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Dissociable Components of Rule-Guided Behavior Depend on Distinct Medial and Prefrontal Regions
Abstract
Card Sorting Monkeys: Single-neuron studies in primates help to establish a detailed understanding of cognitive processing and to provide an experimental base for understanding the cognitive deficits incurred by patients who have suffered damage to areas of the brain. Buckley et al. (p. 52 ) present the results of an intensive behavioral analysis of a group of monkeys bearing lesions to distinct areas of the prefrontal lobe. The Wisconsin Card Sorting Task is widely used in the clinic to assess the flexible learning of abstract rules. In the primates, a functional dissociation was observed across three regions: the principal sulcus, the orbitofrontal cortex, and the anterior cingulate cortex. This set of results contributes to the ongoing discussion of goal-directed behavior and serves to bridge neuropsychological studies in human patients and neurophysiological studies in primates.
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“Related evidence from monkeys performing a Wisconsin Card Sorting Test (WCST) again points to a role for the anterior cingulate cortex in representing error likelihoods and adjusting behavioural patterns following an error (Buckley et al., 2009; Kuwabara et al., 2014).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Buckley et al., 2009
In the citing paper
“Whereas preoperatively their monkeys scored 77% correct on the EC+1 trial type, postoperatively the monkeys with PFo lesions scored only 50% correct.”
From Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala (2011) · cites this paper as [95]
In the citing paper
“Buckley et al. (95) applied the same trial-by-trial analysis to data from monkeys with PFo lesions that had been trained on an analog of the Wisconsin Card Sorting Task.”
From Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala (2011) · cites this paper as [95]
In the citing paper
“Like the monkeys studied by Rudebeck and Murray (91), the PFo lesion group studied by Buckley et al. was inefficient in using positive feedback after rule changes, suggesting that PFo plays an important role in the valuation of rule representations as well as object representations.”
From Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala (2011) · cites this paper as [95]
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Research works printed but not linked: 1
- E. K. Miller T. J. Buschman in Neuroscience of Rule-Guided Behavior S. A. Bunge J. D. Wallis Eds. (Oxford Univ. Press New York 2008) pp. 419–440.
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Metadata
- Authors
- Buckley, M. J., Mansouri, F. A., Hoda, H., Mahboubi, M., Browning, P. G. F., Kwok, S. C., Phillips, A., & Tanaka, K.
- Affiliations
- University of Oxford (GB)
- RIKEN Center for Brain Science (JP)
- Corresponding author
- Buckley, Mark J.
- Mansouri, Farshad A.
- Venue
- Science
- Published
- 2009-07-03
- Volume
- 325
- Issue
- 5936
- Pages
- 52-58
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2078755291
- Cited by
- 319
- References
- 64
- Citations by year
- 2026: 14 · 2025: 14 · 2024: 19 · 2023: 15 · 2022: 14 · 2021: 19 · 2020: 17 · 2019: 12 · 2018: 24 · 2017: 18 · 2016: 28 · 2015: 23 · 2014: 22 · 2013: 14 · 2012: 20
- FWCI
- 10.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- orbitofrontal cortex, anterior cingulate cortex, dorsolateral prefrontal cortex, ventrolateral prefrontal cortex, lesion studies, working memory, rule updating, reward learning, decision-making, Wisconsin Card Sorting Test, macaque
- MeSH terms
- Animals, Behavior, Animal, Brain Mapping, Cues, Decision Making, Frontal Lobe, Learning, Macaca, Macaca mulatta, Memory, Short-Term, Neurons, Neuropsychological Tests, Reinforcement, Psychology, Reward, Prefrontal Cortex
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