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Voltage‐gated and resting membrane currents recorded from B‐cells in intact mouse pancreatic islets
Open accessAbstract
1. The perforated patch whole-cell configuration of the patch-clamp technique was applied to superficial cells in intact pancreatic islets. Immunostaining in combination with confocal microscopy revealed that the superficial cells consisted of 35 % insulin-secreting B-cells and 65 % non-B-cells (A- and D-cells). 2. Two types of cell, with distinct electrophysiological properties, could be functionally identified. One of these generated oscillatory electrical activity when the islet was exposed to 10 mM glucose and had the electrophysiological characteristics of isolated B-cells maintained in tissue culture. 3. The Ca2+ current recorded from B-cells in situ was 80 % larger than that of isolated B-cells. It exhibited significant (70 %) inactivation during 100 ms depolarisations. The inactivation was voltage dependent and particularly prominent during depolarisations evoking the largest Ca2+ currents. 4. Voltage-dependent K+ currents were observed during depolarisations to membrane potentials above -20 mV. These currents inactivated little during a 200 ms depolarisation and were unaffected by varying the holding potential between -90 and -30 mV. 5. The maximum resting conductance in the absence of glucose, which reflects the conductance of ATP-regulated K+ (KATP) channels, amounted to approximately 4 nS. Glucose produced a concentration-dependent reduction of KATP channel conductance with half-maximal inhibition observed with 5 mM glucose. 6. Combining voltage- and current-clamp…
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“The reported (244) current-voltage relationship of the glucose-activated CFTR current in metabolically intact mouse β-cells corresponds to a whole-cell conductance of 20 nS. This is 5-fold larger than the resting conductance recorded from metabolically intact β-cells in the absence of glucose (221), and 10-fold larger than the peak voltage-gated Ca2+ current (see legend to Figure 9) (221). With CF”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [221]
In the citing paper
“Steady-state inactivation is half-maximal at -40 mV, ≈60 mV more positive than the corresponding value in mouse β-cells (221, 514) (Figure 10).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [221]
In the citing paper
“The mouse (and rat) β-cell Na+ channel is highly unusual in the voltage dependence of its inactivation. In most β-cells, it inactivates at such negative membrane potentials that little or no Na+ current remains within the physiological range of membrane potentials (221, 514, 761) (Figure 10).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [221]
In the citing paper
“The membrane conductance of β-cells in intact islets (measured in perforated patch recordings at 20 mM glucose as outlined in Figure 11A) is ~1 nS (221), 10-fold higher than that observed in dispersed single β-cells (631).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [221]
In the citing paper
“The background inward current must depolarize the membrane to ~-50 mV, which is the threshold for electrical activity and the membrane potential at which voltage-gated Ca2+ channels start to open (221) (Figure 9).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [221]
In the citing paper
“A β-cell with a diameter of 15 µm will therefore have a capacitance of ~7 pF, close to that measured experimentally (221).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [221]
Citations
Cites
Electrophysiology of the pancreatic β-cell
Ashcroft, F. M., & Rorsman, P. (1989) · Progress in Biophysics and Molecular Biology · doi:10.1016/0079-6107(89)90013-8 · Cited by 1,122
Self-citationLow access resistance perforated patch recordings using amphotericin B
Rae, J. L., Cooper, K. E., Gates, P., & Watsky, M. A. (1991) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(91)90017-t · Cited by 917
Glucose‐induced electrical activity in pancreatic islet cells
Dean, P. M., & Matthews, E. K. (1970) · The Journal of Physiology · doi:10.1113/jphysiol.1970.sp009207 · Cited by 365
Rorsman, P., & Trube, G. (1986) · The Journal of Physiology · doi:10.1113/jphysiol.1986.sp016096 · Cited by 362
Self-citationHenquin, J. C., & Meissner, H. P. (1984) · Experientia · doi:10.1007/bf01971450 · Cited by 324
Electrical Activity in Pancreatic Islet Cells
Dean, P. M., & Matthews, E. K. (1968) · Nature · doi:10.1038/219389a0 · Cited by 307
Membrane potential of beta-cells in pancreatic islets
Meissner, H. P., & Schmelz, H. (1974) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00586918 · Cited by 298
Emergence of organized bursting in clusters of pancreatic beta-cells by channel sharing
Sherman, A., Rinzel, J., & Keizer, J. (1988) · Biophysical Journal · doi:10.1016/s0006-3495(88)82975-8 · Cited by 294
Ammälä, C., Eliasson, L., Bokvist, K., Larsson, O., Ashcroft, F. M., & Rorsman, P. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019966 · Cited by 270
Self-citationNadal, Á., Quesada, I., & Soria, B. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0085z.x · Cited by 196
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Hellman, B., Salehi, A. A., Grapengiesser, E., & Gylfe, E. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.12.113 · Cited by 54
Castiello, F. R., Heileman, K., & Tabrizian, M. (2015) · Lab on a Chip · doi:10.1039/c5lc01046b · Cited by 61
Roy, S., Ghosh, A., Majie, A., Karmakar, V., Das, S., Dinda, S. C., Bose, A., & Gorain, B. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155638 · Cited by 58
Salehi, A. A., Qader, S. S., Grapengiesser, E., & Hellman, B. (2007) · Regulatory Peptides · doi:10.1016/j.regpep.2007.06.003 · Cited by 51
Dickerson, M. T., Dadi, P. K., Zaborska, K. E., Nakhe, A. Y., Schaub, C. M., Dobson, J. R., Wright, N. M., Lynch, J. C., Scott, C. F., Robinson, L. D., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34166-z · Cited by 47
Dadi, P. K., Vierra, N. C., & Jacobson, D. A. (2014) · Endocrinology · doi:10.1210/en.2013-2051 · Cited by 49
Fridlyand, L. E., & Philipson, L. H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152869 · Cited by 48
Minimized cell usage for stem cell-derived and primary cells on an automated patch clamp system
Becker, N., Stoelzle, S., Göpel, S., Guinot, D., Mumm, P., Haarmann, C., Malan, D., Bohlen, H., Kossolov, E., Kettenhofen, R. F., et al. (2013) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2013.03.009 · Cited by 49
Self-citationRolland, J., Henquin, J., & Gilon, P. (2002) · Diabetes · doi:10.2337/diabetes.51.2.376 · Cited by 49
Rozzo, A., Meneghel‐Rozzo, T., Delakorda, S. L., Yang, S., & Rupnik, M. S. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2008.04003.x · Cited by 48
Proks, P., de Wet, H., & Ashcroft, F. M. (2013) · Diabetes · doi:10.2337/db13-0531 · Cited by 45
High-resolution analysis of the cytosolic Ca 2+ events in β cell collectives in situ
Postić, S., Sarikas, S., Pfabe, J. U., Pohorec, V., Bombek, L. K., Sluga, N., Klemen, M. S., Dolenšek, J., Korošak, D., Stožer, A., et al. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00165.2022 · Cited by 55
Godwin, L. A., Pilkerton, M. E., Deal, K. S., Wanders, D., Judd, R. L., & Easley, C. J. (2011) · Analytical Chemistry · doi:10.1021/ac201598b · Cited by 49
Impaired glucagon secretory responses in mice lacking the type 1 sulfonylurea receptor
Shiota, C., Rocheleau, J. V., Shiota, M., Piston, D. W., & Magnuson, M. A. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00102.2005 · Cited by 44
Interactions of connexins with other membrane channels and transporters
Chanson, M., Kotsias, B. A., Peracchia, C., & O’Grady, S. M. (2007) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2007.03.002 · Cited by 43
Membrane Ion Channels and Diabetes
Proks, P., & Lippiat, J. D. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206775474431 · Cited by 41
Tarasov, A. I., Welters, H. J., Senkel, S., Ryffel, G. U., Hattersley, A. T., Morgan, N. G., & Ashcroft, F. M. (2006) · Diabetes · doi:10.2337/db06-0637 · Cited by 43
Olofsson, C. S., Håkansson, J., Salehi, A. A., Bengtsson, M., Galvanovskis, J., Partridge, C., Sörhede‐Winzell, M., Xian, X., Eliasson, L., Lundquist, I., et al. (2009) · Endocrinology · doi:10.1210/en.2008-0475 · Cited by 42
Self-citationHow Noise and Coupling Induce Bursting Action Potentials in Pancreatic β-Cells
Jo, J., Kang, H., Choi, M. Y., & Koh, D. (2005) · Biophysical Journal · doi:10.1529/biophysj.104.053181 · Cited by 41
Metadata
- Authors
- Göpel, S., Kanno, T., Barg, S., Galvanovskis, J., & Rorsman, P.
- Affiliations
- Lund University (SE)
- ORCID
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 1999-12
- Volume
- 521
- Issue
- 3
- Pages
- 717-728
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- PMC
- PMC2269694
- OpenAlex
- W2017509811
- Cited by
- 226
- References
- 32
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 7 · 2021: 10 · 2020: 7 · 2019: 7 · 2018: 4 · 2017: 10 · 2016: 8 · 2015: 9 · 2014: 8 · 2013: 12 · 2012: 12
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
- Keywords
- pancreatic islets, B cells, voltage-gated calcium currents, voltage-dependent potassium current, ATP-sensitive potassium channels, electrical coupling, glucose stimulation, insulin secretion
- MeSH terms
- Algorithms, Animals, Cell Communication, Electrophysiology, Glucose, Islets of Langerhans, Membrane Potentials, Tetrodotoxin, Calcium Channels, Potassium Channels, Sodium Channels, Ion Channel Gating, Gap Junctions, Patch-Clamp Techniques, ATP-Binding Cassette Transporters, Microscopy, Confocal, Potassium Channels, Inwardly Rectifying, Mice, KATP Channels
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