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Cited by 400

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Systematic review: exercise‐induced gastrointestinal syndrome—implications for health and intestinal disease

Open access
Costa, R. J. S., Snipe, R. M. J., Kitic, C. M., Gibson, P. R.·2017·Alimentary Pharmacology & Therapeutics
DOI 10.1111/apt.14157
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Abstract

Summary: Background: “Exercise‐induced gastrointestinal syndrome” refers to disturbances of gastrointestinal integrity and function that are common features of strenuous exercise. Aim: To systematically review the literature to establish the impact of acute exercise on markers of gastrointestinal integrity and function in healthy populations and those with chronic gastrointestinal conditions. Methods: Search literature using five databases (PubMed, EBSCO, Web of Science, SPORTS discus, and Ovid Medline) to review publications that focused on the impact of acute exercise on markers of gastrointestinal injury, permeability, endotoxaemia, motility and malabsorption in healthy populations and populations with gastrointestinal diseases/disorders. Results: As exercise intensity and duration increases, there is considerable evidence for increases in indices of intestinal injury, permeability and endotoxaemia, together with impairment of gastric emptying, slowing of small intestinal transit and malabsorption. The addition of heat stress and running mode appears to exacerbate these markers of gastrointestinal disturbance. Exercise stress of ≥2 hours at 60% VO2max appears to be the threshold whereby significant gastrointestinal perturbations manifest, irrespective of fitness status. Gastrointestinal symptoms, referable to upper‐ and lower‐gastrointestinal tract, are common and a limiting factor in prolonged strenuous exercise. While there is evidence for health benefits of moderate exercise in patients with inflammatory bowel disease or functional gastrointestinal disorders, the safety of more strenuous exercise has not been established. Conclusions: Strenuous exercise has a major reversible impact on gastrointestinal integrity and function of healthy populations. The safety and health implications of prolonged strenuous exercise in patients with chronic gastrointestinal diseases/disorders, while hypothetically worrying, has not been elucidated and requires further investigation.

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Metadata

Authors
Costa, R. J. S., Snipe, R. M. J., Kitic, C. M., & Gibson, P. R.
Venue
Alimentary Pharmacology & Therapeutics
Publisher
Wiley
Published
2017-06-07
Volume
46
Issue
3
Pages
246-265
ISSN
  • 0269-2813 (ISSN-L)
  • 1365-2036
DOI
10.1111/apt.14157
OpenAlex
W2623082693
Cited by
400
References
32
FWCI
5.53
Type
journal article
Language
en
Open access
green

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