Social stress and the oxytocin receptor gene interact to predict antisocial behavior in an at-risk cohort
Open accessAbstract
Polymorphisms in the oxytocin receptor gene are commonly associated with prosocial behaviors in the extant literature, yet their role in antisocial behaviors has rarely been explored, particularly during the transition from adolescence to early adulthood. We examined a prospective cohort (N = 404), collecting youth, mother, and clinician reports of conduct-disordered and antisocial behavior at ages 15 and 20. The oxytocin receptor gene rs53576 polymorphism was hypothesized to interact with social stress to predict antisocial outcomes. Structural equation modeling results revealed a significant main effect at age 15 (p = .025); those with the G allele exhibited higher levels of conduct problems. Structural equation modeling revealed a significant Gene × Environment interaction at age 20 (p = .029); those with the G allele who experienced high social stress exhibited higher levels of antisocial behavior. Heterozygous (AG) grouping models were compared, and parameter estimations supported G dominant groupings. These novel findings suggest that rs53576 polymorphisms may influence social salience and contribute to risk for antisocial outcomes, particularly under conditions of high social stress.
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Early life stress in humans can interact with OXTR variation to influence adult social behavior and emotional regulation.
“Early life stress in humans can interact with OXTR variation to influence adult social behavior and emotional regulation (28–31).”
From Variation in the Oxytocin Receptor Gene Predicts Brain Region–Specific Expression and Social Attachment (2016) · cites this paper as [30]
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- Authors
- Smearman, E. L., Winiarski, D. A., Brennan, P. A., Najman, J., & Johnson, K. C.
- Affiliations
- Emory University (US)
- The University of Queensland (AU)
- Corresponding author
- Johnson, Katrina C.
- Venue
- Development and Psychopathology
- Publisher
- Cambridge University Press (CUP)
- Published
- 2014-07-08
- Volume
- 27
- Issue
- 1
- Pages
- 309-318
- ISSN
- 0954-5794 (ISSN-L)
- 1469-2198
- PMC
- PMC5506377
- OpenAlex
- W2053129754
- Cited by
- 60
- References
- 58
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 1 · 2022: 7 · 2021: 16 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 8 · 2015: 6
- FWCI
- 8.83
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Development and Psychopathology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH052239)
- National Institute of General Medical Sciences (T32GM008169)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- oxytocin receptor gene, antisocial behavior, conduct disorder, social stress, gene-environment interaction, adolescence, early adulthood, at-risk youth, social salience, genetic risk
- MeSH terms
- Adolescent, Adolescent Behavior, Adult, Alleles, Female, Humans, Male, Polymorphism, Genetic, Prospective Studies, Risk, Social Behavior Disorders, Stress, Psychological, Receptors, Oxytocin, Conduct Disorder, Young Adult, Gene-Environment Interaction
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