The Cerebral Metabolic Landscape in Autism: Intercorrelations of Regional Glucose Utilization
Abstract
Correlations between regional cerebral metabolic rates for glucose (rCMRglc), determined by positron emission tomography using 18F-2-deoxy-2-fluoro-D-glucose, provide a measure of the functional associations between brain regions. We compared correlations between ratios of resting rCMRglc to global brain metabolism from 14 healthy autistic men (ages, 18 to 39 years) with those from 14 matched control subjects. The autistic group showed significantly fewer large positive correlations between frontal and parietal regions, particularly those with the left inferior frontal region and its right hemispheric homologue, and significantly lower correlations of the thalamus, caudate nucleus, lenticular nucleus, and insula with frontal and parietal regions, with many correlations negative in the autistic group that were positive in the control group. These results are compatible with functionally impaired interactions between frontal/parietal regions and the neostriatum and thalamus, regions that subserve directed attention.
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Neuroimaging studies provide evidence that caudate and frontal-striatal circuitries are dysfunctional areas in ASD.
“Neuroimaging studies provide evidence that caudate and frontal-striatal circuitries are dysfunctional areas in ASD28–30.”
From Shank3 mutant mice display autistic-like behaviours and striatal dysfunction (2011) · cites this paper as [29]
The findings are concordant with studies using other imaging methods and support the aberrant connectivity hypothesis in autism.
“Findings were concordant with studies applying other imaging methods, supporting the aberrant connectivity hypothesis in autism (15-18).”
From A Meta-Analysis of the Corpus Callosum in Autism (2009) · cites this paper as [16]
Neuroimaging studies of the thalamus have found atypical functional and anatomical connectivity, decreased thalamic volume, lower levels of metabolites, and reduced neuronal integrity in ASD.
“Neuroimaging studies of the thalamus have found atypical functional and anatomical connectivity (Horwitz et al., 1988, Nair et al., 2013), decreased thalamic volume (Tsatsanis et al., 2003, Tamura et al., 2010), lower levels of N-acetylasparate, phosphocreatine, creatin, and choline-containing metabolites (Hardan et al., 2008, Haznedar et al., 2006), and reduced neuronal integrity (Friedman et al.”
From The impact of atypical sensory processing on social impairments in autism spectrum disorder (2018) · cites this paper as Horwitz et al., 1988
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- Authors
- Horwitz, B.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Horwitz, Barry
- ORCID
- Horwitz, Barry
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 1988-07-01
- Volume
- 45
- Issue
- 7
- Pages
- 749
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W1993621007
- Cited by
- 331
- References
- 43
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 8 · 2021: 6 · 2020: 8 · 2019: 7 · 2018: 5 · 2017: 7 · 2016: 12 · 2015: 8 · 2014: 13 · 2013: 14 · 2012: 12
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, regional cerebral glucose metabolism, brain functional connectivity, inferior frontal cortex, thalamus, caudate nucleus, insula, lentiform nucleus, directed attention, 18F-FDG PET
- MeSH terms
- Adolescent, Adult, Autistic Disorder, Basal Ganglia, Brain, Deoxyglucose, Glucose, Humans, Male, Statistics as Topic, Thalamus, Tissue Distribution, Tomography, Emission-Computed, Fluorodeoxyglucose F18
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