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Cited by 463

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Effects of Testosterone Replacement Therapy in Old Hypogonadal Males: A Preliminary Study

Morley, John E., Perry, H. Michael, Kaiser, Fran E., Kraenzle, Dale, Jensen, Judy, Houston, Kathy, Mattammal, Michael, Perry, H. Mitchell·1993·Journal of the American Geriatrics Society
DOI 10.1111/j.1532-5415.1993.tb02049.x
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Abstract

Objective: To examine the effects of testosterone administration to older hypogonadal males (bioavailable testosterone less than 70 ng/dL). Design: Alternate‐case controlled trial. Setting: St. Louis University. Patients: Eight males (mean age 77.6 ± 2.3 years) who received testosterone and six males (mean age 76 ± 2.3 years) who served as controls. Selected from alumni of the SHEP trial and attendees at the St. Louis University Impotence Clinic. Interventions: Testosterone enanthate (200 mg/mL) was administered intramuscularly to the treatment group every 2 weeks for 3 months. Measurements: Serum testosterone, bioavailable testerone and estradiol, weight, % body fat, right hand muscle strength, balance, cholesterol, HDL‐cholesterol, hematocrit, BUN, creatinine, albumin, calcium, PTH, 25(OH) vitamin D, 1,25 (OH) 2 vitamin D, osteocalcin, prostate‐specific antigen, and fructosamine. Results: Males who received testosterone had a significant increase in testosterone and bioavailable testosterone concentration, hematocrit, right hand muscle strength and osteocalcin concentration. They had a decrease in cholesterol (without a change in HDL‐cholesterol) levels and decreased BUN/Creatinine ratios. Conclusion: These preliminary findings support the need for long term studies of testosterone therapy in older hypogonadal males.

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Metadata

Authors
Morley, J. E., Perry, H. M., Kaiser, F. E., Kraenzle, D., Jensen, J., Houston, K., Mattammal, M., & Perry, H. M.
Venue
Journal of the American Geriatrics Society
Publisher
Wiley
Published
1993-02
Volume
41
Issue
2
Pages
149-152
ISSN
  • 0002-8614 (ISSN-L)
  • 1532-5415
DOI
10.1111/j.1532-5415.1993.tb02049.x
OpenAlex
W1989458934
Cited by
463
References
3
FWCI
9.20
Type
journal article
Language
en
Open access
closed

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