Individual differences in discount rate are associated with demand for self‐administered cocaine, but not sucrose

Koffarnus, Mikhail N.; Woods, James H.

doi:10.1111/j.1369-1600.2011.00361.x

Cited by 63Neurotransmitter Receptor Influence on BehaviorDecision-Making and Behavioral EconomicsNeural and Behavioral Psychology Studies

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Individual differences in discount rate are associated with demand for self‐administered cocaine, but not sucrose

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Koffarnus, Mikhail N., Woods, James H.·2013·Addiction Biology

DOI 10.1111/j.1369-1600.2011.00361.xPMC PMC3209486

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Abstract

Substance abusers, including cocaine abusers, discount delayed rewards to a greater extent than do matched controls. In the current experiment, individual differences in discounting of delayed rewards in rats (choice of one immediate over three delayed sucrose pellets) were assessed for associations with demand for either sucrose pellets or an intravenous dose of 0.1 mg/kg/infusion cocaine. Twenty‐four male Sprague Dawley rats were split into three groups based on sensitivity to delay to reinforcement. Then, demand for sucrose pellets and cocaine was determined across a range of fixed‐ratio values. Delay discounting was then reassessed to determine the stability of this measure over the course of the experiment. Individual differences in impulsive choice were positively associated with elasticity of demand for cocaine, a measure of reinforcer value, indicating that rats having higher discount rates also valued cocaine more. Impulsive choice was not associated with the level of cocaine consumption as price approached 0 or with any parameter associated with demand for sucrose. Individual sensitivity to delay was correlated with the initial assessment when reassessed at the end of the experiment, although impulsive choice increased for this cohort of rats as a whole. These findings suggest that impulsive choice in rats is positively associated with valuation of cocaine, but not sucrose.

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Some evidence suggests impulsive choice predicts more robust cocaine-seeking when price increases are encountered.
“more robust cocaine-seeking when price increases are encountered”
From Changing Delay Discounting and Impulsive Choice: Implications for Addictions, Prevention, and Human Health (2019) · cites this paper as Koffarnus & Woods, 2013

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Authors: Koffarnus, M. N., & Woods, J. H.
Affiliations: Johns Hopkins University (US)
University of Michigan (US)
Corresponding author: Koffarnus, Mikhail N.
ORCID: Koffarnus, Mikhail N.
Venue: Addiction Biology
Publisher: Wiley
Published: 2011-08-04
Volume: 18
Issue: 1
Pages: 8-18
ISSN: 1355-6215 (ISSN-L)
1369-1600
DOI: 10.1111/j.1369-1600.2011.00361.x
PMC: PMC3209486
OpenAlex: W1898180549
Cited by: 63
References: 44
Citations by year: 2026: 2 · 2025: 2 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 6 · 2019: 7 · 2018: 4 · 2017: 4 · 2016: 7 · 2015: 5 · 2014: 11 · 2013: 5 · 2012: 2
FWCI: 2.36
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Addiction Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Deep Blue (University of Michigan) (submittedVersion)
Funders: National Institutes of Health
U.S. Public Health Service (R01 DA020669, DA020669, T32 DA007267)
National Institute on Drug Abuse (DA007267, R01DA015449, T32DA007267, R01DA020669)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: delay discounting, impulsive choice, individual differences, reinforcer value, price elasticity, self-administration, rats, substance use
MeSH terms: Animals, Cocaine, Conditioning, Operant, Impulsive Behavior, Individuality, Male, Reinforcement, Psychology, Statistics as Topic, Sucrose, Time Factors, Rats, Sprague-Dawley, Dopamine Uptake Inhibitors, Cocaine-Related Disorders, Rats, Drug-Seeking Behavior, Economics, Behavioral

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Individual differences in discount rate are associated with demand for self‐administered cocaine, but not sucrose

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