Indoor Aerosol Science Aspects of SARS-CoV-2 Transmission
Open accessAbstract
Knowledge about person-to-person transmission of SARS-CoV-2 is reviewed, emphasizing three components: emission of virus-containing particles and drops from infectious persons; transport and fate of such emissions indoors; and inhalation of viral particles by susceptible persons. Emissions are usefully clustered into three groups: small particles (diameter 0.1-5 µm), large particles (5-100 µm), and ballistic drops (>100 µm). Speaking generates particles and drops across the size spectrum. Small particles are removed from indoor air at room scale by ventilation, filtration, and deposition; large particles mainly deposit onto indoor surfaces. Proximate exposure enhancements are associated with large particles with contributions from ballistic drops. Masking and social distancing are effective in mitigating transmission from proximate exposures. At room scale, masking, ventilation, and filtration can contribute to limit exposures. Important information gaps prevent a quantitative reconciliation of the high overall global spread of COVID-19 with known transmission pathways. Available information supports several findings with moderate-to-high confidence: transmission occurs predominantly indoors; inhalation of airborne particles (up to 50 µm in diameter) contributes substantially to viral spread; transmission occurs in near proximity and at room scale; speaking is a major source of airborne SARS-CoV-2 virus; and emissions can occur without strong illness symptoms.
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For human-emitted infectious particles specifically, masking in the general population also offers a second benefit of reducing source emissions from infected individuals.
“For human-emitted infectious particles specifically, masking in the general population also offers a second benefit of reducing source emissions from infected individuals [3,26,37,60].”
From Comparative Mask Protection against Inhaling Wildfire Smoke, Allergenic Bioaerosols, and Infectious Particles (2022) · cites this paper as [37]
Evaporation can shrink human-emitted particle sizes by 50-75%.
“Evaporation can shrink human-emitted particle sizes by 50–75% [37].”
From Comparative Mask Protection against Inhaling Wildfire Smoke, Allergenic Bioaerosols, and Infectious Particles (2022) · cites this paper as [37]
The larger particle modes may settle out before they shrink appreciably.
“while the larger particle modes may settle out before they shrink appreciably [23,37].”
From Comparative Mask Protection against Inhaling Wildfire Smoke, Allergenic Bioaerosols, and Infectious Particles (2022) · cites this paper as [37]
Evaporation rates strongly depend on particle size.
“Because evaporation rates strongly depend on particle size”
From Comparative Mask Protection against Inhaling Wildfire Smoke, Allergenic Bioaerosols, and Infectious Particles (2022) · cites this paper as [37]
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Bioaerosols in built and natural environments
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Modelling Near‐Field Aerosol Exposure for Respiratory Infection Risk Assessment
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A Study of Expiratory Droplet Dispersion and Deposition Density in an Enclosed Residential Space
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- Authors
- Nazaroff, W. W.
- Affiliations
- University of California, Berkeley (US)
- Corresponding author
- Nazaroff, William W
- ORCID
- Nazaroff, William W
- Venue
- Indoor Air
- Publisher
- Wiley
- Published
- 2021-12-06
- Volume
- 32
- Issue
- 1
- Pages
- e12970-e12970
- ISSN
- 0905-6947 (ISSN-L)
- 1600-0668
- OpenAlex
- W3190948864
- Cited by
- 70
- References
- 143
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 18 · 2023: 20 · 2022: 14 · 2021: 1
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- green
- escholarship.org
- Licence
- Locations
- Indoor Air (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Infection Control and Ventilation
- Physical Sciences › Environmental Science › Global and Planetary Change › COVID-19 impact on air quality
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
- Keywords
- SARS-CoV-2, SARS-CoV-2 transmission, indoor aerosols, airborne transmission, respiratory droplets, particle size, ventilation, air filtration, surface deposition, masking, social distancing, inhalation exposure
- MeSH terms
- COVID-19, SARS-CoV-2, Aerosols, Air Microbiology, Humans, Ventilation, Air Pollution, Indoor
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