Intrinsic connectivity networks in post-traumatic stress disorder during sub- and supraliminal processing of threat-related stimuli
Abstract
Objective: To investigate the functional connectivity of large‐scale intrinsic connectivity networks (ICN s) in post‐traumatic stress disorder (PTSD) during subliminal and supraliminal presentation of threat‐related stimuli. Method: Group independent component analysis was utilized to study functional connectivity within the ICN s most correlated with the Default‐mode Network (DMN), Salience Network (SN), and Central Executive Network (CEN) in PTSD participants (n = 26) as compared to healthy controls (n = 20) during sub‐ and supraliminal processing of threat‐related stimuli. Results: Comparing patients with PTSD with healthy participants, prefrontal and anterior cingulate cortex involved in top‐down regulation showed increased integration during subliminal threat processing within the CEN and SN and during supraliminal threat processing within the DMN. The right amygdala showed increased connectivity with the DMN during subliminal processing in PTSD as compared to controls. Brain regions associated with self‐awareness and consciousness exhibited decreased connectivity during subliminal threat processing in PTSD as compared to controls: the claustrum within the SN and the precuneus within the DMN. Conclusion: Key nodes of the ICN s showed altered functional connectivity in PTSD as compared to controls, and differential results characterized sub‐ and supraliminal processing of threat‐related stimuli. These findings enhance our understanding of ICN s underlying PTSD at different levels of conscious threat perception.
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Increased functional connectivity of the ventrolateral PFC with the CEN was observed as a function of dissociative subtype status among individuals with PTSD.
“Recent work investing functional connectivity of ICNs during supra-and sub-liminal threat processing revealed increased functional connectivity of the ventrolateral PFC with the CEN as a function of dissociative subtype status among individuals with PTSD (Rabellino et al., 2015).”
From A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions (2016) · cites this paper as Rabellino et al., 2015
In individuals with PTSD and PTSD-DS, increased functional connectivity of the vlPFC with the CEN was observed in PTSD-DS as compared to individuals with PTSD without the dissociative subtype.
“Here, the authors reported altered functional connectivity within the CEN, particularly, increased functional connectivity of the vlPFC with the CEN in PTSD-DS as compared to individuals with PTSD without the dissociative subtype.”
From A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions (2016) · cites this paper as Rabellino et al., 2015
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- Authors
- Rabellino, D., Tursich, M., Frewen, P. A., Daniels, J. K., Densmore, M., Théberge, J., & Lanius, R. A.
- Affiliations
- Western University (CA)
- Otto-von-Guericke-Universität Magdeburg (DE)
- Corresponding author
- Lanius, R. A.
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 2015-04-11
- Volume
- 132
- Issue
- 5
- Pages
- 365-378
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W2063809941
- Cited by
- 78
- References
- 27
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 8 · 2022: 7 · 2021: 6 · 2020: 9 · 2019: 6 · 2018: 11 · 2017: 8 · 2016: 7 · 2015: 3
- FWCI
- 5.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institute of Health Research
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Keywords
- post-traumatic stress disorder, resting-state networks, subliminal processing, threat-related stimuli, default mode network, salience network, frontoparietal network, amygdala, claustrum, precuneus, top-down control, functional connectivity
- MeSH terms
- Adult, Amygdala, Fear, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Stress Disorders, Post-Traumatic, Subliminal Stimulation, Prefrontal Cortex
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