Cited by 42Cardiovascular Syncope and Autonomic DisordersAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychosomatic Disorders and Their Treatments

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End-Tidal pCO2 in Blood Phobics During Viewing of Emotion- and Disease-Related Films

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Abstract

Objective Many patients with blood, injection, and injury (BII) phobia respond to specific stimuli with vasovagal dysregulation and fainting. However, little is known about the role of hyperventilation in the distress of these patients. Hyperventilation, defined by subnormal arterial pCO2 levels, induces anxiety and may promote the development of fainting. We studied end-tidal pCO2 in 12 patients with BII phobia and 14 nonanxious controls during presentation of emotional films. Method Ten film clips were shown, two in each of 5 categories: pleasant, unpleasant, neutral, BII-related (surgery), and asthma-related (portraying labored breathing). For each subject, two subsets were created, each containing one clip from each category. For one subset, the instruction was simply to view the film, and for the other subset, to view the film while tensing the leg muscles. PCO2, heart rate, blood pressure, and leg electromyogram were recorded continuously during viewing, and self-report of symptoms and emotion was collected after each film. Results Patients reported the greatest anxiety and disgust during surgery films. PCO2 was relatively stable throughout all categories except surgery films, during which minima were below 30 mm Hg, indicating significant hypocapnia. Cardiovascular variables suggested biphasic patterns in two patients with BII phobia. These patients, together with one additional patient and one control who were close to fainting after or during one surgery film, also s…

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Crossref · 10.1097/01.psy.0000170339.06281.07

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  • Pre-syncopal experiences have not necessarily been restricted to those reporting prior fainting experience or phobic responses to BII material.

    “and pre-syncopal experiences have not necessarily been restricted to those reporting prior fainting experience or phobic responses to BII material (Ritz, Wilhelm, et al., 2005).”
  • According to these criteria, a minority of the 12 examined patients showed a sufficient biphasic pattern: one in HR and SBP, and the other in HR, SBP, and DBP.

    “According to these criteria, a minority of the 12 examined patients showed a sufficient biphasic pattern: one in HR and SBP, and the other in HR, SBP, and DBP.”
  • In the research of the first author, a dual criterion was adopted for which a diphasic response during surgery films was only identified if in subsequent 10-s averages across the film period, the initial activation exceeded the level of a film stimulus of negative valence, and the subsequent deactivation exceeded that during viewing of a neutral film.

    “In the research of the first author, a dual criterion was adopted for which a diphasic response during surgery films was only identified if in subsequent 10-s averages across the film period, (1) the initial activation exceeded the level of a film stimulus of negative valence, and (2) the subsequent deactivation exceeded that during viewing of a neutral film (Ritz, Wilhelm, et al., 2005).”
  • Premature termination of exposure by patients may have prohibited the observation of diphasic patterns in some studies.

    “In other studies, premature termination of exposure by the patients may have prohibited the observation of diphasic patterns, as in our initial study with 3 out of 12 patients terminating one or both of the two 5-min surgery films prematurely (Ritz, Wilhelm, Gerlach, et al., 2005) or in Öst, Sterner et al. (1984) with 14 out of 18 patients terminating a 30-min surgery film early.”

    From The psychophysiology of blood-injection-injury phobia: Looking beyond the diphasic response paradigm (2010) · cites this paper as Ritz, Wilhelm, Gerlach, et al., 2005

  • Overall, these findings closely match the authors' recent observations with BII-phobia patients during exposure to surgery films.

    “Overall, these findings closely match our recent observations with BII-phobia patients during exposure to surgery films (Ayala et al., 2010; Ritz et al., 2005; 2009).”

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Metadata

Authors
Ritz, T., Wilhelm, F. H., Gerlach, A. L., Kullowatz, A., & Roth, W. T.
Affiliations
Universität Hamburg (DE)
Corresponding author
Ritz, Thomas
Venue
Psychosomatic Medicine
Published
2005-07
Volume
67
Issue
4
Pages
661-668
ISSN
0033-3174 (ISSN-L)
OpenAlex
W2169444411
Cited by
42
References
8
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2020: 1 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 4 · 2012: 1
FWCI
2.38
Type
journal article
Language
en
Open access
Locations
  • Psychosomatic Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • edoc (University of Basel) (acceptedVersion)
  • edoc (University of Basel)
Funders
National Institute of Mental Health (R01MH056094)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Keywords
end-tidal PCO2, hypocapnia, hyperventilation, syncope, fear response, disgust, heart rate, blood pressure, anxiety
MeSH terms
Adult, Asthma, Breath Tests, Carbon Dioxide, Fear, Female, Humans, Hyperventilation, Male, Middle Aged, Motion Pictures, Muscle Contraction, Phobic Disorders, Respiratory Function Tests, Surgical Procedures, Operative, Muscle, Skeletal

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