Rapid Communication: Experimental Infection of Domestic Cats with Bartonella henselae by Inoculation of Ctenocephalides fells (Siphonaptera: Pulicidae) Feces

Foil, Lane; Andress, Earl; Freeland, Rebecca L.; Roy, Alma F.; Rutledge, Roxanne; Triche, Patricia C.; O'Reilly, Kathy L.

doi:10.1093/jmedent/35.5.625

Cited by 199Bartonella species infections researchBacillus and Francisella bacterial researchVector-borne infectious diseases

Rapid Communication: Experimental Infection of Domestic Cats with Bartonella henselae by Inoculation of Ctenocephalides fells (Siphonaptera: Pulicidae) Feces

Foil, Lane, Andress, Earl, Freeland, Rebecca L., Roy, Alma F., Rutledge, Roxanne, Triche, Patricia C., O'Reilly, Kathy L.·1998·Journal of Medical Entomology

DOI 10.1093/jmedent/35.5.625

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Abstract

Caged cat fleas, Ctenocephalides felis (Bouché), were fed on 6 cats; 3 cats were injected with 5 x 10(7) colony forming units of Bartonella henselae intradermally and 3 cats were injected with an equal volume of saline. After the fleas fed for 4 d, 5 groups of 50 B. henselae-exposed fleas were caged and allowed to feed on 5 cats for 6 d. Five cats each were injected intradermally with 1 ml of saline containing 45 mg of feces from B. henselae-exposed fleas. Five cats were fed 50 B. henselae-exposed fleas and 45 mg of fresh feces from B. henselae-exposed fleas. Five cats received all 3 treatments by using fleas and feces collected from cats inoculated with saline (controls). Cats were bled weekly and tested by culture and serology. The cats that were injected with feces from infected fleas were positive by culture for B. henselae at 1 or 2 wk after exposure and were the only cats to become bacteremic or seropositive by week 20.

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Infection of cats by bites of infected fleas has been experimentally demonstrated, although it is not considered a primary route of transmission.
“Infection of cats by bites of infected fleas has been experimentally demonstrated, although not considered a primary route of transmission [30,44,45].”
From Fleas infesting pets in the era of emerging extra-intestinal nematodes (2013) · cites this paper as [45]
Fleas of pets are capable of harboring Bartonella spp. and it seems plausible that Ctenocephalides felis transmits Bartonella henselae actively.
“Fleas of pets are capable of harboring Bartonella spp. and it seems plausible that C. felis transmits B. henselae actively.”
From Fleas infesting pets in the era of emerging extra-intestinal nematodes (2013) · cites this paper as [45]
Human infection by flea-borne Bartonella spp. generally occurs via scratches of infected cats, while flea bites do not seem to play a key role in the epidemiology of human bartonellosis.
“The human infection by flea-borne Bartonella spp. generally occurs via scratches of infected cats, whilst flea bites do not seem to play a key role in the epidemiology of human bartonellosis.”
From Fleas infesting pets in the era of emerging extra-intestinal nematodes (2013) · cites this paper as [45]

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Self-citation
Immune response of neonatal specific pathogen-free cats to experimental infection with Bartonella henselae
Guptill, L. F., Slater, L. N., Wu, C., Glickman, L. T., Lin, T., WELCH, D. F., Crippen, J. T., & HogenEsch, H. (1999) · Veterinary Immunology and Immunopathology · doi:10.1016/s0165-2427(99)00104-x · Cited by 39 · see citing works
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“mitted to humans by a scratch or bite from an infected cat, while cat fleas {Ctenocephalides felis) and ticks (Ixodes rucinus) also play a role in transmission of the bacteria in cats [8-11].”
Background
Infection and re-infection of domestic cats with various Bartonella species or types: B. henselae type I is protective against heterologous challenge with B. henselae type II
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“Cat fleas (Ctenocephalides felis) are the main vectors of transmission among cats (Chomel et al., 1996; Higgins et al., 1996; Foil et al., 1998).”
Background
Characterization of ectoparasites in an urban cat (Felis catus Linnaeus, 1758) population of Rio de Janeiro, Brazil
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“Fleas are responsible for the transmission of B. henselae and B. clarridgeiae among cats (Chomel et al. 1996, Foil et al. 1998).”
Background
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A multi-gene analysis of diversity of bartonella detected in fleas from algeria
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Background
Production of recombinant Bartonella henselae 17-kDa protein for antibody-capture enzyme-linked immunosorbent assay
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Self-citation
Seroprevalence of Bartonella infection in American free-ranging and captive pumas (Felis concolor) and bobcats (Lynx rufus)
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Bartonella henselae Infection in Domestic Cat and Dog Fleas
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Authors: Foil, L., Andress, E., Freeland, R. L., Roy, A. F., Rutledge, R., Triche, P. C., & O'Reilly, K. L.
Affiliations: Louisiana State University (US)
ORCID: Foil, Lane
Venue: Journal of Medical Entomology
Publisher: Oxford University Press (OUP)
Published: 1998-09-01
Volume: 35
Issue: 5
Pages: 625-628
ISSN: 0022-2585 (ISSN-L)
1938-2928
DOI: 10.1093/jmedent/35.5.625
OpenAlex: W2409724360
Cited by: 197
References: 0
Citations by year: 2026: 3 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 8 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 3 · 2016: 10 · 2015: 6 · 2014: 8 · 2013: 9 · 2012: 11
FWCI: 4.67
Type: journal article
Language: en
Open access: closed
Locations: Journal of Medical Entomology (publishedVersion)
PubMed (publishedVersion)
Civil War Book Review (submittedVersion)
Funders: National Institutes of Health (1r15ai039720-01)
Agricultural Center, Louisiana State University
National Institute of Allergy and Infectious Diseases (1 R15 AI39720-01)
Topics: Life Sciences › Immunology and Microbiology › Parasitology › Bartonella species infections research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacillus and Francisella bacterial research
Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
Keywords: Bartonella henselae, cats, Ctenocephalides felis, flea-borne transmission, experimental infection, bacteremia, seropositivity
MeSH terms: Animals, Cat-Scratch Disease, Cats, Feces, Siphonaptera, Insect Vectors, Bartonella henselae

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Rapid Communication: Experimental Infection of Domestic Cats with Bartonella henselae by Inoculation of Ctenocephalides fells (Siphonaptera: Pulicidae) Feces

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