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Cited by 1,399

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Muscle damage from eccentric exercise: mechanism, mechanical signs, adaptation and clinical applications

Open access
Proske, U., Morgan, D. L.·2001·The Journal of Physiology
DOI 10.1111/j.1469-7793.2001.00333.x
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Abstract

In eccentric exercise the contracting muscle is forcibly lengthened; in concentric exercise it shortens. While concentric contractions initiate movements, eccentric contractions slow or stop them. A unique feature of eccentric exercise is that untrained subjects become stiff and sore the day afterwards because of damage to muscle fibres. This review considers two possible initial events as responsible for the subsequent damage, damage to the excitation‐contraction coupling system and disruption at the level of the sarcomeres. Other changes seen after eccentric exercise, a fall in active tension, shift in optimum length for active tension, and rise in passive tension, are seen, on balance, to favour sarcomere disruption as the starting point for the damage. As well as damage to muscle fibres there is evidence of disturbance of muscle sense organs and of proprioception. A second period of exercise, a week after the first, produces much less damage. This is the result of an adaptation process. One proposed mechanism for the adaptation is an increase in sarcomere number in muscle fibres. This leads to a secondary shift in the muscle's optimum length for active tension. The ability of muscle to rapidly adapt following the damage from eccentric exercise raises the possibility of clinical applications of mild eccentric exercise, such as for protecting a muscle against more major injuries.

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Research works printed but not linked: 72

  1. 10.1046/j.1365-201x.2001.00833.x · DOI
  2. Allen T. A., 1999, PhD Thesis
  3. 10.2165/00007256-199213020-00006 · DOI
  4. 10.1152/jappl.1983.54.1.80 · DOI · Paper page
  5. 10.2165/00007256-199112030-00004 · DOI · Paper page
  6. 10.1113/jphysiol.1995.sp020943 · DOI
  7. 10.1111/j.1469-7793.1997.649bj.x · DOI
  8. 10.1016/S0304-3959(00)00287-6 · DOI
  9. 10.1016/S0006-8993(97)00808-1 · DOI
  10. 10.1097/00005768-200105000-00017 · DOI · Paper page
  11. Brockett C.L., 2001, Damage in different types of motor units following repeated active, lengthenings of the medial gastrocnemius muscle of the cat., Journal of Applied Physiology
  12. 10.1007/BF01774036 · DOI
  13. 10.1097/00005768-199804000-00010 · DOI
  14. 10.1152/jappl.1988.65.1.1 · DOI · Paper page
  15. 10.1101/SQB.1973.037.01.061 · DOI
  16. 10.1007/s004410051108 · DOI
  17. Friden J., 1983, Adaptive response in human skeletal muscle subjected to prolonged eccentric training, International Journal of Sports Medicine, 4, 177, 10.1055/s-2008-1026031 · DOI
  18. 10.1007/BF01986165 · DOI · Paper page
  19. Gandevia S. C., 1996, Handbook of Physiology, 128
  20. Gandevia S. C.(2001).Spinal and supraspinal factors in human muscle fatigue.Physiological Reviews(in the Press). · DOI
  21. 10.1249/00005768-199008000-00003 · DOI · Paper page
  22. 10.1111/j.1741-2358.1998.00035.x · DOI
  23. Gregory J. E., 2001, Effect of eccentric muscle contractions on Golgi tendon organ responses to passive and active tension in the cat, Journal of Physiology
  24. 10.1098/rspb.1992.0058 · DOI
  25. 10.1042/bj0070471 · DOI · Paper page
  26. 10.1007/BF02346660 · DOI
  27. 10.1152/ajplegacy.1902.7.1.76 · DOI
  28. 10.1152/jappl.1985.58.5.1713 · DOI
  29. 10.1007/s004210050208 · DOI
  30. 10.1016/0304-3959(87)91079-7 · DOI
  31. 10.1113/jphysiol.1989.sp017624 · DOI
  32. 10.1113/jphysiol.1939.sp003756 · DOI · Paper page
  33. Koh T. J., 2001, Lengthening contractions are not required to induce protection from contraction‐induced muscle injury, American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 281, 155, 10.1152/ajpregu.2001.281.1.R155 · DOI
  34. 10.1016/S0021-9290(98)00032-3 · DOI
  35. 10.2165/00007256-199723060-00005 · DOI · Paper page
  36. 10.1016/S1440-2440(99)80177-7 · DOI
  37. 10.1152/jappl.1991.70.6.2498 · DOI · Paper page
  38. 10.1152/jappl.1994.77.3.1439 · DOI · Paper page
  39. 10.1152/jappl.1998.85.1.98 · DOI
  40. 10.2165/00007256-199927030-00002 · DOI · Paper page
  41. 10.2165/00007256-199520010-00003 · DOI · Paper page
  42. 10.1113/jphysiol.1997.sp022038 · DOI
  43. 10.1152/ajpcell.1996.271.5.C1438 · DOI
  44. 10.1152/jappl.1992.72.2.656 · DOI
  45. 10.1007/BF00121296 · DOI · Paper page
  46. 10.1016/S0006-3495(90)82524-8 · DOI · Paper page
  47. 10.1113/expphysiol.1994.sp003811 · DOI
  48. 10.1152/jappl.1999.87.6.2007 · DOI · Paper page
  49. 10.1113/jphysiol.1996.sp021798 · DOI
  50. 10.1111/j.1469-7793.2000.t01-2-00503.x · DOI
  51. 10.1042/cs0640055 · DOI · Paper page
  52. 10.1113/expphysiol.1992.sp003618 · DOI
  53. 10.1002/aja.1001820405 · DOI
  54. 10.1016/S0301-0082(99)00022-2 · DOI
  55. 10.1016/0021-9290(89)90181-4 · DOI · Paper page
  56. 10.1177/036354659602400202 · DOI
  57. 10.1249/00005768-199508000-00013 · DOI
  58. Schwane J. A., 1983, Effect of training on skeletal muscle injury from downhill running in rats, Journal of Applied Physiology, 55, 969, 10.1152/jappl.1983.55.3.969 · DOI
  59. 10.1249/00005768-199105000-00006 · DOI · Paper page
  60. 10.1111/j.1469-7793.2001.0571a.x · DOI
  61. Talbot J., 1997, PhD thesis
  62. 10.1007/BF00124247 · DOI
  63. 10.1023/A:1005325032106 · DOI
  64. 10.1152/jappl.2001.90.3.770 · DOI
  65. 10.1097/00003677-200104000-00008 · DOI · Paper page
  66. 10.1113/jphysiol.1993.sp019783 · DOI · Paper page
  67. 10.1054/jpai.2001.22496 · DOI
  68. 10.1111/j.1469-7793.2001.0593a.x · DOI
  69. 10.1111/j.1469-7793.1998.615be.x · DOI
  70. Williams P. E., 1973, The effect of immobilization on the longitudinal growth of striated muscle fibres, Journal of Anatomy, 116, 45
  71. 10.1152/ajpcell.1993.265.3.C792 · DOI
  72. 10.1111/j.1469-7793.2001.00155.x · DOI

Cited by

Metadata

Authors
Proske, U., & Morgan, D. L.
Venue
The Journal of Physiology
Publisher
Wiley
Published
2001-12
Volume
537
Issue
2
Pages
333-345
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1111/j.1469-7793.2001.00333.x
OpenAlex
W2000661220
Cited by
1,399
References
4
FWCI
24.27
Type
journal article
Language
en
Open access
green
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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