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Activation Status of Human Microglia Is Dependent on Lesion Formation Stage and Remyelination in Multiple Sclerosis
Open accessAbstract
Similar to macrophages, microglia adopt diverse activation states and contribute to repair and tissue damage in multiple sclerosis. Using reverse transcription-quantitative polymerase chain reaction and immunohistochemistry, we show that in vitro M1-polarized (proinflammatory) human adult microglia express the distinctive markers CD74, CD40, CD86, and CCR7, whereas M2 (anti-inflammatory) microglia express mannose receptor and the anti-inflammatory cytokine CCL22. The expression of these markers was assessed in clusters of activated microglia in normal-appearing white matter (preactive lesions) and areas of remyelination, representing reparative multiple sclerosis lesions. We show that activated microglia in preactive and remyelinating lesions express CD74, CD40, CD86, and the M2 markers CCL22 and CD209, but not mannose receptor. To examine whether this intermediate microglia profile is static or dynamic and thus susceptible to changes in the microenvironment, we polarized microglia into M1 or M2 phenotype in vitro and then subsequently treated them with the opposing polarization regimen. These studies revealed that expression of CD40, CXCL10, and mannose receptor is dynamic and that microglia, like macrophages, can switch between M1 and M2 phenotypic profiles. Taken together, our data define the differential activation states of microglia during lesion development in multiple sclerosis-affected CNS tissues and underscore the plasticity of human adult microglia in vitro.
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“Here, we show that the increased TSPO expression in multiple sclerosis lesions primarily represents an intermediate activation state in which cells expressed both CD40 and CD206 (Vogel et al., 2013; Peferoen et al., 2015); microglia solely expressing the pro-inflammatory marker CD40 or the anti-inflammatory marker mannose receptor CD206 were sparsely represented.”
From A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis (2019) · cites this paper as Peferoen et al., 2015
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“Additionally, microglia/macrophages in multiple sclerosis lesions adopt an intermediate phenotype, and the classical M1 (pro-inflammatory) and M2 (anti-inflammatory) phenotypes probably represent extreme states only found in vitro (Peferoen et al., 2015).”
From A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis (2019) · cites this paper as Peferoen et al., 2015
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“Here, we show that the increased TSPO expression in multiple sclerosis lesions primarily represents an intermediate activation state in which cells expressed both CD40 and CD206 (Vogel et al., 2013; Peferoen et al., 2015); microglia solely expressing the pro-inflammatory marker CD40 or the anti-inflammatory marker mannose receptor CD206 were sparsely represented.”
From A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis (2019) · cites this paper as Peferoen et al., 2015
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Citations
Cites
NIH Image to ImageJ: 25 years of image analysis
Schneider, C. A., Rasband, W. S., & Eliceiri, K. W. (2012) · Nature Methods · doi:10.1038/nmeth.2089 · Cited by 64,638
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175
Alternative activation of macrophages: mechanism and functions
Gordon, S., & Martinez, F. O. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.007 · Cited by 4,197
Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data
Ruijter, J. M., Ramakers, C., Hoogaars, W. M. H., Karlen, Y., Bakker, O., van den Hoff, M. J. B., & Moorman, A. F. M. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp045 · Cited by 3,043
Microglial physiology: unique stimuli, specialized responses
Ransohoff, R. M., & Perry, V. H. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132528 · Cited by 1,858
M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
Miron, V. E., Boyd, A., Zhao, J.-W., Yuen, T. J., Ruckh, J. M., Shadrach, J. L., van Wijngaarden, P., Wagers, A. J., Williams, A., Franklin, R. J. M., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3469 · Cited by 1,777
Microglia in neurodegenerative disease
Perry, V. H., Nicoll, J. A. R., & Holmes, C. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.17 · Cited by 1,543
Repertoire of microglial and macrophage responses after spinal cord injury
David, S., & Kroner, A. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3053 · Cited by 1,297
Microglial priming in neurodegenerative disease
Perry, V. H., & Holmes, C. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.38 · Cited by 1,127
Research works printed but not linked: 1
- 10.1097/65.2.124 · DOI
Cited by
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Modulators of microglial activation and polarization after intracerebral haemorrhage
Lan, X., Han, X., Li, Q., Yang, Q.-W., & Wang, J. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.69 · Cited by 915
Loss of ‘homeostatic’ microglia and patterns of their activation in active multiple sclerosis
Zrzavy, T., Hametner, S., Wimmer, I., Butovsky, O., Weiner, H. L., & Lassmann, H. (2017) · Brain · doi:10.1093/brain/awx113 · Cited by 684
Walker, D. G., & Lue, L.-F. (2015) · Alzheimer's Research & Therapy · doi:10.1186/s13195-015-0139-9 · Cited by 562
Slow expansion of multiple sclerosis iron rim lesions: pathology and 7 T magnetic resonance imaging
Dal-Bianco, A., Grabner, G., Kronnerwetter, C., Weber, M., Höftberger, R., Berger, T., Auff, E., Leutmezer, F., Trattnig, S., Lassmann, H., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-016-1636-z · Cited by 463
An Inflammation-Centric View of Neurological Disease: Beyond the Neuron
Skaper, S. D., Facci, L., Zusso, M., & Giusti, P. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00072 · Cited by 477
Lively, S. S., & Schlichter, L. C. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00215 · Cited by 411
The pro-remyelination properties of microglia in the central nervous system
Lloyd, A. F., & Miron, V. E. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0184-2 · Cited by 381
Remyelination in multiple sclerosis: From basic science to clinical translation
Lubetzki, C., Zalc, B., Williams, A., Stadelmann, C., & Stankoff, B. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30140-x · Cited by 350
Persistent 7-tesla phase rim predicts poor outcome in new multiple sclerosis patient lesions
Absinta, M., Sati, P., Schindler, M., Leibovitch, E. C., Ohayon, J., Wu, T., Meani, A., Filippi, M., Jacobson, S., Cortese, I. C. M., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86198 · Cited by 327
Inflammation after Ischemic Stroke: The Role of Leukocytes and Glial Cells
Kim, J. Y., Park, J., Chang, J. Y., Kim, S.-H., & Lee, J. E. (2016) · Experimental Neurobiology · doi:10.5607/en.2016.25.5.241 · Cited by 313
Microglia–Neuron Communication in Epilepsy
Eyo, U. B., Murugan, M., & Wu, L. (2016) · Glia · doi:10.1002/glia.23006 · Cited by 300
Multiple Sclerosis: Immunopathology and Treatment Update
Dargahi, N., Κατσάρα, Μ., Tselios, T. V., Androutsou, M., de Courten, M., Matsoukas, J., & Apostolopoulos, V. (2017) · Brain Sciences · doi:10.3390/brainsci7070078 · Cited by 307
Beyond Activation: Characterizing Microglial Functional Phenotypes
Lier, J., Streit, W. J., & Bechmann, I. (2021) · Cells · doi:10.3390/cells10092236 · Cited by 274
“[74] suggested that CD74 expression represents a pro-inflammatory state.”
BackgroundBrain microglia in psychiatric disorders
Mondelli, V., Vernon, A. C., Turkheimer, F., Dazzan, P., & Pariante, C. M. (2017) · The Lancet Psychiatry · doi:10.1016/s2215-0366(17)30101-3 · Cited by 271
Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target
Du, L., Zhang, Y., Chen, Y., Zhu, J., Yang, Y., & Zhang, H.-L. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0245-0 · Cited by 280
Oxidative stress and its impact on neurons and glia in multiple sclerosis lesions
Lassmann, H., & van Horssen, J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.09.018 · Cited by 245
He, W., Kapate, N., Shields, C. W., & Mitragotri, S. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.12.001 · Cited by 241
Myelin damage and repair in pathologic CNS: challenges and prospects
Alizadeh, A., Dyck, S. M., & Karimi‐Abdolrezaee, S. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00035 · Cited by 246
An Overview of in vitro Methods to Study Microglia
Timmerman, R., Burm, S. M., & Bajramovic, J. J. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00242 · Cited by 243
Acute and non-resolving inflammation associate with oxidative injury after human spinal cord injury
Zrzavy, T., Schwaiger, C., Wimmer, I., Berger, T., Bauer, J., Butovsky, O., Schwab, J. M., Lassmann, H., & Höftberger, R. (2020) · Brain · doi:10.1093/brain/awaa360 · Cited by 212
The role of microglia in multiple sclerosis
Luo, C., Jian, C., Liao, Y., Huang, Q., Wu, Y., Liu, X., Zou, D., & Wu, Y. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s140634 · Cited by 187
Cellular sources of TSPO expression in healthy and diseased brain
Nutma, E., Ceyzériat, K., Amor, S., Tsartsalis, S., Millet, P., Owen, D. R., Papadopoulos, V., & Tournier, B. B. (2021) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-020-05166-2 · Cited by 192
Self-citationRecent developments on PET radiotracers for TSPO and their applications in neuroimaging
Zhang, L., Hu, K., Shao, T., Hou, L., Zhang, S., Ye, W., Josephson, L., Meyer, J. H., Zhang, M., Vasdev, N., et al. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.08.006 · Cited by 195
Myeloid cells — targets of medication in multiple sclerosis
Mishra, M. K., & Yong, V. W. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.110 · Cited by 189
Sabogal-Guáqueta, A. M., Marmolejo-Garza, A., Trombetta-Lima, M., Oun, A., Hunneman, J., Chen, T., Koıstınaho, J., Lehtonen, Š., Kortholt, A., Wolters, J. C., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42096-7 · Cited by 180
Advanced MRI and staging of multiple sclerosis lesions
Absinta, M., Sati, P., & Reich, D. S. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.59 · Cited by 161
van Wageningen, T. A., Vlaar, E., Kooij, G., Jongenelen, C. A. M., Geurts, J. J. G., & van Dam, A.-M. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0850-z · Cited by 147
The C-C Chemokines CCL17 and CCL22 and Their Receptor CCR4 in CNS Autoimmunity
Scheu, S., Ali, S., Ruland, C., Arolt, V., & Alferink, J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112306 · Cited by 150
Beaino, W., Janssen, B., Kooij, G., van der Pol, S. M. A., Hof, B. V. H., van Horssen, J., Windhorst, A. D., & de Vries, H. E. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-1034-z · Cited by 145
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Nutma, E., Stephenson, J. A., Gorter, R. P., de Bruin, J., Boucherie, D. M., Donat, C. K., Breur, M., van der Valk, P., Matthews, P. M., Owen, D. R., et al. (2019) · Brain · doi:10.1093/brain/awz287 · Cited by 138
“In contrast, active and chronic active lesions showed an increase in CD206+CD40+ cells expressing TSPO ( I and J ).”
InfluentialSelf-citationNeuroinflammation, Mast Cells, and Glia: Dangerous Liaisons
Skaper, S. D., Facci, L., Zusso, M., & Giusti, P. (2017) · The Neuroscientist · doi:10.1177/1073858416687249 · Cited by 133
Dulamea, A. O. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-47861-6_7 · Cited by 128
Microglial Phenotypes and Functions in Multiple SclerosisPreprint
O'Loughlin, E. K., Madore, C., Lassmann, H., & Butovsky, O. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a028993 · Cited by 133
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Alghamdi, M. A., Alasmari, D., Assiri, A., Mattar, E. H., Aljaddawi, A. A., Alattas, S. G., & Redwan, E. M. M. M. (2019) · Journal of Immunology Research · doi:10.1155/2019/7592851 · Cited by 129
Maleki, A. F., & Rivest, S. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00355 · Cited by 120
Eles, J. R., Vazquez, A. L., Snyder, N. R., Lagenaur, C. F., Murphy, M. C., Kozai, T. D. Y., & Cui, X. T. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.10.054 · Cited by 117
N-Palmitoylethanolamine and Neuroinflammation: a Novel Therapeutic Strategy of Resolution
Skaper, S. D., Facci, L., Barbierato, M., Zusso, M., Bruschetta, G., Impellizzeri, D., Cuzzocrea, S., & Giusti, P. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9253-8 · Cited by 116
Multiple Sclerosis and Obesity: Possible Roles of Adipokines
Guerrero-García, J. D. J., Carrera-Quintanar, L., López-Roa, R. I., Márquez-Aguirre, A. L., Rojas-Mayorquín, A. E., & Ortuño‐Sahagún, D. (2016) · Mediators of Inflammation · doi:10.1155/2016/4036232 · Cited by 111
Different Approaches to Modulation of Microglia Phenotypes After Spinal Cord Injury
Akhmetzyanova, E. R., Kletenkov, K., Mukhamedshina, Y. O., & Rizvanov, A. A. (2019) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2019.00037 · Cited by 110
Molecular signature of slowly expanding lesions in progressive multiple sclerosis
Jäckle, K., Zeis, T., Schaeren‐Wiemers, N., Junker, A., van der Meer, F., Kramann, N., Stadelmann, C., & Brück, W. (2020) · Brain · doi:10.1093/brain/awaa158 · Cited by 102
Nutma, E., Gebro, E., Marzin, M. C., van der Valk, P., Matthews, P. M., Owen, D. R., & Amor, S. (2021) · Glia · doi:10.1002/glia.24052 · Cited by 95
Self-citationWhite matter microglia heterogeneity in the CNS
Amor, S., McNamara, N. B., Gerrits, E., Marzin, M. C., Kooistra, S. M., Miron, V. E., & Nutma, E. (2022) · Acta Neuropathologica · doi:10.1007/s00401-021-02389-x · Cited by 89
Self-citationMicroglia in action: how aging and injury can change the brain’s guardians
Lourbopoulos, A. I., Ertürk, A., & Hellal, F. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00054 · Cited by 97
Immune changes in peripheral blood and hematoma of patients with intracerebral hemorrhage
Jiang, C. Q., Wang, Y., Hu, Q., Shou, J., Zhu, L., Tian, N., Sun, L., Luo, H., Zuo, F., Li, F., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201902478r · Cited by 85
Microglia activation is associated with IFN-α induced depressive-like behavior
Wachholz, S., Eßlinger, M., Plümper, J., Manitz, M. P., Juckel, G., & Friebe, A. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.09.016 · Cited by 84
Pathological differences between white and grey matter multiple sclerosis lesions
Prins, M., Schul, E., Geurts, J. J. G., van der Valk, P., Drukarch, B., & van Dam, A. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12841 · Cited by 89
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Guo, Y., Dai, W., Zheng, Y., Qiao, W., Chen, W., Peng, L., Zhou, H., Zhao, T., Liu, H., Zheng, F., et al. (2022) · Molecules · doi:10.3390/molecules27207080 · Cited by 83
The CD40–CD40L Dyad in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis
Aarts, S. A. B. M., Seijkens, T. T. P., van Dorst, K. J. F., Dijkstra, C. D., Kooij, G., & Lutgens, E. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01791 · Cited by 76
Self-citationSénécal, V., Deblois, G., Beauseigle, D., Schneider, R., Brandenburg, J., Newcombe, J., Moore, C. S., Prat, A., Antel, J. P., & Arbour, N. (2015) · Glia · doi:10.1002/glia.22948 · Cited by 74
Janssen, B., Vugts, D. J., Funke, U., Molenaar, G. T., Kruijer, P. S., van Berckel, B. N. M., Lammertsma, A. A., & Windhorst, A. D. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.11.011 · Cited by 77
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Wang, H., Li, J., Zhang, H., Wang, M., Xiao, L., Wang, Y., & Cheng, Q. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1182621 · Cited by 81
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Burm, S. M., Peferoen, L. A. N., Zuiderwijk-Sick, E. A., Haanstra, K. G., Hart, B. A. ‘., van der Valk, P., Amor, S., Bauer, J., & Bajramovic, J. J. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0605-8 · Cited by 73
Self-citationOligodendrocyte precursor cells as a therapeutic target for demyelinating diseases
Skaper, S. D. (2019) · Progress in brain research · doi:10.1016/bs.pbr.2019.03.013 · Cited by 73
Thyroid Hormone Potentially Benefits Multiple Sclerosis via Facilitating Remyelination
Zhang, M., Ma, Z., Qin, H., & Yao, Z. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9375-z · Cited by 68
Haber, M., James, J., Kim, J. S., Sangobowale, M., Irizarry, R., Ho, J. S., Nikulina, E., Grinkina, N., Ramadani, A., Hartman, I., et al. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17718106 · Cited by 66
Demyelination patterns in a mathematical model of multiple sclerosis
Lombardo, M. C., Barresi, R., Bilotta, E., Gargano, F., Pantano, P., & Sammartino, M. (2016) · Journal of Mathematical Biology · doi:10.1007/s00285-016-1087-0 · Cited by 64
Galloway, D. A., Blandford, S. N., Berry, T., Williams, J. B., Stefanelli, M., Ploughman, M., & Moore, C. S. (2019) · Glia · doi:10.1002/glia.23576 · Cited by 64
Michailidou, I., Naessens, D., Hametner, S., Guldenaar, W., Kooi, E., Geurts, J., Baas, F., Lassmann, H., & Ramaglia, V. (2016) · Glia · doi:10.1002/glia.23090 · Cited by 75
Towards PET imaging of the dynamic phenotypes of microglia
Beaino, W., Janssen, B., Vugts, D. J., de Vries, H. E., & Windhorst, A. D. (2021) · Clinical & Experimental Immunology · doi:10.1111/cei.13649 · Cited by 63
Sabogal-Guáqueta, A. M., Marmolejo-Garza, A., de Pádua, V. P., Eggen, B. J. L., Boddeke, E., & Dolga, A. M. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101805 · Cited by 65
Mahajan, S. D., Homish, G. G., & Quisenberry, A. J. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.664748 · Cited by 68
Shi, H. R., Zheng, K., Su, Z., Su, H., Zhong, M., He, X., Zhou, C., Chen, H., Xiong, Q., & Zhang, Y. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.08.010 · Cited by 53
Oyanagi, K., Kinoshita, M., Suzuki‐Kouyama, E., Inoue, T., Nakahara, A., Tokiwai, M., Arai, N., Satoh, J., Aoki, N., Jinnai, K., et al. (2016) · Brain Pathology · doi:10.1111/bpa.12443 · Cited by 55
Interferon β-Mediated Protective Functions of Microglia in Central Nervous System Autoimmunity
Scheu, S., Ali, S., Mann‐Nüttel, R., Richter, L., Arolt, V., Dannlowski, U., Kuhlmann, T., Klotz, L., & Alferink, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20010190 · Cited by 49
Human Brain Chemokine and Cytokine Expression in Sepsis: A Report of Three Cases
Warford, J. R., Lamport, A.-C., Kennedy, B. E., & Easton, A. S. (2016) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/cjn.2016.310 · Cited by 48
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Panaro, M. A., Benameur, T., & Porro, C. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051534 · Cited by 50
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Amoriello, R., Memo, C., Ballerini, L., & Ballerini, C. (2024) · Molecular Brain · doi:10.1186/s13041-024-01077-7 · Cited by 47
Oncostatin M-induced astrocytic tissue inhibitor of metalloproteinases-1 drives remyelination
Houben, E., Janssens, K., Hermans, D., Vandooren, J., den Haute, C. V., Schepers, M., Vanmierlo, T., Lambrichts, I., van Horssen, J., Baekelandt, V., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1912910117 · Cited by 44
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Rahat, M. A., & Shakya, J. (2016) · Mediators of Inflammation · doi:10.1155/2016/4375120 · Cited by 49
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Guley, N., Mar, N. A. D., Ragsdale, T. D., Li, C., Perry, A. M., Moore, B. M., II, Honig, M. G., & Reiner, A. J. (2019) · Experimental Eye Research · doi:10.1016/j.exer.2019.03.013 · Cited by 42
Pathology of inflammatory diseases of the nervous system: Human disease versus animal models
Lassmann, H. (2019) · Glia · doi:10.1002/glia.23726 · Cited by 44
Lymphotoxin-alpha expression in the meninges causes lymphoid tissue formation and neurodegeneration
Bates, R. E. J., Browne, E., Schalks, R., Jacobs, H., Tan, L. Y., Parekh, P., Magliozzi, R., Calabrese, M., Mazarakis, N. D., & Reynolds, R. (2022) · Brain · doi:10.1093/brain/awac232 · Cited by 42
de Jong, C. G. H. M., Gabius, H., & Baron, W. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03327-7 · Cited by 44
Peferoen, L. A. N., Breur, M., van de Berg, S., Peferoen‐Baert, R., Boddeke, E. H. W. G. M., van der Valk, P., Pryce, G., van Noort, J. M., Baker, D., & Amor, S. (2016) · Immunology · doi:10.1111/imm.12644 · Cited by 41
Self-citationWang, P., Gorter, R. P., de Jonge, J. C., Nazmuddin, M., Zhao, C., Amor, S., Hoekstra, D., & Baron, W. (2018) · Glia · doi:10.1002/glia.23328 · Cited by 40
Self-citationManipulating Macrophage/Microglia Polarization to Treat Glioblastoma or Multiple Sclerosis
Kuntzel, T., & Bagnard, D. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14020344 · Cited by 43
Pioglitazone regulates myelin phagocytosis and multiple sclerosis monocytes
Natrajan, M. S., Komori, M., Kosa, P. F., Johnson, K. R., Wu, T., Franklin, R. J. M., & Bielekova, B. (2015) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.260 · Cited by 40
Bodini, B., Poirion, É., Tonietto, M., Benoit, C., Palladino, R., Maillart, É., Portera, E., Battaglini, M., Bera, G. C., Kühnast, B., et al. (2020) · Journal of Nuclear Medicine · doi:10.2967/jnumed.119.231340 · Cited by 44
Myeloid cell iron uptake pathways and paramagnetic rim formation in multiple sclerosis
Hofmann, A., Krajnc, N., Dal‐Bianco, A., Riedl, C. J., Zrzavy, T., Lerma-Martin, C., Kasprian, G. J., Weber, C. E., Pezzini, F., Leutmezer, F., et al. (2023) · Acta Neuropathologica · doi:10.1007/s00401-023-02627-4 · Cited by 41
Zhang, C., Kang, J., Zhang, X., Zhang, Y., Huang, N., & Ning, B. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113500 · Cited by 40
Impellizzeri, D., Cordaro, M., Bruschetta, G., Siracusa, R., Crupi, R., Esposito, E., & Cuzzocrea, S. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2016.4808 · Cited by 37
de Jong, J. M., Wang, P., Oomkens, M., & Baron, W. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24582 · Cited by 41
Endogenous neural stem cells modulate microglia and protect against demyelination
Brousse, B., Mercier, O., Magalon, K., Daian, F., Durbec, P., & Cayre, M. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.05.002 · Cited by 38
Cellular and Molecular Mechanisms Underpinning Macrophage Activation during Remyelination
Lloyd, A. F., & Miron, V. E. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00060 · Cited by 37
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Manjili, F. A., Yousefi‐Ahmadipour, A., & Arababadi, M. K. (2020) · Immunology Letters · doi:10.1016/j.imlet.2020.02.004 · Cited by 34
The use and limitations of single‐cell mass cytometry for studying human microglia function
Fernández‐Zapata, C., Leman, J. K. H., Priller, J., & Böttcher, C. (2020) · Brain Pathology · doi:10.1111/bpa.12909 · Cited by 38
Immunopathology of Tumefactive Demyelinating Lesions-From Idiopathic to Drug-Related Cases
Vakrakou, A. G., Brinia, M.-E., Svolaki, I. P., Argyrakos, T., Stefanis, L., & Kilidireas, C. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.868525 · Cited by 32
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Self-citationvan Schaik, P. E. M., Zuhorn, I. S., & Baron, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158418 · Cited by 35
Skaper, S. D. (2017) · International review of neurobiology · doi:10.1016/bs.irn.2017.08.004 · Cited by 31
Kasatkina, L. A., Heinemann, Á., Hudz, Y. A., Thomas, D., & Sturm, E. M. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.113783 · Cited by 30
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Potru, P. S., & Spittau, B. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.371350 · Cited by 28
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Weinstock, L. D., Furness, A., Herron, S., Smith, S., Sankar, S. B., DeRosa, S., Gao, D., Mepyans, M. E., Rosato, A. S., Medina, D. L., et al. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy182 · Cited by 25
Laurikainen, H., Vuorela, A., Toivonen, A., Reinert‐Hartwall, L., Trontti, K., Lindgren, M., Keinänen, J., Mäntylä, T. J. S., Paju, J., Ilonen, T., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0776-z · Cited by 32
Miedema, A., Wijering, M. H. C., Eggen, B. J. L., & Kooistra, S. M. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.583811 · Cited by 24
TMEM106B regulates microglial proliferation and survival in response to demyelination
Zhang, T., Pang, W., Feng, T., Guo, J. D., Wu, K., Santos, M. N., Arthanarisami, A., Nana, A. L., Nguyen, Q., Kim, P. J., et al. (2023) · Science Advances · doi:10.1126/sciadv.add2676 · Cited by 23
Vergara, D., Nigro, A., Romano, A., Domenico, S. D., D’Amato, M., Franck, J., Coricciati, C., Wisztorski, M., Cardon, T., Fournier, I., et al. (2019) · Cells · doi:10.3390/cells8060580 · Cited by 24
Microglia as a Hub for Suicide Neuropathology: Future Investigation and Prevention Targets
de Andrade, E. G., Ibáñez, F. G., & Tremblay, M. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.839396 · Cited by 22
Satoh, J. (2017) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12426 · Cited by 22
Metadata
- Authors
- Peferoen, L. A. N., Vogel, D. Y. S., Ummenthum, K., Breur, M., Heijnen, P. D. A. M., Gerritsen, W. H., Peferoen-Baert, R. M. B., van der Valk, P., Dijkstra, C. D., & Amor, S.
- Affiliations
- Queen Mary University of London (GB)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Amor, Sandra
- Venue
- Journal of Neuropathology & Experimental Neurology
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-01
- Volume
- 74
- Issue
- 1
- Pages
- 48-63
- ISSN
- 0022-3069 (ISSN-L)
- 1554-6578
- OpenAlex
- W2079198405
- Cited by
- 178
- References
- 66
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 10 · 2023: 11 · 2022: 19 · 2021: 11 · 2020: 18 · 2019: 24 · 2018: 13 · 2017: 17 · 2016: 26 · 2015: 15
- FWCI
- 14.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuropathology & Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- microglial activation, multiple sclerosis, remyelination, macrophage polarization, microglial plasticity, CD40, CD74, CCL22, CD206, CD86, CXCL10, normal-appearing white matter, lesion progression, microglial markers
- MeSH terms
- Aged, Aged, 80 and over, Histocompatibility Antigens Class II, Brain, Cell Differentiation, Cells, Cultured, Female, Flow Cytometry, Humans, Macrophages, Male, Middle Aged, Multiple Sclerosis, RNA, Messenger, Antigens, CD, Cytokines, Microglia, Statistics, Nonparametric, Myelin Proteolipid Protein, Transcriptome
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