Cited by 70Infection Control and VentilationCOVID-19 impact on air qualityIndoor Air Quality and Microbial Exposure

Indoor Aerosol Science Aspects of SARS-CoV-2 Transmission

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Nazaroff, William W·2022·Indoor Air

Abstract

Knowledge about person-to-person transmission of SARS-CoV-2 is reviewed, emphasizing three components: emission of virus-containing particles and drops from infectious persons; transport and fate of such emissions indoors; and inhalation of viral particles by susceptible persons. Emissions are usefully clustered into three groups: small particles (diameter 0.1-5 µm), large particles (5-100 µm), and ballistic drops (>100 µm). Speaking generates particles and drops across the size spectrum. Small particles are removed from indoor air at room scale by ventilation, filtration, and deposition; large particles mainly deposit onto indoor surfaces. Proximate exposure enhancements are associated with large particles with contributions from ballistic drops. Masking and social distancing are effective in mitigating transmission from proximate exposures. At room scale, masking, ventilation, and filtration can contribute to limit exposures. Important information gaps prevent a quantitative reconciliation of the high overall global spread of COVID-19 with known transmission pathways. Available information supports several findings with moderate-to-high confidence: transmission occurs predominantly indoors; inhalation of airborne particles (up to 50 µm in diameter) contributes substantially to viral spread; transmission occurs in near proximity and at room scale; speaking is a major source of airborne SARS-CoV-2 virus; and emissions can occur without strong illness symptoms.

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  1. Collins FS. No longer just looking under the lamppost. American Journal of Human Genetics. 2006;79:421-426.
  2. Beard KV. Terminal velocity and shape of cloud and precipitation drops aloft. Journal of the Atmospheric Sciences. 1976;33:851-864.
  3. USEPA. Inhalation rates. Chapter 6. In: Exposure Factors Handbook. United States Environmental Protection Agency; 2011.

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Authors
Nazaroff, W. W.
Affiliations
University of California, Berkeley (US)
Corresponding author
Nazaroff, William W
Venue
Indoor Air
Publisher
Wiley
Published
2021-12-06
Volume
32
Issue
1
Pages
e12970-e12970
ISSN
  • 0905-6947 (ISSN-L)
  • 1600-0668
OpenAlex
W3190948864
Cited by
70
References
143
Citations by year
2026: 6 · 2025: 11 · 2024: 18 · 2023: 20 · 2022: 14 · 2021: 1
FWCI
2.15
Type
journal article
Language
en
Open access
Locations
  • Indoor Air (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Infection Control and Ventilation
  • Physical Sciences › Environmental Science › Global and Planetary Change › COVID-19 impact on air quality
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
Keywords
SARS-CoV-2, SARS-CoV-2 transmission, indoor aerosols, airborne transmission, respiratory droplets, particle size, ventilation, air filtration, surface deposition, masking, social distancing, inhalation exposure
MeSH terms
COVID-19, SARS-CoV-2, Aerosols, Air Microbiology, Humans, Ventilation, Air Pollution, Indoor

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