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Cited by 266

The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.

Down‐regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet

Open access
Jansson, Nina, Pettersson, Jessica, Haafiz, Allah, Ericsson, Anette, Palmberg, Isabelle, Tranberg, Mattias, Ganapathy, Vadivel, Powell, Theresa L., Jansson, Thomas·2006·The Journal of Physiology
DOI 10.1113/jphysiol.2003.550004
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Abstract

Intrauterine growth restriction (IUGR) represents an important risk factor for perinatal complications and for adult disease. IUGR is associated with a down‐regulation of placental amino acid transporters; however, whether these changes are primary events directly contributing to IUGR or a secondary consequence is unknown. We investigated the time course of changes in placental and fetal growth, placental nutrient transport in vivo and the expression of placental nutrient transporters in pregnant rats subjected to protein malnutrition, a model for IUGR. Pregnant rats were given either a low protein (LP) diet (n= 64) or an isocaloric control diet (n= 66) throughout pregnancy. Maternal insulin, leptin and IGF‐I levels decreased, whereas maternal amino acid concentrations increased moderately in response to the LP diet. Fetal and placental weights in the LP group were unaltered compared to control diet at gestational day (GD) 15, 18 and 19 but significantly reduced at GD 21. Placental system A transport activity was reduced at GD 19 and 21 in response to a low protein diet. Placental protein expression of SNAT2 was decreased at GD 21. In conclusion, placental amino acid transport is down‐regulated prior to the development of IUGR, suggesting that these placental transport changes are a cause, rather than a consequence, of IUGR. Reduced maternal levels of insulin, leptin and IGF‐1 may link maternal protein malnutrition to reduced fetal growth by down‐regulation of key placental amino acid transporters.

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  1. 10.1097/00006250-200105000-00018 · doi:10.1097/00006250-200105000-00018

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Metadata

Authors
Jansson, N., Pettersson, J., Haafiz, A., Ericsson, A., Palmberg, I., Tranberg, M., Ganapathy, V., Powell, T. L., & Jansson, T.
Venue
The Journal of Physiology
Publisher
Wiley
Published
2006-10-27
Volume
576
Issue
3
Pages
935-946
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1113/jphysiol.2003.550004
OpenAlex
W4324264902
Cited by
266
References
59
FWCI
0.29
Type
journal article
Language
en
Open access
green
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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