The DOI matches its Crossref record; 73 of the 74 references it cites were found in a registry or an index.
White matter fractional anisotrophy differences and correlates of diagnostic symptoms in autism
Open accessAbstract
Background: Individuals with autism have impairments in 3 domains: communication, social interaction and repetitive behaviours. Our previous work suggested early structural and connectivity abnormalities in prefrontal‐striato‐temporal‐cerebellar networks but it is not clear how these are linked to diagnostic indices. Method: Children with autism (IQ > 70) aged 6 to 14 years old and matched typically developing controls were studied using diffusion tensor imaging. Voxel‐based methods were used to compare fractional anisotrophy (FA) measures in each group and to correlate FA measures in the autism group with the diagnostic phenotype described by the Autism Diagnostic Interview – Revised (ADI‐R) algorithm for ICD‐10. Results: After controlling for the effects of age and white matter volume, we found that FA in the autism group was significantly lower than controls in bilateral prefrontal and temporal regions, especially in the right ventral temporal lobe adjacent to the fusiform gyrus. FA was greater in autism in the right inferior frontal gyrus and left occipital lobe. We observed a tight correlation between lower FA and higher ADI‐R diagnostic algorithm scores across white matter tracts extending from these focal regions of group difference. Communication and social reciprocity impairments correlated with lower FA throughout fronto‐striato‐temporal pathways. Repetitive behaviours correlated with white matter indices in more posterior brain pathways, including splenium of the corpus callosum and cerebellum. Conclusions: Our data support the position that diagnostic symptoms of autism are associated with a core disruption of white matter development.
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“In children aged 6–14 years, cerebellar white matter abnormalities were associated with repetitive behaviors [270];”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [270]
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Metadata
- Authors
- Cheung, C., Chua, S. E., Cheung, V., Khong, P. L., Tai, K. S., Wong, T. K. W., Ho, T. P., & McAlonan, G. M.
- Affiliations
- University of Hong Kong (HK)
- Hospital Authority (HK)
- Corresponding author
- Cheung, C.
- Cheung, V.
- Venue
- Journal of Child Psychology and Psychiatry
- Publisher
- Wiley
- Published
- 2009-08-24
- Volume
- 50
- Issue
- 9
- Pages
- 1102-1112
- ISSN
- 0021-9630 (ISSN-L)
- 1469-7610
- OpenAlex
- W2141186539
- Cited by
- 178
- References
- 74
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 9 · 2023: 5 · 2022: 11 · 2021: 3 · 2020: 8 · 2019: 9 · 2018: 5 · 2017: 9 · 2016: 10 · 2015: 14 · 2014: 15 · 2013: 15 · 2012: 26
- FWCI
- 9.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Child Psychology and Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- University of Hong Kong
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, fractional anisotropy, white matter development, diffusion tensor imaging, fusiform gyrus, inferior frontal gyrus, occipital lobe, communication disorders, social reciprocity, repetitive behavior, ADI-R, corpus callosum, cerebellum, children
- MeSH terms
- Adolescent, Autistic Disorder, Basal Ganglia, Brain, Child, Corpus Callosum, Female, Frontal Lobe, Humans, Male, Parietal Lobe, Stereotyped Behavior, Temporal Lobe, Anisotropy, Diffusion Magnetic Resonance Imaging
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