Improved methods for building protein models in electron density maps and the location of errors in these models

Molecular recognition of p53 and MDM2 by USP7/HAUSP.

Sheng, Y., Saridakis, V., Sarkari, F., Duan, S., Wu, T., Arrowsmith, C. H., & Frappier, L. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1067 · Cited by 315

Crystal Structure of the Ectodomain of Human Transferrin Receptor

Lawrence, C. M., Ray, S., Babyonyshev, M., Galluser, R., Borhani, D. W., & Harrison, S. C. (1999) · Science · doi:10.1126/science.286.5440.779 · Cited by 315

Binding of the Respiratory Chain Inhibitor Antimycin to the Mitochondrial bc1 Complex: A New Crystal Structure Reveals an Altered Intramolecular Hydrogen-bonding Pattern

Huang, L.-S., Cobessi, D., Tung, E. Y., & Berry, E. A. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.05.053 · Cited by 304

Structure of the TPR Domain of p67phox in Complex with Rac·GTP

Lapouge, K., Smith, S. J. M., Walker, P. A., Gamblin, S. J., Smerdon, S. J., & Rittinger, K. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00091-2 · Cited by 311

Structural basis for ATP-dependent DnaA assembly and replication-origin remodeling

Erzberger, J. P., Mott, M. L., & Berger, J. M. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1115 · Cited by 308

Structure of Internalin, a Major Invasion Protein of Listeria monocytogenes, in Complex with Its Human Receptor E-Cadherin

Schubert, W.-D., Urbanke, C., Ziehm, T., Beier, V., Machner, M. P., Domann, E., Wehland, J., Chakraborty, T., & Heinz, D. W. (2002) · Cell · doi:10.1016/s0092-8674(02)01136-4 · Cited by 302

Crystal structure of protoporphyrinogen IX oxidase: a key enzyme in haem and chlorophyll biosynthesis

Koch, M., Breithaupt, C., Kiefersauer, R., Freigang, J., Huber, R., & Messerschmidt, A. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600189 · Cited by 299

Structural and Computational Analysis of the Quinone-binding Site of Complex II (Succinate-Ubiquinone Oxidoreductase)

Horsefield, R., Yankovskaya, V., Sexton, G., Whittingham, W., Shiomi, K., Ōmura, S., Byrne, B., Cecchini, G., & Iwata, S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508173200 · Cited by 292

Docking Motif Interactions in MAP Kinases Revealed by Hydrogen Exchange Mass Spectrometry

Lee, T., Hoofnagle, A. N., Kabuyama, Y., Stroud, J., Min, X., Goldsmith, E. J., Chen, L., Resing, K. A., & Ahn, N. G. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00161-3 · Cited by 282

Structure of a voltage-dependent K+ channel β subunit

Gulbis, J. M., Mann, S., & MacKinnon, R. (1999) · Cell · doi:10.1016/s0092-8674(00)80805-3 · Cited by 283

Crystal structure of the first dissimilatory nitrate reductase at 1.9 Å solved by MAD methods

Dias, J. M., Than, M. E., Humm, A., Huber, R., Bourenkov, G. P., Bartunik, H. D., Bursakov, S., Calvete, J., Caldeira, J., Carneiro, C., et al. (1999) · Structure · doi:10.1016/s0969-2126(99)80010-0 · Cited by 286

Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers

Swanson, K. A., Settembre, E. C., Shaw, C. A., Dey, A. K., Rappuoli, R., Mandl, C. W., Dormitzer, P. R., & Carfi, A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106536108 · Cited by 285

Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex

Esser, L., Quinn, B., Li, Y.-F., Zhang, M., Elberry, M., Yu, L., Yu, C.-A., & Xia, D. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.05.065 · Cited by 285

Structure of the Cand1-Cul1-Roc1 Complex Reveals Regulatory Mechanisms for the Assembly of the Multisubunit Cullin-Dependent Ubiquitin Ligases

Goldenberg, S. J., Cascio, T. C., Shumway, S. D., Garbutt, K. C., Liu, J., Xiong, Y., & Zheng, N. (2004) · Cell · doi:10.1016/j.cell.2004.10.019 · Cited by 280

Comparison of Crystal Structures of Human Androgen Receptor Ligand-Binding Domain Complexed with Various Agonists Reveals Molecular Determinants Responsible for Binding Affinity

Pereira de Jésus‐Tran, K., Côté, P., Cantin, L., Blanchet, J., Labrie, F., & Breton, R. (2006) · Protein Science · doi:10.1110/ps.051905906 · Cited by 278

Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression

Kim, C. A., Phillips, M. L., Kim, W., Gingery, M., Tran, H. H., Robinson, M. A., Faham, S., & Bowie, J. U. (2001) · The EMBO Journal · doi:10.1093/emboj/20.15.4173 · Cited by 254

Engineering and Selection of Shuffled AAV Genomes: A New Strategy for Producing Targeted Biological Nanoparticles

Li, W., Asokan, A., Wu, Z., Van Dyke, T., DiPrimio, N., Johnson, J. S., Govindaswamy, L., Agbandje-McKenna, M., Leichtle, S., Eugene Redmond Jr, D., et al. (2008) · Molecular Therapy · doi:10.1038/mt.2008.100 · Cited by 261

Crystal structure of the Saccharomyces cerevisiae phosphatidylinositol- transfer protein

Sha, B., Phillips, S. E., Bankaitis, V. A., & Luo, M. (1998) · Nature · doi:10.1038/35179 · Cited by 260

Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms

Oganesyan, V., Damschroder, M. M., Cook, K. E., Li, Q., Gao, C., Wu, H., & Dall'Acqua, W. F. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.537563 · Cited by 259

Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein

Jiang, J., Zhang, Y., Krainer, A. R., & Xu, R.-M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3572 · Cited by 253

Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53–MDM2 Pathway

Hu, M., Gu, L., Li, M., Jeffrey, P. D., Gu, W., & Shi, Y. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040027 · Cited by 251

Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release

Nowotny, M., & Yang, W. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601076 · Cited by 250

Structural basis for Duffy recognition by the malaria parasite Duffy-binding-like domain

Singh, S. K., Hora, R., Belrhali, H., Chitnis, C. E., & Sharma, A. (2006) · Nature · doi:10.1038/nature04443 · Cited by 247

Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage

Stella, S., Alcón, P., & Montoya, G. (2017) · Nature · doi:10.1038/nature22398 · Cited by 244

Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis

Shin, O.-H., Lu, J., Rhee, J.-S., Tomchick, D. R., Pang, Z. P., Wojcik, S. M., Camacho-Perez, M., Brose, N., Machius, M., Rizo, J., et al. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1758 · Cited by 243

A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone

Prodromou, C., Roe, S. M., Piper, P. W., & Pearl, L. H. (1997) · Nature Structural Biology · doi:10.1038/nsb0697-477 · Cited by 239

Crystal structures of EF-G-ribosome complexes trapped in intermediate states of translocation

Zhou, J., Lancaster, L., Donohue, J. P., & Noller, H. F. (2013) · Science · doi:10.1126/science.1236086 · Cited by 229

Molecular driving forces determining potassium channel slow inactivation

Cordero-Morales, J. F., Jogini, V., Lewis, A., Vásquez, V., Cortes, D. M., Roux, B., & Perozo, E. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1309 · Cited by 236

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates

Hewitson, K. S., Liénard, B. M. R., McDonough, M. A., Clifton, I. J., Butler, D., Soares, A. S., Oldham, N. J., McNeill, L. A., & Schofield, C. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608337200 · Cited by 235

Structures of the HIV-1 capsid protein dimerization domain at 2.6 Å resolution

Worthylake, D. K., Wang, H., Yoo, S., Sundquist, W. I., & Hill, C. P. (1999) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444998007689 · Cited by 235

Structural basis for recognition of AU-rich element RNA by the HuD protein.

(2001) · Nature Structural Biology · doi:10.1038/84131 · Cited by 234

Structure and metal-dependent mechanism of peptidoglycan deacetylase, a streptococcal virulence factor

Blair, D. E., Schüttelkopf, A. W., MacRae, J. I., & van Aalten, D. M. F. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504339102 · Cited by 230

The cyclin-dependent kinase 8 module sterically blocks Mediator interactions with RNA polymerase II

Elmlund, H., Baraznenok, V., Lindahl, M., Samuelsen, C. O., Koeck, P. J. B., Holmberg, S., Hebert, H., & Gustafsson, C. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607483103 · Cited by 230

Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1

Williams, R. S., Lee, M. S., Hau, D. D., & Glover, J. N. M. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb776 · Cited by 230

All-trans retinoic acid is a ligand for the orphan nuclear receptor RORβ

Stehlin-Gaon, C., Willmann, D., Zeyer, D., Sanglier, S., Van Dorsselaer, A., Renaud, J.-P., Moras, D., & Schüle, R. (2003) · Nature Structural & Molecular Biology · doi:10.1038/nsb979 · Cited by 231

Structure of the conserved GTPase domain of the signal recognition particle.

Freymann, D. M., Keenan, R. J., Stroud, R. M., & Walter, P. (1997) · Nature · doi:10.1038/385361a0 · Cited by 228

Crystal structure of a bacterial sialidase (from Salmonella typhimurium LT2) shows the same fold as an influenza virus neuraminidase.

Crennell, S. J., Garman, E. F., Laver, W. G., Vimr, E. R., & Taylor, G. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.21.9852 · Cited by 228

The 2.0 A structure of human ferrochelatase, the terminal enzyme of heme biosynthesis.

(2001) · Nature Structural Biology · doi:10.1038/84152 · Cited by 227

Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP

Rittinger, K., Walker, P. A., Eccleston, J. F., Nurmahomed, K., Owen, D., Laue, E., Gamblin, S. J., & Smerdon, S. J. (1997) · Nature · doi:10.1038/41805 · Cited by 227

Crystal Structure of Human Frataxin

Dhe-Paganon, S., Shigeta, R., Chi, Y.-I., Ristow, M., & Shoelson, S. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000407200 · Cited by 226

Ubiquitin Recognition by the Human TSG101 Protein

Sundquist, W. I., Schubert, H. L., Kelly, B. N., Hill, G. C., Holton, J. M., & Hill, C. P. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00129-7 · Cited by 223

Crystal structure of an IRF‐DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences

Fujii, Y., Shimizu, T., Kusumoto, M., Kyogoku, Y., Taniguchi, T., & Hakoshima, T. (1999) · The EMBO Journal · doi:10.1093/emboj/18.18.5028 · Cited by 223

A crystallographic view of interactions between Dbs and Cdc42: PH domain‐assisted guanine nucleotide exchange

Rossman, K. L., Worthylake, D. K., Snyder, J. T., Siderovski, D. P., Campbell, S. L., & Sondek, J. (2002) · The EMBO Journal · doi:10.1093/emboj/21.6.1315 · Cited by 222

Replication of a cis–syn thymine dimer at atomic resolution

Ling, H., Boudsocq, F., Plosky, B. S., Woodgate, R., & Yang, W. (2003) · Nature · doi:10.1038/nature01919 · Cited by 216

Functional implications of the structure of the murine parvovirus, minute virus of mice

Agbandje-McKenna, M., Llamas-Saiz, A. L., Wang, F., Tattersall, P., & Rossmann, M. G. (1998) · Structure · doi:10.1016/s0969-2126(98)00137-3 · Cited by 218

Structural mechanism of demethylation and inactivation of protein phosphatase 2A

Xing, Y., Li, Z., Chen, Y., Stock, J. B., Jeffrey, P. D., & Shi, Y. (2008) · Cell · doi:10.1016/j.cell.2008.02.041 · Cited by 206

Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d

Brotherton, D. H., Dhanaraj, V., Wick, S., Brizuela, L., Domaille, P. J., Volyanik, E., Xu, X., Parisini, E., Smith, B. O., Archer, S. J., et al. (1998) · Nature · doi:10.1038/26164 · Cited by 210

Crystal structure of the NG domain from the signal-recognition particle receptor FtsY.

Montoya, G., Svensson, C., Luirink, J., & Sinning, I. (1997) · Nature · doi:10.1038/385365a0 · Cited by 210

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

Snyder, J. T., Worthylake, D. K., Rossman, K. L., Betts, L., Pruitt, W. M., Siderovski, D. P., Der, C. J., & Sondek, J. (2002) · Nature Structural Biology · doi:10.1038/nsb796 · Cited by 209

Crystal structure of Vibrio cholerae neuraminidase reveals dual lectin-like domains in addition to the catalytic domain

Crennell, S., Garman, E., Laver, G., Vimr, E., & Taylor, G. (1994) · Structure · doi:10.1016/s0969-2126(00)00053-8 · Cited by 205

Structurally mapping the diverse phenotype of adeno-associated virus serotype 4

Govindasamy, L., Padron, E., McKenna, R., Muzyczka, N., Kaludov, N., Chiorini, J. A., & Agbandje-McKenna, M. (2006) · Journal of Virology · doi:10.1128/jvi.01536-06 · Cited by 205

Structural Studies of Human Histone Deacetylase 8 and Its Site-Specific Variants Complexed with Substrate and Inhibitors,

Dowling, D. P., Gantt, S. L., Gattis, S. G., Fierke, C. A., & Christianson, D. W. (2008) · Biochemistry · doi:10.1021/bi801610c · Cited by 200

Structure of factor-inhibiting hypoxia-inducible factor 1: an asparaginyl hydroxylase involved in the hypoxic response pathway

Dann, C. E., Bruick, R. K., & Deisenhofer, J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202614999 · Cited by 200

A conformational change in the adeno-associated virus type 2 capsid leads to the exposure of hidden VP1 N termini

Kronenberg, S., Böttcher, B., von der Lieth, C. W., Bleker, S., & Kleinschmidt, J. A. (2005) · Journal of Virology · doi:10.1128/jvi.79.9.5296-5303.2005 · Cited by 198

Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists.

Lühder, F., Huang, Y., Dennehy, K. M., Guntermann, C., Müller, I., Winkler, E., Kerkau, T., Ikemizu, S., Davis, S. J., Hanke, T., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021024 · Cited by 193

Structures of modified eEF2·80S ribosome complexes reveal the role of GTP hydrolysis in translocation

Taylor, D. J., Nilsson, J., Merrill, A. R., Andersen, G. R., Nissen, P., & Frank, J. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601677 · Cited by 193

Structure of a Lipid Droplet Protein

Hickenbottom, S. J., Kimmel, A. R., Londos, C., & Hurley, J. H. (2004) · Structure · doi:10.1016/j.str.2004.04.021 · Cited by 193

Crystal structure of the carbohydrate recognition domain of the H1 subunit of the asialoglycoprotein receptor

Meier, M., Bider, M. D., Malashkevich, V. N., Spiess, M., & Burkhard, P. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.3853 · Cited by 182

Structure of the metal-ion-activated diphtheria toxin repressor/ tox operator complex

White, A., Ding, X., vanderSpek, J. C., Murphy, J. R., & Ringe, D. (1998) · Nature · doi:10.1038/28893 · Cited by 180

Molecular Structure of Human TFIIH

Schultz, P., Fribourg, S., Poterszman, A., Mallouh, V., Moras, D., & Egly, J. M. (2000) · Cell · doi:10.1016/s0092-8674(00)00082-9 · Cited by 180

Crystal structure of a soluble CD28-Fab complex

Evans, E. J., Esnouf, R. M., Manso-Sancho, R., Gilbert, R. J. C., James, J. R., Yu, C., Fennelly, J. A., Vowles, C., Hanke, T., Walse, B., et al. (2005) · Nature Immunology · doi:10.1038/ni1170 · Cited by 180

X-ray structure of a native calicivirus: Structural insights into antigenic diversity and host specificity

Chen, R., Neill, J. D., Estes, M. K., & Prasad, B. V. V. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600421103 · Cited by 180

Crystal Structure of the Human Cytosolic Sialidase Neu2

Chavas, L. M. G., Tringali, C., Fusi, P., Venerando, B., Tettamanti, G., Kato, R., Monti, E., & Wakatsuki, S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411506200 · Cited by 176

Structure of the BRCT Repeats of BRCA1 Bound to a BACH1 Phosphopeptide

Shiozaki, E. N., Gu, L., Yan, N., & Shi, Y. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00238-2 · Cited by 174

Structural Basis for Endosomal Targeting by the Bro1 Domain

Kim, J., Sitaraman, S., Hierro, A., Beach, B. M., Odorizzi, G., & Hurley, J. H. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.04.001 · Cited by 174

Pathological consequences of VCP mutations on human striated muscle

Hubbers, C. U., Clemen, C. S., Kesper, K., Boddrich, A., Hofmann, A., Kamarainen, O., Tolksdorf, K., Stumpf, M., Reichelt, J., Roth, U., et al. (2007) · Brain · doi:10.1093/brain/awl238 · Cited by 170

Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX

Phan, J., Li, Z., Kasprzak, A., Li, B., Sebti, S., Guida, W., Schönbrunn, E., & Chen, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.073056 · Cited by 173

Crystal structure of the amphiphysin‐2 SH3 domain and its role in the prevention of dynamin ring formation

Owen, D. J., Wigge, P., Vallis, Y., Moore, J. D. A., Evans, P. R., & McMahon, H. T. (1998) · The EMBO Journal · doi:10.1093/emboj/17.18.5273 · Cited by 171

Docking Interactions Induce Exposure of Activation Loop in the MAP Kinase ERK2

Zhou, T., Sun, L., Humphreys, J., & Goldsmith, E. J. (2006) · Structure · doi:10.1016/j.str.2006.04.006 · Cited by 164

Haem recognition by a Staphylococcus aureus NEAT domain

Grigg, J. C., Vermeiren, C. L., Heinrichs, D. E., & Murphy, M. E. P. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05502.x · Cited by 166

Sialic acid recognition by Vibrio cholerae neuraminidase

Moustafa, I., Connaris, H., Taylor, M., Zaitsev, V., Wilson, J. C., Kiefel, M. J., von Itzstein, M., & Taylor, G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404965200 · Cited by 165

The Role of Docking Interactions in Mediating Signaling Input, Output, and Discrimination in the Yeast MAPK Network

Reményi, A., Good, M. C., Bhattacharyya, R. P., & Lim, W. A. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.10.030 · Cited by 154

3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex

Wu, B., Li, P., Liu, Y., Lou, Z., Ding, Y., Shu, C., Ye, S., Bartlam, M., Shen, B., & Rao, Z. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305969101 · Cited by 165

Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain

Romanowski, M. J., Soccio, R. E., Breslow, J. L., & Burley, S. K. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052140699 · Cited by 162

Electron cryo‐microscopy and image reconstruction of adeno‐associated virus type 2 empty capsids

Kronenberg, S., Kleinschmidt, J. A., & Böttcher, B. (2001) · The EMBO Reports · doi:10.1093/embo-reports/kve234 · Cited by 161

Epsin 1 Undergoes Nucleocytosolic Shuttling and Its Eps15 Interactor Nh2-Terminal Homology (Enth) Domain, Structurally Similar to Armadillo and Heat Repeats, Interacts with the Transcription Factor Promyelocytic Leukemia Zn2+ Finger Protein (Plzf)

Hyman, J., Chen, H., Di Fiore, P. P., De Camilli, P., & Brunger, A. T. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.3.537 · Cited by 158

Crystal structure of PU. 1/IRF-4/DNA ternary complex

Escalante, C. R., Brass, A. L., Pongubala, J. M. R., Shatova, E., Shen, L., Singh, H., & Aggarwal, A. K. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00703-7 · Cited by 154

Structural basis of adhesion‐molecule recognition by ERM proteins revealed by the crystal structure of the radixin—ICAM‐2 complex

Hamada, K., Shimizu, T., Yonemura, S., Tsukita, S., Tsukita, S., & Hakoshima, T. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg039 · Cited by 155

Inter- and Intragenus Structural Variations in Caliciviruses and Their Functional Implications

Chen, R., Neill, J. D., Noel, J. S., Hutson, A. M., Glass, R. I., Estes, M. K., & Prasad, B. V. V. (2004) · Journal of Virology · doi:10.1128/jvi.78.12.6469-6479.2004 · Cited by 154

Mechanism of IS200/IS605 Family DNA Transposases: Activation and Transposon-Directed Target Site Selection

Barabas, O., Ronning, D. R., Guynet, C., Hickman, A. B., Ton-Hoang, B., Chandler, M., & Dyda, F. (2008) · Cell · doi:10.1016/j.cell.2007.12.029 · Cited by 143

Crystal Structure and Deletion Analysis Show that the Accessory Subunit of Mammalian DNA Polymerase γ, PolγB, Functions as a Homodimer

Carrodeguas, J. A., Theis, K., Bogenhagen, D. F., & Kisker, C. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00153-8 · Cited by 150

Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase

Jin, R., Junutula, J. R., Matern, H. T., Ervin, K. E., Scheller, R. H., & Brunger, A. T. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600699 · Cited by 145

The structural basis for tight control of PP2A methylation and function by LCMT-1

Stanevich, V., Jiang, L., Satyshur, K. A., Li, Y., Jeffrey, P. D., Li, Z., Menden, P., Semmelhack, M. F., & Xing, Y. (2011) · Molecular Cell · doi:10.1016/j.molcel.2010.12.030 · Cited by 142

New aspects of electron transfer revealed by the crystal structure of a truncated bovine adrenodoxin, Adx(4-108)

Müller, A., Müller, J. J., Muller, Y. A., Uhlmann, H., Bernhardt, R., & Heinemann, U. (1998) · Structure · doi:10.1016/s0969-2126(98)00031-8 · Cited by 142

Identification of Diaryl Ether-Based Ligands for Estrogen-Related Receptor α as Potential Antidiabetic Agents

Patch, R. J., Searle, L. L., Kim, A. J., De, D., Zhu, X., Askari, H. B., O’Neill, J. C., Abad, M. C., Rentzeperis, D., Liu, J., et al. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm101063h · Cited by 141

Structure of the E. coli signal recognition particle bound to a translating ribosome.

Schaffitzel, C., Oswald, M., Berger, I., Ishikawa, T., Abrahams, J. P., Koerten, H. K., Koning, R. I., & Ban, N. (2006) · Nature · doi:10.1038/nature05182 · Cited by 136

Structural basis of docking interactions between ERK2 and MAP kinase phosphatase 3

Liu, S., Sun, J.-P., Zhou, B., & Zhang, Z.-Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510506103 · Cited by 140

Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics

Huang, Z., Sutton, S. E., Wallenfang, A. J., Orchard, R. C., Wu, X., Feng, Y., Chai, J., & Alto, N. M. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1647 · Cited by 139

Sequence‐specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain

Zhang, Z., Lee, C., Mandiyan, V., Borg, J., Margolis, B., Schlessinger, J., & Kuriyan, J. (1997) · The EMBO Journal · doi:10.1093/emboj/16.20.6141 · Cited by 140

Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor

Yoshikawa, S., Kukimoto-Niino, M., Parker, L., Handa, N., Terada, T., Fujimoto, T., Terazawa, Y., Wakiyama, M., Sato, M., Sano, S., et al. (2013) · Oncogene · doi:10.1038/onc.2012.21 · Cited by 138

The Structure of Adrenodoxin Reductase of Mitochondrial P 450 Systems: Electron Transfer for Steroid Biosynthesis

Ziegler, G. A., Vonrhein, C., Hanukoglu, I., & Schulz, G. E. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.2807 · Cited by 138

Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design

Krajewski, W. W., Collins, R., Holmberg-Schiavone, L., Jones, T. A., Karlberg, T., & Mowbray, S. L. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.10.029 · Cited by 135

Structure of DNA Polymerase β with the Mutagenic DNA Lesion 8-Oxodeoxyguanine Reveals Structural Insights into Its Coding Potential

Krahn, J. M., Beard, W. A., Miller, H., Grollman, A. P., & Wilson, S. H. (2003) · Structure · doi:10.1016/s0969-2126(02)00930-9 · Cited by 138

Structural basis of sialyltransferase activity in trypanosomal sialidases

Buschiazzo, A., Tavares, G. A., Campetella, O., Spinelli, S., Cremona, M. L., París, G., Fernanda Amaya, M., Frasch, A. C. C., & Alzari, P. M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.1.16 · Cited by 138

Inhibitor-complexed Structures of the Cytochrome bc1 from the Photosynthetic Bacterium Rhodobacter sphaeroides

Esser, L., Elberry, M., Zhou, F., Yu, C.-A., Yu, L., & Xia, D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708608200 · Cited by 137

Crystal Structure and Activity of Human p23, a Heat Shock Protein 90 Co-chaperone

Weaver, A. J., Sullivan, W. P., Felts, S. J., Owen, B. A. L., & Toft, D. O. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003410200 · Cited by 136

Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesis

Zhang, X., Kurnasov, O. V., Karthikeyan, S., Grishin, N. V., Osterman, A. L., & Zhang, H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300073200 · Cited by 136

Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE

Buchwald, G., Friebel, A., Galán, J. E., Hardt, W., Wittinghofer, A., & Scheffzek, K. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf329 · Cited by 135

Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2–Tie2 complex

Barton, W. A., Tzvetkova-Robev, D., Miranda, E. P., Kolev, M. V., Rajashankar, K. R., Himanen, J. P., & Nikolov, D. B. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1101 · Cited by 134

Structural Basis for a Munc13–1 Homodimer to Munc13–1/RIM Heterodimer Switch

Lu, J., Machius, M., Dulubova, I., Dai, H., Südhof, T. C., Tomchick, D. R., & Rizo, J. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040192 · Cited by 132