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Cited by 305

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Catabolism of aging: is it an inflammatory process?

Roubenoff, Ronenn·2003·Current Opinion in Clinical Nutrition & Metabolic Care
DOI 10.1097/01.mco.0000068965.34812.62
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Abstract

PURPOSE OF REVIEW: Research in the field of sarcopenia is evolving rapidly, and the process is now recognized as an important cause of frailty and morbidity in the elderly. This review focuses on recent developments in the field, especially regarding the role of catabolic stimuli in causing sarcopenia. RECENT FINDINGS: There is now an impressive body of literature implicating increased interleukin-6 levels in successfully aging adults. New data indicate that high interleukin-6 levels carry a poor prognosis, although it is not clear if the cytokine has primarily a causal or counter-regulatory function. Interleukin-6 and other cytokines could function through direct catabolic effects, or by causing reduced dietary energy intake (the anorexia of aging), or by inducing insulin resistance or lowering growth hormone-insulin-like growth factor-I concentrations. Furthermore, apoptosis has now been linked to sarcopenia, suggesting that an inflammatory signal could trigger loss of muscle cells in the elderly even in the absence of overt inflammatory disease. SUMMARY: Aging causes loss of many of the anabolic signals to muscle that are present in young adulthood. Recent research suggests that there is also an increase in catabolic signals with age.

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Show all 7 references

Research works printed but not linked: 23

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Cited by

Metadata

Authors
Roubenoff, R.
Venue
Current Opinion in Clinical Nutrition & Metabolic Care
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2003-05
Volume
6
Issue
3
Pages
295-299
ISSN
1363-1950 (ISSN-L)
DOI
10.1097/01.mco.0000068965.34812.62
OpenAlex
W1965658712
Cited by
305
References
7
FWCI
7.60
Type
journal article
Language
en
Open access
closed

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