Optimization of Transcutaneous Vagus Nerve Stimulation Using Functional MRI

The nerve supply of the human auricle

Peuker, E. T., & Filler, T. J. (2002) · Clinical Anatomy · doi:10.1002/ca.1089 · Cited by 779

Non-invasive Access to the Vagus Nerve Central Projections via Electrical Stimulation of the External Ear: fMRI Evidence in Humans

Frangos, E., Ellrich, J., & Komisaruk, B. R. (2015) · Brain Stimulation · doi:10.1016/j.brs.2014.11.018 · Cited by 751

Vagal nerve stimulation: a review of its applications and potential mechanisms that mediate its clinical effects

Groves, D. A., & Brown, V. J. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.01.004 · Cited by 675

Reversing pathological neural activity using targeted plasticity

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Locus Coeruleus Lesions Suppress the Seizure‐Attenuating Effects of Vagus Nerve Stimulation

Krahl, S. E., Clark, K. B., Smith, D. C., & Browning, R. A. (1998) · Epilepsia · doi:10.1111/j.1528-1157.1998.tb01155.x · Cited by 555

VNS therapy in treatment-resistant depression: clinical evidence and putative neurobiological mechanisms

Nemeroff, C. B., Mayberg, H. S., Krahl, S. E., McNamara, J., Frazer, A., Henry, T. R., George, M. S., Charney, D. S., & Brannan, S. K. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301082 · Cited by 496

Neuromodulators control the polarity of spike-timing-dependent synaptic plasticity

Seol, G. H., Ziburkus, J., Huang, S., Song, L., Kim, I. T., Takamiya, K., Huganir, R. L., Lee, H.-K., & Kirkwood, A. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.013 · Cited by 429

Effect of vagus nerve stimulation on serotonergic and noradrenergic transmission

Dorr, A. E., & Debonnel, G. (2006) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.104166 · Cited by 420

BOLD fMRI deactivation of limbic and temporal brain structures and mood enhancing effect by transcutaneous vagus nerve stimulation

Kraus, T., Hösl, K., Kiess, O., Schanze, A., Kornhuber, J., & Forster, C. (2007) · Journal of Neural Transmission · doi:10.1007/s00702-007-0755-z · Cited by 408

Brain Blood Flow Alterations Induced by Therapeutic Vagus Nerve Stimulation in Partial Epilepsy: I. Acute Effects at High and Low Levels of Stimulation

Henry, T. R., Bakay, R. A. E., Votaw, J. R., Pennell, P. B., Epstein, C. M., Faber, T. L., Grafton, S. T., & Hoffman, J. M. (1998) · Epilepsia · doi:10.1111/j.1528-1157.1998.tb01448.x · Cited by 366

Vagus Nerve Stimulation

Schachter, S. C., & Saper, C. B. (1998) · Epilepsia · doi:10.1111/j.1528-1157.1998.tb01151.x · Cited by 348

Duvernoy’s Atlas of the Human Brain Stem and Cerebellum

Naidich, T. P., Duvernoy, H. M., Delman, B. N., Sorensen, A. G., Kollias, S. S., & Haacke, E. M. (2009) · Springer eBooks · doi:10.1007/978-3-211-73971-6 · Cited by 311

Somatic (craniocervical) tinnitus and the dorsal cochlear nucleus hypothesis

Levine, R. A. (1999) · American Journal of Otolaryngology · doi:10.1016/s0196-0709(99)90074-1 · Cited by 310

Vagus nerve stimulation: from epilepsy to the cholinergic anti‐inflammatory pathway

Bonaz, B., Picq, C., Sinniger, V., Mayol, J. F., & Clarençon, D. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12076 · Cited by 309

In vivo mapping of the human locus coeruleus

Keren, N. I., Lozar, C. T., Harris, K. C., Morgan, P. S., & Eckert, M. A. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.06.012 · Cited by 308

CNS BOLD fMRI Effects of Sham-Controlled Transcutaneous Electrical Nerve Stimulation in the Left Outer Auditory Canal – A Pilot Study

Kraus, T., Kiess, O., Hösl, K., Terekhin, P., Kornhuber, J., & Forster, C. (2013) · Brain Stimulation · doi:10.1016/j.brs.2013.01.011 · Cited by 301

Brain parenchyma motion: measurement with cine echo-planar MR imaging.

Poncelet, B. P., Wedeen, V. J., Weisskoff, R. M., & Cohen, M. S. (1992) · Radiology · doi:10.1148/radiology.185.3.1438740 · Cited by 285

A review of functional neuroimaging studies of vagus nerve stimulation (VNS)

Chae, J.-H., Nahas, Z., Lomarev, M., Denslow, S., Lorberbaum, J. P., Bohning, D. E., & George, M. S. (2003) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(03)00074-8 · Cited by 255

A novel transcutaneous vagus nerve stimulation leads to brainstem and cerebral activations measured by functional MRI / Funktionelle Magnetresonanztomographie zeigt Aktivierungen des Hirnstamms und weiterer zerebraler Strukturen unter transkutaner Vagusnervstimulation

Dietrich, S., Smith, J., Scherzinger, C., Hofmann-Preiß, K., Freitag, T., Eisenkolb, A., & Ringler, R. (2008) · Biomedizinische Technik/Biomedical Engineering · doi:10.1515/bmt.2008.022 · Cited by 252

A pilot study of vagus nerve stimulation (VNS) for treatment-resistant anxiety disorders

George, M. S., Ward, H. E., Ninan, P. T., Pollack, M., Nahas, Z., Anderson, B., Kose, S., Howland, R. H., Goodman, W. K., & Ballenger, J. C. (2008) · Brain Stimulation · doi:10.1016/j.brs.2008.02.001 · Cited by 251

Targeting Plasticity with Vagus Nerve Stimulation to Treat Neurological Disease

Hays, S. A., Rennaker, R. L., & Kilgard, M. P. (2013) · Progress in Brain Research · doi:10.1016/b978-0-444-63327-9.00010-2 · Cited by 224

Efferent projections of the nucleus of the solitary tract to peri-locus coeruleus dendrites in rat brain: Evidence for a monosynaptic pathway

Van Bockstaele, E. J., Peoples, J., & Telegan, P. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990927)412:3<410::aid-cne3>3.0.co;2-f · Cited by 221

Mossy fiber projections from the cuneate nucleus to the cochlear nucleus in the rat

Wright, D. D., & Ryugo, D. K. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960129)365:1<159::aid-cne12>3.0.co;2-l · Cited by 207

Somatosensory effects on neurons in dorsal cochlear nucleus

Young, E. D., Nelken, I., & Conley, R. A. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.73.2.743 · Cited by 205

Repeatedly Pairing Vagus Nerve Stimulation with a Movement Reorganizes Primary Motor Cortex

Porter, B. A., Khodaparast, N., Fayyaz, T., Cheung, R. J., Ahmed, S. S., Vrana, W. A., Rennaker, R. L., & Kilgard, M. P. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr316 · Cited by 195

Vagus nerve stimulation for epilepsy: A review of central mechanisms

Krahl, S., & Clark, K. (2012) · Surgical Neurology International · doi:10.4103/2152-7806.103015 · Cited by 185

Recordings from the rat locus coeruleus during acute vagal nerve stimulation in the anaesthetised rat

Groves, D. A., Bowman, E. M., & Brown, V. J. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2004.12.055 · Cited by 181

Vagus nerve stimulation (VNS) synchronized BOLD fMRI suggests that VNS in depressed adults has frequency/dose dependent effects

Lomarev, M., Denslow, S., Nahas, Z., Chae, J.-H., George, M. S., & Bohning, D. E. (2002) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(02)00013-4 · Cited by 175

Vagus nerve stimulation enhances extinction of conditioned fear and modulates plasticity in the pathway from the ventromedial prefrontal cortex to the amygdala

Peña, D. F., Childs, J. E., Willett, S., Vital, A., McIntyre, C. K., & Kroener, S. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00327 · Cited by 165

Somatosensory influence on the cochlear nucleus and beyond

Shore, S. E., & Zhou, J. (2006) · Hearing Research · doi:10.1016/j.heares.2006.01.006 · Cited by 161

Serial Vagus Nerve Stimulation Functional MRI in Treatment-Resistant Depression

Nahas, Z. H., Tenebäck, C. C., Chae, J., Mu, Q., Molnar, C., Kozel, F. A., Walker, J., Anderson, B. S., Koola, J., Köse, S., et al. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301288 · Cited by 160

Cerebral Activation during Vagus Nerve Stimulation: A Functional MR Study

Narayanan, J. T., Watts, R., Haddad, N., Labar, D. R., Li, P. M., & Filippi, C. G. (2002) · Epilepsia · doi:10.1046/j.1528-1157.2002.16102.x · Cited by 159

Brain Blood‐flow Alterations Induced by Therapeutic Vagus Nerve Stimulation in Partial Epilepsy: II. Prolonged Effects at High and Low Levels of Stimulation

Henry, T. R., Bakay, R. A. E., Pennell, P. B., Epstein, C. M., & Votaw, J. R. (2004) · Epilepsia · doi:10.1111/j.0013-9580.2004.03104.x · Cited by 148

Vagus Nerve Stimulation for Epilepsy and Depression

Milby, A. H., Halpern, C. H., & Baltuch, G. H. (2008) · Neurotherapeutics · doi:10.1016/j.nurt.2007.10.071 · Cited by 141

The role of locus coeruleus in the antiepileptic activity induced by vagus nerve stimulation

Fornai, F., Ruffoli, R., Giorgi, F. S., & Paparelli, A. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07707.x · Cited by 136

Feasibility of Vagus Nerve Stimulation–Synchronized Blood Oxygenation Level–Dependent Functional MRI

Bohning, D. E., Lomarev, M. P., Denslow, S., Nahas, Z. H., Shastri, A., & George, M. S. (2001) · Investigative Radiology · doi:10.1097/00004424-200108000-00006 · Cited by 134

Cross-Modal Interactions of Auditory and Somatic Inputs in the Brainstem and Midbrain and Their Imbalance in Tinnitus and Deafness

Dehmel, S., Cui, Y., & Shore, S. E. (2008) · American Journal of Audiology · doi:10.1044/1059-0889(2008/07-0045 · Cited by 130

Transcutaneous Vagus Nerve Stimulation

Ellrich, J. (2011) · European Neurological Review · doi:10.17925/enr.2011.06.04.254 · Cited by 121

Transcutaneous vagus nerve stimulation in tinnitus: a pilot study

Lehtimäki, J., Hyvärinen, P., Ylikoski, M. E., Bergholm, M., Mäkelä, J. P., Aarnisalo, A. A., Pirvola, U., Mäkitie, A. A., & Ylikoski, J. S. (2012) · Acta Oto-Laryngologica · doi:10.3109/00016489.2012.750736 · Cited by 120

Changes in regional cerebral blood flow by therapeutic vagus nerve stimulation in depression: an exploratory approach

Zobel, A., Joe, A., Freymann, N., Clusmann, H., Schramm, J., Reinhardt, M., Biersack, H.-J., Maier, W., & Broich, K. (2005) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2005.02.010 · Cited by 117

Cranial Electrotherapy Stimulation for Treatment of Anxiety, Depression, and Insomnia

Kirsch, D. L., & Nichols, F. H. (2013) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2013.01.006 · Cited by 116

Evidence for a tinnitus subgroup responsive to somatosensory based treatment modalities

Levine, R. A., Nam, E., Oron, Y., & Melcher, J. R. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)66017-8 · Cited by 111

Plasticity of somatosensory inputs to the cochlear nucleus – Implications for tinnitus

Shore, S. E. (2011) · Hearing Research · doi:10.1016/j.heares.2011.05.001 · Cited by 111

Effects of cranial electrotherapy stimulation on resting state brain activity

Feusner, J. D., Madsen, S. K., Moody, T. D., Bohon, C., Hembacher, E., Bookheimer, S. Y., & Bystritsky, A. (2012) · Brain and Behavior · doi:10.1002/brb3.45 · Cited by 92

Vagus nerve stimulation in refractory epilepsy: SPECT activation study.

Laere, K. V., Vonck, K. E. J., Boon, P., Brans, B. T., Vandekerckhove, T., & Dierckx, R. A. J. O. (2000) · PubMed · Cited by 75

Duvernoy's Atlas of the Human Brain Stem and Cerebellum

(2009) · American Journal of Neuroradiology · doi:10.3174/ajnr.a1550 · Cited by 73

Cranial Electrotherapy Stimulation Review: A Safer Alternative to Psychopharmaceuticals in the Treatment of Depression

Gilula, M. F., & Kirsch, D. L. (2005) · Journal of Neurotherapy · doi:10.1300/j184v09n02_02 · Cited by 71

Vagus nerve stimulation

Lulic, D., Ahmadian, A. A., Baaj, A. A., Benbadis, S. R., & Vale, F. Ĺ. (2009) · Neurosurgical FOCUS · doi:10.3171/2009.6.focus09126 · Cited by 71

Vagus nerve stimulation: A new approach to reduce heart failure.

Klein, H., & Ferrari, G. M. D. (2010) · PubMed · Cited by 68

fMRI in patients implanted with a vagal nerve stimulator

Sucholeiki, R., Alsaadi, T. M., Morris, G. L., Ulmer, J. L., Biswal, B. B., & Mueller, W. M. (2002) · Seizure · doi:10.1053/seiz.2001.0601 · Cited by 64

Effect of Electrical Stimulation of the Nucleus of the Solitary Tract on the Development of Electrical Amygdaloid Kindling in the Cat

Magdaleno-Madrigal, V. M., Valdés‐Cruz, A., Martínez-Vargas, D., Martínez, A., Almazán‐Alvarado, S., Fernández‐Mas, R., & Fernández‐Guardiola, A. (2002) · Epilepsia · doi:10.1046/j.1528-1157.2002.05702.x · Cited by 63

Investigation into the mechanisms of vagus nerve stimulation for the treatment of intractable epilepsy, using 99mTc-HMPAO SPET brain images

Barnes, A., Duncan, R., Chisholm, J. A., Lindsay, K. W., Patterson, J. C., & Wyper, D. J. (2003) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-002-1026-8 · Cited by 61

Origin, course and distribution of the nerves to the posterosuperior wall of the external acoustic meatus

Kiyokawa, J., Yamaguchi, K., Okada, R., Maehara, T., & Akita, K. (2014) · Anatomical Science International · doi:10.1007/s12565-014-0231-4 · Cited by 53

Somatosensory context alters auditory responses in the cochlear nucleus

Kanold, P. O., Davis, K. A., & Young, E. D. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00807.2010 · Cited by 44

Neurophysiologic effects of transcutaneous auricular vagus nerve stimulation (taVNS) via electrical stimulation of the tragus: A concurrent taVNS/fMRI study and review

Badran, B. W., Dowdle, L. T., Mithoefer, O. J., LaBate, N. T., Coatsworth, J., Brown, J. C., DeVries, W. H., Austelle, C. W., McTeague, L. M., & George, M. S. (2018) · Brain Stimulation · doi:10.1016/j.brs.2017.12.009 · Cited by 396

International Consensus Based Review and Recommendations for Minimum Reporting Standards in Research on Transcutaneous Vagus Nerve Stimulation (Version 2020)

Farmer, A. D., Strzelczyk, A., Finisguerra, A., Gourine, A. V., Gharabaghi, A., Hasan, A., Burger, A. M., Jaramillo, A. M., Mertens, A., Majid, A., et al. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.568051 · Cited by 355

Vagal nerve stimulation for treatment-resistant depression

Carreno, F. R., & Frazer, A. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0537-8 · Cited by 208

Neural networks and the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation in depression

Liu, C.-H., Yang, M.-H., Zhang, G.-Z., Wang, X.-X., Li, B., Li, M., Woelfer, M., Walter, M., & Wang, L. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01732-5 · Cited by 210

Non-invasive stimulation of vagal afferents reduces gastric frequency

Teckentrup, V., Neubert, S., Santiago, J. C. P., Hallschmid, M., Walter, M., & Kroemer, N. B. (2020) · Brain Stimulation · doi:10.1016/j.brs.2019.12.018 · Cited by 64