Chronic stability and selectivity of four-contact spiral nerve-cuff electrodes in stimulating the human femoral nerve
Open accessAbstract
This study describes the stability and selectivity of four-contact spiral nerve-cuff electrodes implanted bilaterally on distal branches of the femoral nerves of a human volunteer with spinal cord injury as part of a neuroprosthesis for standing and transfers. Stimulation charge threshold, the minimum charge required to elicit a visible muscle contraction, was consistent and low (mean threshold charge at 63 weeks post-implantation: 23.3 +/- 8.5 nC) for all nerve-cuff electrode contacts over 63 weeks after implantation, indicating a stable interface with the peripheral nervous system. The ability of individual nerve-cuff electrode contacts to selectively stimulate separate components of the femoral nerve to activate individual heads of the quadriceps was assessed with fine-wire intramuscular electromyography while measuring isometric twitch knee extension moment. Six of eight electrode contacts could selectively activate one head of the quadriceps while selectively excluding others to produce maximum twitch responses of between 3.8 and 8.1 N m. The relationship between isometric twitch and tetanic knee extension moment was quantified, and selective twitch muscle responses scaled to between 15 and 35 N m in tetanic response to pulse trains with similar stimulation parameters. These results suggest that this nerve-cuff electrode can be an effective and chronically stable tool for selectively stimulating distal nerve branches in the lower extremities for neuroprosthetic applications.
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Helical and spiral extra-neural interfaces have been stable for decades in clinical applications.
“The helical (Agnew et al., 1989) and spiral (Naples et al., 1988) type interfaces have been proven to be stable for decades in clinical applications (Fisher et al., 2009; Polasek et al., 2009).”
From Selectivity and Longevity of Peripheral-Nerve and Machine Interfaces: A Review. (2017) · cites this paper as Fisher et al., 2009
The Abstract and Conclusion report stable stimulation thresholds for spiral nerve-cuff electrodes implanted in one human volunteer over 63 weeks. They do not establish stability for decades or for helical interfaces, so the citing sentence extends beyond this paper's findings. (LLM, conf=0.90)
Experimental — accuracy not yet measuredMotor units in their absolute refractory period, which lasts between 1.5 and 2.1 ms, will not respond to stimulation.
“Another method for quantifying selectivity takes advantage of the concept that motor units in their absolute refractory period, which lasts between 1.5 and 2.1 ms, will not respond to stimulation [1,3,6,11-15].”
From Optimization of selective stimulation parameters for multi-contact electrodes (2013) · cites this paper as [3]
If non-adjacent pairwise combinations of contacts were ignored and a limited data set was used to fit the Gompertz and third-order polynomial models, the method would require approximately 13 hours to completely optimize selective stimulation for a 100-contact Utah slant electrode array, as compared to 11.6 days otherwise.
“If non-adjacent pairwise combinations of contacts were ignored and a limited data set was used to fit the Gompertz and third-order polynomial models, which have three and ten parameters, respectively, the method described above would require approximately 13 hours to completely optimize selective stimulation for a 100-contact Utah slant electrode array, as compared to 11.6 days otherwise [3].”
From Optimization of selective stimulation parameters for multi-contact electrodes (2013) · cites this paper as [3]
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- Authors
- Fisher, L. E., Tyler, D. J., Anderson, J. S., & Triolo, R. J.
- Affiliations
- Case Western Reserve University (US)
- Louis Stokes Cleveland VA Medical Center (US)
- Venue
- Journal of Neural Engineering
- Publisher
- IOP Publishing
- Published
- 2009-07-15
- Volume
- 6
- Issue
- 4
- Pages
- 046010
- ISSN
- 1741-2552 (ISSN-L)
- 1741-2560
- PMC
- PMC2928075
- OpenAlex
- W2054973590
- Cited by
- 89
- References
- 38
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 8 · 2016: 8 · 2015: 9 · 2014: 3 · 2013: 12 · 2012: 5
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neural Engineering (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Case Western Reserve University
- Deutsches Krebsforschungszentrum
- National Institutes of Health
- National Institute of Biomedical Imaging and Bioengineering (R01EB001889, 5-R01-EB001889, T32-EB04314-08, T32EB004314)
- National Center for Research Resources (M01RR000080)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- femoral nerve, spinal cord injury, neural prostheses, stimulation selectivity, quadriceps activation, isometric twitch, lower limb rehabilitation
- MeSH terms
- Adult, Analysis of Variance, Electric Stimulation, Electrodes, Implanted, Electromyography, Femoral Nerve, Humans, Knee, Male, Muscle Contraction, Spinal Cord Injuries, Muscle, Skeletal, Prostheses and Implants
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