Cited by 304RNA Research and SplicingMicroRNA in disease regulationMuscle Physiology and Disorders

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MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development

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Boutz, Paul L., Chawla, Geetanjali, Stoilov, Peter, Black, Douglas L.·2007·Genes & Development

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Abstract

Alternative pre-mRNA splicing determines many changes in gene expression during development. Two regulators known to control splicing patterns during neuron and muscle differentiation are the polypyrimidine tract-binding protein (PTB) and its neuronal homolog nPTB. These proteins repress certain exons in early myoblasts, but upon differentiation of mature myotubes PTB/nPTB expression is reduced, leading to increased inclusion of their target exons. We show here that the repression of nPTB expression during myoblast differentiation results from its targeting by the muscle-restricted microRNA miR-133. During differentiation of C2C12 myoblasts, nPTB protein but not mRNA expression is strongly reduced, concurrent with the up-regulation of miR-133 and the induction of splicing for several PTB-repressed exons. Introduction of synthetic miR-133 into undifferentiated C2C12 cells leads to a decrease in endogenous nPTB expression. Both the miR-133 and the coexpressed miR-1/206 microRNAs are extremely conserved across animal species, and PTB proteins are predicted targets for these miRNAs in Drosophila, mice, and humans. There are two potential miR-133-responsive elements (MRE) within the nPTB 3' untranslated region (UTR), and a luciferase reporter carrying this 3' UTR is repressed by miR-133 in an MRE-dependent manner. Transfection of locked nucleic acid (LNA) oligonucleotides designed to block the function of miR-133 and miR-1/206 increases expression of nPTB and decreases the inclusion of PTB dependent exons. These results indicate that miR-133 directly down-regulates a key splicing factor during muscle development and establishes a role for microRNAs in the control of a developmentally dynamic splicing program.

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Zuker, M. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg595 · Cited by 13,404
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Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948
Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets
Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855
The Human Genome Browser at UCSC
Kent, W. J., Sugnet, C. W., Furey, T. S., Roskin, K. M., Pringle, T. H., Zahler, A. M., & Haussler, A. D. (2002) · Genome Research · doi:10.1101/gr.229102 · Cited by 10,400
Prediction of Mammalian MicroRNA Targets
Lewis, B. P., Shih, I.-H., Jones-Rhoades, M. W., Bartel, D. P., & Burge, C. B. (2003) · Cell · doi:10.1016/s0092-8674(03)01018-3 · Cited by 5,199
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
Reinhart, B. J., Slack, F. J., Basson, M., Pasquinelli, A. E., Bettinger, J. C., Rougvie, A. E., Horvitz, H. R., & Ruvkun, G. (2000) · Nature · doi:10.1038/35002607 · Cited by 4,989
Identification of Novel Genes Coding for Small Expressed RNAs
Lagos-Quintana, M., Rauhut, R., Lendeckel, W., & Tuschl, T. (2001) · Science · doi:10.1126/science.1064921 · Cited by 4,956
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
Lim, L. P., Lau, N. C., Garrett-Engele, P., Grimson, A., Schelter, J. M., Castle, J., Bartel, D. P., Linsley, P. S., & Johnson, J. M. (2005) · Nature · doi:10.1038/nature03315 · Cited by 4,755
Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
Human MicroRNA Targets
John, B., Enright, A. J., Aravin, A., Tuschl, T., Sander, C., & Marks, D. S. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020363 · Cited by 3,796
Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure
Mathews, D. H., Sabina, J., Zuker, M., & Turner, D. H. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.2700 · Cited by 3,795
MicroRNA targets in Drosophila
Enright, A. J., John, B., Gaul, U., Tuschl, T., Sander, C., & Marks, D. S. (2003) · Genome Biology · doi:10.1186/gb-2003-5-1-r1 · Cited by 3,597
Identification of tissue-specific microRNAs from mouse
Lagos-Quintana, M., Rauhut, R., Yalcin, A., Meyer, J., Lendeckel, W., & Tuschl, T. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00809-6 · Cited by 3,355
RNA interference is mediated by 21- and 22-nucleotide RNAsPreprint
Elbashir, S. M., Lendeckel, W., & Tuschl, T. (2001) · Genes & Development · doi:10.1101/gad.862301 · Cited by 3,354
An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans
Lau, N. C., Lim, L. P., Weinstein, E. G., & Bartel, D. P. (2001) · Science · doi:10.1126/science.1065062 · Cited by 3,345
Asymmetry in the Assembly of the RNAi Enzyme Complex
Schwarz, D. S., Hutvágner, G., Du, T., Xu, Z., Aronin, N., & Zamore, P. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00759-1 · Cited by 2,922
An Extensive Class of Small RNAs in Caenorhabditis elegans
Lee, R. C., & Ambros, V. (2001) · Science · doi:10.1126/science.1065329 · Cited by 2,922
The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation
Chen, J., Mandel, E. M., Thomson, J. M., Wu, Q., Callis, T. E., Hammond, S. M., Conlon, F. L., & Wang, D.-Z. (2005) · Nature Genetics · doi:10.1038/ng1725 · Cited by 2,807
Functional siRNAs and miRNAs exhibit strand bias
Khvorova, A., Reynolds, A., & Jayasena, S. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00801-8 · Cited by 2,645
Fast and effective prediction of microRNA/target duplexes
REHMSMEIER, M., STEFFEN, P., HÖCHSMANN, M., & GIEGERICH, R. (2004) · RNA · doi:10.1261/rna.5248604 · Cited by 2,560
MicroRNA-21 Is an Antiapoptotic Factor in Human Glioblastoma Cells
Chan, J. A., Krichevsky, A. M., & Kosik, K. S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0137 · Cited by 2,557
The microRNA Registry
Griffiths-Jones, S. (2004) · Nucleic Acids Res. · doi:10.1093/nar/gkh023 · Cited by 2,446
Principles of MicroRNA–Target Recognition
Brennecke, J., Stark, A., Russell, R. B., & Cohen, S. M. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030085 · Cited by 2,431
c-Myc-regulated microRNAs modulate E2F1 expression
O'Donnell, K. A., Wentzel, E. A., Zeller, K. I., Dang, C. V., & Mendell, J. T. (2005) · Nature · doi:10.1038/nature03677 · Cited by 2,347
The UCSC Table Browser data retrieval tool
Karolchik, D. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkh103 · Cited by 2,314
A pancreatic islet-specific microRNA regulates insulin secretion
Poy, M. N., Eliasson, L., Krutzfeldt, J., Kuwajima, S., Ma, X., MacDonald, P. E., Pfeffer, S., Tuschl, T., Rajewsky, N., Rorsman, P., et al. (2004) · Nature · doi:10.1038/nature03076 · Cited by 2,102
Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals
Xie, X., Lu, J., Kulbokas, E. J., Golub, T. R., Mootha, V., Lindblad-Toh, K., Lander, E. S., & Kellis, M. (2005) · Nature · doi:10.1038/nature03441 · Cited by 1,872
MicroRNA-Directed Cleavage of HOXB8 mRNA
Yekta, S., Shih, I.-H., & Bartel, D. P. (2004) · Science · doi:10.1126/science.1097434 · Cited by 1,702
Specificity of microRNA target selection in translational repressionPreprint
Doench, J. G., & Sharp, P. A. (2004) · Genes & Development · doi:10.1101/gad.1184404 · Cited by 1,685
Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation
Sempere, L. F., Freemantle, S., Pitha-Rowe, I., Moss, E., Dmitrovsky, E., & Ambros, V. (2004) · Genome Biology · doi:10.1186/gb-2004-5-3-r13 · Cited by 1,578
Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis
Zhao, Y. B., Samal, E., & Srivastava, D. P. (2005) · Nature · doi:10.1038/nature03817 · Cited by 1,572
MicroRNA Expression in Zebrafish Embryonic Development
Wienholds, E., Kloosterman, W. P., Miska, E., Alvarez-Saavedra, E., Berezikov, E., de Bruijn, E., Horvitz, H. R., Kauppinen, S., & Plasterk, R. H. A. (2005) · Science · doi:10.1126/science.1114519 · Cited by 1,551
Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes
BASKERVILLE, S., & BARTEL, D. P. (2005) · RNA · doi:10.1261/rna.7240905 · Cited by 1,508
Inhibition of Translational Initiation by Let-7 MicroRNA in Human Cells
Pillai, R. S., Bhattacharyya, S. N., Artus-Revel, C. G., Zoller, T., Cougot, N., Basyuk, E. I., Bertrand, É., & Filipowicz, W. (2005) · Science · doi:10.1126/science.1115079 · Cited by 1,489
The Widespread Impact of Mammalian MicroRNAs on mRNA Repression and Evolution
Farh, K. K.-H., Grimson, A., Jan, C., Lewis, B. P., Johnston, W. K., Lim, L. P., Burge, C. B., & Bartel, D. P. (2005) · Science · doi:10.1126/science.1121158 · Cited by 1,484
Regulation by let-7 and lin-4 miRNAs Results in Target mRNA Degradation
Bagga, S., Bracht, J. R., Hunter, S. E., Massirer, K. B., Holtz, J., Eachus, R., & Pasquinelli, A. E. (2005) · Cell · doi:10.1016/j.cell.2005.07.031 · Cited by 1,347
MicroRNAs Regulate Brain Morphogenesis in Zebrafish
Giraldez, A. J., Cinalli, R. M., Glasner, M. E., Enright, A. J., Thomson, J. M., Baskerville, S., Hammond, S. M., Bartel, D. P., & Schier, A. F. (2005) · Science · doi:10.1126/science.1109020 · Cited by 1,315
siRNAs can function as miRNAsPreprint
Doench, J. G., Petersen, C. P., & Sharp, P. A. (2003) · Genes & Development · doi:10.1101/gad.1064703 · Cited by 1,278
Phylogenetic Shadowing and Computational Identification of Human microRNA Genes
Berezikov, E., Guryev, V., van de Belt, J., Wienholds, E., Plasterk, R. H. A., & Cuppen, E. (2005) · Cell · doi:10.1016/j.cell.2004.12.031 · Cited by 1,270
Pre-mRNA splicing and human diseasePreprint
Faustino, N. A., & Cooper, T. A. (2003) · Genes & Development · doi:10.1101/gad.1048803 · Cited by 1,248
The lin-4 Regulatory RNA Controls Developmental Timing in Caenorhabditis elegans by Blocking LIN-14 Protein Synthesis after the Initiation of Translation
Olsen, P. H., & Ambros, V. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9523 · Cited by 1,234
miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
Mourelatos, Z., Dostie, J., Paushkin, S., Sharma, A., Charroux, B., Abel, L., Rappsilber, J., Mann, M., & Dreyfuss, G. (2002) · Genes & Development · doi:10.1101/gad.974702 · Cited by 1,105
Animal MicroRNAs Confer Robustness to Gene Expression and Have a Significant Impact on 3′UTR Evolution
Stark, A., Brennecke, J., Bushati, N., Russell, R. B., & Cohen, S. M. (2005) · Cell · doi:10.1016/j.cell.2005.11.023 · Cited by 1,080
Using Antibodies: A Laboratory Manual
Harlow, E., & Lane, D. P. (1998) · Cited by 995
New microRNAs from mouse and human
LAGOS-QUINTANA, M., RAUHUT, R., MEYER, J., BORKHARDT, A., & TUSCHL, T. (2003) · RNA · doi:10.1261/rna.2146903 · Cited by 909
A Minicircuitry Comprised of MicroRNA-223 and Transcription Factors NFI-A and C/EBPα Regulates Human Granulopoiesis
Fazi, F., Rosa, A., Fatica, A., Gelmetti, V., De Marchis, M. L., Nervi, C., & Bozzoni, I. (2005) · Cell · doi:10.1016/j.cell.2005.09.023 · Cited by 894
Short RNAs Repress Translation after Initiation in Mammalian Cells
Petersen, C. P., Bordeleau, M.-È., Pelletier, J., & Sharp, P. A. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.031 · Cited by 824
Identification of Drosophila MicroRNA Targets
Stark, A., Brennecke, J., Russell, R. B., & Cohen, S. M. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000060 · Cited by 784
A combined computational-experimental approach predicts human microRNA targetsPreprint
Kiriakidou, M., Nelson, P. T., Kouranov, A., Fitziev, P., Bouyioukos, C., Mourelatos, Z., & Hatzigeorgiou, A. G. (2004) · Genes & Development · doi:10.1101/gad.1184704 · Cited by 774
Muscle-specific microRNA miR-206 promotes muscle differentiation
Kim, H. K., Lee, Y. S., Sivaprasad, U., Malhotra, A., & Dutta, A. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200603008 · Cited by 772
A custom microarray platform for analysis of microRNA gene expression
Thomson, J. M., Parker, J. S., Perou, C. M., & Hammond, S. M. (2004) · Nature Methods · doi:10.1038/nmeth704 · Cited by 742
MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function
Humphreys, D. T., Westman, B. J., Martin, D. I. K., & Preiß, T. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506482102 · Cited by 704
The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb
Harfe, B. D., McManus, M. T., Mansfield, J. H., Hornstein, E., & Tabin, C. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504834102 · Cited by 656
MicroRNAs, SNPs and Cancer
Vitale, A. V., Tan, H., & Jin, P. (2011) · Journal of Nucleic Acids Investigation · doi:10.4081/jnai.2011.2236 · Cited by 626
MicroRNA expression detected by oligonucleotide microarrays: System establishment and expression profiling in human tissues
Barad, O., Meiri, E., Avniel, A., Aharonov, R., Barzilai, A., Bentwich, I., Einav, U., Gilad, S., Hurban, P., Karov, Y., et al. (2004) · Genome Research · doi:10.1101/gr.2845604 · Cited by 582
The microRNA-producing enzyme Dicer1 is essential for zebrafish development
Wienholds, E., Koudijs, M., van Eeden, F. V., Cuppen, E., & Plasterk, R. (2003) · Nature Genetics · doi:10.1038/ng1251 · Cited by 519
The CELF Family of RNA Binding Proteins Is Implicated in Cell-Specific and Developmentally Regulated Alternative Splicing
Ladd, A. N., Charlet‐Berguerand, N., & Cooper, T. A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.4.1285-1296.2001 · Cited by 464
MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling
Kwon, C., Han, Z., Olson, E. N., & Srivastava, D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509535102 · Cited by 427
Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growthPreprint
Sokol, N. S., & Ambros, V. (2005) · Genes & Development · doi:10.1101/gad.1356105 · Cited by 402
Probing microRNAs with microarrays: tissue specificity and functional inference
BABAK, T., ZHANG, W., MORRIS, Q., BLENCOWE, B. J., & HUGHES, T. R. (2004) · RNA · doi:10.1261/rna.7119904 · Cited by 385
LNA-modified oligonucleotides mediate specific inhibition of microRNA function
Ørom, U. A., Kauppinen, S., & Lund, A. H. (2006) · Gene · doi:10.1016/j.gene.2005.12.031 · Cited by 380
Numerous microRNPs in neuronal cells containing novel microRNAs
DOSTIE, J., MOURELATOS, Z., YANG, M., SHARMA, A., & DREYFUSS, G. (2003) · RNA · doi:10.1261/rna.2141503 · Cited by 378
Polypyrimidine Tract Binding Protein Antagonizes Exon Definition
Wagner, E. J., & García-Blanco, M. A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3281-3288.2001 · Cited by 376
Identification and purification of a 62,000-dalton protein that binds specifically to the polypyrimidine tract of introns.Preprint
García-Blanco, M. A., Jamison, S. F., & Sharp, P. A. (1989) · Genes & Development · doi:10.1101/gad.3.12a.1874 · Cited by 346
Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing.Preprint
Patton, J. G., Mayer, S. A., Tempst, P., & Nadal‐Ginard, B. (1991) · Genes & Development · doi:10.1101/gad.5.7.1237 · Cited by 334
Cooperative Assembly of an hnRNP Complex Induced by a Tissue-Specific Homolog of Polypyrimidine Tract Binding Protein
Markovtsov, V. V., Nikolic, J. M., Goldman, J. A., Turck, C. W., Chou, M., & Black, D. L. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.20.7463-7479.2000 · Cited by 311
Self-citation
hnRNP 1, the polyprimidine tract-binding protein: distinct nuclear localization and association with hnRNAs
Ghetti, A., Piñol-Roma, S., Michael, W. M., Morandi, C., & Dreyfuss, G. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.14.3671 · Cited by 311
Homologues of the Caenorhabditis elegans Fox-1 Protein Are Neuronal Splicing Regulators in Mammals
Underwood, J. G., Boutz, P. L., Dougherty, J. D., Stoilov, P., & Black, D. L. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.22.10005-10016.2005 · Cited by 272
Self-citation
The M-band: an elastic web that crosslinks thick filaments in the center of the sarcomere
Agarkova, I., & Perriard, J. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.07.001 · Cited by 240
A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing
Polydorides, A. D., Okano, H. J., Yang, Y. Y. L., Stefani, G., & Darnell, R. B. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.110128397 · Cited by 230
A neuron-specific splicing switch mediated by an array of pre-mRNA repressor sites: evidence of a regulatory role for the polypyrimidine tract binding protein and a brain-specific PTB counterpart.
Ashiya, M., & Grabowski, P. J. (1997) · PubMed · Cited by 220
The Polypyrimidine Tract Binding Protein Binds Upstream of Neural Cell-Specific c- src Exon N1 To Repress the Splicing of the Intron Downstream
Chan, R. C., & Black, D. L. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.8.4667 · Cited by 216
Self-citation
RNA pathogenesis of the myotonic dystrophies
Day, J., & Ranum, L. P. W. (2004) · Neuromuscular Disorders · doi:10.1016/j.nmd.2004.09.012 · Cited by 190
Dynamic Antagonism between ETR-3 and PTB Regulates Cell Type-Specific Alternative Splicing
Charlet‐Berguerand, N., Singh, G., Cooper, T. A., & Logan, P. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00479-3 · Cited by 190
Expression profiling and identification of novel genes involved in myogenic differentiation
Tomczak, K. K., Marinescu, V. D., Ramoni, M. F., Sanoudou, D., Montanaro, F., Han, M., Kunkel, L. M., Kohane, I. S., & Beggs, A. H. (2003) · The FASEB Journal · doi:10.1096/fj.03-0568fje · Cited by 185
Polypyrimidine Tract Binding Protein Blocks the 5′ Splice Site-Dependent Assembly of U2AF and the Prespliceosomal E Complex
Sharma, S., Falick, A. M., & Black, D. L. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.07.014 · Cited by 165
Self-citation
Novel modes of splicing repression by PTB
Spellman, R., & Smith, C. W. J. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.12.003 · Cited by 160
Polypyrimidine tract binding protein interacts with sequences involved in alternative splicing of beta-tropomyosin pre-mRNA.
Mulligan, G., Guo, W., Wormsley, S., & Helfman, D. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74066-6 · Cited by 158
Alternative extracellular and cytoplasmic domains of the integrin alpha 7 subunit are differentially expressed during development.
Ziober, B. L., Vu, M., Waleh, N. S., Crawford, J., Lin, C. S., & Kramer, R. H. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74380-4 · Cited by 149
Predicting and validating microRNA targets.
Lai, E. C. (2004) · Genome biology · doi:10.1186/gb-2004-5-9-115 · Cited by 146
Muscle-specific alternative splicing of myotubularin-related 1 gene is impaired in DM1 muscle cells
Buj‐Bello, A. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.19.2297 · Cited by 144
Polypyrimidine Tract Binding Protein Functions as a Repressor To Regulate Alternative Splicing of α-Actinin Mutally Exclusive Exons
Southby, J., Gooding, C., & Smith, C. W. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2699 · Cited by 139
ASESORÍAS INNOVADORAS EN RECURSOS HUMANOS PARA LAS PYMES MEDIANTE EL USO DE LA RED DE INTERNET
ARTAVIA, N. I. V. (1969) · Revista Nacional de Administración · doi:10.22458/rna.v4i1.535 · Cited by 135
Differential alternative splicing activity of isoforms of polypyrimidine tract binding protein (PTB)
Wollerton, M., Gooding, C., Robinson, F., Brown, E. C., Jackson, R. J., & Smith, C. W. J. (2001) · RNA · doi:10.1017/s1355838201010214 · Cited by 132
Expression and Functional Characteristics of Calpain 3 Isoforms Generated through Tissue-Specific Transcriptional and Posttranscriptional Events
Hérasse, M., Ono, Y., Fougerousse, F., Kimura, E.-I., Stockholm, D., Beley, C., Montarras, D., Pinset, C., Sorimachi, H., Suzuki, K., et al. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.4047 · Cited by 122
Exon repression by polypyrimidine tract binding protein
Amir-Ahmady, B., Boutz, P. L., Markovtsov, V. V., Phillips, M. L., & Black, D. L. (2005) · RNA · doi:10.1261/rna.2250405 · Cited by 118
Self-citation
Coordinate repression of a trio of neuron-specific splicing events by the splicing regulator PTB
ZHANG, L., Liu, W., & Grabowski, P. J. (1999) · RNA · doi:10.1017/s1355838299981530 · Cited by 115
Isolation of a Mammalian Homologue of a Fission Yeast Differentiation Regulator
Yamamoto, H., Tsukahara, K., Kanaoka, Y., Jinno, S., & Okayama, H. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3829 · Cited by 112
Replacement of the Muscle-Specific Sarcoplasmic Reticulum Ca 2+ -ATPase Isoform SERCA2a by the Nonmuscle SERCA2b Homologue Causes Mild Concentric Hypertrophy and Impairs Contraction-Relaxation of the Heart
Heyen, M. V., Heymans, S. R. B., Antoons, G., Reed, T., Periasamy, M., Awede, B. L., Lebacq, J., Vangheluwe, P., Dewerchin, M. A., Collen, D., et al. (2001) · Circulation Research · doi:10.1161/hh2101.098466 · Cited by 105
Spatial regulation of microRNA gene expression in the Drosophila embryo
Biemar, F., Zinzen, R. P., Ronshaugen, M., Sementchenko, V. I., Manak, J. R., & Levine, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507817102 · Cited by 87
Identification of two proteins that bind to a pyrimidine-rich sequence in the 3'-untranslated region of GAP-43 mRNA
Irwin, N. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.6.1281 · Cited by 86
Cardiac Tissue-Specific Repression of CELF Activity Disrupts Alternative Splicing and Causes Cardiomyopathy
Ladd, A. N., Taffet, G. E., Hartley, C. J., Kearney, D. L., & Cooper, T. A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.14.6267-6278.2005 · Cited by 82
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Angelis, L. D., Borghi, S., Melchionna, R., Berghella, L., Baccarani-Contri, M., Parise, F., Ferrari, S., & Cossu, G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12358 · Cited by 71
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Gooding, C., Kemp, P. R., & Smith, C. W. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210131200 · Cited by 48
hephaestusencodes a polypyrimidine tract binding protein that regulates Notch signalling during wing development inDrosophila melanogaster
Dansereau, D. A., Lunke, M. D., Finkielsztein, A., Russell, M. A., & Brook, W. J. (2002) · Development · doi:10.1242/dev.00153 · Cited by 38
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Hamshere, M., Dickson, G., & Eperon, I. C. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.17.4709 · Cited by 31
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Kikuchi, T., Ichikawa, M., Arai, J., Tateiwa, H., Fu, L., Higuchi, K., & Yoshimura, N. (2000) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a022819 · Cited by 30
Lineage-specific expression of polypyrimidine tract binding protein (PTB) in Drosophila embryos
Davis, M. B., Sun, W., & Standiford, D. M. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00595-0 · Cited by 21
GeneKeyDB: A lightweight, gene-centric, relational database to support data mining environments
Kirov, S., Peng, X., Baker, E. J., Schmoyer, D. D., Zhang, B., & Snoddy, J. R. (2005) · BMC Bioinformatics · doi:10.1186/1471-2105-6-72 · Cited by 19
A cis-acting regulatory element that affects the alternative splicing of a muscle-specific exon in the mouse NCAM gene
Kawahigashi, H., Harada, Y., Asano, A., & Nakamura, M. (1998) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(98)00021-9 · Cited by 13
AutoAssembler Sequence Assembly Software
Parker, S. R. (1997) · Humana Press eBooks · doi:10.1385/0-89603-358-9:107 · Cited by 12

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1 of the 105 references couldn’t be matched to a known paper.

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Gooding,, 1998, Role of an inhibitory pyrimidine element and polypyrimidine tract binding protein in repression of a regulated α-tropomyosin exon, RNA, 4, 85

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microRNA Functions
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Makeyev, E. V., Zhang, J., Carrasco, M. A., & Maniatis, T. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.015 · Cited by 1,395
Small non-coding RNAs in animal development
Stefani, G., & Slack, F. J. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2347 · Cited by 1,390
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
David, C. J., Chen, M., Assanah, M., Canoll, P., & Manley, J. L. (2010) · Nature · doi:10.1038/nature08697 · Cited by 1,179
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Callis, T. E., Pandya, K., Seok, H., Tang, R., Tatsuguchi, M., Huang, Z., Chen, J., Deng, Z., Gunn, B. M., Shumate, J., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36154 · Cited by 878

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Authors: Boutz, P. L., Chawla, G., Stoilov, P., & Black, D. L.
Affiliations: University of California, Los Angeles (US)
Howard Hughes Medical Institute (US)
ORCID: Boutz, Paul L.
Chawla, Geetanjali
Stoilov, Peter
Black, Douglas L.
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2007-01-01
Volume: 21
Issue: 1
Pages: 71-84
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.1500707
PMC: PMC1759902
OpenAlex: W2166118364
Cited by: 304
References: 105
Citations by year: 2026: 4 · 2025: 1 · 2024: 3 · 2023: 9 · 2022: 9 · 2021: 5 · 2020: 10 · 2019: 10 · 2018: 14 · 2017: 10 · 2016: 14 · 2015: 13 · 2014: 16 · 2013: 24 · 2012: 18
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health (RO1 GM49662)
National Institute of General Medical Sciences (R01 GM 49662, R01GM049662)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: microRNA, miR-133, polypyrimidine tract-binding protein, alternative splicing, myogenesis, 3' untranslated region, C2C12 myoblasts, LNA oligonucleotides
MeSH terms: Animals, Cell Differentiation, Cells, Cultured, Drosophila, Humans, Luciferases, Muscles, Neurons, Oligonucleotides, RNA Processing, Post-Transcriptional, Transfection, Blotting, Northern, Blotting, Western, Oligonucleotides, Antisense, Alternative Splicing, Gene Targeting, Gene Expression Regulation, Developmental, Reverse Transcriptase Polymerase Chain Reaction, Response Elements, 3' Untranslated Regions, Muscle Development, Myoblasts, RNA, Small Interfering, MicroRNAs, Polypyrimidine Tract-Binding Protein, Mice

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MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development

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