The oral microbiome and nitric oxide homoeostasis

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

Furchgott, R. F., & Zawadzki, J. V. (1980) · Nature · doi:10.1038/288373a0 · Cited by 12,064 · see citing works

The L-Arginine-Nitric Oxide Pathway

Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678 · see citing works

A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure

Appel, L. J., Moore, T. J., Obarzanek, E., Vollmer, W. M., Svetkey, L. P., Sacks, F. M., Bray, G. A., Vogt, T. M., Cutler, J. A., Windhauser, M. M., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704173361601 · Cited by 5,981 · see citing works

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074 · see citing works

Nitric oxide synthases: regulation and function

Forstermann, U., & Sessa, W. C. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr304 · Cited by 4,409 · see citing works

The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics

Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739 · see citing works

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

Bredt, D. S., Hwang, P. M., Glatt, C. E., Lowenstein, C. J., Reed, R. R., & Snyder, S. H. (1991) · Nature · doi:10.1038/351714a0 · Cited by 2,354 · see citing works

Oral Sildenafil in the Treatment of Erectile Dysfunction

Goldstein, I., Lue, T. F., Padma-Nathan, H., Rosen, R. C., Steers, W. D., & Wicker, P. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199805143382001 · Cited by 2,120 · see citing works

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

Xie, Q. W., Cho, H. J., Calaycay, J. R., Mumford, R. A., Swiderek, K. M., Lee, T. D., Ding, A. H., Troso, T., & Nathan, C. (1992) · Science · doi:10.1126/science.1373522 · Cited by 1,888 · see citing works

Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation

Cosby, K., Partovi, K. S., Crawford, J. H., Patel, R. P., Reiter, C. D., Martyr, S., Yang, B. K., Waclawiw, M. A., Zalos, G., Xu, X., et al. (2003) · Nature Medicine · doi:10.1038/nm954 · Cited by 1,807 · see citing works

Antimicrobial reactive oxygen and nitrogen species: concepts and controversies

Fang, F. C. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro1004 · Cited by 1,676 · see citing works

Fruit and vegetable intake and risk of major chronic disease

Hung, H.-C., Joshipura, K. J., Jiang, R., Hu, F. B., Hunter, D., Smith-Warner, S. A., Colditz, G. A., Rosner, B., Spiegelman, D., & Willett, W. C. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh296 · Cited by 1,327 · see citing works

Nitric Oxide Synthases: Properties and Catalytic Mechanism

Griffith, O. W., & Stuehr, D. J. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.003423 · Cited by 1,311 · see citing works

Untitled work

Stamler (2001) · doi:10.1016/s0092-8674(01)00495-0 · Cited by 1,261 · see citing works

Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide: Implications for neurodegenerative diseases

Cleeter, M. W. J., Cooper, J. M., Darley-Usmar, V. M., Moncada, S., & Schapira, A. H. V. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00424-2 · Cited by 1,241 · see citing works

Acute Blood Pressure Lowering, Vasoprotective, and Antiplatelet Properties of Dietary Nitrate via Bioconversion to Nitrite

Webb, A. J., Patel, N., Loukogeorgakis, S., Okorie, M., Aboud, Z., Misra, S., Rashid, R., Miall, P., Deanfield, J., Benjamin, N., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.103523 · Cited by 1,078 · see citing works

Dietary nitrate supplementation reduces the O ₂ cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans

Bailey, S. J., Winyard, P., Vanhatalo, A., Blackwell, J. R., DiMenna, F. J., Wilkerson, D. P., Tarr, J., Benjamin, N., & Jones, A. M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00722.2009 · Cited by 759 · see citing works

Nitrate, bacteria and human health

Lundberg, J. O., Weitzberg, E., Cole, J. A., & Benjamin, N. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro929 · Cited by 739 · see citing works

Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate

Duncan, C., Dougall, H., Johnston, P., Green, S., Brogan, R., Leifert, C., Smith, L., Golden, M., & Benjamin, N. (1995) · Nature Medicine · doi:10.1038/nm0695-546 · Cited by 734 · see citing works

Fruit and vegetable intake and incidence of type 2 diabetes mellitus: systematic review and meta-analysis

Carter, P., Gray, L. J., Troughton, J., Khunti, K., & Davies, M. J. (2010) · BMJ · doi:10.1136/bmj.c4229 · Cited by 728 · see citing works

Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury.

Xia, Y., Dawson, V. L., Dawson, T. M., Snyder, S. H., & Zweier, J. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6770 · Cited by 718 · see citing works

Dietary Inorganic Nitrate Improves Mitochondrial Efficiency in Humans

Larsen, F. J., Schiffer, T. A., Borniquel, S., Sahlin, K., Ekblom, B., Lundberg, J. O., & Weitzberg, E. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.004 · Cited by 689 · see citing works

Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver

Duranski, M. R., Greer, J. J. M., Dejam, A., Jaganmohan, S., Hogg, N., Langston, W., Patel, R. P., Yet, S.-F., Wang, X., Kevil, C. G., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22493 · Cited by 674 · see citing works

Stomach NO synthesis

Benjamin, N., O'Driscoll, F., Dougall, H., Duncan, C., Smith, L., Golden, M., & McKenzie, H. (1994) · Nature · doi:10.1038/368502a0 · Cited by 665 · see citing works

Intragastric nitric oxide production in humans: measurements in expelled air.

Lundberg, J. O., Weitzberg, E., Lundberg, J. M., & Alving, K. (1994) · Gut · doi:10.1136/gut.35.11.1543 · Cited by 661 · see citing works

Inorganic nitrate is a possible source for systemic generation of nitric oxide

Lundberg, J. O., & Govoni, M. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.04.027 · Cited by 657 · see citing works

Effects of dietary nitrate on oxygen cost during exercise

Larsen, F. J., Weitzberg, E., Lundberg, J. O., & Ekblom, B. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01713.x · Cited by 637 · see citing works

Inorganic Nitrate Supplementation Lowers Blood Pressure in Humans: Role for Nitrite-Derived NO

Kapil, V., Milsom, A. B., Okorie, M., Maleki-Toyserkani, S., Akram, F., Rehman, F., Arghandawi, S., Pearl, V., Benjamin, N., Loukogeorgakis, S., et al. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.153536 · Cited by 621 · see citing works

Periodontal disease and systemic conditions: a bidirectional relationship

Kim, J., & Amar, S. (2006) · Odontology · doi:10.1007/s10266-006-0060-6 · Cited by 619 · see citing works

The emerging biology of the nitrite anion

Gladwin, M. T., Schechter, A. N., Kim-Shapiro, D. B., Patel, R. P., Hogg, N., Shiva, S., Cannon, R. O., Kelm, M., Wink, D. A., Espey, M. G., et al. (2005) · Nature Chemical Biology · doi:10.1038/nchembio1105-308 · Cited by 609 · see citing works

Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia–reperfusion damage

Webb, A., Bond, R., McLean, P., Uppal, R., Benjamin, N., & Ahluwalia, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402927101 · Cited by 608 · see citing works

Deoxymyoglobin Is a Nitrite Reductase That Generates Nitric Oxide and Regulates Mitochondrial Respiration

Shiva, S., Huang, Z., Grubina, R., Sun, J., Ringwood, L. A., MacArthur, P. H., Xu, X., Murphy, E., Darley-Usmar, V. M., & Gladwin, M. T. (2007) · Circulation Research · doi:10.1161/01.res.0000260171.52224.6b · Cited by 599 · see citing works

Influence of dietary nitrate on nitrite content of human saliva: Possible relevance to in vivo formation of N-nitroso compounds

Spiegelhalder, B., Eisenbrand, G., & Preussmann, R. (1976) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(76)80005-3 · Cited by 596 · see citing works

Effects of Dietary Nitrate on Blood Pressure in Healthy Volunteers

Larsen, F. J., Ekblom, B., Sahlin, K., Lundberg, J. O., & Weitzberg, E. (2006) · New England Journal of Medicine · doi:10.1056/nejmc062800 · Cited by 587 · see citing works

The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash

Govoni, M., Jansson, E. Å., Weitzberg, E., & Lundberg, J. O. (2008) · Nitric Oxide · doi:10.1016/j.niox.2008.08.003 · Cited by 585 · see citing works

Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer

Shiva, S., Sack, M. N., Greer, J. J., Duranski, M., Ringwood, L. A., Burwell, L., Wang, X., MacArthur, P. H., Shoja, A., Raghavachari, N., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070198 · Cited by 555 · see citing works

Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control

Huang, Z. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24650 · Cited by 520 · see citing works

Oral sildenafil in the treatment of erectile dysfunction

Goldstein, I., Lue, T. F., Padma-Nathan, H., Rosen, R. C., Steers, W. D., Wicker, P. A., & Sildenafil Study Group (2002) · The Journal of Urology · doi:10.1016/s0022-5347(02)80386-x · Cited by 502 · see citing works

Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions

Millar, T. M., Stevens, C. R., Benjamin, N., Eisenthal, R., Harrison, R., & Blake, D. R. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00430-x · Cited by 491 · see citing works

Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase.

Sessa, W. C., Harrison, J. K., Barber, C. M., Zeng, D., Durieux, M. E., d’Angelo, D., Lynch, K. R., & Peach, M. J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49528-8 · Cited by 469 · see citing works

Nitrite as Regulator of Hypoxic Signaling in Mammalian Physiology

van Faassen, E. E., Bahrami, S., Feelisch, M., Hogg, N., Kelm, M., Kim‐Shapiro, D. B., Kozlov, A. V., Li, H., Lundberg, J. O., Mason, R., et al. (2009) · Medicinal Research Reviews · doi:10.1002/med.20151 · Cited by 435 · see citing works

Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury

Hendgen-Cotta, U. B., Merx, M. W., Shiva, S., Schmitz, J., Becher, S., Klare, J. P., Steinhoff, H.-J., Goedecke, A., Schrader, J., Gladwin, M. T., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801336105 · Cited by 418 · see citing works

Physiological role for nitrate-reducing oral bacteria in blood pressure control

Kapil, V., Haydar, S. M. A., Pearl, V., Lundberg, J. O., Weitzberg, E., & Ahluwalia, A. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.11.013 · Cited by 413 · see citing works

Dietary nitrate supplementation reduces the O₂cost of walking and running: a placebo-controlled study

Lansley, K. E., Winyard, P. G., Fulford, J., Vanhatalo, A., Bailey, S. J., Blackwell, J. R., DiMenna, F. J., Gilchrist, M., Benjamin, N., & Jones, A. M. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01070.2010 · Cited by 404 · see citing works

Acute Dietary Nitrate Supplementation Improves Cycling Time Trial Performance

LANSLEY, K. E., WINYARD, P. G., BAILEY, S. J., VANHATALO, A., WILKERSON, D. P., BLACKWELL, J. R., GILCHRIST, M., BENJAMIN, N., & JONES, A. M. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31821597b4 · Cited by 388 · see citing works

The yin and yang of nitric oxide in cancer progression

Burke, A. J., Sullivan, F. J., Giles, F. J., & Glynn, S. A. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt034 · Cited by 372 · see citing works

Nitrate in vegetables - Scientific Opinion of the Panel on Contaminants in the Food chain

(EFSA), E. F. S. A. (2008) · EFSA Journal · doi:10.2903/j.efsa.2008.689 · Cited by 365 · see citing works

Human safety controversies surrounding nitrate and nitrite in the diet

Sindelar, J. J., & Milkowski, A. L. (2012) · Nitric Oxide · doi:10.1016/j.niox.2012.03.011 · Cited by 363 · see citing works

A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis

Jansson, E. Å., Huang, L., Malkey, R., Govoni, M., Nihlén, C., Olsson, A., Stensdotter, M., Petersson, J., Holm, L., Weitzberg, E., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.92 · Cited by 356 · see citing works

Early Inhaled Nitric Oxide Therapy in Premature Newborns with Respiratory Failure

Kinsella, J. P., Cutter, G., Walsh, W. F., Gerstmann, D. R., Bose, C. L., Hart, C., Sekar, K. C., Auten, R. L., Bhutani, V. K., Gerdes, J. S., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa060442 · Cited by 340 · see citing works

Kinetics and mechanism of the oxidation of human deoxyhemoglobin by nitrites.

Doyle, M. P., Pickering, R. A., DeWeert, T. M., Hoekstra, J. W., & Pater, D. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43285-1 · Cited by 334 · see citing works

Impact of dietary nitrate supplementation via beetroot juice on exercising muscle vascular control in rats

Ferguson, S. K., Hirai, D. M., Copp, S. W., Holdsworth, C. T., Allen, J. D., Jones, A. M., Musch, T. I., & Poole, D. C. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.243121 · Cited by 333 · see citing works

Novel Aspects of Dietary Nitrate and Human Health

Weitzberg, E., & Lundberg, J. O. (2013) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161159 · Cited by 324 · see citing works

Dietary nitrate increases tetanic [Ca²⁺]_i and contractile force in mouse fast‐twitch muscle

Hernández, A., Schiffer, T. A., Ivarsson, N., Cheng, A. J., Bruton, J. D., Lundberg, J. O., Weitzberg, E., & Westerblad, H. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.232777 · Cited by 319 · see citing works

Early Inhaled Nitric Oxide Therapy in Premature Newborns With Respiratory Failure

&NA; (2007) · Survey of Anesthesiology · doi:10.1097/01.sa.0000258189.33820.0e · Cited by 288 · see citing works

Human neuroglobin functions as a redox-regulated nitrite reductase

Tiso, M., Tejero, J., Basu, S., Azarov, I., Wang, X., Simplaceanu, V., Frizzell, S., Jayaraman, T., Geary, L., Shapiro, C., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.159541 · Cited by 287 · see citing works

The effect of dietary nitrate on salivary, plasma, and urinary nitrate metabolism in humans

Pannala, A. S., Mani, A. R., Spencer, J. P. E., Skinner, V., Bruckdorfer, K. R., Moore, K. P., & Rice-Evans, C. A. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01353-9 · Cited by 287 · see citing works

Characterization of the Magnitude and Kinetics of Xanthine Oxidase-catalyzed Nitrite Reduction

Li, H., Samouilov, A., Liu, X., & Zweier, J. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011648200 · Cited by 280 · see citing works

Fruit and vegetable intake and type 2 diabetes: EPIC-InterAct prospective study and meta-analysis

Cooper, A., Forouhi, N. G., Ye, Z., Buijsse, B., Arriola, L., Balkau, B., Barricarte, A., Beulens, J. W. J., Boeing, H., Büchner, F. L., et al. (2012) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2012.85 · Cited by 275 · see citing works

Nitric Oxide Production from Nitrite Occurs Primarily in Tissues Not in the Blood

Li, H., Cui, H., Kundu, T. K., Alzawahra, W., & Zweier, J. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801785200 · Cited by 269 · see citing works

Dietary nitrate attenuates oxidative stress, prevents cardiac and renal injuries, and reduces blood pressure in salt-induced hypertension

Carlström, M., Persson, A. E. G., Larsson, E., Hezel, M., Scheffer, P. G., Teerlink, T., Weitzberg, E., & Lundberg, J. O. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvq366 · Cited by 261 · see citing works

Early Intravenous Infusion of Sodium Nitrite Protects Brain Against In Vivo Ischemia-Reperfusion Injury

Jung, K.-H., Chu, K., Ko, S.-Y., Lee, S.-T., Sinn, D.-I., Park, D.-K., Kim, J.-M., Song, E.-C., Kim, M., & Roh, J.-K. (2006) · Stroke · doi:10.1161/01.str.0000245116.40163.1c · Cited by 253 · see citing works

Nitrite in saliva increases gastric mucosal blood flow and mucus thickness

Björne, H., Petersson, J., Phillipson, M., Weitzberg, E., Holm, L., & Lundberg, J. O. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19019 · Cited by 246 · see citing works

Gastroprotective and blood pressure lowering effects of dietary nitrate are abolished by an antiseptic mouthwash

Petersson, J., Carlström, M., Schreiber, O., Phillipson, M., Christoffersson, G., Jägare, A., Roos, S., Jansson, E. Å., Persson, A. E. G., Lundberg, J. O., et al. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.01.011 · Cited by 235 · see citing works

Infantile methemoglobinemia: Reexamining the role of drinking water nitrates

Avery, A. A. (1999) · Environmental Health Perspectives · doi:10.1289/ehp.99107583 · Cited by 218 · see citing works

Enhanced Vasodilator Activity of Nitrite in Hypertension: Critical Role for Erythrocytic Xanthine Oxidoreductase and Translational Potential

Ghosh, S. M., Kapil, V., Fuentes-Calvo, I., Bubb, K. J., Pearl, V., Milsom, A. B., Khambata, R., Maleki-Toyserkani, S., Yousuf, M., Benjamin, N., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00933 · Cited by 218 · see citing works

Sialin ( <i>SLC17A5</i> ) functions as a nitrate transporter in the plasma membrane

Qin, L., Liu, X., Sun, Q., Fan, Z., Xia, D., Ding, G., Ong, H. L., Adams, D., Gahl, W. A., Zheng, C., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116633109 · Cited by 216 · see citing works

Generation of nitric oxide from nitrite by carbonic anhydrase: a possible link between metabolic activity and vasodilation

Aamand, R., Dalsgaard, T., Jensen, F. B., Simonsen, U., Roepstorff, A., & Fago, A. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00525.2009 · Cited by 213 · see citing works

Hypoxic Modulation of Exogenous Nitrite-Induced Vasodilation in Humans

Maher, A. R., Milsom, A. B., Gunaruwan, P., Abozguia, K., Ahmed, I., Weaver, R. A., Thomas, P., Ashrafian, H., Born, G. V. R., James, P. E., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.719591 · Cited by 210 · see citing works

Nitric oxide and quality and safety of muscle based foods

Skibsted, L. H. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.03.307 · Cited by 201 · see citing works

Biology of nitrogen oxides in the gastrointestinal tract

Lundberg, J. O., & Weitzberg, E. (2013) · Gut · doi:10.1136/gutjnl-2011-301649 · Cited by 200 · see citing works

Nitrate in vegetables Scientific Opinion of the Panel on Contaminants in the Food chain 1

Alexander, J., Benford, D., Cockburn, A., Cravedi, J., Eugenia Dogliotti, Y., Domenico, A. D., Fernández‐Cruz, M. L., Fink‐Gremmels, J., Fürst, P., Galli, C. L., et al. (2008) · Cited by 187 · see citing works

Chronic sodium nitrite therapy augments ischemia-induced angiogenesis and arteriogenesis

Kumar, D., Branch, B. G., Pattillo, C. B., Hood, J., Thoma, S., Simpson, S., Illum, S., Arora, N., Chidlow, J. H., Langston, W., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711480105 · Cited by 187 · see citing works

[13] Nitric oxide-cyclic GMP signal transduction system

Hobbs, A. J., & Ignarro, L. J. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)69016-8 · Cited by 181 · see citing works

Salivary contribution to exhaled nitric oxide

Zetterquist, W., Pedroletti, C., Lundberg, J. O., & Alving, K. (1999) · European Respiratory Journal · doi:10.1034/j.1399-3003.1999.13b18.x · Cited by 171 · see citing works

Dietary nitrate increases gastric mucosal blood flow and mucosal defense

Petersson, J., Phillipson, M., Jansson, E. Å., Patzak, A., Lundberg, J. O., & Holm, L. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00435.2006 · Cited by 161 · see citing works

Gastrointestinal bacteria generate nitric oxide from nitrate and nitrite

Sobko, T., Reinders, C. I., Jansson, E. Å., Norin, E., Midtvedt, T., & Lundberg, J. O. (2005) · Nitric Oxide · doi:10.1016/j.niox.2005.08.002 · Cited by 160 · see citing works

The Effect of Nitrate Supplementation on Exercise Performance in Healthy Individuals: A Systematic Review and Meta-Analysis

Hoon, M. W., Johnson, N. A., Chapman, P., & Burke, L. M. (2013) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.23.5.522 · Cited by 157 · see citing works

Nitric oxide synthase reduces nitrite to NO under anoxia

Vanin, A. F., Bevers, L. M., Slama-Schwok, A., & van Faassen, E. E. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6374-2 · Cited by 151 · see citing works

Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: tetrahydrobiopterin binding kinetics and role of haem in dimerization

LIST, B. M., KLÖSCH, B., VÖLKER, C., GORREN, A. C. F., SESSA, W. C., WERNER, E. R., KUKOVETZ, W. R., SCHMIDT, K., & MAYER, B. (1997) · Biochemical Journal · doi:10.1042/bj3230159 · Cited by 147 · see citing works

Conjugated linoleic acid is a preferential substrate for fatty acid nitration

Bonacci, G., Baker, P. R. S., Salvatore, S. R., Shores, D., Khoo, N. K. H., Koenitzer, J. R., Vitturi, D. A., Woodcock, S. R., Golin-Bisello, F., Cole, M. P., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.401356 · Cited by 147 · see citing works

Nitrate-Nitrite-Nitric Oxide Pathway: Implications for Anesthesiology and Intensive Care

Weitzberg, E., Hezel, M., Lundberg, J. O., & Warner, D. S. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181fcf3cc · Cited by 145 · see citing works

Characterization of the Mechanism and Magnitude of Cytoglobin-mediated Nitrite Reduction and Nitric Oxide Generation under Anaerobic Conditions

Li, H., Hemann, C., Abdelghany, T. M., El-Mahdy, M. A., & Zweier, J. L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.342378 · Cited by 132 · see citing works

Nitrate and Nitrite in Saliva

Eisenbrand, G., Spiegelhalder, B., & Preußmann, R. (2009) · Oncology · doi:10.1159/000225441 · Cited by 127 · see citing works

Dietary nitrate supplementation improves revascularization in chronic ischemia

Hendgen-Cotta, U. B., Luedike, P., Totzeck, M., Kropp, M., Schicho, A., Stock, P., Rammos, C., Niessen, M., Heiss, C., Lundberg, J. O., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.112912 · Cited by 110 · see citing works

Immunohistochemical demonstration of nitric oxide synthase in the peripheral autonomic nervous system

Ceccatelli, S., Lundberg, J. M., Zhang, X., Åman, K., & Hökfelt, T. G. M. (1994) · Brain Research · doi:10.1016/0006-8993(94)91483-4 · Cited by 109 · see citing works

Protection from nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers by dietary nitrate

Jansson, E. Å., Petersson, J., Reinders, C., Sobko, T., Björne, H., Phillipson, M., Weitzberg, E., Holm, L., & Lundberg, J. O. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.11.018 · Cited by 106 · see citing works

Nitrate-reducing bacteria on rat tongues

Li, H., Duncan, C., Townend, J., Killham, K., Smith, L. M., Johnston, P., Dykhuizen, R., Kelly, D., Golden, M., Benjamin, N., et al. (1997) · Applied and Environmental Microbiology · doi:10.1128/aem.63.3.924-930.1997 · Cited by 103 · see citing works

Denitrification in human dental plaque

Schreiber, F., Stief, P., Gieseke, A., Heisterkamp, I. M., Verstraete, W., de Beer, D., & Stoodley, P. (2010) · BMC Biology · doi:10.1186/1741-7007-8-24 · Cited by 90 · see citing works

Mitochondria as metabolizers and targets of nitrite

Shiva, S. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.09.002 · Cited by 87 · see citing works

Regulation of mitochondrial function and energetics by reactive nitrogen oxides

Larsen, F. J., Schiffer, T. A., Weitzberg, E., & Lundberg, J. O. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.08.580 · Cited by 87 · see citing works

Quantitative relationship between oral nitrate-reducing activity and the endogenous formation of N-nitrosoamino acids in humans

Shapiro, K. B., Hotchkiss, J. H., & Roe, D. A. (1991) · Food and Chemical Toxicology · doi:10.1016/0278-6915(91)90183-8 · Cited by 86 · see citing works

Nitrate and nitrite concentrations in human saliva: Variations with salivary flow-rate

Granli, T., Dahl, R., Brodin, P., & Bøckman, O. (1989) · Food and Chemical Toxicology · doi:10.1016/0278-6915(89)90122-1 · Cited by 78 · see citing works

Dietary inorganic nitrate mobilizes circulating angiogenic cells

Heiß, C., Meyer, C. G., Totzeck, M., Hendgen-Cotta, U. B., Heinen, Y., Luedike, P., Keymel, S., Ayoub, N., Lundberg, J. O., Weitzberg, E., et al. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.02.051 · Cited by 78 · see citing works

Gastrointestinal nitric oxide generation in germ-free and conventional rats

Sobko, T., Reinders, C., Norin, E., Midtvedt, T., Gustafsson, L. E., & Lundberg, J. O. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00203.2004 · Cited by 75 · see citing works

ANTAGONISM BETWEEN PERCHLORATE, IODIDE, THIOCYANATE, AND NITRATE FOR SECRETION IN HUMAN SALIVA ANALOGY WITH THE IODIDE TRAP OF THE THYROID

Edwards, D. A., Fletcher, K. A., & Rowlands, E. N. (1954) · The Lancet · doi:10.1016/s0140-6736(54)91196-4 · Cited by 67 · see citing works

Nitric oxide and oral cancer: A review

Korde, S., Sridharan, G., Gadbail, A. R., & Poornima, V. (2012) · Oral Oncology · doi:10.1016/j.oraloncology.2012.01.003 · Cited by 67 · see citing works

Intragastric generation of antimicrobial nitrogen oxides from saliva—Physiological and therapeutic considerations

Björne, H., Weitzberg, E., & Lundberg, J. O. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.07.020 · Cited by 65 · see citing works

NO synthesis in human saliva

Palmerini, C. A., Palombari, R., Perito, S., & Arienti, G. (2003) · Free Radical Research · doi:10.1080/1071576021000028398 · Cited by 56 · see citing works

Nitric oxide signalling in salivary glands

Looms, D., Tritsaris, K., Pedersen, A. M. L., Nauntofte, B., & Dissing, S. (2002) · Journal of Oral Pathology and Medicine · doi:10.1034/j.1600-0714.2002.00047.x · Cited by 54 · see citing works

Intragastric nitric oxide is abolished in intubated patients and restored by nitrite*

Björne, H., Govoni, M., Törnberg, D. C., Lundberg, J. O., & Weitzberg, E. (2005) · Critical Care Medicine · doi:10.1097/01.ccm.0000171204.59502.aa · Cited by 53 · see citing works

Nitric oxide synthase in the pig autonomic nervous system in relation to the influence of NG-nitro-L-arginine on sympathetic and parasympathetic vascular control in vivo

Modin, A., Weitzberg, E., Hökfelt, T. G. M., & Lundberg, J. M. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90324-7 · Cited by 46 · see citing works

Nitrate and nitrite concentrations in human saliva for men and women at different ages and times of the day and their consistency over time

Mirvish, S. S., Reimers, K. J., Kutler, B., Chen, S. C., Haorah, J., Morris, C. R., Grandjean, A. C., & Lyden, E. R. (2000) · European Journal of Cancer Prevention · doi:10.1097/00008469-200010000-00008 · Cited by 45 · see citing works

Excretion of nitrates and nitrites in saliva and bile in the dog

Fritsch, P., Blanquat, G. D. S., & Klein, D. (1985) · Food and Chemical Toxicology · doi:10.1016/0278-6915(85)90153-x · Cited by 39 · see citing works

The effect of different sources of nitrate exposure on urinary nitrate recovery in humans and its relevance to the methods of estimating nitrate exposure in epidemiological studies

Packer, P. J., Leach, S. A., Duncan, S. N., THOMPSON, M. H., & Hill, M. J. (1989) · Carcinogenesis · doi:10.1093/carcin/10.11.1989 · Cited by 35 · see citing works

The effect of water-borne nitrate on salivary nitrite

Walters, C. L., & Smith, P. (1981) · Food and Cosmetics Toxicology · doi:10.1016/0015-6264(81)90388-6 · Cited by 33 · see citing works

Nitrate causes a dose-dependent augmentation of nitric oxide status in healthy women

Bondonno, C. P., Croft, K. D., Puddey, I. B., Considine, M. J., Yang, X., Ward, N. C., & Hodgson, J. M. (2012) · Food &amp; Function · doi:10.1039/c2fo10206d · Cited by 31 · see citing works

Nitric oxide synthase in human salivary glands

Soinila, J., Nuorva, K., & Soinila, S. O. (2005) · Histochemistry and Cell Biology · doi:10.1007/s00418-005-0123-8 · Cited by 25 · see citing works

Neurogenic and Endothelial Nitric Oxide Regulates Blood Circulation in Lingual and Other Oral Tissues

Toda, N., Ayajiki, K., & Okamura, T. (2012) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e318252452a · Cited by 25 · see citing works

Modulation by neurogenic acetylcholine of nitroxidergic nerve function in porcine ciliary arteries.

Toda, M., Okamura, T., AZUMA, I., & Toda, N. (1997) · PubMed · Cited by 24 · see citing works

Expression of nitric oxide synthase in pleomorphic adenomas of the parotid

Brennan, P. A., Umar, T., Buckley, J., Zaki, G. A., Langdon, J., Spedding, A. V., & Peters, W. J. N. (2000) · British Journal of Oral and Maxillofacial Surgery · doi:10.1054/bjom.1999.0454 · Cited by 24 · see citing works

The formation of nitrite and N-nitroso compounds in salivas in vitro and in vivo

Hart, R. J., & Walters, C. L. (1983) · Food and Chemical Toxicology · doi:10.1016/0278-6915(83)90208-9 · Cited by 20 · see citing works

Sublethal damage repair capacity in carcinoma cell lines with p53 mutations

Pekkola‐Heino, K., Servomaa, K., Kiuru, A., & Grenman, R. A. (1998) · Head & Neck · doi:10.1002/(sici)1097-0347(199807)20:4 · Cited by 18 · see citing works

Effet d'une charge en nitrate sur le nitrite salivaire et gastrique chez l'homme

Klein, D., Gaconnet, N., Poullain, B., & Debry, G. (1978) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(78)80189-8 · Cited by 17 · see citing works

Detection of Nitric Oxide and Its Derivatives in Human Mixed Saliva and Acidified Saliva

Takahama, U., Hirota, S., & Oniki, T. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)00824-5 · Cited by 14 · see citing works

Methaemoglobinaemia Due to Nitrates and Nitrites in Drinking-water

Fawns, H. T., & Aldridge, A. G. V. (1954) · BMJ · doi:10.1136/bmj.2.4887.575 · Cited by 13 · see citing works

Adrenoceptor-activated Nitric Oxide Synthesis in Salivary Acinar Cells

Looms, D., Dissing, S., Tritsaris, K., Pedersen, A. M. L., & Nauntofte, B. (2000) · Advances in Dental Research · doi:10.1177/08959374000140011001 · Cited by 13 · see citing works

Nitrite and Nitrate: From Bench to Bedside

Kevil, C. G., & Lefer, D. J. (2012) · Nitric Oxide · doi:10.1016/j.niox.2012.04.165 · Cited by 9 · see citing works

Drinking Water Nitrate and Human Health: An Updated Review

Ward, M., Jones, R., Brender, J., De Kok, T., Weyer, P., Nolan, B., Villanueva, C., & Van Breda, S. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15071557 · Cited by 1,576 · see citing works

Resilience of the Oral Microbiota in Health: Mechanisms That Prevent Dysbiosis

Rosier, B. T., Marsh, P. D., & Mira, A. (2018) · Journal of Dental Research · doi:10.1177/0022034517742139 · Cited by 448 · see citing works

A practical guide to the oral microbiome and its relation to health and disease

Krishnan, K., Chen, T., & Paster, B. (2017) · Oral Diseases · doi:10.1111/odi.12509 · Cited by 347 · see citing works

Oral Microbiome Geography: Micron-Scale Habitat and Niche

Welch, J. L. M., Ramírez-Puebla, S. T., & Borisy, G. G. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.07.009 · Cited by 267 · see citing works

Functional properties of beetroot (Beta vulgaris) in management of cardio-metabolic diseases

Mirmiran, P., Houshialsadat, Z., Gaeini, Z., Bahadoran, Z., & Azizi, F. (2020) · Nutrition &amp; Metabolism · doi:10.1186/s12986-019-0421-0 · Cited by 215 · see citing works

Nitrate as a potential prebiotic for the oral microbiome

Rosier, B. T., Buetas, E., Moya-Gonzalvez, E. M., Artacho, A., & Mira, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-69931-x · Cited by 194 · see citing works

Spatial Ecology of the Human Tongue Dorsum Microbiome

Wilbert, S. A., Welch, J. L. M., & Borisy, G. G. (2019) · Cell Reports · doi:10.1016/j.celrep.2020.02.097 · Cited by 194 · see citing works

Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health

Koch, C. D., Gladwin, M. T., Freeman, B. A., Lundberg, J. O., Weitzberg, E., & Morris, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.015 · Cited by 186 · see citing works

The influence of the human microbiome and probiotics on cardiovascular health

Ettinger, G., MacDonald, K., Reid, G., & Burton, J. P. (2014) · Gut Microbes · doi:10.4161/19490976.2014.983775 · Cited by 180 · see citing works

The Importance of Nitrate Reduction for Oral Health

Rosier, B. T., Takahashi, N., Zaura, E., Krom, B. P., MartÍnez-Espinosa, R. M., van Breda, S. G. J., Marsh, P. D., & Mira, A. (2022) · Journal of Dental Research · doi:10.1177/00220345221080982 · Cited by 175 · see citing works

Therapeutic effects of inorganic nitrate and nitrite in cardiovascular and metabolic diseases

Omar, S. A., Webb, A. J., Lundberg, J. O., & Weitzberg, E. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12441 · Cited by 175 · see citing works

Betel nut chewing, oral premalignant lesions, and the oral microbiome

Hernandez, B. Y., Zhu, X., Goodman, M. T., Gatewood, R. R., Mendiola, P., Quinata, K. M. G., & Paulino, Y. C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172196 · Cited by 174 · see citing works

Neuromodulatory effects and targets of the SCFAs and gasotransmitters produced by the human symbiotic microbiota

Oleskin, A. V., & Shenderov, B. A. (2016) · Microbial Ecology in Health &amp; Disease · doi:10.3402/mehd.v27.30971 · Cited by 145 · see citing works

Isolation and Characterization of Nitrate-Reducing Bacteria as Potential Probiotics for Oral and Systemic Health

Rosier, B. T., Moya-Gonzálvez, E. M., Corell-Escuin, P., & Mira, Á. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.555465 · Cited by 142 · see citing works

Nutritional Correlates of Human Oral Microbiome

Kato, I., Vasquez, A. A., Moyerbrailean, G. A., Land, S. J., Djurić, Z., Sun, J., Lin, H.-S., & Ram, J. L. (2016) · Journal of the American College of Nutrition · doi:10.1080/07315724.2016.1185386 · Cited by 129 · see citing works

Oral biofilms exposure to chlorhexidine results in altered microbial composition and metabolic profile

Chatzigiannidou, I., Teughels, W., de Wiele, T. V., & Boon, N. (2020) · npj Biofilms and Microbiomes · doi:10.1038/s41522-020-0124-3 · Cited by 118 · see citing works

From Nitrate to Nitric Oxide: The Role of Salivary Glands and Oral Bacteria

Qu, X. M., Wu, Z. F., Pang, B. X., Jin, L. Y., Qin, L. Z., & Wang, S. L. (2016) · Journal of Dental Research · doi:10.1177/0022034516673019 · Cited by 110 · see citing works

Microbiota metabolites: Pivotal players of cardiovascular damage in chronic kidney disease

Cosola, C., Rocchetti, M. T., Cupisti, A., & Gesualdo, L. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.03.003 · Cited by 99 · see citing works

Enrichment of periodontal pathogens from the biofilms of healthy adults

Naginyte, M., Do, T., Meade, J. L., DeVine, D., & Marsh, P. D. (2019) · Scientific Reports · doi:10.1038/s41598-019-41882-y · Cited by 99 · see citing works

Candida Interactions with the Oral Bacterial Microbiota

Montelongo‐Jauregui, D., & Lopez-Ribot, J. L. (2018) · Journal of Fungi · doi:10.3390/jof4040122 · Cited by 93 · see citing works

The oral microbiota and cardiometabolic health: A comprehensive review and emerging insights

Li, Y. H., Zhu, M., Liu, Y., Luo, B., Cui, J., Huang, L., Chen, K., & Liu, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1010368 · Cited by 88 · see citing works

Nitrate reduction capacity of the oral microbiota is impaired in periodontitis: potential implications for systemic nitric oxide availability

Rosier, B. T., Johnston, W., Carda-Diéguez, M., Simpson, A., Cabello-Yeves, E., Piela, K., Reilly, R., Artacho, A., Easton, C., Burleigh, M., et al. (2024) · International Journal of Oral Science · doi:10.1038/s41368-023-00266-9 · Cited by 85 · see citing works

Role of oral and gut microbiome in nitric oxide-mediated colon motility

Walker, M., Pratap, S., Southerland, J. H., Farmer‐Dixon, C. M., Kesavalu, L. N., & Gangula, P. R. (2017) · Nitric Oxide · doi:10.1016/j.niox.2017.06.003 · Cited by 81 · see citing works

Regulation of MicroRNA Machinery and Development by Interspecies S-Nitrosylation

Seth, P., Hsieh, P. N., Jamal, S., Wang, L., Gygi, S. P., Jain, M. K., Coller, J. M., & Stamler, J. S. (2019) · Cell · doi:10.1016/j.cell.2019.01.037 · Cited by 81 · see citing works

Distribution of N-nitrosamines in drinking water and human urinary excretions in high incidence area of esophageal cancer in Huai'an, China

Zhao, C., Lü, Q., Gu, Y., Pan, E., Sun, Z., Hu, Z., Zhou, J., Du, Y., Zhang, Y., Feng, Y., et al. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.06.124 · Cited by 79 · see citing works

Age and sex-associated variation in the multi-site microbiome of an entire social group of free-ranging rhesus macaques

Janiak, M. C., Montague, M. J., Villamil, C. I., Stock, M. K., Trujillo, A. E., DePasquale, A. N., Orkin, J. D., Bauman, S. E., González, O., Platt, M. L., et al. (2021) · Microbiome · doi:10.1186/s40168-021-01009-w · Cited by 79 · see citing works

Current Knowledge on Beetroot Bioactive Compounds: Role of Nitrate and Betalains in Health and Disease

Milton-Laskibar, I., Martínez, J. A., & Portillo, M. P. (2021) · Foods · doi:10.3390/foods10061314 · Cited by 77 · see citing works

Interplay Among the Oral Microbiome, Oral Cavity Conditions, the Host Immune Response, Diabetes Mellitus, and Its Associated-Risk Factors—An Overview

Negrini, T. D. C., Carlos, I. Z., Duque, C., Caiaffa, K. S., & Arthur, R. A. (2021) · Frontiers in Oral Health · doi:10.3389/froh.2021.697428 · Cited by 76 · see citing works

Oral microbiota and oral cancer: Review

Kakabadze, M., Paresishvili, T., Karalashvili, L., Chakhunashvili, D., & Kakabadze, Z. (2020) · Oncology Reviews · doi:10.4081/oncol.2020.476 · Cited by 75 · see citing works

Oral microbiota dysbiosis accelerates the development and onset of mucositis and oral ulcers

Min, Z., Yang, L., Hu, Y., & Huang, R. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1061032 · Cited by 74 · see citing works

Antiseptic mouthwash, the nitrate–nitrite–nitric oxide pathway, and hospital mortality: a hypothesis generating review

Blot, S. (2021) · Intensive Care Medicine · doi:10.1007/s00134-020-06276-z · Cited by 73 · see citing works

Dental caries and their microbiomes in children: what do we do now?

Ribeiro, A. A., & Paster, B. J. (2023) · Journal of Oral Microbiology · doi:10.1080/20002297.2023.2198433 · Cited by 73 · see citing works

Salivary Factors that Maintain the Normal Oral Commensal Microflora

Carpenter, G. H. (2020) · Journal of Dental Research · doi:10.1177/0022034520915486 · Cited by 72 · see citing works

Pathways Linking Oral Bacteria, Nitric Oxide Metabolism, and Health

Morou-Bermúdez, E., Torres-Colón, J. E., Bermúdez, N. S., Patel, R. P., & Joshipura, K. J. (2022) · Journal of Dental Research · doi:10.1177/00220345211064571 · Cited by 70 · see citing works

Nitrate and the origin of saliva influence composition and short chain fatty acid production of oral microcosms

Koopman, J. E., Buijs, M. J., Brandt, B. W., Keijser, B. J. F., Crielaard, W., & Zaura, E. (2016) · Microbial Ecology · doi:10.1007/s00248-016-0775-z · Cited by 66 · see citing works

Recent advances in diverse nanosystems for nitric oxide delivery in cancer therapy

Gao, D., Asghar, S., Hu, R., Chen, S., Niu, R., Liu, J., Chen, Z., & Xiao, Y. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.11.016 · Cited by 66 · see citing works

Physiological Changes and Interactions Between Microbiome and the Host During Pregnancy

Zakaria, Z. Z., Al-Rumaihi, S. F., Al-Absi, R. S., Farah, H., Elamin, M., Nader, R., Bouabidi, S., Suleiman, S. E. K., Nasr, S., & Al‐Asmakh, M. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.824925 · Cited by 61 · see citing works

Oral microbiome in human health and diseases

Tian, S., Ding, T., & Li, H. (2024) · mLife · doi:10.1002/mlf2.12136 · Cited by 61 · see citing works

Mechanisms impairing blood pressure responses to nitrite and nitrate

Oliveira‐Paula, G. H., Pinheiro, L. C., & Tanus-Santos, J. E. (2019) · Nitric Oxide · doi:10.1016/j.niox.2019.01.015 · Cited by 60 · see citing works

Nitrate and a nitrate-reducing Rothia aeria strain as potential prebiotic or synbiotic treatments for periodontitis

Mazurel, D., Carda‐Diéguez, M., Langenburg, T., Žiemytė, M., Johnston, W., Martínez, C. P., Albalat, F., Llena, C., Al-Hebshi, N. N., Culshaw, S., et al. (2023) · npj Biofilms and Microbiomes · doi:10.1038/s41522-023-00406-3 · Cited by 59 · see citing works

From nitrate to NO: potential effects of nitrate-reducing bacteria on systemic health and disease

Liu, H., Huang, Y., Huang, M., Wang, M., Ming, Y., Chen, W., Chen, Y., Tang, Z., & Jia, B. (2023) · European Journal of Medical Research · doi:10.1186/s40001-023-01413-y · Cited by 58 · see citing works

Over-the-counter mouthwash use, nitric oxide and hypertension risk

Joshipura, K., Muñoz-Torres, F., Fernández-Santiago, J., Patel, R. P., & Lopez-Candales, A. (2020) · Blood Pressure · doi:10.1080/08037051.2019.1680270 · Cited by 58 · see citing works

Role of Oral and Gut Microbiota in Dietary Nitrate Metabolism and Its Impact on Sports Performance

González-Soltero, R., Bailén, M., de Lucas, B., Ramírez-Goercke, M. I., Pareja-Galeano, H., & Larrosa, M. (2020) · Nutrients · doi:10.3390/nu12123611 · Cited by 54 · see citing works

Fate of β-Carotene within Loaded Delivery Systems in Food: State of Knowledge

Maurya, V. K., Shakya, A., Aggarwal, M., Muthukaliannan, G. K., Bohn, T., & Pareek, S. (2021) · Antioxidants · doi:10.3390/antiox10030426 · Cited by 53 · see citing works

The Role of Bacterial and Fungal Human Respiratory Microbiota in COVID‐19 Patients

Soltani, S., Zakeri, A., Zandi, M., Kesheh, M. M., Tabibzadeh, A., Dastranj, M., Faramarzi, S., Didehdar, M., Hafezi, H., Hosseini, P., et al. (2021) · BioMed Research International · doi:10.1155/2021/6670798 · Cited by 52 · see citing works

Microbiota, diet and the generation of reactive nitrogen compounds

Carlström, M., Moretti, C. H., Weitzberg, E., & Lundberg, J. O. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.10.025 · Cited by 51 · see citing works

Inflammatory and Immunological Basis of Periodontal Diseases

Baima, G., Arce, M., Romandini, M., & Dyke, T. E. V. (2025) · Journal of Periodontal Research · doi:10.1111/jre.70040 · Cited by 49 · see citing works

Impact of air pollution on respiratory microbiome: A narrative review

Vieceli, T., Tejada, S., Martínez-Reviejo, R., Pumarola, T., Schrenzel, J., WATERER, G. W., & Rello, J. (2022) · Intensive and Critical Care Nursing · doi:10.1016/j.iccn.2022.103336 · Cited by 48 · see citing works

A Single Dose of Nitrate Increases Resilience Against Acidification Derived From Sugar Fermentation by the Oral Microbiome

Rosier, B. T., Carlos, P., García‐Esteban, S., Artacho, A., Galiana, A., & Mira, Á. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.692883 · Cited by 47 · see citing works

Effects of antiseptic mouthwash on resting metabolic rate: a randomized, double-blind, crossover study

Sundqvist, M. L., Lundberg, J. O., & Weitzberg, E. (2016) · Nitric Oxide · doi:10.1016/j.niox.2016.10.003 · Cited by 46 · see citing works

The emerging roles of neuroactive components produced by gut microbiota

Dezfouli, M. A., Rashidi, S. K., Yazdanfar, N., Khalili, H., Goudarzi, M., Saadi, A., & Kiani, A. A. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-10097-4 · Cited by 45 · see citing works

Influential factors of saliva microbiota composition

Wells, P. M., Sprockett, D. D., Bowyer, R. C. E., Kurushima, Y., Relman, D. A., Williams, F. M. K., & Steves, C. J. (2022) · Scientific Reports · doi:10.1038/s41598-022-23266-x · Cited by 43 · see citing works

Oxidative Stress in the Pathogenesis of Oral Cancer

Ionescu, C., Kamal, F. Z., Ciobica, A. S., Halitchi, G., Burlui, V., & Petroaie, A. D. (2024) · Biomedicines · doi:10.3390/biomedicines12061150 · Cited by 43 · see citing works

Manipulating the diseased oral microbiome: the power of probiotics and prebiotics

Yu, X., DeVine, D., & Vernon, J. J. (2024) · Journal of Oral Microbiology · doi:10.1080/20002297.2024.2307416 · Cited by 40 · see citing works

Microbiotal-Host Interactions and Hypertension

Galla, S., Chakraborty, S., Mell, B., Vijay–Kumar, M., & Joe, B. (2017) · Physiology · doi:10.1152/physiol.00003.2017 · Cited by 40 · see citing works

Dietary nitrate and population health: a narrative review of the translational potential of existing laboratory studies

Shannon, O. M., Easton, C., Shepherd, A. I., Siervo, M., Bailey, S. J., & Clifford, T. (2021) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-021-00292-2 · Cited by 40 · see citing works

The role of dietary nitrate and the oral microbiome on blood pressure and vascular tone

Alzahrani, H., Jackson, K. G., Hobbs, D. A., & Lovegrove, J. A. (2020) · Nutrition Research Reviews · doi:10.1017/s0954422420000281 · Cited by 37 · see citing works

A review on nitrates’ health benefits and disease prevention

Apte, M., Nadavade, N., & Sheikh, S. S. (2023) · Nitric Oxide · doi:10.1016/j.niox.2023.11.003 · Cited by 35 · see citing works

Nitrate: “the source makes the poison”

Bowles, E., Burleigh, M. C., Mira, Á., van Breda, S. G., Weitzberg, E., & Rosier, B. T. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2024.2395488 · Cited by 33 · see citing works

A Review of the Role of Oral Microbiome in the Development, Detection, and Management of Head and Neck Squamous Cell Cancers

Burcher, K. M., Burcher, J. T., Inscore, L., Bloomer, C. H., Furdui, C. M., & Porosnicu, M. (2022) · Cancers · doi:10.3390/cancers14174116 · Cited by 32 · see citing works

Could intramuscular storage of dietary nitrate contribute to its ergogenic effect? A mini-review

Nyakayiru, J., van Loon, L. J. C., & Verdijk, L. B. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.03.025 · Cited by 32 · see citing works

Beetroot juice versus chard gel: A pharmacokinetic and pharmacodynamic comparison of nitrate bioavailability

McIlvenna, L. C., Monaghan, C., Liddle, L., Fernandez, B. O., Feelisch, M., Muggeridge, D. J., & Easton, C. (2016) · Nitric Oxide · doi:10.1016/j.niox.2016.12.006 · Cited by 31 · see citing works

The obligatory role of host microbiota in bioactivation of dietary nitrate

Moretti, C. H., Zhuge, Z., Zhang, G., Haworth, S. M., Paulo, L. L., Guimarães, D. D., Cruz, J. C., Montenegro, M. F., Cordero‐Herrera, I., Braga, V. A., et al. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.10.003 · Cited by 31 · see citing works

Nitrite reductase is critical for Pseudomonas aeruginosa survival during co-infection with the oral commensal Streptococcus parasanguinis

Scoffield, J. A., & Wu, H. (2015) · Microbiology · doi:10.1099/mic.0.000226 · Cited by 30 · see citing works

Measuring nitrate reductase activity from human and rodent tongues

Ahmed, K. A., Nichols, A., Honavar, J., Dransfield, M. T., Matalon, S., & Patel, R. P. (2017) · Nitric Oxide · doi:10.1016/j.niox.2017.04.001 · Cited by 30 · see citing works

Effects of processed meat and drinking water nitrate on oral and fecal microbial populations in a controlled feeding study

Sinha, R. R., Zhao, N., Goedert, J. J., Byrd, D. A., Wan, Y., Hua, X., Hullings, A. G., Knight, R. D., Breda, S. G. J. V., Mathijs, K., et al. (2021) · Environmental Research · doi:10.1016/j.envres.2021.111084 · Cited by 27 · see citing works

Intestinal microbiota as a tetrahydrobiopterin exogenous source in hph-1 mice

Belik, J., Shifrin, Y., Arning, E., Bottiglieri, T., Pan, J., Daigneault, M. C., & Allen‐Vercoe, E. (2017) · Scientific Reports · doi:10.1038/srep39854 · Cited by 27 · see citing works

Influence of dietary nitrate supplementation on lung function and exercise gas exchange in COPD patients

Behnia, M. M., Wheatley, C. M., Avolio, A. P., & Johnson, B. D. (2018) · Nitric Oxide · doi:10.1016/j.niox.2018.03.009 · Cited by 27 · see citing works

Association of Periodontal Disease and Edentulism With Hypertension Risk in Postmenopausal Women

Gordon, J. H., LaMonte, M. J., Zhao, J., Genco, R. J., Cimato, T. R., Hovey, K. M. O., Allison, M., Mouton, C. P., & Wactawski‐Wende, J. (2018) · American Journal of Hypertension · doi:10.1093/ajh/hpy164 · Cited by 26 · see citing works

Ecology, Not Host Phylogeny, Shapes the Oral Microbiome in Closely Related Species

Moraitou, M., Forsythe, A., Yates, J. A. F., Brealey, J. C., Warinner, C., & Guschanski, K. (2022) · Molecular Biology and Evolution · doi:10.1093/molbev/msac263 · Cited by 25 · see citing works

Whole beetroot consumption reduces systolic blood pressure and modulates diversity and composition of the gut microbiota in older participants

Capper, T. E., Houghton, D., Stewart, C. J., Blain, A. P., McMahon, N. F., Siervo, M., West, D. J., & Stevenson, E. (2020) · NFS Journal · doi:10.1016/j.nfs.2020.08.001 · Cited by 24 · see citing works

The State of the Nitric Oxide Cycle in Respiratory Tract Diseases

Келдибековна, С. С., Klimanov, I. A., Kubysheva, N. I., Попова, Н. А., & Batyrshin, I. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/4859260 · Cited by 24 · see citing works

Effect of an oxygenating agent on oral bacteria in vitro and on dental plaque composition in healthy young adults

y Mostajo, M. F., van der Reijden, W. A., Buijs, M. J., Beertsen, W., van der Weijden, G. A., Wim Crielaard, A., & Zaura, E. (2014) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2014.00095 · Cited by 24 · see citing works

Mechanism-based strategies to prevent salt sensitivity and salt-induced hypertension

Kurtz, T. W., Pravenec, M., & DiCarlo, S. E. (2022) · Clinical Science · doi:10.1042/cs20210566 · Cited by 23 · see citing works

Effects of Dietary Nitrate Supplementation on Performance and Muscle Oxygenation during Resistance Exercise in Men

Tan, R., Pennell, A., Price, K. M., Karl, S. T., Seekamp-Hicks, N. G., Paniagua, K. K., Weiderman, G. D., Powell, J. P., Sharabidze, L. K., Lincoln, I. G., et al. (2022) · Nutrients · doi:10.3390/nu14183703 · Cited by 21 · see citing works

Current clinical framework on nitric oxide role in periodontal disease and blood pressure

Lima, L. L. L., Gaspar, S. R., Rocha, B. S., Alves, R. C., & Almeida, M. G. (2024) · Clinical Oral Investigations · doi:10.1007/s00784-024-05913-x · Cited by 21 · see citing works

Effects of inorganic nitrate supplementation on cardiovascular function and exercise tolerance in heart failure

Ferguson, S. K., Woessner, M. N., Holmes, M. J., Belbis, M. D., Carlström, M., Weitzberg, E., Allen, J. D., & Hirai, D. M. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00780.2020 · Cited by 21 · see citing works

Identifying oral microbiome alterations in adult betel quid chewing population of Delhi, India

Bahuguna, M., Hooda, S., Mohan, L., Gupta, R. K., & Diwan, P. (2023) · PLoS ONE · doi:10.1371/journal.pone.0278221 · Cited by 20 · see citing works

Organ uptake and release of inorganic nitrate and nitrite in the pig

Eriksson, K. E., Yang, T., Carlström, M., & Weitzberg, E. (2018) · Nitric Oxide · doi:10.1016/j.niox.2018.02.001 · Cited by 20 · see citing works

Oral Cavity is the Gateway to the Body: Role of Oral Health Professionals: A Narrative Review

Iyer, P. (2023) · Journal of the California Dental Association · doi:10.1080/19424396.2023.2193372 · Cited by 19 · see citing works

Iron Deficiency Modulates Metabolic Landscape of Bacteroidetes Promoting Its Resilience during Inflammation

Lewis, J. P., & Gui, Q. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.04733-22 · Cited by 19 · see citing works

Effectiveness of thyme honey in the management of xerostomia in geriatric patients with end-stage renal disease: a randomized controlled clinical trial with a biochemical assessment

Ibrahim, S. S., Abou‐Bakr, A., Ghalwash, D. M., & Hussein, R. R. (2023) · European journal of medical research · doi:10.1186/s40001-023-01351-9 · Cited by 19 · see citing works

Effects of age, sex and diet on salivary nitrate and nitrite in infants

Timby, N., Domellöf, M., Hernell, O., Lönnerdal, B. L., Nihlén, C., Johansson, I., & Weitzberg, E. (2019) · Nitric Oxide · doi:10.1016/j.niox.2019.10.012 · Cited by 18 · see citing works

Adaptation and Probiotic Potential of Lactobacilli, Isolated from the Oral Cavity and Intestines of Healthy People

Chervinets, Y. V., Червинец, В. М., Ba, S., Belyaeva, E. A., Трошин, А. В., Lebedev, S., & Даниленко, В. Н. (2017) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-017-9348-9 · Cited by 18 · see citing works

Nitrate and Body Homeostasis

Zhou, J., Liu, H., Hu, L., Kagami, H., & Wang, S. (2024) · Medicine Plus · doi:10.1016/j.medp.2023.100003 · Cited by 17 · see citing works

The Porphyromonas gingivalis Hybrid Cluster Protein Hcp Is Required for Growth with Nitrite and Survival with Host Cells

Belvin, B. R., Gui, Q., Hutcherson, J. A., & Lewis, J. P. (2019) · Infection and Immunity · doi:10.1128/iai.00572-18 · Cited by 17 · see citing works

Boosting nitric oxide in stress and respiratory infection: Potential relevance for asthma and COVID-19

Ritz, T., Salsman, M. L., Young, D. A., Lippert, A. R., Khan, D. A., & Ginty, A. T. (2021) · Brain, Behavior, &amp; Immunity - Health · doi:10.1016/j.bbih.2021.100255 · Cited by 17 · see citing works

Noninvasive Electrochemical Nitric Oxide Detection in Human Saliva Using Pt and TiO2 Nanoparticle Composite Electrodes

Patra, D. C., Deka, N., Dash, A., Khan, S., Misra, T. K., & Mondal, S. P. (2023) · ACS Applied Electronic Materials · doi:10.1021/acsaelm.2c01408 · Cited by 17 · see citing works

Advances in the prevention and treatment of Alzheimer’s disease based on oral bacteria

Zhang, M., Mi, N., Zheng, Y., Lin, X., & Jin, Y. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1291455 · Cited by 17 · see citing works

Comparison of salivary nitric oxide and oral health in diabetic patients with and without xerostomia

Abadi, P. A., Koopaie, M., & Montazeri, R. (2019) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2019.11.014 · Cited by 17 · see citing works

Renal handling of nitrate in women and men with elevated blood pressure

Sundqvist, M. L., Lundberg, J. O., Weitzberg, E., & Carlström, M. (2021) · Acta Physiologica · doi:10.1111/apha.13637 · Cited by 17 · see citing works

Effects of oral sodium nitrate on forearm blood flow, oxygenation and exercise performance during acute exposure to hypobaric hypoxia (4300 m)

Gasier, H. G., Reinhold, A. R., Loiselle, A. R., Soutière, S. E., & Fothergill, D. M. (2017) · Nitric Oxide · doi:10.1016/j.niox.2017.07.001 · Cited by 17 · see citing works

Functional foods for augmenting nitric oxide activity and reducing the risk for salt-induced hypertension and cardiovascular disease in Japan

Kurtz, T. W., DiCarlo, S. E., Pravenec, M., & Morris, R. C. (2018) · Journal of Cardiology · doi:10.1016/j.jjcc.2018.02.003 · Cited by 17 · see citing works

Nitric Oxide Donor Modulates a Multispecies Oral Bacterial Community—An In Vitro Study

Nambu, T., Wang, D., Mashimo, C., Maruyama, H., Kashiwagi, K., Yoshikawa, K., Yamamoto, K., & Okinaga, T. (2019) · Microorganisms · doi:10.3390/microorganisms7090353 · Cited by 16 · see citing works

Nitrite Triggers Reprogramming of the Oral Polymicrobial Metabolome by a Commensal Streptococcus

Huffines, J. T., Stoner, S. N., Baty, J. J., & Scoffield, J. A. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.833339 · Cited by 16 · see citing works

From Mouth to Brain: Distinct Supragingival Plaque Microbiota Composition in Cerebral Palsy Children With Caries

Liu, M., Shi, Y., Wu, K., Xie, W., Ser, H., Jiang, Q., & Wu, L. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.814473 · Cited by 16 · see citing works

The impact of Mediterranean diet on coronary plaque vulnerability, microvascular function, inflammation and microbiome after an acute coronary syndrome: study protocol for the MEDIMACS randomized, controlled, mechanistic clinical trial

Fernández, A. I., Bermejo, J., Yotti, R., Martínez‐González, M. Á., Mira, Á., Gophna, U., Karlsson, R., Al‐Daccak, R., de Miguel, I. M., Gutiérrez, E., et al. (2021) · Trials · doi:10.1186/s13063-021-05746-z · Cited by 15 · see citing works

The level of dysbiosis of the oral cavity depends on the type of dental prosthesis of the patient

Perepelova, T. V., Faustova, M. O., Dvornyk, V. M., Dobrovolskyi, O. V., KOVAL, Y., & Лобань, Г. А. (2023) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.4149/bll_2023_093 · Cited by 15 · see citing works

Influence of acute dietary nitrate supplementation timing on nitrate metabolism, central and peripheral blood pressure and exercise tolerance in young men

Rowland, S. N., James, L. J., O’Donnell, E., & Bailey, S. J. (2023) · European Journal of Applied Physiology · doi:10.1007/s00421-023-05369-z · Cited by 15 · see citing works

Periodontal treatment causes a longitudinal increase in nitrite‐producing bacteria

Simpson, A., Johnston, W., Carda‐Diéguez, M., Mira, A., Easton, C., Henriquez, F. L., Culshaw, S., Rosier, B. T., & Burleigh, M. C. (2024) · Molecular Oral Microbiology · doi:10.1111/omi.12479 · Cited by 15 · see citing works

Nitrate-Reducing Oral Bacteria: Linking Oral and Systemic Health

Bryan, N. S., & Petrosino, J. F. (2017) · Springer eBooks · doi:10.1007/978-3-319-46189-2_3 · Cited by 10 · see citing works

Oral Nitrate-Reducing Bacteria and Nitric Oxide Homeostasis: Functional Host–Microbe Interactions in Oral and Vascular Health

Altamura, S., Lombardi, F., Ciafarone, A., Palumbo, P., Cinque, B., Cifone, M. G., & Pietropaoli, D. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27209012

From Nitrate to Nitric Oxide: The Role of Salivary Glands and Oral Bacteria

Qu, X. M., Wu, Z. F., Pang, B. X., Jin, L. Y., Qin, L. Z., & Wang, S. L. (2016) · Journal of Dental Research · doi:10.1177/0022034516673019 · Cited by 110 · see citing works

Nitrite Production from Nitrate in the Oral Microbiome and Its Contribution to Oral and Systemic Health

Washio, J., & Takahashi, N. (2025) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-031-79146-8_6 · Cited by 7 · see citing works

Nitric oxide formation in the metabolism of nitrates in the oral cavity

Romanenko, Y. H., Hryhorenko, L. V., Komskyi, M. P., Срібник, П. Л., & Sinkovska, O. O. (2019) · Zaporozhye Medical Journal · doi:10.14739/2310-1210.2019.5.179472 · Cited by 2 · see citing works