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Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy After Repetitive Head Injury
Open accessAbstract
Since the 1920s, it has been known that the repetitive brain trauma associated with boxing may produce a progressive neurological deterioration, originally termed dementia pugilistica, and more recently, chronic traumatic encephalopathy (CTE). We review 48 cases of neuropathologically verified CTE recorded in the literature and document the detailed findings of CTE in 3 profession althletes, 1 football player and 2 boxers. Clinically, CTE is associated with memory disturbances, behavioral and personality changes, parkinsonism, and speech and gait abnormalities. Neuropathologically, CTE is characterized by atrophy of the cerebral hemispheres, medial temporal lobe, thalamus, mammillary bodies, and brainstem, with ventricular dilatation and a fenestrated cavum septum pellucidum. Microscopically, there are extensive tau-immunoreactive neurofibrillary tangles, astrocytic tangles, and spindle-shaped and threadlike neurites throughout the brain. The neurofibrillary degeneration of CTE is distinguished from other tauopathies by preferential involvement of the superficial cortical layers, irregular patchy distribution in the frontal and temporal cortices, propensity for sulcal depths, prominent perivascular, periventricular, and subpial distribution, and marked accumulation of tau-immunoreactive astrocytes. Deposition of beta-amyloid, most commonly as diffuse plaques, occurs in fewer than half the cases. Chronic traumatic encephalopathy is a neuropathologically distinct slowly progressive tauopathy with a clear environmental etiology.
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“However, despite evidence for Ab deposition in moderate to severe TBI [94], Ab plaques have not been found in early or mild stages of CTE in young individuals [65, 66, 72, 91, 126] but occur in older subjects with CTE in association with increased age at death [128].”
From The neuropathology of sport (2014) · cites this paper as [126]
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“It is now well established that a large percentage of former athletes identified as having CTE neuropathology also have neuropathology associated with age related neurodegenerative diseases such as AD, PD, Lewy body disease, hippocampal sclerosis, and ALS [14, 41–44] to the extent that they meet full neuropathological criteria for an alternative, well-characterized neurodegenerative disease [16].”
From The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features (2017) · cites this paper as [14]
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“In publications from 2005–2015, CTE has been described as a progressive neurodegenerative disease characterized by a broad and diverse range of both macroscopic and microscopic neuropathology.”
From The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features (2017) · cites this paper as [14]
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“The clinical syndrome of CTE continues to be refined but includes behavioral, mood, and cognitive dysfunction as well as occasional motor symptoms that are typically extrapyramidal (1,2).”
From Chronic Traumatic Encephalopathy Within an Amyotrophic Lateral Sclerosis Brain Bank Cohort (2018) · cites this paper as [1]
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“In conclusion, the prevailing theory of CTE, often expressed in articles as fact, is that it is a distinct (1, 3, 9-11) and unique (10) neurodegenerative disease (9-13).”
From Mild Chronic Traumatic Encephalopathy Neuropathology in People With No Known Participation in Contact Sports or History of Repetitive Neurotrauma (2019) · cites this paper as [3]
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“The clinical symptoms associated with this disease were examined in case summaries throughout the twentieth century; however, the disease presentation described in these reports was inconsistent [38, 65, 92, 100, 126].”
From The neuropathology of sport (2014) · cites this paper as [126]
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Citations
Cites
The Epidemiology and Impact of Traumatic Brain Injury: A Brief Overview
Langlois, J., Rutland-Brown, W., & Wald, M. (2006) · The journal of head trauma rehabilitation · doi:10.1097/00001199-200609000-00001 · Cited by 3,893
A PROPOSED MECHANISM OF EMOTION
PAPEZ, J. W. (1937) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1937.02260220069003 · Cited by 3,563
Measurement of Functional Activities in Older Adults in the Community
PFEFFER, R. I., Kurosaki, T., Harrah, C. H., Chance, J. M., & Filos, S. (1982) · Journal of Gerontology · doi:10.1093/geronj/37.3.323 · Cited by 2,978
Guskiewicz, K. M., McCrea, M., Marshall, S. W., Cantu, R. C., Randolph, C., Barr, W., Onate, J. A., & Kelly, J. P. (2003) · JAMA · doi:10.1001/jama.290.19.2549 · Cited by 1,712
Self-citationEnhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
Lewis, J., Dickson, D. W., Lin, W.-L., Chisholm, L., Corral, A., Jones, G., Yen, S.-H., Sahara, N., Skipper, L., Yager, D., et al. (2001) · Science · doi:10.1126/science.1058189 · Cited by 1,611
Lewis, J., McGowan, E., Rockwood, J., Melrose, H., Nacharaju, P., Van Slegtenhorst, M., Gwinn-Hardy, K., Murphy, M. P., Baker, M., Yu, X., et al. (2000) · Nature Genetics · doi:10.1038/78078 · Cited by 1,371
The Neurometabolic Cascade of Concussion.
Giza, C. C., & Hovda, D. A. (2001) · PubMed Central · Cited by 1,342
The hippocampus and memory: insights from spatial processing
Bird, C. M., & Burgess, N. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2335 · Cited by 1,313
Galvin, J. E., Roe, C. M., Powlishta, K. K., Coats, M. A., Muich, S. J., Grant, E., Miller, J. P., Storandt, M., & Morris, J. C. (2005) · Neurology · doi:10.1212/01.wnl.0000172958.95282.2a · Cited by 1,157
OMMAYA, A. K., & GENNARELLI, T. A. (1974) · Brain · doi:10.1093/brain/97.1.633 · Cited by 1,026
Kraus, M. F., Susmaras, T. M., Caughlin, B., Walker, C. J., Sweeney, J. A., & Little, D. M. (2007) · Brain · doi:10.1093/brain/awm216 · Cited by 994
Corsellis, J. A. N., Bruton, C. J., & Freeman-Browne, D. (1973) · Psychological Medicine · doi:10.1017/s0033291700049588 · Cited by 836
MARTLAND, H. S. (1928) · Journal of the American Medical Association · doi:10.1001/jama.1928.02700150029009 · Cited by 774
Diffusion tensor MR imaging in diffuse axonal injury.
Arfanakis, K., Haughton, V. M., Carew, J. D., Rogers, B. P., Dempsey, R. J., & Meyerand, M. E. (2002) · PubMed Central · Cited by 750
DIFFUSE DEGENERATION OF THE CEREBRAL WHITE MATTER IN SEVERE DEMENTIA FOLLOWING HEAD INJURY
Strich, S. J. (1956) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.19.3.163 · Cited by 728
CHRONIC TRAUMATIC ENCEPHALOPATHY IN A NATIONAL FOOTBALL LEAGUE PLAYER: PART II
Omalu, B. I., DeKosky, S. T., Hamilton, R. L., Minster, R. L., Kamboh, M. I., Shakir, A. M., & Wecht, C. H. (2006) · Neurosurgery · doi:10.1227/01.neu.0000245601.69451.27 · Cited by 694
Chronic Traumatic Encephalopathy in a National Football League Player
Kelly, D. F. (2006) · Neurosurgery · doi:10.1097/00006123-200605000-00037 · Cited by 694
Holbourn, A. (1943) · The Lancet · doi:10.1016/s0140-6736(00)87453-x · Cited by 681
β-Amyloid precursor protein (βAPP) as a marker for axonal injury after head injury
Gentleman, S. M., Nash, M. J., Sweeting, C. J., Graham, D. I., & Roberts, G. W. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90398-5 · Cited by 570
Roberts, G. W., Gentleman, S. M., Lynch, A., Murray, L., Landon, M., & Graham, D. I. (1994) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.4.419 · Cited by 569
The occult aftermath of boxing.
Roberts, G. W., Allsop, D., & Bruton, C. (1990) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.53.5.373 · Cited by 518
Apolipoprotein E ε4 allele is associated with deposition of amyloid β-protein following head injury
Nicoll, J. A. R., Roberts, G. W., & Graham, D. I. (1995) · Nature Medicine · doi:10.1038/nm0295-135 · Cited by 486
HEAD IMPACT SEVERITY MEASURES FOR EVALUATING MILD TRAUMATIC BRAIN INJURY RISK EXPOSURE
Greenwald, R., Gwin, J. T., Chu, J., & Crisco, J. (2008) · Neurosurgery · doi:10.1227/01.neu.0000318162.67472.ad · Cited by 476
Litvan, I., Hauw, J., Bartko, J. J., Lantos, P. L., Daniel, S. E., Horoupian, D. S., McKee, A. C., Dickson, D. W., Bancher, C., Tabaton, M., et al. (1996) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199601000-00010 · Cited by 474
Self-citationCumulative Effects of Concussion in High School Athletes
Collins, M. W., Lovell, M. R., Iverson, G. L., Cantu, R. C., Maroon, J. C., & Field, M. (2002) · Neurosurgery · doi:10.1097/00006123-200211000-00011 · Cited by 471
Self-citationStalning af amyloid percursor protein to study axonal damage in mild head Injury
Blumbergs, P. C., Scott, G., Manavis, J., Wainwright, H., Simpson, D. A., & McLean, A. J. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91712-4 · Cited by 454
βA4 amyloid protein deposition in brain after head trauma
Roberts, G., Gentleman, S., Lynch, A., & Graham, D. I. (1991) · The Lancet · doi:10.1016/0140-6736(91)92724-g · Cited by 440
Progressive atrophy and neuron death for one year following brain trauma in the rat
Smith, D. H., Chen, X.-H., Pierce, J. E. S., Wolf, J. A., Trojanowski, J. Q., Graham, D. I., & McIntosh, T. K. (1997) · Journal of Neurotrauma · doi:10.1089/neu.1997.14.715 · Cited by 440
Apolipoprotein E-ε4 genotype predicts a poor outcome in survivors of traumatic brain injury
Friedman, G., Froom, P., Sazbon, L., Grinblatt, I., Shochina, M., Tsenter, J., Babaey, S., Yehuda, A. B., & Groswasser, Z. (1999) · Neurology · doi:10.1212/wnl.52.2.244 · Cited by 437
Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury
Ikonomovic, M. D., Uryu, K., Abrahamson, E. E., Ciallella, J. R., Trojanowski, J. Q., Lee, V. M.-Y., Clark, R. S., Marion, D. W., Wisniewski, S. R., & DeKosky, S. T. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.06.011 · Cited by 399
The neurophysiology of brain injury
Gaetz, M. (2003) · Clinical Neurophysiology · doi:10.1016/s1388-2457(03)00258-x · Cited by 395
A proposed mechanism of emotion. 1937 [classical article]
Papez, J. W. (1995) · Journal of Neuropsychiatry · doi:10.1176/jnp.7.1.103 · Cited by 389
Use-Dependent Exaggeration of Neuronal Injury after Unilateral Sensorimotor Cortex Lesions
Kozlowski, D. A., James, D. C., & Schallert, T. J. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-15-04776.1996 · Cited by 389
Neuropsychological Functioning and Recovery after Mild Head Injury in Collegiate Athletes
Macciocchi, S. N., Barth, J. T., Alves, W. M., Rimel, R. W., & Jane, J. A. (1996) · Neurosurgery · doi:10.1097/00006123-199609000-00014 · Cited by 370
Uryu, K., Chen, X.-H., Martinez, D., Browne, K. D., Johnson, V. E., Graham, D. I., Lee, V. M.-Y., Trojanowski, J. Q., & Smith, D. H. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.06.018 · Cited by 360
Thurman, D. J., Branche, C. M., & Sniezek, J. E. (1998) · Journal of Head Trauma Rehabilitation · doi:10.1097/00001199-199804000-00003 · Cited by 342
Uryu, K., Laurer, H., McIntosh, T., Praticò, D., Martinez, D., Leight, S., Lee, V. M.-Y., & Trojanowski, J. Q. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-02-00446.2002 · Cited by 337
Buée, L., Hof, P. R., Bouras, C., Delacourte, A., Perl, D. P., Morrison, J. H., & Fillit, H. M. (1994) · Acta Neuropathologica · doi:10.1007/bf00294173 · Cited by 331
Recent advances in neurotrauma
Graham, D. I., McIntosh, T. K., Maxwell, W. L., & Nicoll, J. A. R. (2000) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/59.8.641 · Cited by 328
Neuronal cytoskeletal changes are an early consequence of repetitive head injury
Geddes, J. F., Vowles, G. H., Nicoll, J. A. R., & Révész, T. (1999) · Acta Neuropathologica · doi:10.1007/s004010051066 · Cited by 323
Chronic traumatic brain injury in professional soccer players
Matser, J. T., Kessels, A. G. H., Jordan, B. D., Lezak, M. D., & Troost, J. (1998) · Neurology · doi:10.1212/wnl.51.3.791 · Cited by 319
Conformational change as one of the earliest alterations of tau in Alzheimer's disease
Weaver, C. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00157-3 · Cited by 310
Dixon, C. E., Kochanek, P. M., Yan, H. Q., Schiding, J. K., GRIFFITH, R. G., Baum, E., Marion, D. W., & DeKosky, S. T. (1999) · Journal of Neurotrauma · doi:10.1089/neu.1999.16.109 · Cited by 303
Amyloid-β Dynamics Correlate with Neurological Status in the Injured Human Brain
Brody, D. L., Magnoni, S., Schwetye, K. E., Spinner, M. L., Esparza, T. J., Stocchetti, N., Zipfel, G. J., & Holtzman, D. M. (2008) · Science · doi:10.1126/science.1161591 · Cited by 295
Medical Aspects of Boxing, Particularly from a Neurological Standpoint
Critchley, M. (1957) · BMJ · doi:10.1136/bmj.1.5015.357 · Cited by 285
Bergsneider, M. D., Hovda, D. A., Lee, S. M., Kelly, D. F., McArthur, D. L., Vespa, P. M., Lee, J. H., Huang, S., Martin, N. A., Phelps, M. E., et al. (2000) · Journal of Neurotrauma · doi:10.1089/neu.2000.17.389 · Cited by 278
Feany, M. Β., Mattiace, L. A., & Dickson, D. W. (1996) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199601000-00006 · Cited by 264
Smith, D. H., Chen, X.-H., Nonaka, M., Trojanowski, J. Q., Lee, V.-Y., Saatman, K. E., Leoni, M. J., Xu, B.-N., Wolf, J. A., & Meaney, D. F. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199909000-00008 · Cited by 260
Pierce, J., Trojanowski, J., Graham, D., Smith, D., & McIntosh, T. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-03-01083.1996 · Cited by 239
The Neurochemical and Metabolic Cascade Following Brain Injury: Moving from Animal Models to Man
Hovda, D. A., LEE, S. M., Smith, M. L., Stuck, S., Bergsneider, M., Kelly, D. F., Shalmon, E., Martin, N. A., Caron, M., Mazziotta, J. C., et al. (1995) · Journal of Neurotrauma · doi:10.1089/neu.1995.12.903 · Cited by 231
Schmidt, M., Zhukareva, V., Newell, K., Lee, V., & Trojanowski, J. (2001) · Acta Neuropathologica · doi:10.1007/s004010000330 · Cited by 230
Hughes, D., Jackson, A., Mason, D., Berry, E., Hollis, S., & Yates, D. W. (2004) · Neuroradiology · doi:10.1007/s00234-004-1227-x · Cited by 225
BRAMLETT, H. M., KRAYDIEH, S., GREEN, E. J., & DIETRICH, W. D. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199710000-00007 · Cited by 225
Electrophysiological evidence for the cumulative effects of concussion
Gaetz, D. G. M. (2000) · Brain Injury · doi:10.1080/02699050050203577 · Cited by 225
Long-term electrophysiological changes in athletes with a history of multiple concussions
Beaumont, L. D., Brisson, B., Lassonde, M. C., & Jolicœur, P. (2007) · Brain Injury · doi:10.1080/02699050701426931 · Cited by 218
Hof, P. R., Bouras, C., Bu�e, L., Delacourte, A., Perl, D. P., & Morrison, J. H. (1992) · Acta Neuropathologica · doi:10.1007/bf00304630 · Cited by 213
Colicos, M. A., Dixon, C. E., & Dash, P. K. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00819-0 · Cited by 205
Tokuda, T., Ikeda, S., Yanagisawa, N., Ihara, Y., & Glenner, G. G. (1991) · Acta Neuropathologica · doi:10.1007/bf00308813 · Cited by 202
Salmond, C. H., Menon, D. K., Chatfield, D. A., Williams, G. B., Peña, A., Sahakian, B. J., & Pickard, J. D. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.07.012 · Cited by 197
Is β-APP a marker of axonal damage in short-surviving head injury?
McKenzie, K. J., McLellan, D. R., Gentleman, S. M., Maxwell, W., Gennarelli, T. A., & Graham, D. I. (1996) · Acta Neuropathologica · doi:10.1007/s004010050568 · Cited by 193
Neurophysiological Anomalies in Symptomatic and Asymptomatic Concussed Athletes
Gosselin, N., Thériault, M., Leclerc, S., Montplaisir, J. Y., & Lassonde, M. C. (2006) · Neurosurgery · doi:10.1227/01.neu.0000215953.44097.fa · Cited by 192
Bailes, J. E., & Cantu, R. C. (2001) · Neurosurgery · doi:10.1097/00006123-200101000-00005 · Cited by 184
Self-citationNeurological disease in boxers
Mawdsley, C., & Ferguson, F. R. (1963) · The Lancet · doi:10.1016/s0140-6736(63)90498-7 · Cited by 167
Dementia pugilistica mit anatomischem Befund
Brandenburg, W., & Hallervorden, J. (1954) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00955101 · Cited by 164
DeKosky, S. T., Abrahamson, E. E., Ciallella, J. R., Paljug, W. R., Wisniewski, S. R., Clark, R. S. B., & Ikonomovic, M. D. (2007) · Archives of Neurology · doi:10.1001/archneur.64.4.541 · Cited by 152
Neuropathological observations in a case of autism presenting with self-injury behavior
Hof, P. R., Knabe, R., Bovier, P., & Bouras, C. (1991) · Acta Neuropathologica · doi:10.1007/bf00308819 · Cited by 151
Smith, D. H., Nakamura, M., McIntosh, T. K., Wang, J., Rodríguez, A., Chen, X.-H., Raghupathi, R., Saatman, K. E., Clemens, J., Schmidt, M. L., et al. (1998) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65643-x · Cited by 143 · cited 1×
“Increased amyloid precursor protein production in experimental TBI has also been associated with heightened neuronal loss in the hippocampus (73, 79).”
BackgroundDistribution of β‐amyloid protein in the brain following severe head injury
Graham, D. I., Gentleman, S., Lynch, A., & Roberts, G. (1995) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1995.tb01025.x · Cited by 140
Susceptibility of hippocampal neurons to mechanically induced injury.
Geddes, D. M., LaPlaca, M., & Cargill, R. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00254-1 · Cited by 133
Thalamic Nuclei After Human Blunt Head Injury
Maxwell, W., MacKinnon, M., Smith, D. H., McIntosh, T., & Graham, D. (2006) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/01.jnen.0000229241.28619.75 · Cited by 132
Hof, P. R., Delacourte, A., & Bouras, C. (1992) · Acta Neuropathologica · doi:10.1007/bf00427214 · Cited by 128
Dementia in a punch-drunk wife
Roberts, G. W., Whitwell, H., Acland, P. R., & Bruton, C. J. (1990) · The Lancet · doi:10.1016/0140-6736(90)90520-f · Cited by 126
Electrophysiological indices of persistent post-concussion symptoms
Gaetz, M., & Weinberg, H. (2000) · Brain Injury · doi:10.1080/026990500421921 · Cited by 119
Recurrent athletic head injury: risks and when to retire
Cantu, R. C. (2003) · Clinics in Sports Medicine · doi:10.1016/s0278-5919(02)00095-9 · Cited by 117
Self-citationAriza, M. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2005.085167 · Cited by 117
Neurofibrillary tangles, but not Alzheimer‐type pathology, in a young boxer
Geddes, J. F., Vowles, G. H., Robinson, S. F. D., & Sutcliffe, J. C. (1996) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1996.tb00840.x · Cited by 116
Hartman, R. E., Laurer, H., Longhi, L., Bales, K. R., Paul, S. M., McIntosh, T. K., & Holtzman, D. M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10083.2002 · Cited by 115
Maxwell, W. L., McCreath, B. J., Graham, D. I., & Gennarelli, T. A. (1995) · Journal of Neurocytology · doi:10.1007/bf01215643 · Cited by 114
Bouras, C., Giannakopoulos, P., Good, P. F., Hsu, A., Hof, P. R., & Perl, D. P. (2007) · European Neurology · doi:10.1159/000112903 · Cited by 112
Soccer injuries to the brain. A neurologic and electroencephalographic study of former players
Tysvaer, A., Storli, O. V., & Bachen, N. I. (1989) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1989.tb03858.x · Cited by 111
Gentleman, S. M., Greenberg, B., Savage, M. J., Noori, M., Newman, S. J., Roberts, G. W., Griffin, W. S. T., & Graham, D. I. (1997) · Neuroreport · doi:10.1097/00001756-199704140-00039 · Cited by 110
Su, J. H., Cummings, B. J., & Cotman, C. W. (1994) · Neuroreport · doi:10.1097/00001756-199411000-00037 · Cited by 110
Tysvaer, A., & Storli, O. V. (1989) · The American Journal of Sports Medicine · doi:10.1177/036354658901700421 · Cited by 105
(2003) · PubMed Central · Cited by 103
MURAKAMI, N., YAMAKI, T., IWAMOTO, Y., SAKAKIBARA, T., KOBORI, N., FUSHIKI, S., & UEDA, S. (1998) · Journal of Neurotrauma · doi:10.1089/neu.1998.15.993 · Cited by 100 · cited 2×
“In acute TBI, diffuse cortical AA plaques have been found in 30% to 38% of cases as early as 2 hours after injury (73, 76, 80).”
BackgroundDistribution of microstructural damage in the brains of professional boxers: A diffusion MRI study
Chappell, M. H., Uluğ, A. M., Zhang, L., Heitger, M. H., Jordan, B. D., Zimmerman, R. D., & Watts, R. (2006) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.20656 · Cited by 100
Amyloid β‐Protein, APOE Genotype and Head Injury
Nicoll, J. A. R., Roberts, G. W., & Graham, D. I. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb34431.x · Cited by 96
Beitrag zur Kenntnis der chronischen cerebralen Krankheitsbilder bei Boxern
Grahmann, H., & Ule, G. (2008) · Psychiatria et Neurologia · doi:10.1159/000138743 · Cited by 95
Association between apolipoprotein E genotype and outcome of traumatic brain injury
Chiang, M.-F., Chang, J., & Hu, C. (2003) · Acta Neurochirurgica · doi:10.1007/s00701-003-0069-3 · Cited by 95
Pirotte, B. J. M., Goldman, S., Bogaert, P. V., David, P., Wikler, D., Rorive, S., Brotchi, J., & Levivier, M. (2005) · Operative Neurosurgery · doi:10.1227/01.neu.0000163598.59870.6d · Cited by 94
Posttraumatic Premature Alzheimer's Disease
Rudelli, R. P. (1982) · Archives of Neurology · doi:10.1001/archneur.1982.00510210040009 · Cited by 88
Post-Acute Alterations in the Axonal Cytoskeleton after Traumatic Axonal Injury
Maxwell, W. L., Domleo, A., McColl, G., Jafari, S. S., & Graham, D. I. (2003) · Journal of Neurotrauma · doi:10.1089/08977150360547071 · Cited by 85
Observations on the Pathology of Insidious Dementia Following Head Injury
Corsellis, J., & Brierley, J. B. (1959) · Journal of Mental Science · doi:10.1192/bjp.105.440.714 · Cited by 79
Increased numbers of βAPP-immunoreactive neurones in the entorhinal cortex after head injury
McKenzie, J. E., Gentleman, S. M., Roberts, G. W., Graham, D. I., & Royston, M. C. (1994) · Neuroreport · doi:10.1097/00001756-199412300-00041 · Cited by 74
Validation of a Noninvasive System for Measuring Head Acceleration for Use during Boxing Competition
Beckwith, J. G., Chu, J. J., & Greenwald, R. M. (2007) · Journal of Applied Biomechanics · doi:10.1123/jab.23.3.238 · Cited by 70
Thurman, D. J., Branche, C. M., & Sniezek, J. E. (1998) · Excerpta medica. Section 35, Occupational health and industrial medicine · Cited by 70
Payne, E. (1968) · min - Minimally Invasive Neurosurgery · doi:10.1055/s-0028-1095326 · Cited by 66
Short-term and long-term outcome of athletic closed head injuries
Webbe, F. M., & Barth, J. T. (2003) · Clinics in Sports Medicine · doi:10.1016/s0278-5919(02)00103-5 · Cited by 66
Cerebral atrophy associated with boxing
NEUBUERGER, K. T. (1959) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1959.02340160001001 · Cited by 66
Graham, D. I., Gentleman, S., Nicoll, J. A. R., Royston, M. C., McKenzie, J. E., Roberts, G. W., & Griffin, W. S. T. (1996) · Springer eBooks · doi:10.1007/978-3-7091-9465-2_17 · Cited by 59
Grahmann, H., & Ule, G. (2000) · PubMed · Cited by 58
Apolipoprotein E ϵ4 and fatal cerebral amyloid angiopathy associated with dementia pugilistica
Jordan, B. D., Kanik, A. B., Horwich, M. S., Sweeney, D., Relkin, N. R., Petito, C. K., & Gandy, S. (1995) · Annals of Neurology · doi:10.1002/ana.410380429 · Cited by 55
Remodeling of Cerebrospinal Fluid Lipoprotein Particles after Human Traumatic Brain Injury
Kay, A. D., Day, S., Kerr, M., Nicoll, J. A. R., Packard, C. J., & CASLAKE, M. J. (2003) · Journal of Neurotrauma · doi:10.1089/089771503767869953 · Cited by 54
Punch drunk. Its pathogenesis and pathology on the basis of a verified case.
Cb, C. (1962) · PubMed · Cited by 53
Rapid Neurofibrillary Tangle Formation after Localized Gene Transfer of Mutated Tau
Klein, R. L., Lin, W.-L., Dickson, D. W., Lewis, J. M., Hutton, M. L., Duff, K., Meyer, E. M., & King, M. A. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63124-0 · Cited by 52
Cognitive reserve and anosognosia in questionable and mild dementia
Spitznagel, M. B., & Tremont, G. N. (2004) · Archives of Clinical Neuropsychology · doi:10.1016/j.acn.2004.11.003 · Cited by 42
Redrawing Papez’ circuit: A theory about how acute stress becomes chronic and causes disease
Eggers, A. E. (2007) · Medical Hypotheses · doi:10.1016/j.mehy.2007.01.074 · Cited by 41
Dementia Pugilistica with clinical features of Alzheimer's disease
Areza‐Fegyveres, R., Rosemberg, S., Castro, R. M. R. P. S., Porto, C. S., Bahia, V. S., Caramelli, P., & Nitríni, R. (2007) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2007000500019 · Cited by 41
Dementia pugilistica in an alcoholic achondroplastic dwarf
Williams, D. J., & Tannenberg, A. E. G. (1996) · Pathology · doi:10.1080/00313029600169653 · Cited by 40
Return-to-Play Criteria After Athletic Concussion
MAYERS, L. B. (2008) · Archives of Neurology · doi:10.1001/archneur.65.9.1158 · Cited by 39
Drachman, D. A., & Newell, K. L. (1999) · New England Journal of Medicine · doi:10.1056/nejm199904223401609 · Cited by 35
MASUMURA, M., HATA, R., URAMOTO, H., MURAYAMA, N., OHNO, T., & SAWADA, T. (2000) · Journal of Neurotrauma · doi:10.1089/neu.2000.17.123 · Cited by 34
Head Games: Football's Concussion Crisis from the NFL to Youth Leagues
Nowinski, C. J., & Ventura, J. L. L. (2020) · Cited by 32
Self-citationMcCrory, P. R., Turner, M., & Murray, J. (2004) · British Journal of Sports Medicine · doi:10.1136/bjsm.2003.006338 · Cited by 32
Constantinidis, J., & Tissot, R. (1967) · PubMed · Cited by 24
Perl, D. P., Hof, P. R., Purohit, D. P., Loerzel, A. J., & Kakulas, B. A. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.4.381 · Cited by 24
Hirano, A. (1992) · The Keio Journal of Medicine · doi:10.2302/kjm.41.6 · Cited by 16
[Punch drunk syndrome due to repeated karate kicks and punches].
Aotsuka, A., Kojima, S., Furumoto, H., Hattori, T., & Hirayama, K. (1990) · PubMed · Cited by 15
Drachman, D. A., & Newell, K. L. (1999) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · Cited by 13
A Temperamental Model of Borderline Personality Disorder and Its Implications for Psychotherapy
Herpertz, S. C. (2005) · Psychopathology · doi:10.1159/000084811 · Cited by 12
Brain Damage May Have Contributed to Former Wrestler's Violent Demise
Cajigal, S. (2007) · Neurology Today · doi:10.1097/01.nt.0000295249.54180.50 · Cited by 9
The Pathophysiology of Brain Injury
ZAFONTE, R. D., Muizelaar, J. P., & Peterson, P. L. (1998) · Journal of Head Trauma Rehabilitation · doi:10.1097/00001199-199802000-00004 · Cited by 8
Timing weight-control measures in obese children
Rolland‐Cachera, M., & Bellisle, F. (1990) · The Lancet · doi:10.1016/0140-6736(90)90519-b · Cited by 5
Research works printed but not linked: 4
- Millspaugh JA . Dementia pugilistica. US Naval Med Bull 1937;35:297–303
- 10.1046/j.1365-2990.1996.2598025.x · DOI · Paper page
- 10.1097/62.4.381 · DOI
- 10.1097/59-8-641 · DOI
Cited by
Sorted by citations
Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research
Maas, A. I. R., Menon, D. K., Adelson, P. D., Andelic, N., Bell, M. J., Belli, A., Bragge, P., Brazinova, A., Büki, A., Chesnut, R. M., et al. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30371-x · Cited by 2,609
The spectrum of disease in chronic traumatic encephalopathy
McKee, A. C., Stein, T. D., Nowinski, C. J., Stern, R. A., Daneshvar, D. H., Alvarez, V. E., Lee, H.-S., Hall, G., Wojtowicz, S. M., Baugh, C. M., et al. (2013) · Brain · doi:10.1093/brain/aws307 · Cited by 2,098
Self-citationAmyloid Precursor Protein Processing and Alzheimer's Disease
O'Brien, R. J., & Wong, P. C. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113613 · Cited by 2,061
Nelson, P. T., Alafuzoff, I., Bigio, E. H., Bouras, C., Braak, H., Cairns, N. J., Castellani, R. J., Crain, B. J., Davies, P., Tredici, K. D., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31825018f7 · Cited by 2,050
Self-citationPathology of Neurodegenerative Diseases
Dugger, B. N., & Dickson, D. W. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028035 · Cited by 1,665
Metadata
- Authors
- McKee, A. C., Cantu, R. C., Nowinski, C. J., Hedley-Whyte, E. T., Gavett, B. E., Budson, A. E., Santini, V. E., Lee, H.-S., Kubilus, C. A., & Stern, R. A.
- Affiliations
- Boston University (US)
- ORCID
- Venue
- Journal of Neuropathology & Experimental Neurology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-07
- Volume
- 68
- Issue
- 7
- Pages
- 709-735
- ISSN
- 0022-3069 (ISSN-L)
- 1554-6578
- PMC
- PMC2945234
- OpenAlex
- W2081325915
- Cited by
- 2,295
- References
- 123
- Citations by year
- 2026: 47 · 2025: 77 · 2024: 95 · 2023: 106 · 2022: 117 · 2021: 143 · 2020: 186 · 2019: 184 · 2018: 160 · 2017: 179 · 2016: 178 · 2015: 183 · 2014: 176 · 2013: 189 · 2012: 115
- FWCI
- 60.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neuropathology & Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Institute on Aging (P30AG013846, P30-AG13846))
- Topics
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- chronic traumatic encephalopathy, tauopathy, repetitive head injury, boxing, professional athletes, neurofibrillary tangles, brain atrophy, amyloid plaques, memory impairment, behavioral and personality changes, neuropathology
- MeSH terms
- Adult, Aged, Aged, 80 and over, Athletic Injuries, Brain, Brain Chemistry, Female, Humans, Male, Middle Aged, Neurons, Sports, Amyloid beta-Peptides, Head Injuries, Closed, Cell Death, Disease Progression, Genetic Predisposition to Disease, Brain Injury, Chronic, Tauopathies, Apolipoprotein E4
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