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Cited by 6Genetic Associations and EpidemiologyLipoproteins and Cardiovascular HealthAtherosclerosis and Cardiovascular Diseases

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Dab2 gene variant is associated with increased coronary artery disease risk in Chinese Han population

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Wang, Yinghong, Wang, Yongtao, Adi, Dilare, He, XiaoDong, Liu, Fen, Abudesimu, Asiya, Fu, Zhenyan, Ma, Yitong·2020·Medicine
DOI 10.1097/md.0000000000020924PMC PMC7337449
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Abstract

Disabled-2 (Dab2) is a clathrin and cargo-binding endocytic adaptor protein that plays a role in cellular trafficking of low-density lipoprotein receptor (LDLR). However, little is known about its involvement in coronary artery disease (CAD). Here, we aimed to investigate the association between Dab2 single-nucleotide polymorphisms (SNPs) and CAD in Chinese Han and Uyghur populations.We performed a case-control study in CAD group that consisted of 621 Han and 346 Uygurs, and the age and gender matched control group consisted of 611 Han and 405 Uygurs. The clinicopathological characteristics of these subjects were analyzed. Genotyping of 4 SNPs (rs1050903, rs2855512, rs11959928, and rs2255280) of the Dab2 gene was performed in all subjects with an improved multiplex ligase detection reaction method.The distribution of the genotype, dominant model (AA vs. AC + CC), as well as allele frequencies of both rs2855512 and rs2255280, was significantly different between CAD patients and control subjects in Han population but not in Uyghur population. AA genotype may be a risk factor for CAD. For Han population, statistical significant correlation between dominant model for both SNPs (AA) and CAD was found after multivariate adjustment. After multivariate adjustment in the Han population, we speculate that rs285512 A allele and rs2255280 A allele may be potentially associated with the onset of coronary heart disease. Individuals with the AA genotype had an OR of 1.44 (95% CI: 1.10-1.88, P = .01, rs2855512) and 1.41 (95% CI: 1.08-1.85, P = .01, rs2255280) for CAD compared with individuals with the AC or CC genotype, respectively.Our data indicates that the AA genotype of rs2855512 and rs2255280 in the Dab2 gene may be a genetic marker of CAD risk in Chinese Han population.

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  • Dab2 gene variant is associated with increased risk of coronary artery disease.

    “An earlier study shown that the Dab2 gene variant is associated with increased risk of coronary artery disease [136].”

    From Insights of Endocytosis Signaling in Health and Disease (2023) · cites this paper as [136]

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Metadata

Authors
Wang, Y., Wang, Y., Adi, D., He, X., Liu, F., Abudesimu, A., Fu, Z., & Ma, Y.
Affiliations
  • First Affiliated Hospital of Xinjiang Medical University (CN)
  • Department of Cardiology
  • Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, China.
ORCID
Venue
Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2020-07-02
Volume
99
Issue
27
Pages
e20924
ISSN
  • 0025-7974 (ISSN-L)
  • 1536-5964
DOI
10.1097/md.0000000000020924
PMC
PMC7337449
OpenAlex
W3040651242
Cited by
6
References
4
Citations by year
2026: 1 · 2024: 1 · 2023: 2 · 2021: 1 · 2020: 1
FWCI
0.59
Type
journal article
Language
en
Open access
Licence
Locations
  • Medicine (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
  • Xinjiang Uygur Autonomous Region Natural Science Foundation Project (2017D01C295)
  • Xinjiang Uygur Autonomous Region science and technology branch project (2017E0269)
  • Xinjiang graduate research innovation project (XJGRI2016068)
  • Postgraduate Innovation Project of Xinjiang Medical University (CXCY001)
  • National Natural Science Foundation of China (91957208,81970380)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords
Dab2, Disabled-2, coronary artery disease, single nucleotide polymorphisms, genetic susceptibility, Han Chinese, Uygur population, endocytic adaptor proteins, genetic association
MeSH terms
China, Coronary Artery Disease, Female, Humans, Male, Middle Aged, Risk Factors, Case-Control Studies, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Asian People, Adaptor Proteins, Signal Transducing, Apoptosis Regulatory Proteins

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