Cited by 588Retinal Diseases and TreatmentsRetinal Imaging and AnalysisRetinal Development and Disorders

The DOI matches its Crossref record.

SENILE MACULAR DEGENERATION: A CASE-CONTROL STUDY

HYMAN, LESLIE G., LILIENFELD, ABRAHAM M., FERRIS, FREDERICK L., FINE, STUART L.·1983·American Journal of Epidemiology

Open this paper in CoChat — free account

Abstract

Senile macular degeneration, although a leading cause of visual loss in the United States, remains a poorly understood disease. To assess the effects of host and environmental factors on this condition, a study of 228 cases and 237 controls matched by age and sex, who had visited any of 34 Baltimore ophthalmologists between September 1, 1978 and March 31, 1980, was conducted. Study participants were interviewed for past medical, residential, occupational, smoking and family histories, as well as social and demographic factors. Diagnoses were validated by means of fundus photographs. The 162 cases and 175 controls who met the study diagnostic criteria for cases and controls were included in the analysis. Statistically significant associations were demonstrated between senile macular degeneration and family history of macular disease (odds ratio (OR) = 2.9), chemical work exposures (OR = 4.2), blue or medium pigmented eyes (OR = 3.5), history of one or more cardiovascular diseases (OR = 1.7), decreased hand grip strength, and hyperopia. The risk of macular degeneration in cigarette smokers was significant for males only (OR = 2.6). The study results suggest that the development of macular degeneration is mainly influenced by familial, genetic, and personal characteristics, rather than by the few environmental factors studied. Additional studies are needed to further evaluate the role of environmental factors.

Integrity signals

Registry

Crossref · 10.1093/oxfordjournals.aje.a113629

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 101–200 of 588

Vitamin E supplementation and macular degeneration: randomised controlled trial
Taylor, H. R., Tikellis, G., Robman, L. D., McCarty, C. A., & McNeil, J. J. (2002) · BMJ · doi:10.1136/bmj.325.7354.11 · Cited by 165
Risk factors for age-related macular degeneration: an update
Hyman, L., & Neborsky, R. (2002) · Current Opinion in Ophthalmology · doi:10.1097/00055735-200206000-00007 · Cited by 163
Self-citation
Case-control study of the risk factors for age related macular degeneration
Chaine, G., Hullo, A., Sahel, J., Soubrane, G., Espinasse-Berrod, M.-A., Schutz, D., Bourguignon, C., Harpey, C., Brault, Y., Coste, M., et al. (1998) · British Journal of Ophthalmology · doi:10.1136/bjo.82.9.996 · Cited by 161
“10 11 In a study by Hyman et al , 5 83% of patients with AMD were smokers, in comparison with 65% in the control group, but this was signiﬁcant only for men.”
BackgroundInfluential
Iris color, skin sun sensitivity, and age-related maculopathy
Mitchell, P., Smith, W. H., & Wang, J. J. (1998) · Ophthalmology · doi:10.1016/s0161-6420(98)98013-7 · Cited by 162
Multiple Recurrent Serosanguineous Retinal Pigment Epithelial Detachments in Black Women
Stern, R. M., Zakov, Z. N., Zegarra, H., et al. (1985) · American Journal of Ophthalmology · doi:10.1016/0002-9394(85)90682-8 · Cited by 162
The role of antioxidants in the retina and retinal pigment epithelium and the nature of prooxidant-induced damage
Handelman, G. J., & Dratz, E. A. (1986) · Advances in free radical biology and medicine · doi:10.1016/s8755-9668(86)80024-2 · Cited by 158
Changes in select redox proteins of the retinal pigment epithelium in age-related macular degeneration
Decanini, A., Nordgaard, C. L., Feng, X., Ferrington, D. A., & Olsen, T. W. (2007) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2006.12.006 · Cited by 157
An update on the genetics of age-related macular degeneration
Scholl, H. P. N., Fleckenstein, M., Issa, P. C., Keilhauer, C. N., Holz, F. G., & Weber, B. H. F. (2007) · PubMed Central · doi:10.5283/epub.35844 · Cited by 156
Prevalence of Age-related Maculopathy in the Atherosclerosis Risk in Communities Study
Klein, R. (1999) · Archives of Ophthalmology · doi:10.1001/archopht.117.9.1203 · Cited by 155
NATURE AND RISK OF NEOVASCULARIZATION IN THE FELLOW EYE OF PATIENTS WITH UNILATERAL RETINAL ANGIOMATOUS PROLIFERATION
GROSS, N. E., Aizman, A., BRUCKER, A. J., Klancnik, J. M., & Yannuzzi, L. A. (2005) · Retina · doi:10.1097/00006982-200509000-00005 · Cited by 148
Systemic Hypertension and Age-Related Maculopathy in the Framingham Study
Sperduto, R. D., & Hiller, R. (1986) · Archives of Ophthalmology · doi:10.1001/archopht.1986.01050140070022 · Cited by 152
Gonadal Hormones and Retinal Disorders: A Review
Nuzzi, R., Scalabrin, S., Becco, A., & Panzica, G. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00066 · Cited by 152
A pooled case-control study of the apolipoprotein E (APOE) gene in age-related maculopathy
Schmidt, S., Klaver, C. C. W., Saunders, A. M., Postel, E. A., De La Paz, M. A., Agarwal, A., Small, K. W., Udar, N., Ong, J. M., Chalukya, M. V., et al. (2002) · Ophthalmic Genetics · doi:10.1076/opge.23.4.209.13883 · Cited by 149
Cardiovascular Disease and Hypertension Are Strong Risk Factors for Choroidal Neovascularization
Hogg, R. E., Woodside, J. V., Gilchrist, S. E. C. M., Graydon, R., Fletcher, A. E., Chan, W., Knox, A., Cartmill, B., & Chakravarthy, U. (2008) · Ophthalmology · doi:10.1016/j.ophtha.2007.07.031 · Cited by 148
Body Mass Index and the Incidence of Visually Significant Age-Related Maculopathy in Men
Schaumberg, D. A. (2001) · Archives of Ophthalmology · doi:10.1001/archopht.119.9.1259 · Cited by 147
Is genetic predisposition an important risk factor in age-related macular degeneration?
Silvestri, G., Johnston, P. B., & Hughes, A. E. (1994) · Eye · doi:10.1038/eye.1994.138 · Cited by 142
Light history and age-related changes in retinal light damage.
Organisciak, D. T., Darrow, R. M., Barsalou, L., Darrow, R. M., Kutty, R. K., Kutty, G., & Wiggert, B. O. (1998) · PubMed · Cited by 142
Cardiovascular disease, its risk factors and treatment and age-related macular degeneration: Women's Health Initiative Sight Exam ancillary Study
Klein, R., Deng, Y., Klein, B. E. K., Hyman, L., Seddon, J., Frank, R. N., Wallace, R. B., Hendrix, S. L., Kuppermann, B. D., Langer, R. D., et al. (2007) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2006.11.058 · Cited by 142
Risk Factors for Age-Related Macular Degeneration: Findings from the Andhra Pradesh Eye Disease Study in South India
Krishnaiah, S., Das, T., Nirmalan, P. K., Nutheti, R., Shamanna, B. R., Rao, G. N., & Thomas, R. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-0853 · Cited by 140
Light Exposure and the Risk of Age-Related Macular Degeneration: The Pathologies Oculaires Liées à l'Age (POLA) Study
Delcourt, C. (2001) · Archives of Ophthalmology · doi:10.1001/archopht.119.10.1463 · Cited by 140
“8 Time spent at place of birth, median (range), y South of France 65 (1-88) 66 (1-91) Central France 20 (1-66) 22 (1-80) Northern France 23 (1-67) 32 (1-76) Southern Europe 14 (1-38) 11 (1-38) Northern Africa 32 (5-52) 33 (1-70) Other 16.”
Age-related Macular Degeneration: Genetic and Environmental Factors of Disease
Chen, Y., Bedell, M., & Zhang, K. (2010) · Molecular Interventions · doi:10.1124/mi.10.5.4 · Cited by 143
Iris Color and Macular Pigment Optical Density
Hammond, B. R., Fuld, K., & Snodderly, D. M. (1996) · Experimental Eye Research · doi:10.1006/exer.1996.0035 · Cited by 139
Epidemiology of eye disease in the elderly
Hyman, L. (1987) · Eye · doi:10.1038/eye.1987.53 · Cited by 139
Self-citation
Elevated retinal zeaxanthin and prevention of light-induced photoreceptor cell death in quail.
Thomson, L. R., Toyoda, Y., Langner, A., Delori, F. C., Garnett, K. M., Craft, N. E., Nichols, C. R., Cheng, K. M., & Dorey, C. K. (2002) · PubMed · Cited by 137
Intravenous Infusion of Liposomal Benzoporphyrin Derivative for Photodynamic Therapy of Experimental Choroidal Neovascularization
Husain, D. (1996) · Archives of Ophthalmology · doi:10.1001/archopht.1996.01100140186012 · Cited by 137
A full genome scan for age-related maculopathy
Weeks, D. E. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.9.1329 · Cited by 139
Risk factors for age‐related maculopathy in a 14‐year follow‐up study: the Copenhagen City Eye Study
Buch, H., Vinding, T., La Cour, M., Jensen, G. B., Prause, J. U., & Nielsen, N. V. (2005) · Acta Ophthalmologica Scandinavica · doi:10.1111/j.1600-0420.2005.00492.x · Cited by 136
“In accordance with previous studies (Hyman et al. 1983; Smith & Mitchell 1998), we found that individuals reporting a family history of ARM are at risk of this disease.”
BackgroundResult
Age-Related Macular Degeneration and Risk for Stroke
Wong, T. Y., Klein, R., Sun, C., Mitchell, P., Couper, D. J., Lai, H. C., Hubbard, L. D., Sharrett, A. R., & Study, F. T. A. R. I. C. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-145-2-200607180-00007 · Cited by 139
Photodynamic therapy of subfoveal choroidal neovascularization: clinical and angiographic examples
Schmidt-Erfurth, U. M., Miller, J. W., Sickenberg, M., Bunse, A., Laqua, H., Gragoudas, E. S., Zografos, L., Birngruber, R., van den Bergh, H., Strong, A., et al. (1998) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s004170050092 · Cited by 134
“Age-related macular degeneration (AMD) is one of the leading causes of severe and irreversible visual loss [11, 13].”
Background
DNA Methylation Is Associated with Altered Gene Expression in AMD
Hunter, A. A., Spechler, P., Cwanger, A., Song, Y., Zhang, Z., Ying, G., Hunter, A. K., de Zoeten, E. F., & Dunaief, J. L. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8449 · Cited by 136
VITAMIN D STATUS AND EARLY AGE-RELATED MACULAR DEGENERATION IN POSTMENOPAUSAL WOMEN
Abraham, A., & Grigorian, A. P. (2011) · Evidence-Based Ophthalmology · doi:10.1001/archophthalmol.2011.48 · Cited by 134
“40 Of the observational studies 41-53 investigatingthisrelationship,onlyafewfound directassociationsbetweensunlightandAMD.”
Background
Macular pigment and melanin in age-related maculopathy in a general population.
Berendschot, T. T. J. M., Willemse-Assink, J. J. M., Bastiaanse, M., de Jong, P. T. V. M., & Norren, D. V. (2002) · PubMed · Cited by 131
Age-related macular degeneration is associated with incident myocardial infarction among elderly Americans
Duan, Y., Mo, J., Klein, R., Scott, I. U., Lin, H.-M., Caulfield, J., Patel, M., & Liao, D. (2007) · Ophthalmology · doi:10.1016/j.ophtha.2006.07.045 · Cited by 128
Associated factors for age related maculopathy in the adult population in China: the Beijing eye study
Xu, L. (2006) · British Journal of Ophthalmology · doi:10.1136/bjo.2006.096123 · Cited by 128
Photoacoustic imaging of the eye: A mini review
Liu, W., & Zhang, H. F. (2016) · Photoacoustics · doi:10.1016/j.pacs.2016.05.001 · Cited by 128
The Macular Xanthophylls
Ahmed, S. S., Lott, M. N., & Marcus, D. M. (2005) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2004.12.009 · Cited by 128
Evaluation of an iris color classification system. The Eye Disorders Case-Control Study Group.
Seddon, J. M., Sahagian, C. R., Glynn, R. J., Sperduto, R. D., & Gragoudas, E. S. (1990) · PubMed · Cited by 125
Age-Related Macular Degeneration and Risk of Coronary Heart Disease
Wong, T. Y., Tikellis, G., Sun, C., Klein, R., Couper, D. J., & Sharrett, A. R. (2007) · Ophthalmology · doi:10.1016/j.ophtha.2006.06.039 · Cited by 123
Age related macular degeneration and sun exposure, iris colour, and skin sensitivity to sunlight
Khan, J. C. (2006) · British Journal of Ophthalmology · doi:10.1136/bjo.2005.073825 · Cited by 121
CHOROIDAL NEOVASCULARIZATION IN AGE-RELATED MACULAR DEGENERATION—WHAT IS THE CAUSE?
Spaide, R. F., Armstrong, D., & Browne, R. W. (2003) · Retina · doi:10.1097/00006982-200310000-00001 · Cited by 122
A Systematic Comparison of Spectral-Domain Optical Coherence Tomography and Fundus Autofluorescence in Patients with Geographic Atrophy
Sayegh, R. G., Simader, C., Scheschy, U., Montuoro, A., Kiss, C., Sacu, S., Kreil, D. P., Prünte, C. F., & Schmidt-Erfurth, U. M. (2011) · Ophthalmology · doi:10.1016/j.ophtha.2011.01.043 · Cited by 123
The Age-Related Eye Disease 2 Study: Micronutrients in the Treatment of Macular Degeneration
Gorusupudi, A., Nelson, K., & Bernstein, P. S. (2017) · Advances in Nutrition · doi:10.3945/an.116.013177 · Cited by 130
Further Observations on the Association Between Smoking and the Long-term Incidence and Progression of Age-related Macular Degeneration
Klein, R. (2008) · Archives of Ophthalmology · doi:10.1001/archopht.126.1.115 · Cited by 118
Macular pigments: their characteristics and putative role
Davies, N. (2004) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2004.05.004 · Cited by 117
“This study was performed based on the finding that a dark iris was associated with reduced risk of AMD (Hyman et al., 1983; Weiter et al., 1985).”
MethodInfluential
Risk factor analysis for atrophic and exudative age‐related macular degeneration: An epidemiological study of 1000 aged individuals
Vinding, T., Appleyard, M., Nyboe, J., & Jensen, G. (1992) · Acta Ophthalmologica · doi:10.1111/j.1755-3768.1992.tb02093.x · Cited by 117
Metabolome-Wide Association Study of Neovascular Age-Related Macular Degeneration
Osborn, M. P., Park, Y. H., Parks, M. B., Burgess, L. G., Uppal, K., Lee, K., Jones, D. P., & Brantley, M. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072737 · Cited by 115
“Specifically, coronary artery disease and associated conditions have been linked to AMD [22].”
Background
The Relation of Socioeconomic Factors to Age-related Cataract, Maculopathy, and Impaired Vision
Klein, R., Klein, R., Jensen, S. C., et al. (1994) · Ophthalmology · doi:10.1016/s0161-6420(13)31077-x · Cited by 117
Photodegradation of retinal bisretinoids in mouse models and implications for macular degeneration
Ueda, K., Zhao, J., Kim, H. J., & Sparrow, J. R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1524774113 · Cited by 115
Alcohol Consumption and the Risk of Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis
Chong, E. W.-T., Kreis, A. J., Wong, T. Y., Simpson, J. A., & Guymer, R. H. (2008) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2007.12.005 · Cited by 112
Radiation Therapy for Subretinal Neovascularizadon
Finger, P. T., Berson, A. M., Sherr, D. L., et al. (1996) · Ophthalmology · doi:10.1016/s0161-6420(96)30592-7 · Cited by 114
Fundus reflectance—historical and present ideas
Berendschot, T. T. J. M. (2003) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(02)00060-5 · Cited by 113
“However, controversial results on the possible protective properties were reported (Hyman et al., 1983; Weiter et al., 1985; Darzins et al., 1997; Klein et al., 1999a,b; Smith et al., 2001).”
Result
Overview of progress in the epidemiology of age-related macular degeneration
Klein, R. (2007) · Ophthalmic Epidemiology · doi:10.1080/09286580701344381 · Cited by 110
Age-Related Macular Degeneration
la Cour, M., Kiilgaard, J. F., & Nissen, M. H. (2002) · Drugs & Aging · doi:10.2165/00002512-200219020-00003 · Cited by 111
“Blue iris colour, hyperopia and cataracts have been reported to be associated with AMD in some[59,105,106,113,116,125-128] but not all studies.”
BackgroundMethodInfluential
Vision-related quality of life in patients suffering from age-related macular degeneration
Berdeaux, G., Jp, N., Colin, E., & Arnould, B. (2005) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2004.09.028 · Cited by 110
Blue-blocking IOLs Decrease Photoreception Without Providing Significant Photoprotection
Mainster, M. A., & Turner, P. L. (2009) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2009.07.006 · Cited by 109
Relationship of dietary fat to age-related maculopathy in the Third National Health and Nutrition Examination Survey
Heuberger, R. A. (2001) · Archives of Ophthalmology · doi:10.1001/archopht.119.12.1833 · Cited by 105
Review of Genetics in Age Related Macular Degeneration
Montezuma, S. R., Sobrin, L., & Seddon, J. M. (2007) · Seminars in Ophthalmology · doi:10.1080/08820530701745140 · Cited by 108
Family history and age‐related maculopathy: The Blue Mountains Eye Study
Smith, W. H., & Mitchell, P. L. R. (1998) · Australian and New Zealand Journal of Ophthalmology · doi:10.1111/j.1442-9071.1998.tb01311.x · Cited by 106
Relationship between Refraction and Prevalent as well as Incident Age-Related Maculopathy: The Rotterdam Study
Ikram, M. K., van Leeuwen, R., Vingerling, J. R., et al. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-0120 · Cited by 107
On the origin of proteins in human drusen: The meet, greet and stick hypothesis
Bergen, A. A., Arya, S., Koster, C., Pilgrim, M. G., Wiatrek-Moumoulidis, D., van der Spek, P. J., Hauck, S. M., Boon, C. J. F., Emri, E., Stewart, A. J., et al. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.12.003 · Cited by 101
Analysis of the Stargardt disease gene (ABCR) in age-related macular degeneration
De La Paz, M. A., Guy, V. K., Abou-Donia, S., Heinis, R., Bracken, B., Vance, J. M., Gilbert, J. R., Gass, J. D. M., Haines, J. L., & Pericak-Vance, M. A. (1999) · Ophthalmology · doi:10.1016/s0161-6420(99)90449-9 · Cited by 106
The Epidemiology of Age-Related Macular Degeneration
Seddon, J. M., & Chen, C. A. (2004) · International Ophthalmology Clinics · doi:10.1097/00004397-200404440-00004 · Cited by 106
“In addition, a case-controlled study found a relationship between AMD and a history of 1 or more cardiovascular diseases.(60) The NHANES I study reported a positive association between AMD and cerebrovascular disease, but positive associations with other vascular diseases did not reach statistical significance.”
Background
Visual Impairment, Age-Related Macular Degeneration, Cataract, and Long-term Mortality
Cugati, S. (2007) · Archives of Ophthalmology · doi:10.1001/archopht.125.7.917 · Cited by 106
Prospective Study of Alcohol Consumption and the Risk of Age-Related Macular Degeneration
Cho, E. (2000) · Archives of Ophthalmology · doi:10.1001/archopht.118.5.681 · Cited by 102
Presumed macular choroidal watershed vascular filling, choroidal neovascularization, and systemic vascular disease in patients with age-related macular degeneration
Ross, R. D., Barofsky, J. M., Cohen, G., Baber, W. B., Palao, S. W., & Gitter, K. A. (1998) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(99)80237-2 · Cited by 100
Psychophysical Function in Age-related Maculopathy
Neelam, K., Nolan, J. M., Chakravarthy, U., & Beatty, S. (2009) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2008.12.003 · Cited by 108
“Currently, AMD is the leading cause of blind registration in the developed world,(73,113,119) with CNV accounting for 80--90% of these cases.(149,196) In the future, the prevalence and incidence of ARM is expected to rise because of an increase in”
Background
The association between cigarette smoking and ocular diseases.
Cheng, A. C. K., Pang, C., Leung, A. T. S., Chua, J. K. H., Fan, D. S. P., & Lam, D. S. C. (2000) · PubMed · Cited by 97
Linkage of Autosomal Dominant Radial Drusen (Malattia Leventinese) to Chromosome 2p16-21
Héon, E. (1996) · Archives of Ophthalmology · doi:10.1001/archopht.1996.01100130187014 · Cited by 97
In vivo uptake of liposomal benzoporphyrin derivative and photothrombosis in experimental corneal neovascularization
Schmidt-Erfurth, U. M., Hasan, T. G., Schomacker, K. T., Flotte, T. J., & Birngruber, R. (1995) · Lasers in Surgery and Medicine · doi:10.1002/lsm.1900170207 · Cited by 99
The molecular genetic basis of age-related macular degeneration: an overview
Katta, S., Kaur, I., & Chakrabarti, S. (2009) · Journal of Genetics · doi:10.1007/s12041-009-0064-4 · Cited by 97
Blue light induced A2E oxidation in rat eyes — experimental animal model of dry AMD
Wielgus, A. R., Collier, R. J., Martin, E. A., Lih, F. B., Tomer, K. B., Chignell, C. F., & Roberts, J. E. (2010) · Photochemical & Photobiological Sciences · doi:10.1039/c0pp00133c · Cited by 97
Age-related Bruch's membrane change: a clinical study of the relative role of heredity and environment.
Piguet, B., Wells, J. A., Palmvang, I. B., Wormald, R., Chisholm, I. H., & Bird, A. C. (1993) · British Journal of Ophthalmology · doi:10.1136/bjo.77.7.400 · Cited by 92
Genetics of age-related macular degeneration: current concepts, future directions
DeAngelis, M. M., Silveira, A. C., Carr, E. A., & Kim, I. K. (2011) · Seminars in Ophthalmology · doi:10.3109/08820538.2011.577129 · Cited by 94
Smoking and the Risk of Age-related Macular Degeneration: A Meta-Analysis
Cong, R., Zhou, B., Sun, Q., Gu, H., Tang, N., & Wang, B. (2008) · Annals of Epidemiology · doi:10.1016/j.annepidem.2008.04.002 · Cited by 101
Antiretinal Antibodies in Serum of Patients with Age-related Macular Degeneration
Gurne, D. H., Tso, M. O. M., Edward, D. P., & Ripps, H. (1991) · Ophthalmology · doi:10.1016/s0161-6420(91)32252-8 · Cited by 93
Age-related macular degeneration: The importance of family history as a risk factor
Shahid, H., Khan, J. C., Cipriani, V., Sepp, T., Matharu, B. K., Bunce, C., Harding, S. P., Clayton, D. G., Moore, A. T., Yates, J. R. W., et al. (2012) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2011-300193 · Cited by 84
“Some reports of family history in AMD have given lower ORs, which in some studies can be attributed to the inclusion of cases with less severe disease.(4) 7 9 11 Table 2 Demographic characteristics of study participants”
Result
Effects of cholesterol and apolipoprotein E on retinal abnormalities in ApoE-deficient mice.
Ong, J. M., Zorapapel, N. C., Rich, K. A., Wagstaff, R. E., Lambert, R. W., Rosenberg, S., Moghaddas, F., Pirouzmanesh, A., Aoki, A. M., & Kenney, M. C. (2001) · PubMed · Cited by 92
The Minnesota Grading System of Eye Bank Eyes for Age-Related Macular Degeneration
Olsen, T. W., & Feng, X. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0342 · Cited by 90
Genetic susceptibility to age related macular degeneration
Yates, J., & Moore, A. (2000) · Journal of Medical Genetics · doi:10.1136/jmg.37.2.83 · Cited by 99
Age‐related macular degeneration. Macular changes, prevalence and sex ratio
Vinding, T. (1989) · Acta Ophthalmologica · doi:10.1111/j.1755-3768.1989.tb04392.x · Cited by 90
RADIATION AND THE AGEING EYE*
Marshall, J. (1985) · Ophthalmic and Physiological Optics · doi:10.1111/j.1475-1313.1985.tb00666.x · Cited by 96
Pathogenetic Factors of Aging Macular Degeneration
Tso, M. O. M. (1985) · Ophthalmology · doi:10.1016/s0161-6420(85)33992-1 · Cited by 89
Age-Related Maculopathy in a Randomized Trial of Low-Dose Aspirin Among US Physicians
Christen, W. G. (2001) · Archives of Ophthalmology · doi:10.1001/archopht.119.8.1143 · Cited by 88
AAV-Mediated Expression of Vascular Endothelial Growth Factor Induces Choroidal Neovascularization in Rat
Wang, F., Rendahl, K. G., Manning, W. C., Quiroz, D., Coyne, M. Y., & Miller, S. S. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-0281 · Cited by 88
Is Age-Related Maculopathy Associated With Cataracts?
Klein, R. (1994) · Archives of Ophthalmology · doi:10.1001/archopht.1994.01090140067025 · Cited by 87
Antiangiogenic therapy with anti-vascular endothelial growth factor modalities for neovascular age-related macular degeneration
Vedula, S. S., & Krzystolik, M. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005139.pub2 · Cited by 87
Fluorescein angiographic lesion type frequency in neovascular Age-Related macular degeneration11Drs Olsen and Steuer serve as retinal consultants to the Northwest Eye Clinic, Plymouth, Minnesota.
Olsen, T. W., Feng, X., Kasper, T. J., Rath, P. P., & Steuer, E. (2004) · Ophthalmology · doi:10.1016/j.ophtha.2003.05.030 · Cited by 86
The Photopathology and Nature of the Blue Light and Near-UV Retinal Lesions Produced by Lasers and Other Optical Sources
Ham, W. T., & Mueller, H. A. (1989) · Springer eBooks · doi:10.1007/978-1-4613-0745-7_5 · Cited by 89
Association of neovascular age-related macular degeneration and hyperhomocysteinemia
Axer‐Siegel, R., Bourla, D. H., Ehrlich, R., Dotan, G., Benjamini, Y., Gavendo, S., Weinberger, D., & Sela, B. (2003) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(03)00864-x · Cited by 84
Decreasing Stromal Iris Pigmentation as a Risk Factor for Age-related Macular Degeneration
Holz, F. G., Piguet, B., Minassian, D. C., et al. (1994) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(14)73010-7 · Cited by 84
Gene–environment interactions in ocular diseases
Saccà, S. C., Bolognesi, C., Battistella, A., Bagnis, A., & Izzotti, A. (2008) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2008.11.002 · Cited by 84
Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration
Morrison, M. A., Silveira, A. C., Huynh, N., Jun, G., Smith, S. E., Zacharaki, F., Satō, H., Loomis, S. J., Andreoli, M. T., Adams, S. M., et al. (2011) · Human Genomics · doi:10.1186/1479-7364-5-6-538 · Cited by 84
“Some studies suggested a positive association,(69,76,91,92) while others found no correlation.(71,78,93) To our knowledge, our study was the first to show a protective influence of UV light on neovascular AMD.”
Result
Murine High-Fat Diet and Laser Photochemical Model of Basal Deposits in Bruch Membrane
Dithmar, S. (2001) · Archives of Ophthalmology · doi:10.1001/archopht.119.11.1643 · Cited by 81
Diabetes, Hyperglycemia, and Age-related Maculopathy
Klein, R., Klein, B. E. K., & Moss, S. E. (1992) · Ophthalmology · doi:10.1016/s0161-6420(92)31770-1 · Cited by 81
Prevalence of age-related macular degeneration in a large European cohort: Results from the population-based Gutenberg Health Study
Korb, C. A., Kottler, U. B., Wolfram, C., Höhn, R., Schulz, A., Zwiener, I., Wild, P. S., Pfeiffer, N., & Mirshahi, A. (2014) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-014-2591-9 · Cited by 79
“A review and meta-analysis performed by Chakravarthy and co-workers evaluating three prospective cohort studies [27–29], two control studies [30, 31], and a pooled estimate from a cross-sectional study [32] suggested that darker iris pigmentation (brown vs.”
Background
Molecular genetics of age-related macular degeneration
Stone, E. M. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.20.2285 · Cited by 79
Risk Factors for Five-Year Incident Age-related Macular Degeneration: The Reykjavik Eye Study
Arnarsson, Á. M., Sverrisson, T., Stefánsson, E., Sigurðsson, H., Sasaki, H., Sasaki, K., & Jónasson, F. (2006) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2006.04.015 · Cited by 82
Annual Rates of Arterial Thromboembolic Events in Medicare Neovascular Age-Related Macular Degeneration Patients
Alexander, S. L., Linde‐Zwirble, W. T., Werther, W., Depperschmidt, E. E., Wilson, L., Palanki, R., Saroj, N., Butterworth, S. L., & Ianchulev, T. (2007) · Ophthalmology · doi:10.1016/j.ophtha.2007.09.017 · Cited by 79
Sensitivities in older eyes with good acuity: eyes whose fellow eye has exudative AMD.
Eisner, A., Fleming, S. A., Klein, M. L., & Mauldin, W. M. (1987) · PubMed · Cited by 77
A Dominant Stargardt's Macular Dystrophy Locus Maps to Chromosome 13q34
Zhang, K. (1994) · Archives of Ophthalmology · doi:10.1001/archopht.1994.01090180057035 · Cited by 75

Authors: HYMAN, L. G., LILIENFELD, A. M., FERRIS, F. L., & FINE, S. L.
Affiliations: State University of New York (US)
Johns Hopkins University (US)
National Institutes of Health (US)
Corresponding author: HYMAN, LESLIE G.
ORCID: HYMAN, LESLIE G.
FERRIS, FREDERICK L.
Venue: American Journal of Epidemiology
Publisher: Oxford University Press (OUP)
Published: 1983-08
Volume: 118
Issue: 2
Pages: 213-227
ISSN: 0002-9262 (ISSN-L)
1476-6256
DOI: 10.1093/oxfordjournals.aje.a113629
OpenAlex: W2147440920
Cited by: 587
References: 0
Citations by year: 2026: 2 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 9 · 2021: 7 · 2020: 6 · 2019: 4 · 2018: 6 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 13 · 2013: 16 · 2012: 18
FWCI: 9.53
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Epidemiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
Keywords: senile macular degeneration, risk factors, family history (medicine), genetic susceptibility, chemical exposure, occupational exposure, eye pigmentation, cardiovascular disease, grip strength, hyperopia, smoking, vision loss
MeSH terms: Aged, Cardiovascular Diseases, Environmental Exposure, Eye Color, Female, Humans, Macular Degeneration, Male, Maryland, Refractive Errors, Risk, Sex Factors, Smoking

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

SENILE MACULAR DEGENERATION: A CASE-CONTROL STUDY

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks