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Cited by 423

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Emerging endocrine disrupters: perfluoroalkylated substances

Open access
Jensen, Allan Astrup, Leffers, Henrik·2008·International Journal of Andrology
DOI 10.1111/j.1365-2605.2008.00870.x
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Abstract

Summary: In recent years, polyfluorinated chemicals (PFCs) have increasingly been used as surfactants in various industry‐ and consumer products, because of their unique properties as repellents of dirt, water and oils. The most well‐known PFCs are perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA) and their derivatives belonging to the group of perfluoroalkylated substances. The PFCs are very persistent in the environment, and some of them have been discovered as global pollutants of air, water, soil and wildlife and even found in remote polar areas. Bioaccumulation occurs also in humans, and everybody in our society has traces of these PFCs in their blood and internal organs such as the liver, kidneys, spleen, gall bladder and testes. In the blood, PFOS and PFOA are bound to serum proteins. The acute toxicity of the polyfluorinated substances is moderate but some substances can induce peroxisome proliferation in rat livers and may change the fluidity of cell membranes. Some of these PFCs, such as PFOS and PFOA, are potential developmental toxicants and are suspected endocrine disruptors with effects on sex hormone levels resulting in lower testosterone levels and higher oestradiol level. Other PFCs have oestrogenic effects in cell cultures. The industrial production of PFOS and its derivatives stopped in 2000, and the European Union has banned most uses from the summer of 2008. However, hundreds of related chemicals: homologues with shorter or longer alkyl chain, PFOA and telomers, which potentially may degrade to perfluoroalkanoic (carboxylic) acids, are not regulated.

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Citations

Cites

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Cited by

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Metadata

Authors
Jensen, A. A., & Leffers, H.
Venue
International Journal of Andrology
Publisher
Wiley
Published
2008-03-03
Volume
31
Issue
2
Pages
161-169
ISSN
  • 0105-6263 (ISSN-L)
  • 1365-2605
DOI
10.1111/j.1365-2605.2008.00870.x
OpenAlex
W1997592674
Cited by
423
References
10
FWCI
19.88
Type
journal article
Language
en
Open access
bronze
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.