The light-dark cycle controls peripheral rhythmicity in mice with a genetically ablated suprachiasmatic nucleus clock
Abstract
The mammalian circadian timing system consists of a master pacemaker in the suprachiasmatic nucleus (SCN), which is thought to synchronize peripheral clocks in various organs with each other and with external time. Our knowledge about the role of the SCN clock is based mainly on SCN lesion and transplantation studies. We have now directly deleted the SCN clock using the Cre/LoxP system and investigated how this affects synchronization of peripheral rhythms. Impaired locomotor activity and arrhythmic clock gene expression in the SCN confirm that the SCN clockwork was efficiently abolished in our mouse model. Nonetheless, under light-dark (LD) conditions, peripheral clocks remained rhythmic and synchronized to the LD cycle, and phase relationships between peripheral clocks were sustained. Adaptation to a shifted LD cycle was accelerated in SCN clock-deficient mice. Moreover, under zeitgeber-free conditions, rhythmicity of the peripheral clock gene expression was initially dampened, and after several days peripheral clocks were desynchronized. These findings suggest that the SCN clock is dispensable for the synchronization of peripheral clocks to the LD cycle. A model describing an SCN clock-independent pathway that synchronizes peripheral clocks with the LD cycle is discussed.
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Peripheral clocks may synchronize to photic cues in the absence of a functional molecular clock in the SCN.
“Recent evidence also suggests that peripheral clocks may synchronize to photic cues in the absence of a functional molecular clock in the SCN (18), although the mechanisms involved are not yet clear.”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [18]
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- Authors
- Husse, J., Leliavski, A., Tsang, A. H., Oster, H., & Eichele, G.
- Affiliations
- Max Planck Society (DE)
- Max Planck Institute for Biophysical Chemistry Göttingen Germany
- Corresponding author
- Oster, Henrik
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2014-07-25
- Volume
- 28
- Issue
- 11
- Pages
- 4950-4960
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2131227905
- Cited by
- 133
- References
- 49
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 12 · 2023: 7 · 2022: 15 · 2021: 10 · 2020: 15 · 2019: 17 · 2018: 9 · 2017: 7 · 2016: 16 · 2015: 11 · 2014: 3
- FWCI
- 6.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The FASEB Journal (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Max-Planck-Gesellschaft
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Physical Sciences › Computer Science › Computer Networks and Communications › Network Time Synchronization Technologies
- Keywords
- suprachiasmatic nucleus, circadian clock, light-dark cycle, clock gene expression, locomotor activity, zeitgebers, phase equilibria, Cre-loxP system, circadian system
- MeSH terms
- Animals, Circadian Rhythm, Motor Activity, Suprachiasmatic Nucleus, Gene Expression, Photoperiod, Mice, CLOCK Proteins, Circadian Clocks
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