., Noël, S., Paris, G., & Tchernof, A. (2013) · Metabolism · doi:10.1016/j.metabol.2013.11.007 · Cited by 50 · see citing works
Eagleson, C. A., Bellows, A. B., Hu, K., Gingrich, M. B., & Marshall, J. C. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030167 · Cited by 46 · see citing works
Varlamov, O., Chu, M. P., McGee, W. K., Cameron, J. L., O’Rourke, R. W., Meyer, K. A., Bishop, C. V., Stouffer, R. L., & Roberts, C. T. (2013) · Endocrinology · doi:10.1210/en.2013-1428 · Cited by 44 · see citing works
Self-citationWu, H.-L., Heneidi, S. G., Chuang, T.-Y., Diamond, M. P., Layman, L. C., Azziz, R., & Chen, Y.-H. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4435 · Cited by 42 · see citing works
Rodent models of polycystic ovary syndrome
McNeilly, A. S., & Duncan, W. C. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.10.007 · Cited by 38 · see citing works
Gourgari, E., Lodish, M. B., Shamburek, R. D., Keil, M. F., WESLEY, R. A., Walter, M. F., Sampson, M. L., Bernstein, S. B., Khurana, D., Lyssikatos, C., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2566 · Cited by 35 · see citing works
True, C. A., Takahashi, D. L., Burns, S. E., Mishler, E., Bond, K., Wilcox, M. C., Calhoun, A. R., Bader, L., Dean, T. A., Ryan, N. D., et al. (2017) · Human Reproduction · doi:10.1093/humrep/dex246 · Cited by 32 · see citing works
Self-citationNikolič, M., Μacut, D., Djordjevic, A. D., Veličković, N. A., Nestorović, N. M., Bursać, B. N., Antić, I. B., Macut, J. B., Matić, G. M., & Milutinović, D. V. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.08.013 · Cited by 31 · see citing works
Seow, K., Tsai, Y.-L., Hwang, J.-L., Hsu, W.-Y., Ho, L. T., & Juan, C. (2009) · Human Reproduction · doi:10.1093/humrep/dep122 · Cited by 28 · see citing works
Cell-autonomous heterogeneity of nutrient uptake in white adipose tissue of rhesus macaques
Varlamov, O., Chu, M., Cornea, A., Sampath, H., & Roberts, C. T. (2015) · Endocrinology · doi:10.1210/en.2014-1699 · Cited by 25 · see citing works
Self-citationPerpetuating effects of androgen deficiency on insulin resistance
Cameron, J. L., Jain, R., Rais, M., White, A. E., Beer, T. M., Kievit, P., Winters‐Stone, K. M., Messaoudi, I., & Varlamov, O. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.148 · Cited by 19 · see citing works
Self-citationSpatiotemporal dynamics of triglyceride storage in unilocular adipocytes
Chu, M., Sampath, H., Cahana, D. Y., et al. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-06-1085 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Witchel, S. F., Oberfield, S. E., & Peña, A. S. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2019-00078 · Cited by 653 · see citing works
Current concepts of polycystic ovary syndrome pathogenesis
Rosenfield, R. L. (2020) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000945 · Cited by 77 · see citing works
Sex differences in androgen regulation of metabolism in nonhuman primates
True, C., Abbott, D. H., Roberts, C. T., & Varlamov, O. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-70178-3_24 · Cited by 10 · see citing works
Self-citation
- Authors
- Varlamov, O., Bishop, C. V., Handu, M., Takahashi, D., Srinivasan, S., White, A., & Roberts, C. T.
- Affiliations
- Oregon National Primate Research Center (US)
- Corresponding author
- Varlamov, Oleg
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-07-20
- Volume
- 32
- Issue
- 9
- Pages
- 1892-1902
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- PMC
- PMC6074799
- OpenAlex
- W2737855310
- Cited by
- 34
- References
- 75
- Citations by year
- 2025: 4 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 5 · 2018: 1 · 2017: 3
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Human Reproduction (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health & Human Development
- National Institutes of Health (P50 HD071836)
- Oregon National Primate Research Center (P51 OD011092)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- hyperandrogenemia, Western diet, subcutaneous adipose tissue, adipocyte hypertrophy, testosterone, cholesterol, polycystic ovary syndrome, free fatty acid uptake, lipolysis, adipose tissue vascularization, rhesus monkeys, young adult women, dietary fat, insulin sensitivity
- MeSH terms
- Adipose Tissue, Animals, Female, Macaca mulatta, Testosterone, Hyperandrogenism, Adipocytes, Cell Size, Diet, Western
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
