The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
The oral microbiome and nitric oxide homoeostasis
Open accessAbstract
The tiny radical nitric oxide (NO) participates in a vast number of physiological functions including vasodilation, nerve transmission, host defence and cellular energetics. Classically produced by a family of specific enzymes, NO synthases (NOS s), NO signals via reactions with other radicals or transition metals. An alternative pathway for the generation of NO is the nitrate–nitrite–NO pathway in which the inorganic anions nitrate () and nitrite () are reduced to NO and other reactive nitrogen intermediates. Nitrate and nitrite are oxidation products from NOS‐dependent NO generation but also constituents in our diet, mainly in leafy green vegetables. Irrespective of origin, active uptake of circulating nitrate in the salivary glands, excretion in saliva and subsequent reduction to nitrite by oral commensal bacteria are all necessary steps for further NO generation. This central role of the oral cavity in regulating NO generation from nitrate presents a new and intriguing aspect of the human microbiome in health and disease. In this review, we present recent advances in our understanding of the nitrate–nitrite–NO pathway and specifically highlight the importance of the oral cavity as a hub for its function.
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In the citing paper
“Since humans lack efficient endogenous nitrate reductases, this step is crucial for the nitrate-nitrite-NO pathway [29].”
From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [29]
In the citing paper
“Disruption to the oral microbiome by antibacterial mouthwashes, such as chlorhexidine, significantly impairs nitrate reduction and decreases nitrite bioavailability, thereby attenuating the blood-pressure-lowering effects of dietary nitrate [29,31,33].”
From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [29]
In the citing paper
“Although there is no formal protocol for dietary nitrate intake”
From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [29]
In the citing paper
“These include avoiding antibacterial mouthwashes around the time of consumption, ensuring adequate salivary flow and consuming nitrate-rich beetroot products 1–2 h prior to the desired physiological effect.”
From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [29]
In the citing paper
“dietary nitrate can theoretically enhance the vasodilatory effects of pharmacological NO donors by providing additional nitrite-derived NO [29,31,33,108].”
From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [29]
In the citing paper
“there are several practical guidelines that can enhance nitrate reduction and NO bioavailability [29,31,33,108].”
From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [29]
In the citing paper
“the majority of nitrate and nitrite are absorbed in the proximal small intestine[233,270].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [270]
In the citing paper
“it is unlikely they significantly contribute to the enterosalivary circulation given that the majority of nitrate and nitrite are absorbed in the proximal small intestine[233,270].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [270]
Citations
Cites
Furchgott, R. F., & Zawadzki, J. V. (1980) · Nature · doi:10.1038/288373a0 · Cited by 12,064
The L-Arginine-Nitric Oxide Pathway
Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678
A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure
Appel, L. J., Moore, T. J., Obarzanek, E., Vollmer, W. M., Svetkey, L. P., Sacks, F. M., Bray, G. A., Vogt, T. M., Cutler, J. A., Windhauser, M. M., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704173361601 · Cited by 5,981
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074
Nitric oxide synthases: regulation and function
Forstermann, U., & Sessa, W. C. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr304 · Cited by 4,409
The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739
Self-citationCloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase
Bredt, D. S., Hwang, P. M., Glatt, C. E., Lowenstein, C. J., Reed, R. R., & Snyder, S. H. (1991) · Nature · doi:10.1038/351714a0 · Cited by 2,354
Oral Sildenafil in the Treatment of Erectile Dysfunction
Goldstein, I., Lue, T. F., Padma-Nathan, H., Rosen, R. C., Steers, W. D., & Wicker, P. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199805143382001 · Cited by 2,120
Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages
Xie, Q. W., Cho, H. J., Calaycay, J. R., Mumford, R. A., Swiderek, K. M., Lee, T. D., Ding, A. H., Troso, T., & Nathan, C. (1992) · Science · doi:10.1126/science.1373522 · Cited by 1,888
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
Cosby, K., Partovi, K. S., Crawford, J. H., Patel, R. P., Reiter, C. D., Martyr, S., Yang, B. K., Waclawiw, M. A., Zalos, G., Xu, X., et al. (2003) · Nature Medicine · doi:10.1038/nm954 · Cited by 1,807
Antimicrobial reactive oxygen and nitrogen species: concepts and controversies
Fang, F. C. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro1004 · Cited by 1,676
Fruit and vegetable intake and risk of major chronic disease
Hung, H.-C., Joshipura, K. J., Jiang, R., Hu, F. B., Hunter, D., Smith-Warner, S. A., Colditz, G. A., Rosner, B., Spiegelman, D., & Willett, W. C. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh296 · Cited by 1,327
Nitric Oxide Synthases: Properties and Catalytic Mechanism
Griffith, O. W., & Stuehr, D. J. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.003423 · Cited by 1,311
Stamler (2001) · doi:10.1016/s0092-8674(01)00495-0 · Cited by 1,261
Cleeter, M. W. J., Cooper, J. M., Darley-Usmar, V. M., Moncada, S., & Schapira, A. H. V. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00424-2 · Cited by 1,241
Webb, A. J., Patel, N., Loukogeorgakis, S., Okorie, M., Aboud, Z., Misra, S., Rashid, R., Miall, P., Deanfield, J., Benjamin, N., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.103523 · Cited by 1,078
Bailey, S. J., Winyard, P., Vanhatalo, A., Blackwell, J. R., DiMenna, F. J., Wilkerson, D. P., Tarr, J., Benjamin, N., & Jones, A. M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00722.2009 · Cited by 759
Nitrate, bacteria and human health
Lundberg, J. O., Weitzberg, E., Cole, J. A., & Benjamin, N. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro929 · Cited by 739
Self-citationDuncan, C., Dougall, H., Johnston, P., Green, S., Brogan, R., Leifert, C., Smith, L., Golden, M., & Benjamin, N. (1995) · Nature Medicine · doi:10.1038/nm0695-546 · Cited by 734
Carter, P., Gray, L. J., Troughton, J., Khunti, K., & Davies, M. J. (2010) · BMJ · doi:10.1136/bmj.c4229 · Cited by 728
Xia, Y., Dawson, V. L., Dawson, T. M., Snyder, S. H., & Zweier, J. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6770 · Cited by 717
Dietary Inorganic Nitrate Improves Mitochondrial Efficiency in Humans
Larsen, F. J., Schiffer, T. A., Borniquel, S., Sahlin, K., Ekblom, B., Lundberg, J. O., & Weitzberg, E. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.004 · Cited by 689
Self-citationCytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver
Duranski, M. R., Greer, J. J. M., Dejam, A., Jaganmohan, S., Hogg, N., Langston, W., Patel, R. P., Yet, S.-F., Wang, X., Kevil, C. G., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22493 · Cited by 674
Benjamin, N., O'Driscoll, F., Dougall, H., Duncan, C., Smith, L., Golden, M., & McKenzie, H. (1994) · Nature · doi:10.1038/368502a0 · Cited by 665
Intragastric nitric oxide production in humans: measurements in expelled air.
Lundberg, J. O., Weitzberg, E., Lundberg, J. M., & Alving, K. (1994) · Gut · doi:10.1136/gut.35.11.1543 · Cited by 661
Self-citationInorganic nitrate is a possible source for systemic generation of nitric oxide
Lundberg, J. O., & Govoni, M. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.04.027 · Cited by 657
Effects of dietary nitrate on oxygen cost during exercise
Larsen, F. J., Weitzberg, E., Lundberg, J. O., & Ekblom, B. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01713.x · Cited by 637
Self-citationInorganic Nitrate Supplementation Lowers Blood Pressure in Humans: Role for Nitrite-Derived NO
Kapil, V., Milsom, A. B., Okorie, M., Maleki-Toyserkani, S., Akram, F., Rehman, F., Arghandawi, S., Pearl, V., Benjamin, N., Loukogeorgakis, S., et al. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.153536 · Cited by 621
Periodontal disease and systemic conditions: a bidirectional relationship
Kim, J., & Amar, S. (2006) · Odontology · doi:10.1007/s10266-006-0060-6 · Cited by 619
The emerging biology of the nitrite anion
Gladwin, M. T., Schechter, A. N., Kim-Shapiro, D. B., Patel, R. P., Hogg, N., Shiva, S., Cannon, R. O., Kelm, M., Wink, D. A., Espey, M. G., et al. (2005) · Nature Chemical Biology · doi:10.1038/nchembio1105-308 · Cited by 609
Webb, A., Bond, R., McLean, P., Uppal, R., Benjamin, N., & Ahluwalia, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402927101 · Cited by 608
Govoni, M., Jansson, E. Å., Weitzberg, E., & Lundberg, J. O. (2008) · Nitric Oxide · doi:10.1016/j.niox.2008.08.003 · Cited by 602
Self-citationShiva, S., Huang, Z., Grubina, R., Sun, J., Ringwood, L. A., MacArthur, P. H., Xu, X., Murphy, E., Darley-Usmar, V. M., & Gladwin, M. T. (2007) · Circulation Research · doi:10.1161/01.res.0000260171.52224.6b · Cited by 599
Spiegelhalder, B., Eisenbrand, G., & Preussmann, R. (1976) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(76)80005-3 · Cited by 596
Effects of Dietary Nitrate on Blood Pressure in Healthy Volunteers
Larsen, F. J., Ekblom, B., Sahlin, K., Lundberg, J. O., & Weitzberg, E. (2006) · New England Journal of Medicine · doi:10.1056/nejmc062800 · Cited by 587
Self-citationShiva, S., Sack, M. N., Greer, J. J., Duranski, M., Ringwood, L. A., Burwell, L., Wang, X., MacArthur, P. H., Shoja, A., Raghavachari, N., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070198 · Cited by 555
Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control
Huang, Z. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24650 · Cited by 520
Oral sildenafil in the treatment of erectile dysfunction
Goldstein, I., Lue, T. F., Padma-Nathan, H., Rosen, R. C., Steers, W. D., Wicker, P. A., & Sildenafil Study Group (2002) · The Journal of Urology · doi:10.1016/s0022-5347(02)80386-x · Cited by 499
Millar, T. M., Stevens, C. R., Benjamin, N., Eisenthal, R., Harrison, R., & Blake, D. R. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00430-x · Cited by 491
Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase.
Sessa, W. C., Harrison, J. K., Barber, C. M., Zeng, D., Durieux, M. E., d’Angelo, D., Lynch, K. R., & Peach, M. J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49528-8 · Cited by 469
Nitrite as Regulator of Hypoxic Signaling in Mammalian Physiology
van Faassen, E. E., Bahrami, S., Feelisch, M., Hogg, N., Kelm, M., Kim‐Shapiro, D. B., Kozlov, A. V., Li, H., Lundberg, J. O., Mason, R., et al. (2009) · Medicinal Research Reviews · doi:10.1002/med.20151 · Cited by 435
Self-citationHendgen-Cotta, U. B., Merx, M. W., Shiva, S., Schmitz, J., Becher, S., Klare, J. P., Steinhoff, H.-J., Goedecke, A., Schrader, J., Gladwin, M. T., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801336105 · Cited by 418
Physiological role for nitrate-reducing oral bacteria in blood pressure control
Kapil, V., Haydar, S. M. A., Pearl, V., Lundberg, J. O., Weitzberg, E., & Ahluwalia, A. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.11.013 · Cited by 413
Self-citationLansley, K. E., Winyard, P. G., Fulford, J., Vanhatalo, A., Bailey, S. J., Blackwell, J. R., DiMenna, F. J., Gilchrist, M., Benjamin, N., & Jones, A. M. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01070.2010 · Cited by 404
Acute Dietary Nitrate Supplementation Improves Cycling Time Trial Performance
LANSLEY, K. E., WINYARD, P. G., BAILEY, S. J., VANHATALO, A., WILKERSON, D. P., BLACKWELL, J. R., GILCHRIST, M., BENJAMIN, N., & JONES, A. M. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31821597b4 · Cited by 388
The yin and yang of nitric oxide in cancer progression
Burke, A. J., Sullivan, F. J., Giles, F. J., & Glynn, S. A. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt034 · Cited by 383
Nitrate in vegetables - Scientific Opinion of the Panel on Contaminants in the Food chain
(EFSA), E. F. S. A. (2008) · EFSA Journal · doi:10.2903/j.efsa.2008.689 · Cited by 374
Human safety controversies surrounding nitrate and nitrite in the diet
Sindelar, J. J., & Milkowski, A. L. (2012) · Nitric Oxide · doi:10.1016/j.niox.2012.03.011 · Cited by 363
A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis
Jansson, E. Å., Huang, L., Malkey, R., Govoni, M., Nihlén, C., Olsson, A., Stensdotter, M., Petersson, J., Holm, L., Weitzberg, E., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.92 · Cited by 356
Self-citationEarly Inhaled Nitric Oxide Therapy in Premature Newborns with Respiratory Failure
Kinsella, J. P., Cutter, G., Walsh, W. F., Gerstmann, D. R., Bose, C. L., Hart, C., Sekar, K. C., Auten, R. L., Bhutani, V. K., Gerdes, J. S., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa060442 · Cited by 343
Kinetics and mechanism of the oxidation of human deoxyhemoglobin by nitrites.
Doyle, M. P., Pickering, R. A., DeWeert, T. M., Hoekstra, J. W., & Pater, D. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43285-1 · Cited by 334
Ferguson, S. K., Hirai, D. M., Copp, S. W., Holdsworth, C. T., Allen, J. D., Jones, A. M., Musch, T. I., & Poole, D. C. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.243121 · Cited by 333
Novel Aspects of Dietary Nitrate and Human Health
Weitzberg, E., & Lundberg, J. O. (2013) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161159 · Cited by 324
Self-citationDietary nitrate increases tetanic [Ca2+]i and contractile force in mouse fast‐twitch muscle
Hernández, A., Schiffer, T. A., Ivarsson, N., Cheng, A. J., Bruton, J. D., Lundberg, J. O., Weitzberg, E., & Westerblad, H. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.232777 · Cited by 319
Self-citationEarly Inhaled Nitric Oxide Therapy in Premature Newborns With Respiratory Failure
&NA; (2007) · Survey of Anesthesiology · doi:10.1097/01.sa.0000258189.33820.0e · Cited by 288
Human neuroglobin functions as a redox-regulated nitrite reductase
Tiso, M., Tejero, J., Basu, S., Azarov, I., Wang, X., Simplaceanu, V., Frizzell, S., Jayaraman, T., Geary, L., Shapiro, C., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.159541 · Cited by 287
The effect of dietary nitrate on salivary, plasma, and urinary nitrate metabolism in humans
Pannala, A. S., Mani, A. R., Spencer, J. P. E., Skinner, V., Bruckdorfer, K. R., Moore, K. P., & Rice-Evans, C. A. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01353-9 · Cited by 287
Fruit and vegetable intake and type 2 diabetes: EPIC-InterAct prospective study and meta-analysis
Cooper, A., Forouhi, N. G., Ye, Z., Buijsse, B., Arriola, L., Balkau, B., Barricarte, A., Beulens, J. W. J., Boeing, H., Büchner, F. L., et al. (2012) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2012.85 · Cited by 282
Characterization of the Magnitude and Kinetics of Xanthine Oxidase-catalyzed Nitrite Reduction
Li, H., Samouilov, A., Liu, X., & Zweier, J. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011648200 · Cited by 280
Nitric Oxide Production from Nitrite Occurs Primarily in Tissues Not in the Blood
Li, H., Cui, H., Kundu, T. K., Alzawahra, W., & Zweier, J. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801785200 · Cited by 269
Carlström, M., Persson, A. E. G., Larsson, E., Hezel, M., Scheffer, P. G., Teerlink, T., Weitzberg, E., & Lundberg, J. O. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvq366 · Cited by 261
Self-citationJung, K.-H., Chu, K., Ko, S.-Y., Lee, S.-T., Sinn, D.-I., Park, D.-K., Kim, J.-M., Song, E.-C., Kim, M., & Roh, J.-K. (2006) · Stroke · doi:10.1161/01.str.0000245116.40163.1c · Cited by 253
Nitrite in saliva increases gastric mucosal blood flow and mucus thickness
Björne, H., Petersson, J., Phillipson, M., Weitzberg, E., Holm, L., & Lundberg, J. O. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19019 · Cited by 246
Self-citationPetersson, J., Carlström, M., Schreiber, O., Phillipson, M., Christoffersson, G., Jägare, A., Roos, S., Jansson, E. Å., Persson, A. E. G., Lundberg, J. O., et al. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.01.011 · Cited by 235
Infantile methemoglobinemia: Reexamining the role of drinking water nitrates
Avery, A. A. (1999) · Environmental Health Perspectives · doi:10.1289/ehp.99107583 · Cited by 218
Ghosh, S. M., Kapil, V., Fuentes-Calvo, I., Bubb, K. J., Pearl, V., Milsom, A. B., Khambata, R., Maleki-Toyserkani, S., Yousuf, M., Benjamin, N., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00933 · Cited by 218
Sialin ( SLC17A5 ) functions as a nitrate transporter in the plasma membrane
Qin, L., Liu, X., Sun, Q., Fan, Z., Xia, D., Ding, G., Ong, H. L., Adams, D., Gahl, W. A., Zheng, C., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116633109 · Cited by 216
Aamand, R., Dalsgaard, T., Jensen, F. B., Simonsen, U., Roepstorff, A., & Fago, A. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00525.2009 · Cited by 213
Hypoxic Modulation of Exogenous Nitrite-Induced Vasodilation in Humans
Maher, A. R., Milsom, A. B., Gunaruwan, P., Abozguia, K., Ahmed, I., Weaver, R. A., Thomas, P., Ashrafian, H., Born, G. V. R., James, P. E., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.719591 · Cited by 210
Nitric oxide and quality and safety of muscle based foods
Skibsted, L. H. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.03.307 · Cited by 201
Biology of nitrogen oxides in the gastrointestinal tract
Lundberg, J. O., & Weitzberg, E. (2013) · Gut · doi:10.1136/gutjnl-2011-301649 · Cited by 200
Self-citationNitrate in vegetables Scientific Opinion of the Panel on Contaminants in the Food chain 1
Alexander, J., Benford, D., Cockburn, A., Cravedi, J., Eugenia Dogliotti, Y., Domenico, A. D., Fernández‐Cruz, M. L., Fink‐Gremmels, J., Fürst, P., Galli, C. L., et al. (2008) · Cited by 187
Chronic sodium nitrite therapy augments ischemia-induced angiogenesis and arteriogenesis
Kumar, D., Branch, B. G., Pattillo, C. B., Hood, J., Thoma, S., Simpson, S., Illum, S., Arora, N., Chidlow, J. H., Langston, W., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711480105 · Cited by 187
[13] Nitric oxide-cyclic GMP signal transduction system
Hobbs, A. J., & Ignarro, L. J. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)69016-8 · Cited by 181
Salivary contribution to exhaled nitric oxide
Zetterquist, W., Pedroletti, C., Lundberg, J. O., & Alving, K. (1999) · European Respiratory Journal · doi:10.1034/j.1399-3003.1999.13b18.x · Cited by 171
Hoon, M. W., Johnson, N. A., Chapman, P., & Burke, L. M. (2013) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.23.5.522 · Cited by 166
Dietary nitrate increases gastric mucosal blood flow and mucosal defense
Petersson, J., Phillipson, M., Jansson, E. Å., Patzak, A., Lundberg, J. O., & Holm, L. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00435.2006 · Cited by 161
Gastrointestinal bacteria generate nitric oxide from nitrate and nitrite
Sobko, T., Reinders, C. I., Jansson, E. Å., Norin, E., Midtvedt, T., & Lundberg, J. O. (2005) · Nitric Oxide · doi:10.1016/j.niox.2005.08.002 · Cited by 160
Nitric oxide synthase reduces nitrite to NO under anoxia
Vanin, A. F., Bevers, L. M., Slama-Schwok, A., & van Faassen, E. E. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6374-2 · Cited by 151
LIST, B. M., KLÖSCH, B., VÖLKER, C., GORREN, A. C. F., SESSA, W. C., WERNER, E. R., KUKOVETZ, W. R., SCHMIDT, K., & MAYER, B. (1997) · Biochemical Journal · doi:10.1042/bj3230159 · Cited by 147
Conjugated linoleic acid is a preferential substrate for fatty acid nitration
Bonacci, G., Baker, P. R. S., Salvatore, S. R., Shores, D., Khoo, N. K. H., Koenitzer, J. R., Vitturi, D. A., Woodcock, S. R., Golin-Bisello, F., Cole, M. P., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.401356 · Cited by 147
Nitrate-Nitrite-Nitric Oxide Pathway: Implications for Anesthesiology and Intensive Care
Weitzberg, E., Hezel, M., Lundberg, J. O., & Warner, D. S. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181fcf3cc · Cited by 145
Self-citationLi, H., Hemann, C., Abdelghany, T. M., El-Mahdy, M. A., & Zweier, J. L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.342378 · Cited by 132
Eisenbrand, G., Spiegelhalder, B., & Preußmann, R. (2009) · Oncology · doi:10.1159/000225441 · Cited by 127
Dietary nitrate supplementation improves revascularization in chronic ischemia
Hendgen-Cotta, U. B., Luedike, P., Totzeck, M., Kropp, M., Schicho, A., Stock, P., Rammos, C., Niessen, M., Heiss, C., Lundberg, J. O., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.112912 · Cited by 110
Self-citationCeccatelli, S., Lundberg, J. M., Zhang, X., Åman, K., & Hökfelt, T. G. M. (1994) · Brain Research · doi:10.1016/0006-8993(94)91483-4 · Cited by 109
Jansson, E. Å., Petersson, J., Reinders, C., Sobko, T., Björne, H., Phillipson, M., Weitzberg, E., Holm, L., & Lundberg, J. O. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.11.018 · Cited by 106
Self-citationNitrate-reducing bacteria on rat tongues
Li, H., Duncan, C., Townend, J., Killham, K., Smith, L. M., Johnston, P., Dykhuizen, R., Kelly, D., Golden, M., Benjamin, N., et al. (1997) · Applied and Environmental Microbiology · doi:10.1128/aem.63.3.924-930.1997 · Cited by 103
Denitrification in human dental plaque
Schreiber, F., Stief, P., Gieseke, A., Heisterkamp, I. M., Verstraete, W., de Beer, D., & Stoodley, P. (2010) · BMC Biology · doi:10.1186/1741-7007-8-24 · Cited by 90
Mitochondria as metabolizers and targets of nitrite
Shiva, S. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.09.002 · Cited by 87
Regulation of mitochondrial function and energetics by reactive nitrogen oxides
Larsen, F. J., Schiffer, T. A., Weitzberg, E., & Lundberg, J. O. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.08.580 · Cited by 87
Self-citationShapiro, K. B., Hotchkiss, J. H., & Roe, D. A. (1991) · Food and Chemical Toxicology · doi:10.1016/0278-6915(91)90183-8 · Cited by 86
Dietary inorganic nitrate mobilizes circulating angiogenic cells
Heiß, C., Meyer, C. G., Totzeck, M., Hendgen-Cotta, U. B., Heinen, Y., Luedike, P., Keymel, S., Ayoub, N., Lundberg, J. O., Weitzberg, E., et al. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.02.051 · Cited by 81
Self-citationNitrate and nitrite concentrations in human saliva: Variations with salivary flow-rate
Granli, T., Dahl, R., Brodin, P., & Bøckman, O. (1989) · Food and Chemical Toxicology · doi:10.1016/0278-6915(89)90122-1 · Cited by 78
Gastrointestinal nitric oxide generation in germ-free and conventional rats
Sobko, T., Reinders, C., Norin, E., Midtvedt, T., Gustafsson, L. E., & Lundberg, J. O. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00203.2004 · Cited by 75
Edwards, D. A., Fletcher, K. A., & Rowlands, E. N. (1954) · The Lancet · doi:10.1016/s0140-6736(54)91196-4 · Cited by 67
Björne, H., Weitzberg, E., & Lundberg, J. O. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.07.020 · Cited by 67
Self-citationNitric oxide and oral cancer: A review
Korde, S., Sridharan, G., Gadbail, A. R., & Poornima, V. (2012) · Oral Oncology · doi:10.1016/j.oraloncology.2012.01.003 · Cited by 67
Palmerini, C. A., Palombari, R., Perito, S., & Arienti, G. (2003) · Free Radical Research · doi:10.1080/1071576021000028398 · Cited by 56
Intragastric nitric oxide is abolished in intubated patients and restored by nitrite*
Björne, H., Govoni, M., Törnberg, D. C., Lundberg, J. O., & Weitzberg, E. (2005) · Critical Care Medicine · doi:10.1097/01.ccm.0000171204.59502.aa · Cited by 54
Self-citationNitric oxide signalling in salivary glands
Looms, D., Tritsaris, K., Pedersen, A. M. L., Nauntofte, B., & Dissing, S. (2002) · Journal of Oral Pathology and Medicine · doi:10.1034/j.1600-0714.2002.00047.x · Cited by 54
Modin, A., Weitzberg, E., Hökfelt, T. G. M., & Lundberg, J. M. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90324-7 · Cited by 46
Self-citationMirvish, S. S., Reimers, K. J., Kutler, B., Chen, S. C., Haorah, J., Morris, C. R., Grandjean, A. C., & Lyden, E. R. (2000) · European Journal of Cancer Prevention · doi:10.1097/00008469-200010000-00008 · Cited by 45
Excretion of nitrates and nitrites in saliva and bile in the dog
Fritsch, P., Blanquat, G. D. S., & Klein, D. (1985) · Food and Chemical Toxicology · doi:10.1016/0278-6915(85)90153-x · Cited by 37
Packer, P. J., Leach, S. A., Duncan, S. N., THOMPSON, M. H., & Hill, M. J. (1989) · Carcinogenesis · doi:10.1093/carcin/10.11.1989 · Cited by 35
The effect of water-borne nitrate on salivary nitrite
Walters, C. L., & Smith, P. (1981) · Food and Cosmetics Toxicology · doi:10.1016/0015-6264(81)90388-6 · Cited by 33
Nitrate causes a dose-dependent augmentation of nitric oxide status in healthy women
Bondonno, C. P., Croft, K. D., Puddey, I. B., Considine, M. J., Yang, X., Ward, N. C., & Hodgson, J. M. (2012) · Food & Function · doi:10.1039/c2fo10206d · Cited by 31
Nitric oxide synthase in human salivary glands
Soinila, J., Nuorva, K., & Soinila, S. O. (2005) · Histochemistry and Cell Biology · doi:10.1007/s00418-005-0123-8 · Cited by 25
Toda, N., Ayajiki, K., & Okamura, T. (2012) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e318252452a · Cited by 25
Modulation by neurogenic acetylcholine of nitroxidergic nerve function in porcine ciliary arteries.
Toda, M., Okamura, T., AZUMA, I., & Toda, N. (1997) · PubMed · Cited by 24
Expression of nitric oxide synthase in pleomorphic adenomas of the parotid
Brennan, P. A., Umar, T., Buckley, J., Zaki, G. A., Langdon, J., Spedding, A. V., & Peters, W. J. N. (2000) · British Journal of Oral and Maxillofacial Surgery · doi:10.1054/bjom.1999.0454 · Cited by 24
The formation of nitrite and N-nitroso compounds in salivas in vitro and in vivo
Hart, R. J., & Walters, C. L. (1983) · Food and Chemical Toxicology · doi:10.1016/0278-6915(83)90208-9 · Cited by 20
Sublethal damage repair capacity in carcinoma cell lines with p53 mutations
Pekkola‐Heino, K., Servomaa, K., Kiuru, A., & Grenman, R. A. (1998) · Head & Neck · doi:10.1002/(sici)1097-0347(199807)20:4 · Cited by 18
Effet d'une charge en nitrate sur le nitrite salivaire et gastrique chez l'homme
Klein, D., Gaconnet, N., Poullain, B., & Debry, G. (1978) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(78)80189-8 · Cited by 17
Detection of Nitric Oxide and Its Derivatives in Human Mixed Saliva and Acidified Saliva
Takahama, U., Hirota, S., & Oniki, T. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)00824-5 · Cited by 14
Methaemoglobinaemia Due to Nitrates and Nitrites in Drinking-water
Fawns, H. T., & Aldridge, A. G. V. (1954) · BMJ · doi:10.1136/bmj.2.4887.575 · Cited by 13
Adrenoceptor-activated Nitric Oxide Synthesis in Salivary Acinar Cells
Looms, D., Dissing, S., Tritsaris, K., Pedersen, A. M. L., & Nauntofte, B. (2000) · Advances in Dental Research · doi:10.1177/08959374000140011001 · Cited by 13
Nitrite and Nitrate: From Bench to Bedside
Kevil, C. G., & Lefer, D. J. (2012) · Nitric Oxide · doi:10.1016/j.niox.2012.04.165 · Cited by 9
Flagged first, then by citations
Research works printed but not linked: 2
- Speijers GJA, 2003, Nitrate (and potential endogenous formation of N‐nitroso compounds), WHO FAS, 50
- Wang J, 2011, Novel funcftion of sulphite oxidase as a nitrite reductase that generates nitric oxide
Cited by
Sorted by citations
Drinking Water Nitrate and Human Health: An Updated Review
Ward, M., Jones, R., Brender, J., De Kok, T., Weyer, P., Nolan, B., Villanueva, C., & Van Breda, S. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15071557 · Cited by 1,576
Resilience of the Oral Microbiota in Health: Mechanisms That Prevent Dysbiosis
Rosier, B. T., Marsh, P. D., & Mira, A. (2018) · Journal of Dental Research · doi:10.1177/0022034517742139 · Cited by 448
A practical guide to the oral microbiome and its relation to health and disease
Krishnan, K., Chen, T., & Paster, B. (2017) · Oral Diseases · doi:10.1111/odi.12509 · Cited by 347
“An intriguing suggestion has been that oral bacteria may play a role in nitric oxide (NO) homeostasis, which is important in renal and cardiovascular health (Hezel & Weitzberg, 2015).”
BackgroundOral Microbiome Geography: Micron-Scale Habitat and Niche
Welch, J. L. M., Ramírez-Puebla, S. T., & Borisy, G. G. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.07.009 · Cited by 267
Functional properties of beetroot (Beta vulgaris) in management of cardio-metabolic diseases
Mirmiran, P., Houshialsadat, Z., Gaeini, Z., Bahadoran, Z., & Azizi, F. (2020) · Nutrition & Metabolism · doi:10.1186/s12986-019-0421-0 · Cited by 215
Metadata
- Authors
- Hezel, M., & Weitzberg, E.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Weitzberg, E
- ORCID
- Weitzberg, E
- Venue
- Oral Diseases
- Publisher
- Wiley
- Published
- 2013-07-10
- Volume
- 21
- Issue
- 1
- Pages
- 7-16
- ISSN
- 1354-523X (ISSN-L)
- 1601-0825
- OpenAlex
- W2113616233
- Semantic Scholar
- 3b5c2b57f5b193c903aecf55ee5f4d077dc8f448
- Cited by
- 201
- References
- 118
- Citations by year
- 2026: 24 · 2025: 18 · 2024: 20 · 2023: 24 · 2022: 24 · 2021: 18 · 2020: 18 · 2019: 16 · 2018: 11 · 2017: 9 · 2016: 13 · 2015: 3 · 2014: 3
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Oral Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Swedish Research Council
- Torsten and Ragnar Söderbergs Foundation
- David and Astrid Hagelén Foundation
- Stockholm City Council (ALF) and Funds
- Karolinska Institutet
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- nitric oxide, nitrate-nitrite-NO pathway, oral microbiota, nitrate uptake, nitrite reduction, salivary glands, oral commensal bacteria, nitric oxide synthase, reactive nitrogen species, saliva
- MeSH terms
- Homeostasis, Humans, Mouth, Nitrates, Nitric Oxide, Nitrites, Signal Transduction, Microbiota
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