CoChat
Sign Up
Cited by 92Sleep and Wakefulness ResearchSleep and related disordersSleep and Work-Related Fatigue

Alterations in sleep architecture in response to experimental sleep curtailment are associated with signs of positive energy balance

Open access
Shechter, Ari, O'Keeffe, Majella, Roberts, Amy L., Zammit, Gary K., RoyChoudhury, Arindam, St-Onge, Marie-Pierre·2012·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
DOI 10.1152/ajpregu.00222.2012PMC PMC3517705
Open this paper in CoChat — free account

Abstract

Sleep reduction is associated with increased energy intake and weight gain, though few studies have explored the relationship between sleep architecture and energy balance measures in the context of experimental sleep restriction. Fourteen males and 13 females (body mass index: 22-26 kg/m(2)) participated in a crossover sleep curtailment study. Participants were studied under two sleep conditions: short (4 h/night; 0100-0500 h) and habitual (9 h/night; 2200-0700 h), for 5 nights each. Sleep was polysomnographically recorded nightly. Outcome measures included resting metabolic rate (RMR), feelings of appetite-satiety, and ad libitum food intake. Short sleep resulted in reductions in stage 2 sleep and rapid eye movement (REM) sleep duration (P < 0.001), as well as decreased percentage of stage 2 sleep and REM sleep and increased slow wave sleep (SWS) percentage (P < 0.05). Linear mixed model analysis demonstrated a positive association between stage 2 sleep duration and RMR (P = 0.051). Inverse associations were observed between REM sleep duration and hunger (P = 0.031) and between stage 2 sleep duration and appetite for sweet (P = 0.015) and salty (P = 0.046) foods. Stage 2 sleep percentage was inversely related to energy consumed (P = 0.024). Stage 2 sleep (P = 0.005), SWS (P = 0.008), and REM sleep (P = 0.048) percentages were inversely related to fat intake, and SWS (P = 0.040) and REM sleep (P = 0.050) were inversely related to carbohydrate intake. This study demonstrates that changes in sleep architecture are associated with markers of positive energy balance and indicate a means by which exposure to short sleep duration and/or an altered sleep architecture profile may lead to excess weight gain over time.

Integrity signals

Registry

Crossref · 10.1152/ajpregu.00222.2012

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Inverse associations between REM sleep duration and hunger (p<0.031) and between stage 2 sleep and appetite for sweet (p<0.015) and salty (p<0.046) foods were detected.

    “Specifically, inverse associations between REM sleep duration and hunger (p<0.031) and between stage 2 sleep and appetite for sweet (p<0.015) and salty (p<0.046) foods were detected in one study [57].”

    From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [57]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Shechter, A., O'Keeffe, M., Roberts, A. L., Zammit, G. K., RoyChoudhury, A., & St-Onge, M.-P.
Affiliations
  • St. Luke's-Roosevelt Hospital Center (US)
  • Clinilabs (United States) (US)
  • Columbia University (US)
  • New York Obesity Nutrition Research Center, St. Luke's-Roosevelt Hospital, New York, New York;
ORCID
Venue
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher
American Physiological Society
Published
2012-11-01
Volume
303
Issue
9
Pages
R883-R889
ISSN
  • 0363-6119 (ISSN-L)
  • 1522-1490
DOI
10.1152/ajpregu.00222.2012
PMC
PMC3517705
OpenAlex
W2116596924
Cited by
92
References
32
Citations by year
2026: 2 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 3 · 2021: 12 · 2020: 8 · 2019: 5 · 2018: 2 · 2017: 7 · 2016: 14 · 2015: 3 · 2014: 10 · 2013: 12
FWCI
4.09
Type
journal article
Language
en
Open access
Locations
  • American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (R01HL091352)
  • National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK-26687, P30DK026687, T32DK007559)
  • National Center for Research Resources (UL1RR024156)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
sleep architecture, sleep restriction, short sleep duration, energy balance, resting metabolic rate, stage 2 sleep, REM sleep, slow-wave sleep, appetite, hunger, dietary intake, dietary fat intake, carbohydrate intake, weight gain
MeSH terms
Adult, Appetite, Basal Metabolism, Eating, Energy Metabolism, Female, Homeostasis, Humans, Male, Middle Aged, Obesity, Sleep, Sleep Deprivation, Sleep Stages, Sleep, REM, Time Factors, Outcome Assessment, Health Care, Polysomnography, Cross-Over Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review