Initiation and perpetuation of NLRP 3 inflammasome activation and assembly

The Inflammasome

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A role for mitochondria in nlrp3 inflammasome activation

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Gout-associated uric acid crystals activate the NALP3 inflammasome

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Autophagy and Viruses: Adversaries or Allies?

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Succinate is an inflammatory signal that induces IL-1β through HIF-1α

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Circulating mitochondrial DAMPs cause inflammatory responses to injury

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Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

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Cryopyrin activates the inflammasome in response to toxins and ATP

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

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Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

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Mitochondria and cell death: outer membrane permeabilization and beyond

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Calcium, ATP, and ROS: a mitochondrial love-hate triangle

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The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

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Mitofusin 2 tethers endoplasmic reticulum to mitochondria

de Brito, O. M., & Scorrano, L. (2008) · Nature · doi:10.1038/nature07534 · Cited by 2,442

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

Halle, A., Hornung, V., Petzold, G. C., Stewart, C. R., Monks, B. G., Reinheckel, T., Fitzgerald, K. A., Latz, E., Moore, K. J., & Golenbock, D. T. (2008) · Nature Immunology · doi:10.1038/ni.1636 · Cited by 2,441

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

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Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

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Close Contacts with the Endoplasmic Reticulum as Determinants of Mitochondrial Ca 2+ Responses

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mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

Cheng, S.-C., Quintin, J., Cramer, R. A., Shepardson, K. M., Saeed, S., Kumar, V., Giamarellos-Bourboulis, E. J., Martens, J. H. A., Rao, N. A., Aghajanirefah, A., et al. (2014) · Science · doi:10.1126/science.1250684 · Cited by 2,224

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

Muñoz-Planillo, R., Kuffa, P., Martínez-Colón, G. J., Smith, B. L., Rajendiran, T. M., & Núñez, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.016 · Cited by 2,167

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

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NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

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TRP Channels

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A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

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Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

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Mitochondria as sensors and regulators of calcium signalling

Rizzuto, R., De Stefani, D., Raffaello, A., & Mammucari, C. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3412 · Cited by 1,781

NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

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The Cytolytic P 2Z Receptor for Extracellular ATP Identified as a P 2X Receptor (P2X 7 )

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Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

Wen, H., Gris, D., Lei, Y., Jha, S., Zhang, L., Huang, M. T.-H., Brickey, W. J., & Ting, J. P.-Y. (2011) · Nature Immunology · doi:10.1038/ni.2022 · Cited by 1,698

Metabolic Pathways in Immune Cell Activation and Quiescence

Pearce, E. L., & Pearce, E. J. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.005 · Cited by 1,692

Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome

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Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

Eisenbarth, S. C., Colegio, O. R., O’Connor, W., Sutterwala, F. S., & Flavell, R. A. (2008) · Nature · doi:10.1038/nature06939 · Cited by 1,542

Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor

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Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

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Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels

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BAX and BAK Regulation of Endoplasmic Reticulum Ca 2+ : A Control Point for Apoptosis

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Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

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Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

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The growing landscape of lysine acetylation links metabolism and cell signalling

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Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors

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Microdomains with High Ca 2+ Close to IP 3 -Sensitive Channels that Are Sensed by Neighboring Mitochondria

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Caspase‐1‐induced pyroptotic cell death

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The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

Lee, G., Subramanian, N., Kim, A. I., Aksentijevich, I. A., Goldbach‐Mansky, R. T., Sacks, D. B., Germain, R. N., Kastner, D. L., & Chae, J. J. (2012) · Nature · doi:10.1038/nature11588 · Cited by 1,077

Sensing and reacting to microbes through the inflammasomes

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The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation

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The NLR Gene Family: A Standard Nomenclature

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Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

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Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

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Critical role for calcium mobilization in activation of the NLRP3 inflammasome

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Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

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Three-Dimensional Structure of the Apoptosome

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The Nalp3 inflammasome is essential for the development of silicosis

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Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

Misawa, T., Takahama, M., Kozaki, T., Lee, H., Zou, J., Saitoh, T., & Akira, S. (2013) · Nature Immunology · doi:10.1038/ni.2550 · Cited by 894

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

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IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

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Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation

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Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

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Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

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The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

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ATP Activates a Reactive Oxygen Species-dependent Oxidative Stress Response and Secretion of Proinflammatory Cytokines in Macrophages

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Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity.

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The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

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De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal‐onset multisystem inflammatory disease (NOMID): A new member of the expanding family of pyrin‐associated autoinflammatory diseases

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Mechanism of NLRP3 inflammasome activation

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Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

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Reconstituted NALP1 Inflammasome Reveals Two-Step Mechanism of Caspase-1 Activation

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IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

Kerur, N., Veettil, M. V., Sharma-Walia, N., Bottero, V., Sadagopan, S., Otageri, P., & Chandran, B. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.04.008 · Cited by 702

Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

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The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

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Mitochondrial calcium and the permeability transition in cell death

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Cutting Edge: Inflammasome Activation by Alum and Alum’s Adjuvant Effect Are Mediated by NLRP3

Li, H., Willingham, S. B., Ting, J. P. ‐., & Re, F. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.1.17 · Cited by 674

STIM proteins: dynamic calcium signal transducers

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Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis

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Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome

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Making heads or tails of phospholipids in mitochondria

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Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome

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Cutting Edge: TNF-α Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation

Franchi, L., Eigenbrod, T., & Núñez, G. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900173 · Cited by 574

Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation

Heid, M. E., Keyel, P. A., Kamga, C., Shiva, S., Watkins, S. C., & Salter, R. D. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301490 · Cited by 570

Oxidative stress caused by mitochondrial calcium overload

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Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation

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Cardiolipin‐enriched raft‐like microdomains are essential activating platforms for apoptotic signals on mitochondria

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Structural mechanisms in NLR inflammasome signaling

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Reduced IRE1α mediates apoptotic cell death by disrupting calcium homeostasis via the InsP3 receptor

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NLRC5 Deficiency Does Not Influence Cytokine Induction by Virus and Bacteria Infections

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Human Monocyte Interleukin-1β Posttranslational Processing

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Defects in Mitochondrial Clearance Predispose Human Monocytes to Interleukin-1β Hypersecretion

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Keeping the immune system in check: a role for mitophagy

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CA-074Me Protection against Anthrax Lethal Toxin

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The E3 Ubiquitin Ligase Tripartite Motif 33 Is Essential for Cytosolic RNA–Induced NLRP3 Inflammasome Activation

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Special regulatory T‐cell review: FOXP3 biochemistry in regulatory T cells – how diverse signals regulate suppression

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Coordinate control of cytoskeletal remodeling and calcium mobilization during T‐cell activation

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Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation

Wu, Y., Kuo, W.-C., Wu, Y.-J., Yang, K.-T., Chen, S.-T., Jiang, S.-T., Gordy, C. L., He, Y., & Lai, M.-Z. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.165 · Cited by 75

TXNIP Deficiency Exacerbates Endotoxic Shock via the Induction of Excessive Nitric Oxide Synthesis

Park, Y., Yoon, S., Suh, H., Kim, D. O., Park, J.-R., Jung, H., Kim, T., Yoon, S. R., Min, J., Na, H.-J., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003646 · Cited by 61

Cellular localization of NLRP3 inflammasome

Wang, Y., Yang, C., Mao, K., Chen, S., Meng, G., & Sun, B. (2013) · Protein & Cell · doi:10.1007/s13238-013-2113-2 · Cited by 58

Modeling AAA+ ring complexes from monomeric structures

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The cardiolipin-binding domain of Bid affects mitochondrial respiration and enhances cytochrome c release

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Calmodulin kinase II regulates the maturation and antigen presentation of human dendritic cells

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Rift Valley fever virus infection induces activation of the NLRP3 inflammasome

Ermler, M. E., Traylor, Z., Patel, K., Schattgen, S., Vanaja, S. K., Fitzgerald, K. A., & Hise, A. G. (2013) · Virology · doi:10.1016/j.virol.2013.11.015 · Cited by 48

Mechanistic Issues of the Interaction of the Hairpin-Forming Domain of tBid with Mitochondrial Cardiolipin

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Changes in mitochondrial surface charge mediate recruitment of signaling molecules during apoptosis

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Caspase-8 Binding to Cardiolipin in Giant Unilamellar Vesicles Provides a Functional Docking Platform for Bid

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The interaction between tBid and cardiolipin or monolysocardiolipin

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Pannexin-1 influences peritoneal cavity cell population but is not involved in NLRP3 inflammasome activation

Wang, H., Xing, Y., Mao, L., Luo, Y., Kang, L., & Meng, G. (2013) · Protein & Cell · doi:10.1007/s13238-013-2114-1 · Cited by 23

Mechanism and Regulation of NLRP3 Inflammasome Activation

He, Y., Hara, H., & Núñez, G. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.09.002 · Cited by 2,759

Pattern recognition receptors in health and diseases

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NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

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Reactive oxygen species and mitochondria: A nexus of cellular homeostasis

Dunn, J. D., Álvarez, L., Zhang, X., & Soldati, T. (2015) · Redox Biology · doi:10.1016/j.redox.2015.09.005 · Cited by 1,233

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

Zhong, Z., Liang, S., Sanchez-Lopez, E., He, F., Shalapour, S., Lin, X.-J., Wong, J., Ding, S., Seki, E., Schnabl, B., et al. (2018) · Nature · doi:10.1038/s41586-018-0372-z · Cited by 1,208

Regulation of NLRP3 inflammasome activation by mitochondria

Elliott, E. I., Colgan, J. D., Grumbach, I. M., Strack, S., Cassel, S. L., Weiss, J. P., & Sutterwala, F. S. (2018) · doi:10.17077/etd.sjblxfjh · Cited by 1

Ambiguities in NLRP3 inflammasome regulation: Is there a role for mitochondria?

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A role for mitochondria in nlrp3 inflammasome activation

Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602

The role of mitochondria in NLRP3 inflammasome activation

Liu, Q., Zhang, D., Hu, D., Zhou, X., & Zhou, Y. (2018) · Molecular Immunology · doi:10.1016/j.molimm.2018.09.010 · Cited by 475

Cutting Edge: Mitochondrial Assembly of the NLRP3 Inflammasome Complex Is Initiated at Priming

Elliott, E. I., Miller, A. N., Banoth, B., Iyer, S. S., Stotland, A., Weiss, J. P., Gottlieb, R. A., Sutterwala, F. S., & Cassel, S. L. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701723 · Cited by 195