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Breakdown of within- and between-network Resting State Functional Magnetic Resonance Imaging Connectivity during Propofol-induced Loss of Consciousness
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Background: Mechanisms of anesthesia-induced loss of consciousness remain poorly understood. Resting-state functional magnetic resonance imaging allows investigating whole-brain connectivity changes during pharmacological modulation of the level of consciousness. Methods: Low-frequency spontaneous blood oxygen level-dependent fluctuations were measured in 19 healthy volunteers during wakefulness, mild sedation, deep sedation with clinical unconsciousness, and subsequent recovery of consciousness. Results: Propofol-induced decrease in consciousness linearly correlates with decreased corticocortical and thalamocortical connectivity in frontoparietal networks (i.e., default- and executive-control networks). Furthermore, during propofol-induced unconsciousness, a negative correlation was identified between thalamic and cortical activity in these networks. Finally, negative correlations between default network and lateral frontoparietal cortices activity, present during wakefulness, decreased proportionally to propofol-induced loss of consciousness. In contrast, connectivity was globally preserved in low-level sensory cortices, (i.e., in auditory and visual networks across sedation stages). This was paired with preserved thalamocortical connectivity in these networks. Rather, waning of consciousness was associated with a loss of cross-modal interactions between visual and auditory networks. Conclusions: Our results shed light on the functional significance of spontaneous brain activity fluctuations observed in functional magnetic resonance imaging. They suggest that propofol-induced unconsciousness could be linked to a breakdown of cerebral temporal architecture that modifies both within- and between-network connectivity and thus prevents communication between low-level sensory and higher-order frontoparietal cortices, thought to be necessary for perception of external stimuli. They emphasize the importance of thalamocortical connectivity in higher-order cognitive brain networks in the genesis of conscious perception.
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“Based on fMRI, functional disconnections of frontal-parietal networks have been shown during general anesthesia in humans induced by structurally and pharmacologically diverse agents, including the volatile anesthetic sevoflurane [131, 139–141]”
From The Biology of General Anesthesia from Paramecium to Primate (2019) · cites this paper as [140]
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Sanders, R. D., Tononi, G., Laureys, S., Sleigh, J. W., & Warner, D. S. (2012) · Anesthesiology · doi:10.1097/aln.0b013e318249d0a7 · Cited by 474
Self-citation
Metadata
- Authors
- Boveroux, P., Vanhaudenhuyse, A., Bruno, M.-A., Noirhomme, Q., Lauwick, S., Luxen, A., Degueldre, C., Plenevaux, A., Schnakers, C., Phillips, C., Brichant, J.-F., Bonhomme, V., Maquet, P., Greicius, M. D., Laureys, S., & Boly, M.
- Affiliations
- University of Liège (BE)
- Ph.D. Student, A.R.C. Research Fellow.
- Ph.D. Student, F.N.R.S. Research Fellow.
- F.N.R.S. Postdoctoral Researcher.
- Staff Anesthesiologist.
- Professor.
- Research Assistant.
- F.N.R.S. Postdoctoral Research Fellow.
- Stanford Medicine (US)
- Professor, F.N.R.S. Senior Research Associate.
- ORCID
- Venue
- Anesthesiology
- Published
- 2010-11-01
- Volume
- 113
- Issue
- 5
- Pages
- 1038-1053
- ISSN
- 0003-3022 (ISSN-L)
- OpenAlex
- W2112639978
- Cited by
- 630
- References
- 93
- Citations by year
- 2026: 32 · 2025: 27 · 2024: 33 · 2023: 27 · 2022: 33 · 2021: 37 · 2020: 50 · 2019: 41 · 2018: 39 · 2017: 56 · 2016: 45 · 2015: 51 · 2014: 35 · 2013: 55 · 2012: 37
- FWCI
- 24.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Anesthesiology (publishedVersion)
- PubMed (publishedVersion)
- ORBi (University of Liège) (submittedVersion, other-oa)
- Open Repository and Bibliography (University of Liège) (submittedVersion, other-oa)
- Funders
- James S. McDonnell Foundation
- Mind Science Foundation
- European Commission
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- propofol, loss of consciousness, anesthesia, resting-state functional connectivity, thalamocortical connections, corticocortical connectivity, default mode network, frontoparietal network, frontoparietal cortex, cross-modal interaction, consciousness, consciousness recovery, sedation
- MeSH terms
- Adolescent, Adult, Consciousness, Female, Humans, Magnetic Resonance Imaging, Male, Nerve Net, Rest, Unconsciousness, Propofol, Procedural Sedation, Conscious Sedation, Deep Sedation, Young Adult
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