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Cited by 396

The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.

Age-Related Hearing Loss

Open access
Bowl, Michael R., Dawson, Sally J.·2019·Cold Spring Harbor Perspectives in Medicine
DOI 10.1101/cshperspect.a033217
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Abstract

Age-related hearing loss (ARHL) is the most prevalent sensory deficit in the elderly. This progressive hearing impairment leads to social isolation and is also associated with comorbidities, such as frailty, falls, and late-onset depression. Moreover, there is a growing evidence linking it with cognitive decline and increased risk of dementia. Given the large social and welfare burden that results from ARHL, and because ARHL is potentially a modifiable risk factor for dementia, there is an urgent need for therapeutic interventions to ameliorate age-related auditory decline. However, a prerequisite for design of therapies is knowledge of the underlying molecular mechanisms. Currently, our understanding of ARHL is very limited. Here, we review recent findings from research into ARHL from both human and animal studies and discuss future prospects for advances in our understanding of genetic susceptibility, pathology, and potential therapeutic approaches in ARHL.

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Metadata

Authors
Bowl, M. R., & Dawson, S. J.
Venue
Cold Spring Harbor Perspectives in Medicine
Publisher
Cold Spring Harbor Laboratory
Published
2018-10-05
Volume
9
Issue
8
Pages
a033217
ISSN
2157-1422 (ISSN-L)
DOI
10.1101/cshperspect.a033217
OpenAlex
W2894881177
Cited by
396
References
91
Type
posted content
Language
en
Open access
green

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