Cited by 304RNA Research and SplicingMicroRNA in disease regulationMuscle Physiology and Disorders

The DOI matches its Crossref record; 104 of the 105 references it cites were found in a registry or an index.

MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development

Open access

Boutz, Paul L., Chawla, Geetanjali, Stoilov, Peter, Black, Douglas L.·2007·Genes & Development

Open this paper in CoChat — free account Open PDF

Abstract

Alternative pre-mRNA splicing determines many changes in gene expression during development. Two regulators known to control splicing patterns during neuron and muscle differentiation are the polypyrimidine tract-binding protein (PTB) and its neuronal homolog nPTB. These proteins repress certain exons in early myoblasts, but upon differentiation of mature myotubes PTB/nPTB expression is reduced, leading to increased inclusion of their target exons. We show here that the repression of nPTB expression during myoblast differentiation results from its targeting by the muscle-restricted microRNA miR-133. During differentiation of C2C12 myoblasts, nPTB protein but not mRNA expression is strongly reduced, concurrent with the up-regulation of miR-133 and the induction of splicing for several PTB-repressed exons. Introduction of synthetic miR-133 into undifferentiated C2C12 cells leads to a decrease in endogenous nPTB expression. Both the miR-133 and the coexpressed miR-1/206 microRNAs are extremely conserved across animal species, and PTB proteins are predicted targets for these miRNAs in Drosophila, mice, and humans. There are two potential miR-133-responsive elements (MRE) within the nPTB 3' untranslated region (UTR), and a luciferase reporter carrying this 3' UTR is repressed by miR-133 in an MRE-dependent manner. Transfection of locked nucleic acid (LNA) oligonucleotides designed to block the function of miR-133 and miR-1/206 increases expression of nPTB and decreases the inclusion of PTB dependent exons. These results indicate that miR-133 directly down-regulates a key splicing factor during muscle development and establishes a role for microRNAs in the control of a developmentally dynamic splicing program.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1101/gad.1500707

Cites

104 of 104 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Mfold web server for nucleic acid folding and hybridization prediction
Zuker, M. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg595 · Cited by 13,404
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948
Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets
Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855
The Human Genome Browser at UCSC
Kent, W. J., Sugnet, C. W., Furey, T. S., Roskin, K. M., Pringle, T. H., Zahler, A. M., & Haussler, A. D. (2002) · Genome Research · doi:10.1101/gr.229102 · Cited by 10,400
Prediction of Mammalian MicroRNA Targets
Lewis, B. P., Shih, I.-H., Jones-Rhoades, M. W., Bartel, D. P., & Burge, C. B. (2003) · Cell · doi:10.1016/s0092-8674(03)01018-3 · Cited by 5,199
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
Reinhart, B. J., Slack, F. J., Basson, M., Pasquinelli, A. E., Bettinger, J. C., Rougvie, A. E., Horvitz, H. R., & Ruvkun, G. (2000) · Nature · doi:10.1038/35002607 · Cited by 4,989
Identification of Novel Genes Coding for Small Expressed RNAs
Lagos-Quintana, M., Rauhut, R., Lendeckel, W., & Tuschl, T. (2001) · Science · doi:10.1126/science.1064921 · Cited by 4,956
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
Lim, L. P., Lau, N. C., Garrett-Engele, P., Grimson, A., Schelter, J. M., Castle, J., Bartel, D. P., Linsley, P. S., & Johnson, J. M. (2005) · Nature · doi:10.1038/nature03315 · Cited by 4,755
Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
Human MicroRNA Targets
John, B., Enright, A. J., Aravin, A., Tuschl, T., Sander, C., & Marks, D. S. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020363 · Cited by 3,796

Show all 105 references

Research works printed but not linked: 1

Gooding,, 1998, Role of an inhibitory pyrimidine element and polypyrimidine tract binding protein in repression of a regulated α-tropomyosin exon, RNA, 4, 85

Sorted by citations

microRNA Functions
Bushati, N., & Cohen, S. M. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123406 · Cited by 2,750
The MicroRNA miR-124 Promotes Neuronal Differentiation by Triggering Brain-Specific Alternative Pre-mRNA Splicing
Makeyev, E. V., Zhang, J., Carrasco, M. A., & Maniatis, T. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.015 · Cited by 1,395
Small non-coding RNAs in animal development
Stefani, G., & Slack, F. J. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2347 · Cited by 1,390
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
David, C. J., Chen, M., Assanah, M., Canoll, P., & Manley, J. L. (2010) · Nature · doi:10.1038/nature08697 · Cited by 1,179
MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice
Callis, T. E., Pandya, K., Seok, H., Tang, R., Tatsuguchi, M., Huang, Z., Chen, J., Deng, Z., Gunn, B. M., Shumate, J., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36154 · Cited by 878
MEF2: a central regulator of diverse developmental programs
Potthoff, M. J., & Olson, E. N. (2007) · Development · doi:10.1242/dev.008367 · Cited by 834
miR-133 and miR-30 Regulate Connective Tissue Growth Factor
Duisters, R. F. J. J., Tijsen, A. J., Schroen, B. L. M., Leenders, J. J., Lentink, V., van der Made, I., Hérias, V., van Leeuwen, R. E. W., Schellings, M. W. M., Barenbrug, P. J. C., et al. (2008) · Circulation Research · doi:10.1161/circresaha.108.182535 · Cited by 816
Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhingedPreprint
David, C. J., & Manley, J. L. (2010) · Genes & Development · doi:10.1101/gad.1973010 · Cited by 848
microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heartPreprint
Liu, N., Bezprozvannaya, S., Williams, A. H., Qi, X., Richardson, J. A., Bassel‐Duby, R., & Olson, E. N. (2008) · Genes & Development · doi:10.1101/gad.1738708 · Cited by 809
Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis
Braun, T., & Gautel, M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3118 · Cited by 713
Non-coding RNAs as regulators of embryogenesis
Pauli, A., Rinn, J. L., & Schier, A. F. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2904 · Cited by 637
ESRP1 and ESRP2 Are Epithelial Cell-Type-Specific Regulators of FGFR2 Splicing
Warzecha, C. C., Sato, T. K., Nabet, B., Hogenesch, J. B., & Carstens, R. P. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.01.025 · Cited by 580
A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons
Boutz, P. L., Stoilov, P., Li, Q., Lin, C.-H., Chawla, G., Ostrow, K., Shiue, L., Ares, M., & Black, D. L. (2007) · Genes & Development · doi:10.1101/gad.1558107 · Cited by 577
Self-citation
Mechanisms of microRNA-mediated gene regulation in animal cells
Nilsen, T. W. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.02.011 · Cited by 580
A new view of transcriptome complexity and regulation through the lens of local splicing variations
Vaquero-Garcia, J., Barrera, A., Gazzara, M. R., González-Vallinas, J., Lahens, N. F., Hogenesch, J. B., Lynch, K. W., & Barash, Y. (2016) · eLife · doi:10.7554/elife.11752 · Cited by 488
A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart
Kalsotra, A., Xiao, X., Ward, A. J., Castle, J. C., Johnson, J. M., Burge, C. B., & Cooper, T. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809045105 · Cited by 508
MicroRNA Regulatory Networks in Cardiovascular Development
Liu, N., & Olson, E. N. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.03.010 · Cited by 497
Muscle-specific microRNAs in skeletal muscle development
Horak, M., Novák, J., & Vašků, J. B. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.12.013 · Cited by 485
The Role of miRNAs in Regulating Gene Expression Networks
Gurtan, A. M., & Sharp, P. A. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.03.007 · Cited by 456
Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy
Tatsuguchi, M., Seok, H., Callis, T. E., Thomson, J. M., Chen, J., Newman, M. A., Rojas, M., Hammond, S. M., & Wang, D.-Z. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.04.004 · Cited by 432
MicroRNA-206: The skeletal muscle-specific myomiR
McCarthy, J. J. (2008) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2008.03.001 · Cited by 433
Neuronal regulation of alternative pre-mRNA splicing
Li, Q., Lee, J.-A., & Black, D. L. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2237 · Cited by 376
Self-citation
MicroRNAs 1, 133, and 206: Critical factors of skeletal and cardiac muscle development, function, and disease
Townley-Tilson, W. H. D., Callis, T. E., & Wang, D. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.03.002 · Cited by 358
MicroRNA control of muscle development and disease
Williams, A. H., Liu, N., van Rooij, E., & Olson, E. N. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.01.029 · Cited by 347
Posttranscriptional Regulation of BK Channel Splice Variant Stability by miR-9 Underlies Neuroadaptation to Alcohol
Pietrzykowski, A. Z., Friesen, R. M., Martin, G. E., Puig, S. I., Nowak, C. L., Wynne, P. M., Siegelmann, H. T., & Treistman, S. N. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.032 · Cited by 348
MicroRNAs and Cell Cycle Regulation
Carleton, M. O., Cleary, M. A., & Linsley, P. S. (2007) · Cell Cycle · doi:10.4161/cc.6.17.4641 · Cited by 342
The role of microRNAs in cancer: No small matter
Wiemer, E. A. C. (2007) · European Journal of Cancer · doi:10.1016/j.ejca.2007.04.002 · Cited by 348
MicroRNAs flex their muscles
van Rooij, E., Liu, N., & Olson, E. N. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.01.007 · Cited by 347
MicroRNAs (miRNAs) in Neurodegenerative Diseases
Nelson, P. T., Wang, W., & Rajeev, B. W. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00120.x · Cited by 335
Crossregulation and Functional Redundancy between the Splicing Regulator PTB and Its Paralogs nPTB and ROD1
Spellman, R., Llorian, M., & Smith, C. W. J. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.06.016 · Cited by 313
Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2
Zhang, C., Zhang, Z., Castle, J., Sun, S., Johnson, J., Krainer, A. R., & Zhang, M. Q. (2008) · Genes & Development · doi:10.1101/gad.1703108 · Cited by 300
Multilevel Regulation of Gene Expression by MicroRNAs
Makeyev, E. V., & Maniatis, T. (2008) · Science · doi:10.1126/science.1152326 · Cited by 296
Transforming growth factor- -regulated miR-24 promotes skeletal muscle differentiation
Sun, Q., Zhang, Y., Yang, G., Chen, X., Zhang, Y., Cao, G., Wang, J., Sun, Y., Zhang, Y., Fan, M., et al. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn032 · Cited by 266
The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation
Taulli, R., Bersani, F., Foglizzo, V., Linari, A., Vigna, E., Ladanyi, M., Tuschl, T., & Ponzetto, C. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38075 · Cited by 260
Analysis of alternative splicing associated with aging and neurodegeneration in the human brain
Tollervey, J. R., Wang, Z., Hortobágyi, T., Witten, J. T., Zarnack, K., Kayikci, M., Clark, T. A., Schweitzer, A. C., Rot, G., Curk, T., et al. (2011) · Genome Research · doi:10.1101/gr.122226.111 · Cited by 252
MicroRNAs in development and disease
Erson-Bensan, A. E., & Petty, E. (2008) · Clinical Genetics · doi:10.1111/j.1399-0004.2008.01076.x · Cited by 235
MiR-206, a Key Modulator of Skeletal Muscle Development and Disease
Ma, G., Wang, Y., Li, Y., Cui, L., Zhao, Y., Zhao, B., & Li, K. (2015) · International Journal of Biological Sciences · doi:10.7150/ijbs.10921 · Cited by 239
The Cardiac Transcription Network Modulated by Gata4, Mef2a, Nkx2.5, Srf, Histone Modifications, and MicroRNAs
Schlesinger, J., Schueler, M., Grunert, M., Fischer, J. J., Zhang, Q., Krueger, T., Lange, M., Tönjes, M., Dunkel, I., & Sperling, S. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001313 · Cited by 224
Acceleration of muscle regeneration by local injection of muscle‐specific microRNAs in rat skeletal muscle injury model
Nakasa, T., Ishikawa, M., Shi, M., Shibuya, H., Adachi, N., & Ochi, M. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00898.x · Cited by 220
Evidence of MyomiR network regulation of β-myosin heavy chain gene expression during skeletal muscle atrophy
McCarthy, J. J., Esser, K. A., Peterson, C. A., & Dupont‐Versteegden, E. E. (2009) · Physiological Genomics · doi:10.1152/physiolgenomics.00042.2009 · Cited by 209
In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs: APP splicing is regulated by microRNAs
Smith, P., Al Hashimi, A., Girard, J., Delay, C., & Hébert, S. S. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07097.x · Cited by 182
Alternative splicing in cancer: Noise, functional, or systematic?
Skotheim, R. I., & Nees, M. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.02.016 · Cited by 211
MicroRNA-9 Modulates Cajal–Retzius Cell Differentiation by Suppressing Foxg1 Expression in Mouse Medial Pallium
Shibata, M., Kurokawa, D., Nakao, H., Ohmura, T., & Aizawa, S. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3219-08.2008 · Cited by 210
MiR-322/424 and -503 Are Induced during Muscle Differentiation and Promote Cell Cycle Quiescence and Differentiation by Down-Regulation of Cdc25A
Sarkar, S., Dey, B. K., & Dutta, A. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-01-0062 · Cited by 209
Neuronal regulation of pre-mRNA splicing by polypyrimidine tract binding proteins, PTBP1 and PTBP2
Keppetipola, N., Sharma, S., Li, Q., & Black, D. L. (2012) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2012.691456 · Cited by 201
Self-citation
SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control
Sun, S., Zhang, Z., Sinha, R., Karni, R., & Krainer, A. R. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1750 · Cited by 204
The utility of LNA in microRNA-based cancer diagnostics and therapeutics
Stenvang, J., Silahtaroglu, A., Lindow, M., Elmén, J., & Kauppinen, S. (2008) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2008.01.004 · Cited by 196
Tissue-specific splicing factor gene expression signatures
Grosso, A. R., Gomes, A. Q., Barbosa‐Morais, N. L., Caldeira, S., Thorne, N., Grech, G., Lindern, M. V., & Carmo‐Fonseca, M. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn463 · Cited by 200
microRNAs and the regulation of glucose and lipid metabolism
Poy, M. N., Spranger, M., & Stoffel, M. (2007) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2007.00775.x · Cited by 185
Deciphering the role of RNA-binding proteins in the post-transcriptional control of gene expression
Kishore, S., Luber, S., & Zavolan, M. (2010) · Briefings in Functional Genomics · doi:10.1093/bfgp/elq028 · Cited by 186
Muscle weakness in myotonic dystrophy associated with misregulated splicing and altered gating of CaV1.1 calcium channel
Tang, Z. Z., Yarotskyy, V., Wei, L., Sobczak, K., Nakamori, M., Eichinger, K. J., Moxley, R. T., Dirksen, R. T., & Thornton, C. A. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr568 · Cited by 181
Vascular smooth muscle phenotypic diversity and function
Fisher, S. A. (2010) · Physiological Genomics · doi:10.1152/physiolgenomics.00111.2010 · Cited by 180
Roles of the canonical myomiRs miR-1, -133 and -206 in cell development and disease
Mitchelson, K. R. (2015) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v6.i3.162 · Cited by 179
RBM24 Is a Major Regulator of Muscle-Specific Alternative Splicing
Yang, J., Hung, L.-H., Licht, T., Sawa Kostin, D., Looso, M., Khrameeva, E. E., Bindereif, A., Schneider, A., & Braun, T. W. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.08.025 · Cited by 170
Quantitation of MicroRNAs by Real-Time RT-qPCR
Chen, C., Tan, R., Wong, L., Fekete, R. A., & Halsey, J. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-944-4_8 · Cited by 165
MicroRNA miR-133b is essential for functional recovery after spinal cord injury in adult zebrafish
Yu, Y., Gibbs, K. M., Davila, J., Campbell, N., Sung, S., Todorova, T. I., Otsuka, S., Sabaawy, H. E., Hart, R. P., & Schachner, M. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07643.x · Cited by 167
Insulin-Like Growth Factor-1 Receptor Is Regulated by microRNA-133 during Skeletal Myogenesis
Huang, M., Xu, H. M., Xie, S., Zhou, H., & Qu, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029173 · Cited by 166
MicroRNAs Involved in Skeletal Muscle Differentiation
Luo, W., Nie, Q., & Zhang, X. (2013) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2013.02.002 · Cited by 164
Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development
Giudice, J., Xia, Z., Wang, E. T., Scavuzzo, M. A., Ward, A. J., Kalsotra, A., Wang, W., Wehrens, X. H. T., Burge, C. B., Li, W., et al. (2014) · Nature Communications · doi:10.1038/ncomms4603 · Cited by 169
microRNAs and muscle disorders
Chen, J., Callis, T. E., & Wang, D. (2008) · Journal of Cell Science · doi:10.1242/jcs.041723 · Cited by 163
MicroRNAs in skeletal myogenesis
Ge, Y., & Chen, J. (2011) · Cell Cycle · doi:10.4161/cc.10.3.14710 · Cited by 163
Quaking and PTB control overlapping splicing regulatory networks during muscle cell differentiation
Hall, M. P., Nagel, R. J., Fagg, W. S., Shiue, L., Cline, M., Perriman, R., Donohue, J. P., & Ares, M. (2013) · RNA · doi:10.1261/rna.038422.113 · Cited by 160
MicroRNAs: roles in cardiovascular development and disease
Kalayinia, S., Arjmand, F., Maleki, M., Malakootian, M., & Singh, C. P. (2020) · Cardiovascular Pathology · doi:10.1016/j.carpath.2020.107296 · Cited by 159
MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy
Smith, P. Y., Delay, C., Girard, J., Papon, M.-A., Planel, E., Sergeant, N., Buée, L., & Hébert, S. S. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr330 · Cited by 136
Genome-wide Analysis of Alternative Pre-mRNA Splicing
Ben-Dov, C., Hartmann, B., Lundgren, J., & Valcárcel, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r700033200 · Cited by 151
The role of microRNAs in self-renewal and differentiation of mesenchymal stem cells
Guo, L., Zhao, R. C., & Wu, Y. (2011) · Experimental Hematology · doi:10.1016/j.exphem.2011.01.011 · Cited by 149
Auto- and Cross-Regulation of the hnRNP L Proteins by Alternative Splicing
Rossbach, O., Hung, L.-H., Schreiner, S., Grishina, I., Heiner, M., Hui, J., & Bindereif, A. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01689-08 · Cited by 141
MicroRNAs regulate synthesis of the neurotransmitter substance P in human mesenchymal stem cell-derived neuronal cells
Greco, S. J., & Rameshwar, P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703037104 · Cited by 137
Inhibition of Myogenic MicroRNAs 1, 133, and 206 by Inflammatory Cytokines Links Inflammation and Muscle Degeneration in Adult Inflammatory Myopathies
Georgantas, R. W., Streicher, K. L., Greenberg, S. A., Greenlees, L. M., Zhu, W. P., Brohawn, P. Z., Higgs, B. W., Czapiga, M., Morehouse, C. A., Amato, A. A., et al. (2013) · Arthritis & Rheumatology · doi:10.1002/art.38292 · Cited by 136
Muscling Through the microRNA World
Callis, T. E., Deng, Z., Chen, J., & Wang, D. (2008) · Experimental Biology and Medicine · doi:10.3181/0709-mr-237 · Cited by 132
New Insights into Functional Roles of the Polypyrimidine Tract-Binding Protein
Romanelli, M. G., Diani, E., & Lievens, P. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141122906 · Cited by 141
Splicing factor and exon profiling across human tissues
de la Grange, P., Gratadou, L., Delord, M., Dutertre, M., & Auboeuf, D. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq008 · Cited by 142
More than a splicing code: integrating the role of RNA, chromatin and non-coding RNA in alternative splicing regulation
Luco, R. F., & Misteli, T. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2011.03.004 · Cited by 134
MicroRNAs coordinate an alternative splicing network during mouse postnatal heart development
Kalsotra, A., Wang, K., Li, P.-F., & Cooper, T. A. (2010) · Genes & Development · doi:10.1101/gad.1894310 · Cited by 129
MicroRNAs-10a and -10b Contribute to Retinoic Acid-induced Differentiation of Neuroblastoma Cells and Target the Alternative Splicing Regulatory Factor SFRS1 (SF2/ASF)
Meseguer, S., Mudduluru, G., Escamilla, J. M., Allgayer, H., & Barettino, D. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.167817 · Cited by 107
Sam68 Regulates a Set of Alternatively Spliced Exons during Neurogenesis
Chawla, G., Lin, C.-H., Han, A., Shiue, L., Ares, M., & Black, D. L. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01349-08 · Cited by 126
Self-citation
Autoregulation of Fox protein expression to produce dominant negative splicing factors
Damianov, A., & Black, D. L. (2010) · RNA · doi:10.1261/rna.1838210 · Cited by 120
Self-citation
Upregulated microRNA-301a in breast cancer promotes tumor metastasis by targeting PTEN and activating Wnt/β-catenin signaling
Ma, F., Zhang, J., Zhong, L., Wang, L., Liu, Y., Wang, Y., Lin, P., & Guo, B. (2013) · Gene · doi:10.1016/j.gene.2013.11.035 · Cited by 118
MicroRNAs as targets for antisense-based therapeutics
Stenvang, J., & Kauppinen, S. (2007) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.8.1.59 · Cited by 115
c-Myb Is an Evolutionary Conserved miR-150 Target and miR-150/c-Myb Interaction Is Important for Embryonic Development
Lin, Y.-C., Kuo, M.-W., Yu, J., Kuo, H.-H., Lin, R., Lo, W., & Yu, A. L.-T. (2008) · Molecular Biology and Evolution · doi:10.1093/molbev/msn165 · Cited by 115
Taking microRNAs to heart
Callis, T. E., & Wang, D. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.03.006 · Cited by 116
Myomaker, Regulated by MYOD, MYOG and miR-140-3p, Promotes Chicken Myoblast Fusion
Luo, W., Li, E., Nie, Q., & Zhang, X. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161125946 · Cited by 113
miR-1 and miR-206 regulate angiogenesis by modulating VegfA expression in zebrafish
Stahlhut, C. E., Suárez, Y., Lü, J., Mishima, Y., & Giráldez, A. J. (2012) · Development · doi:10.1242/dev.083774 · Cited by 109
ESRP2 controls an adult splicing programme in hepatocytes to support postnatal liver maturation
Bhate, A., Parker, D. J., Bebee, T. W., Ahn, J., Arif, W., Rashan, E. H., Chorghade, S., Chau, A., Lee, J.-H., Anakk, S., et al. (2015) · Nature Communications · doi:10.1038/ncomms9768 · Cited by 103
The role of miR-103 and miR-107 in regulation of CDK5R1 expression and in cellular migration
Moncini, S., Salvi, A., Zuccotti, P., Viero, G., Quattrone, A., Barlati, S., De Petro, G., Venturin, M., & Riva, P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020038 · Cited by 104
MicroRNA identity and abundance in porcine skeletal muscles determined by deep sequencing
Nielsen, M. M., Hansen, J., Hedegaard, J., Nielsen, R. O., Panitz, F., Bendixen, C., & Thomsen, B. (2009) · Animal Genetics · doi:10.1111/j.1365-2052.2009.01981.x · Cited by 97
NFATc4 is negatively regulated in miR-133a-mediated cardiomyocyte hypertrophic repression
Li, Q., Lin, X., Yang, X., & Chang, J. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00592.2009 · Cited by 98
Alternative RNA splicing and cancer
Liu, S., & Cheng, C. (2013) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1178 · Cited by 96
Diversification of the muscle proteome through alternative splicing
Nakka, K. K., Ghigna, C., Gabellini, D., & Dilworth, F. J. (2018) · Skeletal Muscle · doi:10.1186/s13395-018-0152-3 · Cited by 97
microRNA Expression during Trophectoderm Specification
Viswanathan, S. R., Mermel, C. H., Lü, J., Lu, C.-W., Golub, T. R., & Daley, G. Q. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006143 · Cited by 88
MicroRNA-regulation of Anopheles gambiae immunity to Plasmodium falciparum infection and midgut microbiota
Dennison, N. J., BenMarzouk‐Hidalgo, O. J., & Dimopoulos, G. (2014) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2014.10.016 · Cited by 87
Simultaneous miRNA and mRNA transcriptome profiling of human myoblasts reveals a novel set of myogenic differentiation-associated miRNAs and their target genes
Dmitriev, P., Barat, A., Polesskaya, A., O’Connell, M. J., Robert, T., Dessen, P., Walsh, T., Lazar, V., Turki, A., Carnac, G., et al. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-265 · Cited by 89
Developmental regulation of ecdysone receptor (EcR) and EcR-controlled gene expression during pharate-adult development of honeybees (Apis mellifera)
Mello, T. R. P., Aleixo, A. C., Pinheiro, D. G., Nunes, F. M. F., Bitondi, M. M. G., Hartfelder, K., Barchuk, A. R., & Simões, Z. L. P. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00445 · Cited by 87
Human TRIM71 and Its Nematode Homologue Are Targets of let-7 MicroRNA and Its Zebrafish Orthologue Is Essential for Development
Lin, Y.-C., Hsieh, L., Kuo, M.-W., Yu, J., Kuo, H.-H., Lo, W., Lin, R., Yu, A. L.-T., & Li, W. (2007) · Molecular Biology and Evolution · doi:10.1093/molbev/msm195 · Cited by 84
Structure-function relationships of the polypyrimidine tract binding protein
Auweter, S., & Allain, F. H. ‐. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7378-2 · Cited by 89
High Glucose Suppresses Human Islet Insulin Biosynthesis by Inducing miR-133a Leading to Decreased Polypyrimidine Tract Binding Protein-Expression
Fred, R. G., Bang-Berthelsen, C., Mandrup-Poulsen, T., Grunnet, L., & Welsh, N. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010843 · Cited by 82
RBM4 down-regulates PTB and antagonizes its activity in muscle cell–specific alternative splicing
Lin, J.-C., & Tarn, W. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201007131 · Cited by 85
PTB/nPTB: master regulators of neuronal fate in mammals
Hu, J., Qian, H., Xue, Y., & Fu, X. (2018) · Biophysics Reports · doi:10.1007/s41048-018-0066-y · Cited by 90
Effects of microRNAs on skeletal muscle development
Wang, J., Yang, L., Zhang, J. S., Gong, J. X., Wang, Y. H., Zhang, C. L., Chen, H., & Fang, X. (2018) · Gene · doi:10.1016/j.gene.2018.05.039 · Cited by 83
Polypyrimidine tract-binding protein homologues from Arabidopsis underlie regulatory circuits based on alternative splicing and downstream control
Stauffer, E., Westermann, A. J., Wagner, G., & Wachter, A. (2010) · The Plant Journal · doi:10.1111/j.1365-313x.2010.04321.x · Cited by 80

Authors: Boutz, P. L., Chawla, G., Stoilov, P., & Black, D. L.
Affiliations: University of California, Los Angeles (US)
Howard Hughes Medical Institute (US)
ORCID: Boutz, Paul L.
Chawla, Geetanjali
Stoilov, Peter
Black, Douglas L.
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2007-01-01
Volume: 21
Issue: 1
Pages: 71-84
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.1500707
PMC: PMC1759902
OpenAlex: W2166118364
Cited by: 304
References: 105
Citations by year: 2026: 4 · 2025: 1 · 2024: 3 · 2023: 9 · 2022: 9 · 2021: 5 · 2020: 10 · 2019: 10 · 2018: 14 · 2017: 10 · 2016: 14 · 2015: 13 · 2014: 16 · 2013: 24 · 2012: 18
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health (RO1 GM49662)
National Institute of General Medical Sciences (R01 GM 49662, R01GM049662)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: microRNA, miR-133, polypyrimidine tract-binding protein, alternative splicing, myogenesis, 3' untranslated region, C2C12 myoblasts, LNA oligonucleotides
MeSH terms: Animals, Cell Differentiation, Cells, Cultured, Drosophila, Humans, Luciferases, Muscles, Neurons, Oligonucleotides, RNA Processing, Post-Transcriptional, Transfection, Blotting, Northern, Blotting, Western, Oligonucleotides, Antisense, Alternative Splicing, Gene Targeting, Gene Expression Regulation, Developmental, Reverse Transcriptase Polymerase Chain Reaction, Response Elements, 3' Untranslated Regions, Muscle Development, Myoblasts, RNA, Small Interfering, MicroRNAs, Polypyrimidine Tract-Binding Protein, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks