The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Analysis of p53-regulated gene expression patterns using oligonucleotide arrays
Open accessAbstract
Oligonucleotide microarrays were employed to quantitate mRNA levels from a large number of genes regulated by the p53 transcription factor. Responses to DNA damage and to zinc-inducible p53 were compared for their transcription patterns in cell culture. A cluster analysis of these data demonstrates that genes induced by γ radiation, UV radiation, and the zinc-induced p53 form distinct sets and subsets with a few genes in common to all these treatments. Cell type- or cell line-specific p53 responses were detected. When p53 proteins were induced with zinc, the kinetics of induction or repression of mRNAs from p53-responsive genes fell into eight distinct classes, five different kinetics of induction, and three different kinetics of repression. In addition, low levels of p53 in a cell induced or repressed only a subset of genes observed at higher p53 levels. The results of this study demonstrate that the nature of the p53 response in diverse mRNA species depends on the levels of p53 protein in a cell, the type of inducing agent or event, and the cell type employed. Of 6000 genes examined for p53 regulatory responses, 107 induced and 54 repressed genes fell into categories of apoptosis and growth arrest, cytoskeletal functions, growth factors and their inhibitors, extracellular matrix, and adhesion genes.
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Cites
Cluster analysis and display of genome-wide expression patterns
Eisen, M. B., Spellman, P. T., Brown, P. O., & Botstein, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14863 · Cited by 16,184
p53 Mutations in Human Cancers
Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649
Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations
Cho, Y., Gorina, S., Jeffrey, P. D., & Pavletich, N. P. (1994) · Science · doi:10.1126/science.8023157 · Cited by 2,551 · cited 1×
“The interaction between p53 and its target sequence has been illustrated by crystal structures (Cho et al. 1994).”
BackgroundThe p53 proto-oncogene can act as a suppressor of transformation
Finlay, C. A., Hinds, P. W., & Levine, A. J. (1989) · Cell · doi:10.1016/0092-8674(89)90045-7 · Cited by 1,987
Self-citationDefinition of a consensus binding site for p53
El-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W., & Vogelstein, B. (1992) · Nature Genetics · doi:10.1038/ng0492-45 · Cited by 1,985
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
Zindy, F., Eischen, C. M., Randle, D. H., Kamijo, T., Cleveland, J. L., Sherr, C. J., & Roussel, M. F. (1998) · Genes & Development · doi:10.1101/gad.12.15.2424 · Cited by 1,245
p53 Activates the CD95 (APO-1/Fas) Gene in Response to DNA Damage by Anticancer Drugs
Müller, M., Wilder, S., Bannasch, D., Israeli, D., Lehlbach, K., Li-Weber, M., Friedman, S. L., Galle, P. R., Stremmel, W., Oren, M., et al. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.11.2033 · Cited by 878
Wild-type p53 activates transcription in vitro
Farmer, G., Bargonetti, J., Zhu, H., Friedman, P., Prywes, R., & Prives, C. (1992) · Nature · doi:10.1038/358083a0 · Cited by 579
Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53
Mack, D. H., Vartikar, J., Pipas, J. M., & Laimins, L. A. (1993) · Nature · doi:10.1038/363281a0 · Cited by 322 · cited 1×
“In addition to its sequencespecific transactivation, p53 is also capable of repressing gene expression from a broad spectrum of promoters that do not appear to contain p53-responsive elements (Mack et al. 1993; Murphy et al. 1996).”
Self-citation
Research works printed but not linked: 50
- 10.1073/pnas.96.12.6745 · DOI · Paper page
- 10.1126/science.2144057 · DOI · Paper page
- 10.1126/science.281.5383.1674 · DOI · Paper page
- 10.1101/gad.7.12b.2565 · DOI · Paper page
- Bennett, 1992, Mutational spectra and immunohistochemical analyses of p53 in human cancers., Chest, 101, 19S, 10.1378/chest.101.3_Supplement.19S · DOI
- 10.1126/science.281.5383.1677 · DOI · Paper page
- 10.1101/gad.12.15.2434 · DOI · Paper page
- 10.1126/science.278.5338.680 · DOI · Paper page
- 10.1016/0092-8674(93)90500-P · DOI · Paper page
- 10.1073/pnas.86.22.8763 · DOI · Paper page
- 10.1083/jcb.128.6.1043 · DOI
- 10.1126/science.2144363 · DOI · Paper page
- 10.1074/jbc.273.42.27047 · DOI
- 10.1016/0092-8674(93)90499-G · DOI · Paper page
- 10.1016/S1097-2765(00)80002-7 · DOI · Paper page
- Iwabuchi, 1993, Use of the two-hybrid system to identify the domain of p53 involved in oligomerization., Oncogene, 8, 1693
- 10.1126/science.283.5398.83 · DOI · Paper page
- 10.1101/gad.11.5.558 · DOI · Paper page
- 10.1126/science.2047879 · DOI · Paper page
- 10.1038/3882 · DOI · Paper page
- 10.1083/jcb.141.3.553 · DOI
- 10.1016/S0092-8674(00)81871-1 · DOI · Paper page
- 10.1038/sj.onc.1202574 · DOI
- 10.1101/gad.8.10.1235 · DOI · Paper page
- 10.1038/nbt1296-1675 · DOI · Paper page
- 10.1126/science.2547247 · DOI · Paper page
- 10.1006/scbi.1998.0096 · DOI
- 10.1073/pnas.95.11.6399 · DOI · Paper page
- 10.1126/science.1978757 · DOI · Paper page
- 10.1073/pnas.93.24.13555 · DOI · Paper page
- 10.1016/0092-8674(90)90113-S · DOI · Paper page
- 10.1101/gad.10.23.2971 · DOI · Paper page
- 10.1016/S0955-0674(96)80033-0 · DOI · Paper page
- 10.1101/gad.7.12b.2556 · DOI · Paper page
- 10.1073/pnas.91.6.1998 · DOI · Paper page
- 10.1038/38525 · DOI · Paper page
- 10.1002/(SICI)1096-9896(199901)187:1<112::AID-PATH250>3.0.CO;2-3 · doi:10.1002/(sici)1096-9896(199901)187:1<112::aid-path250>3.0.co;2-3
- 10.1126/science.2144364 · DOI · Paper page
- 10.1126/science.270.5235.467 · DOI · Paper page
- 10.1073/pnas.89.24.12028 · DOI · Paper page
- 10.1073/pnas.89.10.4495 · DOI · Paper page
- 10.1089/dna.1994.13.125 · DOI
- 10.1073/pnas.96.12.6937 · DOI · Paper page
- Unger, 1992, p53: A transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer., EMBO J., 11, 1383, 10.1002/j.1460-2075.1992.tb05183.x · DOI · Paper page
- Wang, 1994, p53 domains: Structure, oligomerization, and transformation., Mol. Cell. Biol., 14, 5182
- 10.1101/gad.7.12b.2575 · DOI · Paper page
- 10.1038/nbt1297-1359 · DOI · Paper page
- 10.1038/ng1097-141 · DOI · Paper page
- 10.1038/366701a0 · DOI · Paper page
- 10.1016/S1097-2765(00)80351-2 · DOI · Paper page
Cited by
Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607
Self-citationThe first 30 years of p53: growing ever more complex.
Levine, A. J., & Oren, M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2723 · Cited by 1,967
Self-citationTranscriptional control of human p53-regulated genes
Riley, T., Sontag, E., Chen, P., & Levine, A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2395 · Cited by 1,921
Self-citationFridman, J. S., & Lowe, S. W. (2003) · Oncogene · doi:10.1038/sj.onc.1207116 · Cited by 1,401
A Global Map of p53 Transcription-Factor Binding Sites in the Human Genome
Wei, C.-L., Wu, Q., Vega, V. B., Chiu, K. P., Ng, P., Zhang, T., Shahab, A., Yong, H. C., Fu, Y., Weng, Z., et al. (2006) · Cell · doi:10.1016/j.cell.2005.10.043 · Cited by 1,141
Metadata
- Authors
- Zhao, R., Gish, K., Murphy, M., Yin, Y., Notterman, D., Hoffman, W. H., Tom, E., Mack, D. H., & Levine, A. J.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2000-04-15
- Volume
- 14
- Issue
- 8
- Pages
- 981-993
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2165204791
- Cited by
- 634
- References
- 10
- Type
- posted content
- Language
- en
- Open access
- diamond
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