The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Vitamin E and immune response in the aged: molecular mechanisms and clinical implications
Open accessAbstract
Summary: Nutritional status has been indicated as a contributing factor to age‐related dysregulation of the immune response. Vitamin E, a lipid‐soluble antioxidant vitamin, is important for normal function of the immune cells. The elderly are at a greater risk for vitamin E intake that is lower than recommended levels. Vitamin E supplementation above currently recommended levels has been shown to improve immune functions in the aged including delayed‐type hypersensitivity skin response and antibody production in response to vaccination, which was shown to be mediated through increased production of interleukin (IL)‐2, leading to enhanced proliferation of T cells, and through reduced production of prostaglandin E 2, a T‐cell suppressive factor, as a result of a decreased peroxynitrite formation. Vitamin E increased both cell‐dividing and IL‐producing capacities of naïve T cells, but not memory T cells. The vitamin E‐induced enhancement of immune functions in the aged was associated with significant improvement in resistance to influenza infection in aged mice and a reduced risk of acquiring upper respiratory infections in nursing home residents. Further studies are needed to determine the signaling mechanisms involved in the upregulation of naïve T‐cell function by vitamin E as well as the specific mechanisms involved in reduction of risk for upper respiratory infections.
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Cites
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“Decreased production of and responsiveness to IL-2 as a result of aging have been demonstrated (66).”
Backgroundγ-Tocopherol, the major form of vitamin E in the US diet, deserves more attention
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Cited by
Contribution of Selected Vitamins and Trace Elements to Immune Function
Wintergerst, E. S., Maggini, S., & Hornig, D. H. (2007) · Annals of Nutrition and Metabolism · doi:10.1159/000107673 · Cited by 692
The Role of Vitamin E in Immunity
Lee, G. Y., & Han, S. N. (2018) · Nutrients · doi:10.3390/nu10111614 · Cited by 582
Self-citationNutritional considerations for healthy aging and reduction in age-related chronic disease
Shlisky, J., Bloom, D. E., Beaudreault, A. R., Tucker, K. L., Keller, H. H., Freund-Levi, Y., Fielding, R. A., Cheng, F. W., Jensen, G. L., Wu, D., et al. (2017) · Advances in Nutrition · doi:10.3945/an.116.013474 · Cited by 462
Self-citationNutrition, immunity and COVID-19
Calder, P. C. (2020) · BMJ Nutrition, Prevention & Health · doi:10.1136/bmjnph-2020-000085 · Cited by 426
Calder, P. C. (2013) · Proceedings of The Nutrition Society · doi:10.1017/s0029665113001286 · Cited by 283
Vitamin E ingestion improves several immune functions in elderly men and women
De la Fuente, M., Hernanz, A., Guayerbas, N., Manuel Victor, V., & Arnalich, F. (2008) · Free Radical Research · doi:10.1080/10715760801898838 · Cited by 124
Nutrition, diet and immunosenescence
Maijó, M., Clements, S. J., Ivory, K., Nicoletti, C., & Carding, S. R. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.12.003 · Cited by 85
A combination of high-dose vitamin C plus zinc for the common cold
Maggini, S., Beveridge, S., & Suter, M. (2012) · Journal of International Medical Research · doi:10.1177/147323001204000104 · Cited by 70
Vitamin C and vitamin C plus E improve the immune function in the elderly
De la Fuente, M., Sánchez, C., Vallejo, C., Díaz-Del Cerro, E., Arnalich, F., & Hernanz, Á. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111118 · Cited by 68
Prentice, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01641 · Cited by 52
Metadata
- Authors
- Meydani, S. N., Han, S. N., & Wu, D.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2005-05-09
- Volume
- 205
- Issue
- 1
- Pages
- 269-284
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W1993849713
- Cited by
- 235
- References
- 7
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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