CoChat
Sign Up
Cited by 361Neural and Behavioral Psychology StudiesNeurobiology of Language and BilingualismNeural dynamics and brain function

Neural Circuits Subserving the Retrieval and Maintenance of Abstract Rules

Bunge, Silvia A., Kahn, Itamar, Wallis, Jonathan D., Miller, Earl K., Wagner, Anthony D.·2003·Journal of Neurophysiology
DOI 10.1152/jn.00910.2002
Open this paper in CoChat — free account

Abstract

Behavior is often governed by abstract rules or instructions for behavior that can be abstracted from one context and applied to another. Prefrontal cortex (PFC) is thought to be important for representing rules, although the contributions of ventrolateral (VLPFC) and dorsolateral (DLPFC) regions remain under-specified. In the present study, event-related fMRI was used to examine abstract rule representation in humans. Prior to scanning, subjects learned to associate unfamiliar shapes and nonwords with particular rules. During each fMRI trial, presentation of one of these cues was followed by a delay and then by sample and probe stimuli. Match and non-match rules required subjects to indicate whether or not the sample and probe matched; go rules required subjects to make a response that was not contingent on the sample/probe relation. Left VLPFC, parietal cortex, and pre-SMA exhibited sensitivity to rule type during the cue and delay periods. Delay-period activation in these regions, but not DLPFC, was greater when subjects had to maintain response contingencies (match, non-match) relative to when the cue signaled a specific response (go). In contrast, left middle temporal cortex exhibited rule sensitivity during the cue but not delay period. These results support the hypothesis that VLPFC interacts with temporal cortex to retrieve semantic information associated with a cue and with parietal cortex to retrieve and maintain relevant response contingencies across delays. Future…

Integrity signals

Registry

Crossref · 10.1152/jn.00910.2002

Cites

70 of 70 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The PMv and middle frontal gyrus regions observed in the present study are similar to regions observed in relation to response selection by Bunge et al. (2003) and Schumacher and D'Esposito (2002).

    “The PMv and middle frontal gyrus regions observed in the present study are similar to regions observed in relation to response selection by Bunge et al. (2003) and Schumacher and D'Esposito (2002).”

    From The Neural Correlates of Motor Skill Automaticity (2005) · cites this paper as Bunge et al., 2003

  • Increased activity of bilateral ventrolateral prefrontal cortex (PMv/IFG) in the dual-task condition before training suggests that dual-task conditions may require greater control over stimulus-response mapping rules, even when the mappings are spatially compatible.

    “The increased activity of bilateral ventrolateral prefrontal cortex (PMv/IFG) in our dual-task condition before training suggests that dual-task conditions may require greater control over stimulus-response mapping rules, even in cases in which the mappings are spatially compatible.”

    From The Neural Correlates of Motor Skill Automaticity (2005) · cites this paper as Bunge et al., 2003

Cites

Flagged first, then by citations

1 of the 71 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Bunge, S. A., Kahn, I., Wallis, J. D., Miller, E. K., & Wagner, A. D.
Affiliations
University of California, Davis (US)
ORCID
Venue
Journal of Neurophysiology
Publisher
American Physiological Society
Published
2003-11
Volume
90
Issue
5
Pages
3419-3428
ISSN
  • 0022-3077 (ISSN-L)
  • 1522-1598
DOI
10.1152/jn.00910.2002
OpenAlex
W2080225983
Cited by
361
References
71
Citations by year
2026: 1 · 2025: 5 · 2024: 10 · 2023: 7 · 2022: 6 · 2021: 9 · 2020: 7 · 2019: 8 · 2018: 13 · 2017: 12 · 2016: 17 · 2015: 18 · 2014: 19 · 2013: 15 · 2012: 22
FWCI
7.82
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neurophysiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
rule retrieval, rule maintenance, ventrolateral prefrontal cortex, dorsolateral prefrontal cortex, parietal cortex, pre-supplementary motor area, middle temporal cortex, delay-period activity, response contingency, semantic search
MeSH terms
Acoustic Stimulation, Adolescent, Adult, Analysis of Variance, Cerebral Cortex, Cues, Female, Humans, Magnetic Resonance Imaging, Male, Nerve Net, Photic Stimulation, Psychomotor Performance, Reaction Time

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review