Developing Functional Network Connectivity of the Dorsal Anterior Cingulate Cortex Mediates Externalizing Psychopathology in Adolescents with Child Neglect
Open accessPreprint — published as 10.1016/j.dcn.2021.100962 · Paper page
Abstract
Childhood adversity in form of child abuse and neglect is associated with elevated risk for psychopathologies. We investigated whether development of functional brain networks important for executive function (EF) could serve as potential mediators of this association. We analyzed data of 475 adolescents, a subsample of the multisite longitudinal NCANDA (National Consortium on Alcohol and Neurodevelopment in Adolescence) cohort with completed measures of childhood trauma, resting-state functional brain connectivity data, and internalizing/externalizing psychopathological syndrome data at baseline and follow-up years 1-4. Using parallel process latent growth models, we found that childhood adversity was associated with increased risk for externalizing/internalizing behaviors. We specifically investigated whether functional connectivity of the dorsal anterior cingulate cortex (dACC) to brain regions within the cingulo-opercular (CO) network, a well-known EF network that underlies control of attention and self-regulation, mediates the association between adversity and psychopathological behaviors. We found that childhood adversity, specifically neglect was negatively associated with functional connectivity of the dACC within the CO network, and that this connectivity mediated the association between child neglect and externalizing behaviors. Our study advances a mechanistic understanding of how childhood adversity may impact the development of psychopathology, highlighting the relevance of dACC functional networks particularly for externalizing psychopathology.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Modularity and community structure in networks
Newman, M. E. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601602103 · Cited by 12,256 · see citing works
Dissociable intrinsic connectivity networks for salience processing and executive control
Seeley, W. W., Menon, V., Schatzberg, A. F., Keller, J., Glover, G. H., Kenna, H., Reiss, A. L., & Greicius, M. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5587-06.2007 · Cited by 7,426 · see citing works
Development and validation of a brief screening version of the Childhood Trauma Questionnaire
Bernstein, D. P., Stein, J. A., Newcomb, M. D., Walker, E., Pogge, D., Ahluvalia, T., Stokes, J., Handelsman, L., Medrano, M., Desmond, D., et al. (2003) · Child Abuse & Neglect · doi:10.1016/s0145-2134(02)00541-0 · Cited by 6,419 · see citing works
Dynamic mapping of human cortical development during childhood through early adulthood
Gogtay, N., Giedd, J. N., Lusk, L., Hayashi, K. M., Greenstein, D., Vaituzis, A. C., Nugent, T. F., Herman, D. H., Clasen, L. S., Toga, A. W., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402680101 · Cited by 5,604 · see citing works
<i>Conn</i> : A Functional Connectivity Toolbox for Correlated and Anticorrelated Brain Networks
Whitfield-Gabrieli, S., & Nieto-Castanon, A. (2012) · Brain Connectivity · doi:10.1089/brain.2012.0073 · Cited by 4,885 · see citing works
Functional Network Organization of the Human Brain
Power, J. D., Cohen, A. L., Nelson, S. M., Wig, G. S., Barnes, K. A., Church, J. A., Vogel, A. C., Laumann, T. O., Miezin, F. M., Schlaggar, B. L., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.006 · Cited by 4,124 · see citing works
Why do many psychiatric disorders emerge during adolescence?
Paus, T., Keshavan, M., & Giedd, J. N. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2513 · Cited by 3,123 · see citing works
A Developmental Perspective on Executive Function
Best, J. R., & Miller, P. H. (2010) · Child Development · doi:10.1111/j.1467-8624.2010.01499.x · Cited by 2,692 · see citing works
Prediction of individual brain maturity using fMRI
Dosenbach, N. U. F., Nardos, B., Cohen, A. L., Fair, D. A., Power, J. D., Church, J. A., Nelson, S. M., Wig, G. S., Vogel, A. C., Lessov-Schlaggar, C. N., et al. (2010) · Science · doi:10.1126/science.1194144 · Cited by 2,183 · see citing works
The effects of childhood maltreatment on brain structure, function and connectivity
Teicher, M. H., Samson, J. A., Anderson, C. M., & Ohashi, K. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.111 · Cited by 1,856 · see citing works
A Core System for the Implementation of Task Sets
Dosenbach, N. U. F., Visscher, K. M., Palmer, E. D., Miezin, F. M., Wenger, K. K., Kang, H. C., Burgund, E. D., Grimes, A. L., Schlaggar, B. L., & Petersen, S. E. (2006) · Neuron · doi:10.1016/j.neuron.2006.04.031 · Cited by 1,772 · see citing works
Functional brain networks develop from a local to distributed organization
Fair, D. A., Cohen, A. L., Power, J. D., Dosenbach, N. U. F., Church, J. A., Miezin, F. M., Schlaggar, B. L., & Petersen, S. E. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000381 · Cited by 1,530 · see citing works
Annual research review: enduring neurobiological effects of childhood abuse and neglect
Teicher, M. H., & Samson, J. A. (2016) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12507 · Cited by 1,473 · see citing works
Extraordinary neoteny of synaptic spines in the human prefrontal cortex
Petanjek, Z., Judaš, M., Šimić, G., Rašin, M. R., Uylings, H. B. M., Rakic, P., & Kostović, I. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105108108 · Cited by 1,411 · see citing works
Identification of a Common Neurobiological Substrate for Mental Illness
Goodkind, M., Eickhoff, S. B., Oathes, D. J., Jiang, Y., Chang, A., Jones-Hagata, L. B., Ortega, B. N., Zaiko, Y. V., Roach, E. L., Korgaonkar, M. S., et al. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.2206 · Cited by 1,404 · see citing works
McLaughlin, K. A., Sheridan, M. A., & Lambert, H. K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.10.012 · Cited by 1,389 · see citing works
Development of distinct control networks through segregation and integration
Fair, D. A., Dosenbach, N. U. F., Church, J. A., Cohen, A. L., Brahmbhatt, S., Miezin, F. M., Barch, D. M., Raichle, M. E., Petersen, S. E., & Schlaggar, B. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705843104 · Cited by 1,244 · see citing works
Teicher, M. H., & Samson, J. A. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.12070957 · Cited by 1,050 · see citing works
McLaughlin, K. A., Greif Green, J., Gruber, M. J., Sampson, N. A., Zaslavsky, A. M., & Kessler, R. C. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.2277 · Cited by 992 · see citing works
Childhood Adversity and Neural Development: A Systematic Review
McLaughlin, K. A., Weissman, D., & Bitrán, D. (2019) · Annual Review of Developmental Psychology · doi:10.1146/annurev-devpsych-121318-084950 · Cited by 892 · see citing works
Walk on the Wild Side: Estimating the Global Magnitude of Visits to Protected Areas
Balmford, A. P., Green, J., Anderson, M., Beresford, J., Huang, C., Naidoo, R., Walpole, M., & Manica, A. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002074 · Cited by 869 · see citing works
Lifetime Prevalence of Investigating Child Maltreatment Among US Children
Kim, H., Wildeman, C., Jonson-Reid, M., & Drake, B. (2017) · American Journal of Public Health · doi:10.2105/ajph.2016.303545 · Cited by 640 · see citing works
Development of Anterior Cingulate Functional Connectivity from Late Childhood to Early Adulthood
Kelly, A. M. C., Di Martino, A., Uddin, L. Q., Shehzad, Z., Gee, D. G., Reiss, P. T., Margulies, D. S., Castellanos, F. X., & Milham, M. P. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn117 · Cited by 572 · see citing works
An Integrative Model of the Maturation of Cognitive Control
Luna, B., Marek, S., Larsen, B., Tervo-Clemmens, B., & Chahal, R. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-034054 · Cited by 550 · see citing works
Childhood externalizing and internalizing psychopathology in the prediction of early substance use
King, S. M., Iacono, W. G., & McGue, M. K. (2004) · Addiction · doi:10.1111/j.1360-0443.2004.00893.x · Cited by 549 · see citing works
Improper Solutions in Structural Equation Models: Causes, Consequences, and Strategies
CHEN, F., BOLLEN, K. A., PAXTON, P., CURRAN, P. J., & KIRBY, J. B. (2001) · Sociological Methods & Research · doi:10.1177/0049124101029004003 · Cited by 512 · see citing works
LUNA, B., & SWEENEY, J. A. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1308.035 · Cited by 467 · see citing works
Rindskopf, D. M. (1984) · Sociological Methods & Research · doi:10.1177/0049124184013001004 · Cited by 450 · see citing works
Simmonds, D. J., Hallquist, M. N., Asato, M. R., & Luna, B. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2013.12.044 · Cited by 443 · see citing works
von Rueden, U., Gosch, A., Rajmil, L., Bisegger, C., Ravens-Sieberer, U., & the European KIDSCREEN group (2006) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2005.039792 · Cited by 434 · see citing works
Hofstra, M. B., van der Ende, J., & Verhulst, F. C. (2002) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200202000-00012 · Cited by 396 · see citing works
Heleniak, C., Jenness, J. L., Vander Stoep, A., McCauley, E., & McLaughlin, K. A. (2016) · Cognitive Therapy and Research · doi:10.1007/s10608-015-9735-z · Cited by 371 · see citing works
Transdiagnostic impairment of cognitive control in mental illness
McTeague, L. M., Goodkind, M. S., & Etkin, A. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.08.001 · Cited by 368 · see citing works
The contribution of network organization and integration to the development of cognitive control
Marek, S., Hwang, K., Foran, W., Hallquist, M. N., & Luna, B. (2015) · PLOS Biology · doi:10.1371/journal.pbio.1002328 · Cited by 337 · see citing works
Dillon, W. R., Kumar, A. S., & Mulani, N. (1987) · Psychological Bulletin · doi:10.1037/0033-2909.101.1.126 · Cited by 334 · see citing works
Control-related systems in the human brain
Power, J. D., & Petersen, S. E. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.12.009 · Cited by 331 · see citing works
Tests for linkage of multiple cohorts in an accelerated longitudinal design.
Miyazaki, Y., & Raudenbush, S. W. (2000) · Psychological Methods · doi:10.1037/1082-989x.5.1.44 · Cited by 321 · see citing works
Longitudinal Growth Curves of Brain Function Underlying Inhibitory Control through Adolescence
Ordaz, S. J., Foran, W., Velanova, K., & Luna, B. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1741-13.2013 · Cited by 302 · see citing works
Executive functions in adolescence: inferences from brain and behavior
Crone, E. A. (2009) · Developmental Science · doi:10.1111/j.1467-7687.2009.00918.x · Cited by 298 · see citing works
Sheridan, M. A., Peverill, M., Finn, A. S., & McLaughlin, K. A. (2017) · Development and Psychopathology · doi:10.1017/s0954579417001390 · Cited by 276 · see citing works
Hughes, C. H., & Ensor, R. (2010) · Journal of Experimental Child Psychology · doi:10.1016/j.jecp.2010.06.005 · Cited by 275 · see citing works
Lambert, H. K., King, K. M., Monahan, K. C., & McLaughlin, K. A. (2017) · Development and Psychopathology · doi:10.1017/s0954579416000584 · Cited by 267 · see citing works
Brown, S. A., Brumback, T., Tomlinson, K., Cummins, K., Thompson, W. K., Nagel, B. J., De Bellis, M. D., Hooper, S. R., Clark, D. B., Chung, T., et al. (2015) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2015.76.895 · Cited by 255 · see citing works
Self-citationAnalysis of longitudinal data within accelerated longitudinal designs.
Duncan, S. C., Duncan, T. E., & Hops, H. (1996) · Psychological Methods · doi:10.1037/1082-989x.1.3.236 · Cited by 228 · see citing works
Miller, A. B., Sheridan, M. A., Hanson, J. L., McLaughlin, K. A., Bates, J. E., Lansford, J. E., Pettit, G. S., & Dodge, K. A. (2018) · Journal of Abnormal Psychology · doi:10.1037/abn0000331 · Cited by 225 · see citing works
On Various Causes of Improper Solutions in Maximum Likelihood Factor Analysis
van Driel, O. P. (1978) · Psychometrika · doi:10.1007/bf02293865 · Cited by 214 · see citing works
The effects of early neglect on cognitive, language, and behavioral functioning in childhood
Spratt, E. G., Friedenberg, S., LaRosa, A., Bellis, M. D. D., Macias, M. M., Summer, A. P., Hulsey, T. C., Runyan, D. K., & Brady, K. T. (2012) · Psychology · doi:10.4236/psych.2012.32026 · Cited by 187 · see citing works
Altered Brain Developmental Trajectories in Adolescents After Initiating Drinking
Pfefferbaum, A., Kwon, D., Brumback, T., Thompson, W. K., Cummins, K. M., Tapert, S. F., Brown, S. A., Colrain, I. M., Baker, F. C., Prouty, D., et al. (2017) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.17040469 · Cited by 182 · see citing works
Self-citationTowards an Ontology of Cognitive Control
Lenartowicz, A., Kalar, D. J., Congdon, E. L., & Poldrack, R. A. (2010) · Topics in Cognitive Science · doi:10.1111/j.1756-8765.2010.01100.x · Cited by 177 · see citing works
Prediction complements explanation in understanding the developing brain
Rosenberg, M. D., Casey, B. J., & Holmes, A. J. (2018) · Nature Communications · doi:10.1038/s41467-018-02887-9 · Cited by 167 · see citing works
Evaluating measures of family history of alcoholism: density versus dichotomy
Stoltenberg, S. F., Mudd, S. A., Blow, F. C., & Hill, E. M. (1998) · Addiction · doi:10.1046/j.1360-0443.1998.931015117.x · Cited by 131 · see citing works
Hussong, A. M., Wirth, R. J., Edwards, M. C., Curran, P. J., Chassin, L., & Zucker, R. A. (2007) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.116.3.529 · Cited by 120 · see citing works
Mediation Analysis in a Latent Growth Curve Modeling Framework
von Soest, T., & Hagtvet, K. A. (2011) · Structural Equation Modeling A Multidisciplinary Journal · doi:10.1080/10705511.2011.557344 · Cited by 119 · see citing works
Reef, J., Diamantopoulou, S., van Meurs, I., Verhulst, F. C., & van der Ende, J. (2010) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-010-0088-6 · Cited by 117 · see citing works
Neurobiological models of the impact of adversity on education
Sheridan, M. A., & McLaughlin, K. A. (2016) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.05.013 · Cited by 116 · see citing works
Herringa, R. J., Burghy, C. A., Stodola, D. E., Fox, M. E., Davidson, R. J., & Essex, M. J. (2016) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2016.03.003 · Cited by 101 · see citing works
Finn, E. S., & Constable, R. T. (2016) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2016.18.3/efinn · Cited by 100 · see citing works
Hussong, A. M., Cai, L., Curran, P. J., Flora, D. B., Chassin, L., & Zucker, R. A. (2007) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-007-9181-9 · Cited by 85 · see citing works
Primitive mechanisms of trauma response: an evolutionary perspective on trauma-related disorders.
Baldwin, D. V. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.06.004 · Cited by 85 · see citing works
Residual Structures in Latent Growth Curve Modeling
Grimm, K. J., & Widaman, K. F. (2010) · Structural Equation Modeling A Multidisciplinary Journal · doi:10.1080/10705511.2010.489006 · Cited by 84 · see citing works
Wu, W., & Jia, F. (2013) · Multivariate Behavioral Research · doi:10.1080/00273171.2013.816235 · Cited by 77 · see citing works
Sullivan, E. V., Brumback, T., Tapert, S. F., Fama, R., Prouty, D., Brown, S. A., Cummins, K. M., Thompson, W. K., Colrain, I. M., Baker, F. C., et al. (2016) · Neuropsychology · doi:10.1037/neu0000259 · Cited by 72 · see citing works
Self-citationFunctional Fractionation of the Cingulo-opercular Network: Alerting Insula and Updating Cingulate
Han, S. W., Eaton, H. P., & Marois, R. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy130 · Cited by 69 · see citing works
Silveira, S., Shah, R., Nooner, K. B., Nagel, B. J., Tapert, S. F., de Bellis, M. D., & Mishra, J. (2020) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.01.011 · Cited by 68 · see citing works
Self-citationBarch, D. M., Belden, A. C., Tillman, R., Whalen, D. J., & Luby, J. L. (2017) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2017.12.011 · Cited by 68 · see citing works
Cheung, M. W. ‐. (2007) · Organizational Research Methods · doi:10.1177/1094428106295499 · Cited by 53 · see citing works
Defining an Ontology of Cognitive Control Requires Attention to Component Interactions
Badre, D. (2011) · Topics in Cognitive Science · doi:10.1111/j.1756-8765.2011.01141.x · Cited by 40 · see citing works
van Ginkel, J. R. (2020) · Psychometrika · doi:10.1007/s11336-020-09696-4 · Cited by 31 · see citing works
Critical periods for the neurodevelopmental processes of externalizing and internalizing
Tucker, D. M., Poulsen, C., & Luu, P. (2015) · Development and Psychopathology · doi:10.1017/s0954579415000024 · Cited by 26 · see citing works
Flagged first, then by citations
1 of the 70 references couldn’t be matched to a known paper.
Cited by
Still being checked.
- Authors
- Silveira, S., Boney, S., Tapert, S. F., & Mishra, J.
- Affiliations
- University of California San Diego (US)
- East Carolina University (US)
- Corresponding author
- Mishra, Jyoti
- Venue
- medRxiv
- Publisher
- openRxiv
- Published
- 2021-02-01
- OpenAlex
- W3128376464
- Cited by
- 0
- References
- 70
- Type
- posted content
- Language
- en
- Open access
- green
- doi.org
- Locations
- medRxiv (acceptedVersion)
- The Scholarship East Carolina University's Institutional Repository (East Carolina University) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Deutsche Akademie der Naturforscher Leopoldina - Nationale Akademie der Wissenschaften (AA021697, AA021692, AA021681, AA021691, AA021696, AA021690, AA021695)
- University of California, San Diego (AA021681, AA021691, AA021690, AA021696, AA021697, AA021695, AA021692)
- National Institute of Mental Health
- National Institute on Drug Abuse
- National Institute of Child Health and Human Development (AA021691, AA021692, AA021695, AA021696, AA021690, AA021697, AA021681)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- child neglect, childhood adversity, child abuse, externalizing psychopathology, internalizing psychopathology, dorsal anterior cingulate cortex, cingulo-opercular network, brain functional connectivity, executive function, adolescent development, mediation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
