The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Functional magnetic resonance imaging of reward prediction
Abstract
PURPOSE OF REVIEW: Technical and conceptual advances in functional magnetic resonance imaging now allow visualization of real-time changes in oxygenation of deep subcortical regions, leading to rapid advances in scientific characterization of the neural substrates that underlie reward prediction in humans. RECENT FINDINGS: Neuroimaging research over the past year has focused on determining the necessary neural substrates for reward prediction. SUMMARY: While the orbitofrontal cortex has long been implicated in modality-specific reward representation, the ventral striatum (particularly the nucleus accumbens) may play a role in modality-independent representations of predicted reward. On the other hand, the mesial prefrontal cortex appears to play a role in representing reward prediction error and the dorsal caudate in linking reward to behavior. Theoretically, future studies will need to establish the specificity of these responses to reward versus punishment and anticipation versus outcome. Clinically, current findings suggest that patients can predict reward without a prefrontal cortex, but should experience difficulty correcting their behavior when reward predictions are violated.
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“The ventral striatum (VS) is central to reward processing (Knutson and Cooper 2005), and is activated by a range of rewarding stimuli including drugs of abuse (Gilman et al. 2008).”
From Effects of MDMA on sociability and neural response to social threat and social reward (2009) · cites this paper as Knutson and Cooper 2005
In the citing paper
“The affective pathway described in dual-systems models is most closely associated with a network of limbic and paralimbic areas involved in emotion- and reward-related processing, most notably the ventral striatum (which subsumes the nucleus accumbens), but also the orbitofrontal cortex, ventromedial prefrontal cortex, amygdala, and superior temporal sulcus”
From Impact of socio-emotional context, brain development, and pubertal maturation on adolescent risk-taking (2013) · cites this paper as Knutson & Cooper, 2005
In the citing paper
“The striatum is a key neural structure involved in reward-related processing, from recognizing and evaluating rewards to learning from them as to predict the best potential reward in the future for review see 1, 10, 11.”
From The social brain and reward: Social information processing in the human striatum (2014) · cites this paper as [10]
In the citing paper
“Thus, reward-related signals in the striatum appear to be crucial for alerting and motivating an organism to a reward opportunity, associating predictive cues with reward outcomes, and learning through trial and error in order to adapt behavior to attain rewards in the future1, 10, 11.”
From The social brain and reward: Social information processing in the human striatum (2014) · cites this paper as [10]
Citations
Cites
A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388
(1998) · Cited by 4,012
Separate neural systems value immediate and delayed monetary rewards
McClure, S. M., Laibson, D. I., Loewenstein, G., & Cohen, J. D. (2004) · Science · doi:10.1126/science.1100907 · Cited by 3,089
The role of the medial frontal cortex in cognitive control
Ridderinkhof, K. R., Ullsperger, M., Crone, E. A., & Nieuwenhuis, S. (2004) · Science · doi:10.1126/science.1100301 · Cited by 2,974
Dissociable Roles of Ventral and Dorsal Striatum in Instrumental Conditioning
O'Doherty, J., Dayan, P., Schultz, J., Deichmann, R., Friston, K., & Dolan, R. J. (2004) · Science · doi:10.1126/science.1094285 · Cited by 2,088
The Neural Basis of Altruistic Punishment
de Quervain, D. J.-F., Fischbacher, U., Treyer, V., Schellhammer, M., Schnyder, U., Buck, A., & Fehr, E. (2004) · Science · doi:10.1126/science.1100735 · Cited by 1,768
The neural correlates of maternal and romantic love
Bartels, A., & Zeki, S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.003 · Cited by 1,497 · cited 1×
“including putamen, caudate, and ventral striatum) [ 24 ].”
A neural basis for social cooperation
Rilling, J. K., Gutman, D. A., Zeh, T. R., Pagnoni, G., Berns, G. S., & Kilts, C. D. (2002) · Neuron · doi:10.1016/s0896-6273(02)00755-9 · Cited by 1,451
Reward representations and reward-related learning in the human brain: Insights from neuroimaging
O’Doherty, J. P. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.10.016 · Cited by 1,426
FMRI visualization of brain activity during a monetary incentive delay task
Knutson, B., Westdorp, A., Kaiser, E., & Hommer, D. (2000) · NeuroImage · doi:10.1006/nimg.2000.0593 · Cited by 1,414
Self-citationNeural Correlates of Behavioral Preference for Culturally Familiar Drinks
McClure, S. M., Li, J., Tomlin, D., Cypert, K. S., Montague, L. M., & Montague, P. R. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.019 · Cited by 1,413
Dissociation of reward anticipation and outcome with event-related fMRI
Knutson, B., Fong, G. W., Adams, C. M., Varner, J. L., & Hommer, D. (2001) · Neuroreport · doi:10.1097/00001756-200112040-00016 · Cited by 1,300
Self-citationEvidence for striatal dopamine release during a video game
Koepp, M. J., Gunn, R. N., Lawrence, A. D., Cunningham, V. J., Dagher, A., Jones, T., Brooks, D. J., Bench, C. J., & Grasby, P. M. (1998) · Nature · doi:10.1038/30498 · Cited by 1,279
Acute effects of cocaine on human brain activity and emotion
Breiter, H. C., Gollub, R. L., Weisskoff, R. M., Kennedy, D. N., Makris, N., Berke, J. D., Goodman, J. M., Kantor, H. L., Gastfriend, D. R., Riorden, J. P., et al. (1997) · Neuron · doi:10.1016/s0896-6273(00)80374-8 · Cited by 1,270
Tracking the Hemodynamic Responses to Reward and Punishment in the Striatum
Delgado, M. R., Nystrom, L. E., Fissell, C., Noll, D. C., & Fiez, J. A. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.6.3072 · Cited by 1,116
Neural responses during anticipation of a primary taste reward
O'Doherty, J. P., Deichmann, R., Critchley, H. D., & Dolan, R. J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00603-7 · Cited by 1,076
Kawabata, H., & Zeki, S. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00696.2003 · Cited by 880
Knutson, B. D., Fong, G., Bennett, S. M., Adams, C. M., & Hommer, D. W. (2003) · NeuroImage · doi:10.1016/s1053-8119(02)00057-5 · Cited by 868
Self-citationPrediction of immediate and future rewards differentially recruits cortico-basal ganglia loops
Tanaka, S. C., Doya, K., Okada, G., Ueda, K., Okamoto, Y., & Yamawaki, S. (2004) · Nature Neuroscience · doi:10.1038/nn1279 · Cited by 779
Neuroeconomics: The Consilience of Brain and Decision
Glimcher, P. W., & Rustichini, A. (2004) · Science · doi:10.1126/science.1102566 · Cited by 748
Dissociable Neural Responses in Human Reward Systems
Elliott, R., Friston, K. J., & Dolan, R. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06159.2000 · Cited by 740
APPETITES AND AVERSIONS AS CONSTITUENTS OF INSTINCTS
CRAIG, W. (1918) · The Biological Bulletin · doi:10.2307/1536346 · Cited by 702
Wittmann, B. C., Schott, B. H., Guderian, S., Frey, J. U., Heinze, H.-J., & Düzel, E. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.010 · Cited by 698
Men and women differ in amygdala response to visual sexual stimuli
Hamann, S., Herman, R. A., Nolan, C. L., & Wallen, K. (2004) · Nature Neuroscience · doi:10.1038/nn1208 · Cited by 603
Gr�sser, S. M., Wrase, J., Klein, S., Hermann, D., Smolka, M. N., Ruf, M., Weber-Fahr, W., Flor, H., Mann, K., Braus, D. F., et al. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1828-4 · Cited by 598
Modulation of Caudate Activity by Action Contingency
Tricomi, E. M., Delgado, M. R., & Fiez, J. A. (2004) · Neuron · doi:10.1016/s0896-6273(03)00848-1 · Cited by 592
Incentive-elicited brain activation in adolescents: Similarities and differences from young adults
Bjork, J. M., Knutson, B., Fong, G. W., Caggiano, D. M., Bennett, S. M., & Hommer, D. W. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4862-03.2004 · Cited by 567
Self-citationSchultz, W. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.03.017 · Cited by 517
The neural substrates of reward processing in humans: the modern role of FMRI
McClure, S. M., York, M. K., & Montague, P. R. (2004) · The Neuroscientist · doi:10.1177/1073858404263526 · Cited by 480 · cited 1×
“These findings have been well-summarized by a spate of recent reviews [12,13, 14 ,15].”
BackgroundGottfried, J. A., O’Doherty, J. P., & Dolan, R. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10829.2002 · Cited by 474
Neuroanatomical correlates of aesthetic preference for paintings
Vartanian, O. A., & Goel, V. (2004) · Neuroreport · doi:10.1097/00001756-200404090-00032 · Cited by 470
Human Striatal Responses to Monetary Reward Depend On Saliency
Zink, C. F., Pagnoni, G., Martin-Skurski, M. E., Chappelow, J., & Berns, G. S. (2004) · Neuron · doi:10.1016/s0896-6273(04)00183-7 · Cited by 432
Rogers, R. D., Ramnani, N., Mackay, C. E., Wilson, J. L., Jezzard, P., Carter, C. S., & Smith, S. M. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.11.012 · Cited by 414
Brain Responses to the Acquired Moral Status of Faces
Singer, T., Kiebel, S. J., Winston, J. S., Dolan, R. J., & Frith, C. (2004) · Neuron · doi:10.1016/s0896-6273(04)00014-5 · Cited by 410
Heinz, A., Siessmeier, T., Wrase, J., Hermann, D., Klein, S., Grüsser-Sinopoli, S. M., Flor, H., Braus, D. F., Buchholz, H. G., Gründer, G., et al. (2004) · American Journal of Psychiatry · doi:10.1176/ajp.161.10.1783 · Cited by 408
Choice selection and reward anticipation: an fMRI study
Ernst, M., Nelson, E. E., McClure, E. B., Monk, C. S., Munson, S., Eshel, N., Zarahn, E., Leibenluft, E., Zametkin, A., Towbin, K., et al. (2004) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2004.05.011 · Cited by 377
An fMRI study of reward-related probability learning
Delgado, M. R., Miller, M. M., Inati, S., & Phelps, E. A. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.10.002 · Cited by 337
Haruno, M., Kuroda, T., Doya, K., Toyama, K., Kimura, M., Samejima, K., Imamizu, H., & Kawato, M. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3417-03.2004 · Cited by 300
Transient changes in mesolimbic dopamine and their association with ‘reward’
Wightman, R. M., & Robinson, D. L. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01005.x · Cited by 285
Motivation-dependent responses in the human caudate nucleus.
Delgado, M. R. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh062 · Cited by 246
Dopamine Transmission in the Human Striatum during Monetary Reward Tasks
Zald, D. H., Boileau, I., El-Dearedy, W., Gunn, R., McGlone, F., Dichter, G. S., & Dagher, A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4643-03.2004 · Cited by 238
A functional neuroimaging study of motivation and executive function
Taylor, S. F., Welsh, R. C., Wager, T. D., Luan Phan, K., Fitzgerald, K. D., & Gehring, W. J. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.10.032 · Cited by 222
May, J. C., Delgado, M. R., Dahl, R. E., Stenger, V. A., Ryan, N. D., Fiez, J. A., & Carter, C. S. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.11.008 · Cited by 193
Amphetamine modulates human incentive processing
Knutson, B., Bjork, J. M., Fong, G. W., Hommer, D., Mattay, V. S., & Weinberger, D. R. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.030 · Cited by 174
Self-citationMethamphetamine Activates Reward Circuitry in Drug Naïve Human Subjects
Vӧllm, B., de Araújo, I. E., Cowen, P. J., Rolls, E. T., Kringelbach, M. L., Smith, K., Jezzard, P., Heal, R. J., & Matthews, P. M. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300481 · Cited by 160
The central basis of motivation: intracranial self-stimulation studies.
Olds, M., & Fobes, J. (1981) · Annual Review of Psychology · doi:10.1146/annurev.ps.32.020181.002515 · Cited by 160
Selective activation of the nucleus accumbens during risk-taking decision making
Matthews, S. C., Simmons, A. N., Lane, S. D., & Paulus, M. P. (2004) · NeuroReport · doi:10.1097/00001756-200409150-00025 · Cited by 157
Prediction error for free monetary reward in the human prefrontal cortex
Ramnani, N., Elliott, R., Athwal, B. S., & Passingham, R. E. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.028 · Cited by 136
Elliott, R., Newman, J. L., Longe, O. A., & Deakin, J. F. W. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.10.010 · Cited by 134
Macmillan, M. (2000) · Cited by 28
Becerra, L. R., Iadarola, M. J., & Borsook, D. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00326.2003 · Cited by 19
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Ochsner, K. N., Silvers, J. A., & Buhle, J. T. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06751.x · Cited by 1,879
A new look at habits and the habit-goal interface.
Wood, W., & Neal, D. T. (2007) · Psychological Review · doi:10.1037/0033-295x.114.4.843 · Cited by 1,470
Pizzagalli, D. A., Holmes, A. J., Dillon, D. G., Goetz, E. L., Birk, J. L., Bogdan, R., Dougherty, D. D., Iosifescu, D. V., Rauch, S. L., & Fava, M. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08081201 · Cited by 1,232
Functional connectivity of human striatum: a resting state FMRI study
Di Martino, A., Scheres, A., Margulies, D. S., Kelly, A. M. C., Uddin, L. Q., Shehzad, Z., Biswal, B., Walters, J. R., Castellanos, F. X., & Milham, M. P. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn041 · Cited by 1,090
Metadata
- Authors
- Knutson, B., & Cooper, J. C.
- Affiliations
- Stanford University (US)
- Corresponding author
- Knutson, Brian
- ORCID
- Knutson, Brian
- Venue
- Current Opinion in Neurology
- Published
- 2005-08
- Volume
- 18
- Issue
- 4
- Pages
- 411-417
- ISSN
- 1350-7540 (ISSN-L)
- OpenAlex
- W2141927127
- Cited by
- 736
- References
- 51
- Citations by year
- 2026: 14 · 2025: 16 · 2024: 14 · 2023: 17 · 2022: 16 · 2021: 23 · 2020: 24 · 2019: 30 · 2018: 27 · 2017: 31 · 2016: 34 · 2015: 48 · 2014: 45 · 2013: 62 · 2012: 44
- FWCI
- 3.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
- Keywords
- reward prediction, reward prediction error, orbitofrontal cortex, ventral striatum, nucleus accumbens, dorsal caudate, punishment, reward anticipation, rectifying behavior
- MeSH terms
- Cognition, Humans, Magnetic Resonance Imaging, Nucleus Accumbens, Reward, Prefrontal Cortex
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