Insomnia and High-Sensitivity C-Reactive Protein: The HUNT Study, Norway
Abstract
OBJECTIVE: To explore the hypothesis that insomnia may increase the risk of coronary heart disease through inflammatory mechanisms. METHODS: The association of high-sensitivity C-reactive protein (hsCRP) with self-reported symptoms of insomnia was examined. Participants were 8547 men and nonpregnant women who answered one or more insomnia-related questions and who had available hsCRP measurements in the Nord-Trøndelag Health Study. In multivariable linear regression analyses of the logarithm of hsCRP, we adjusted for established cardiovascular risk factors, psychosocial distress, chronic pain, and chronic somatic disorders. RESULTS: Among men, difficulties initiating sleep and nonrestorative sleep were associated with increasing hsCRP levels after adjusting for age (B = 0.07, 95% confidence interval [CI] = 0.01-0.14, p for trend = .02 and B = 0.09, 95% CI = 0.02-0.15, p for trend = .006), but after multivariable adjustment, the associations were attenuated (B = 0.03, 95% CI = -0.03 to 0.09, p for trend = .30 and B = 0.06, 95% CI = -0.00 to 0.12, p for trend = .05). HsCRP was not associated with other insomnia-related symptoms. In women, there was no evidence for any association of symptoms of insomnia with hsCRP levels. Results indicated sex differences in the association between sleep characteristics and CRP (difficulties maintaining sleep, p interaction = .018; cumulative number of symptoms of insomnia, p interaction = .014; and symptoms of insomnia influencing work performance, p interaction = .039). CONCLUSIONS: There were no consistent associations between symptoms of insomnia and hsCRP levels. Our results do not support the hypothesis that inflammation, as reflected by elevated levels of hsCRP, is an important factor linking insomnia to coronary heart disease.
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In a cross-sectional study in more than 8,500 participants, self-reported complaints of difficulty initiating sleep and feelings of nonrestorative sleep were associated with CRP levels in men only.
“a study in more than 8,500 participants showed that self-reported complaints of difficulty initiating sleep and feelings of nonrestorative sleep were associated with CRP levels in men only”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [328]
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Insomnia and risk for cardiovascular disease
Laugsand, L. E. (2012) · BIBSYS Brage (BIBSYS (Norway))
Self-citationSleep, health-Related Biological Function and Well-Being
Jackowska, M. (2013) · UCL Discovery (University College London)
Reyt, M., Jarrin, D. C., Perrault, A. A., Pomares, F. B., Smith, D., Gong, K., Tarelli, L., Savard, J., Dang‐Vu, T. T., & Gouin, J. (2026) · Sleep Medicine · doi:10.1016/j.sleep.2026.109234
- Authors
- Laugsand, L. E., Vatten, L. J., Bjørngaard, J. H., Hveem, K., & Janszky, I.
- Affiliations
- Norwegian University of Science and Technology (NO)
- Corresponding author
- Laugsand, Lars Erik
- Venue
- Psychosomatic Medicine
- Published
- 2012-06
- Volume
- 74
- Issue
- 5
- Pages
- 543-553
- ISSN
- 0033-3174 (ISSN-L)
- OpenAlex
- W1976216721
- Cited by
- 47
- References
- 58
- Citations by year
- 2025: 4 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 6 · 2015: 5 · 2014: 10 · 2013: 2 · 2012: 1
- FWCI
- 7.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- insomnia, high-sensitivity C-reactive protein, inflammation, coronary heart disease risk, sex differences, sleep initiation difficulty, non-restorative sleep, employee performance, cardiovascular risk factors
- MeSH terms
- Adult, Age Factors, Aged, C-Reactive Protein, Coronary Disease, Epidemiologic Methods, Female, Humans, Inflammation, Sleep Initiation and Maintenance Disorders, Male, Middle Aged, Norway, Psychiatric Status Rating Scales, Stress, Psychological, Sex Distribution, Young Adult, Chronic Pain
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