Neurogliaform cortical interneurons derive from cells in the preoptic area
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Delineating the basic cellular components of cortical inhibitory circuits remains a fundamental issue in order to understand their specific contributions to microcircuit function. It is still unclear how current classifications of cortical interneuron subtypes relate to biological processes such as their developmental specification. Here we identified the developmental trajectory of neurogliaform cells (NGCs), the main effectors of a powerful inhibitory motif recruited by long-range connections. Using in vivo genetic lineage-tracing in mice, we report that NGCs originate from a specific pool of 5-HT3AR-expressing Hmx3+ cells located in the preoptic area (POA). Hmx3-derived 5-HT3AR+ cortical interneurons (INs) expressed the transcription factors PROX1, NR2F2, the marker reelin but not VIP and exhibited the molecular, morphological and electrophysiological profile of NGCs. Overall, these results indicate that NGCs are a distinct class of INs with a unique developmental trajectory and open the possibility to study their specific functional contribution to cortical inhibitory microcircuit motifs.
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Most neurogliaform cells and multipolar NPY+ interneurons do not derive from Nkx2-1-expressing progenitors and most likely originate from the POH domain.
“Most of these cells do not derive from Nkx2-1-expressing progenitor cells”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Niquille et al., 2018
The CGE produces all VIP+ and CCK+ cortical interneurons along with several less abundant types such as single bouquet cells.
“the CGE produces all VIP+ and CCK+ cortical interneurons along with several other less abundant types of interneurons such as single bouquet cells”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Niquille et al., 2018
Neurogliaform cells and multipolar NPY+ interneurons are born in the preoptic region.
“Neurogliaform cells and multipolar NPY+ interneurons are born in the preoptic region”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Niquille et al., 2018
Interneurons generated in the preoptic region, especially neurogliaform cells, preferentially reach the cortex through the marginal zone.
“In addition, it has been suggested that interneurons generated in the preoptic region – most notably neurogliaform cells (Niquille et al., 2018) – preferentially reach the cortex through the MZ (Zimmer et al., 2011).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Niquille et al., 2018
Some CGE cell types (e.g., some neurogliaform cells) may be developmentally derived from the nearby preoptic region (PO).
“Note that some of the CGE cell types (e.g., some neurogliaform cells) may, in fact, be developmentally derived from the nearby preoptic region (PO) (Niquille et al., 2018).”
From A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation (2021) · cites this paper as Niquille et al., 2018
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Parvalbumin neurons and gamma rhythms enhance cortical circuit performance
Sohal, V. S., Zhang, F., Yizhar, O., & Deisseroth, K. (2009) · Nature · doi:10.1038/nature07991 · Cited by 2,606 · see citing works
Driving fast-spiking cells induces gamma rhythm and controls sensory responses
Cardin, J. A., Carlén, M., Meletis, K., Knoblich, U., Zhang, F., Deisseroth, K., Tsai, L.-H., & Moore, C. I. (2009) · Nature · doi:10.1038/nature08002 · Cited by 2,603 · see citing works
(2012) · doi:10.1016/j.jmoldx.2011.08.002 · Cited by 2,567 · see citing works
Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
Rudy, B., Fishell, G., Lee, S., & Hjerling‐Leffler, J. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20853 · Cited by 1,420 · see citing works
Pfeffer, C. K., Xue, M., He, M., Huang, Z. J., & Scanziani, M. (2013) · Nature Neuroscience · doi:10.1038/nn.3446 · Cited by 1,353 · see citing works
Cortical interneurons that specialize in disinhibitory control
Pi, H.-J., Hangya, B., Kvitsiani, D., Sanders, J. I., Huang, Z. J., & Kepecs, A. (2013) · Nature · doi:10.1038/nature12676 · Cited by 1,136 · see citing works
Interneuron cell types are fit to function
Kepecs, A., & Fishell, G. (2014) · Nature · doi:10.1038/nature12983 · Cited by 1,110 · see citing works
The origin and specification of cortical interneurons
Wonders, C. P., & Anderson, S. A. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1954 · Cited by 980 · see citing works
A Cortical Circuit for Gain Control by Behavioral State
Fu, Y., Tucciarone, J. M., Espinosa, J. S., Sheng, N., Darcy, D. P., Nicoll, R. A., Huang, Z. J., & Stryker, M. P. (2014) · Cell · doi:10.1016/j.cell.2014.01.050 · Cited by 937 · cited 5× · see citing works
“…the canonical cortical microcircuit have mainly relied on the use of the mutually exclusive SST-, PV- and VIP-Cre driver lines (Cardin et al., 2009; Fu et al., 2014; Kepecs and Fishell, 2014; Pfeffer et al., 2013; Pi et al., 2013; Pinto and Dan, 2015; Sohal et al., 2009; Zhang et al., 2014) but…”
BackgroundInfluentialPrinciples of connectivity among morphologically defined cell types in adult neocortex
Jiang, X., Shen, S., Cadwell, C. R., Berens, P., Sinz, F., Ecker, A. S., Patel, S., & Tolias, A. S. (2015) · Science · doi:10.1126/science.aac9462 · Cited by 908 · see citing works
Long-range and local circuits for top-down modulation of visual cortex processing
Zhang, S., Xu, M., Kamigaki, T., Hoang Do, J. P., Chang, W.-C., Jenvay, S., Miyamichi, K., Luo, L., & Dan, Y. (2014) · Science · doi:10.1126/science.1254126 · Cited by 804 · see citing works
Lee, S., Hjerling-Leffler, J., Zagha, E., Fishell, G., & Rudy, B. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1869-10.2010 · Cited by 600 · see citing works
The temporal and spatial origins of cortical interneurons predict their physiological subtype
Butt, S. J. B., Fuccillo, M., Nery, S., Noctor, S., Kriegstein, A., Corbin, J. G., & Fishell, G. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.034 · Cited by 587 · see citing works
Electrophysiological, transcriptomic and morphologic profiling of single neurons using Patch-seq
Cadwell, C. R., Palasantza, A., Jiang, X., Berens, P., Deng, Q., Yilmaz, M., Reimer, J., Shen, S., Bethge, M., Tolias, K. F., et al. (2016) · Nature Biotechnology · doi:10.1038/nbt.3445 · Cited by 581 · see citing works
Fate mapping Nkx2.1‐lineage cells in the mouse telencephalon
Xu, Q., Tam, M., & Anderson, S. A. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21529 · Cited by 560 · see citing works
Flames, N., Pla, R., Gelman, D. M., Rubenstein, J. L. R., Puelles, L., & Marín, O. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2750-07.2007 · Cited by 560 · see citing works
Miyoshi, G., Hjerling-Leffler, J., Karayannis, T., Sousa, V. H., Butt, S. J. B., Battiste, J., Johnson, J. E., Machold, R. P., & Fishell, G. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4515-09.2010 · Cited by 559 · see citing works
The caudal ganglionic eminence is a source of distinct cortical and subcortical cell populations
Nery, S., Fishell, G., & Corbin, J. G. (2002) · Nature Neuroscience · doi:10.1038/nn971 · Cited by 558 · see citing works
Fogarty, M., Grist, M., Gelman, D., Marín, O., Pachnis, V., & Kessaris, N. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1629-07.2007 · Cited by 412 · see citing works
Liodis, P., Denaxa, M., Grigoriou, M., Akufo-Addo, C., Yanagawa, Y., & Pachnis, V. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3055-06.2007 · Cited by 377 · see citing works
Intrinsically determined cell death of developing cortical interneurons
Southwell, D. G., Paredes, M. F., Galvao, R. P., Jones, D. L., Froemke, R. C., Sebe, J. Y., Alfaro-Cervello, C., Tang, Y., Garcia-Verdugo, J. M., Rubenstein, J. L., et al. (2012) · Nature · doi:10.1038/nature11523 · Cited by 365 · see citing works
Identified sources and targets of slow inhibition in the neocortex
Tamás, G., Simon, A. L., & Szabadics, J. (2003) · Science · doi:10.1126/science.1082053 · Cited by 359 · see citing works
Strategies and Tools for Combinatorial Targeting of GABAergic Neurons in Mouse Cerebral Cortex
He, M., Tucciarone, J., Lee, S., Nigro, M. J., Kim, Y., Levine, J. M., Kelly, S. M., Krugikov, I., Wu, P., Chen, Y., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.08.021 · Cited by 339 · see citing works
The organization of two new cortical interneuronal circuits
Jiang, X., Wang, G., Lee, A. J., Stornetta, R. L., & Zhu, J. J. (2013) · Nature Neuroscience · doi:10.1038/nn.3305 · Cited by 338 · see citing works
The requirement of Nkx2-1 in the temporal specification of cortical interneuron subtypes
Butt, S. J. B., Sousa, V. H., Fuccillo, M. V., Hjerling-Leffler, J., Miyoshi, G., Kimura, S., & Fishell, G. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.031 · Cited by 330 · see citing works
Cell-Type-Specific Activity in Prefrontal Cortex during Goal-Directed Behavior
Pinto, L., & Dan, Y. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.021 · Cited by 323 · see citing works
The Cellular Basis of GABA <sub>B</sub> -Mediated Interhemispheric Inhibition
Palmer, L. M., Schulz, J. M., Murphy, S. C., Ledergerber, D., Murayama, M., & Larkum, M. E. (2012) · Science · doi:10.1126/science.1217276 · Cited by 284 · see citing works
The embryonic preoptic area is a novel source of cortical GABAergic interneurons
Gelman, D. M., Martini, F. J., Nóbrega-Pereira, S., Pierani, A., Kessaris, N., & Marín, O. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0604-09.2009 · Cited by 280 · see citing works
The spatial and temporal origin of chandelier cells in mouse neocortex
Taniguchi, H., Lu, J., & Huang, Z. J. (2013) · Science · doi:10.1126/science.1227622 · Cited by 278 · see citing works
Nóbrega-Pereira, S., Kessaris, N., Du, T., Kimura, S., Anderson, S. A., & Marín, O. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.024 · Cited by 256 · see citing works
Mechanisms of Inhibition within the Telencephalon: “Where the Wild Things Are”
Fishell, G., & Rudy, B. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113717 · Cited by 233 · see citing works
NKX2.1 specifies cortical interneuron fate by activatingLhx6
Du, T., Xu, Q., Ocbina, P. J. R., & Anderson, S. A. (2008) · Development · doi:10.1242/dev.015123 · Cited by 220 · see citing works
The Cell-Intrinsic Requirement of Sox6 for Cortical Interneuron Development
Batista-Brito, R., Rossignol, E., Hjerling-Leffler, J., Denaxa, M., Wegner, M., Lefebvre, V., Pachnis, V., & Fishell, G. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.005 · Cited by 214 · cited 10× · see citing works
“1-expressing progenitors located in the medial ganglionic eminence (MGE) (Butt et al., 2008; Xu et al., 2008) and their specification is under the control of the TFs LHX6 (Du et al., 2008; Liodis et al., 2007) and SOX6 (Azim et al., 2009; Batista-Brito et al., 2009).”
BackgroundInfluentialPrönneke, A., Scheuer, B., Wagener, R. J., Möck, M., Witte, M., & Staiger, J. F. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv202 · Cited by 204 · see citing works
SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development
Azim, E., Jabaudon, D., Fame, R. M., & Macklis, J. D. (2009) · Nature Neuroscience · doi:10.1038/nn.2387 · Cited by 202 · see citing works
Integration of GABAergic interneurons into cortical cell assemblies: lessons from embryos and adults
Bartolini, G., Ciceri, G., & Marín, O. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.014 · Cited by 185 · see citing works
A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area
Gelman, D., Griveau, A., Dehorter, N., Teissier, A., Varela, C., Pla, R., Pierani, A., & Marín, O. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4068-11.2011 · Cited by 179 · see citing works
Kanatani, S., Yozu, M., Tabata, H., & Nakajima, K. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2132-08.2008 · Cited by 163 · see citing works
Vucurovic, K., Gallopin, T., Ferezou, I., Rancillac, A., Chameau, P., van Hooft, J. A., Geoffroy, H., Monyer, H., Rossier, J., & Vitalis, T. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhp310 · Cited by 139 · see citing works
Basket cell dichotomy in microcircuit function
Armstrong, C., & Soltész, I. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.223669 · Cited by 136 · see citing works
Miyoshi, G., Young, A., Petros, T., Karayannis, T., McKenzie Chang, M., Lavado, A., Iwano, T., Nakajima, M., Taniguchi, H., Huang, Z. J., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1164-15.2015 · Cited by 135 · see citing works
Toward a Genetic Dissection of Cortical Circuits in the Mouse
Huang, Z. J. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.041 · Cited by 123 · see citing works
Genetic programs controlling cortical interneuron fate
Kessaris, N., Magno, L., Rubin, A. N., & Oliveira, M. G. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.12.012 · Cited by 122 · see citing works
Sensory inputs control the integration of neurogliaform interneurons into cortical circuits
De Marco García, N. V., Priya, R., Tuncdemir, S. N., Fishell, G., & Karayannis, T. (2015) · Nature Neuroscience · doi:10.1038/nn.3946 · Cited by 117 · see citing works
Serotonin receptor 3A controls interneuron migration into the neocortex
Murthy, S. S., Niquille, M., Hurni, N., Limoni, G., Frazer, S. L., Chameau, P. J. P., van Hooft, J. A., Vitalis, T., & Dayer, A. G. (2014) · Nature Communications · doi:10.1038/ncomms6524 · Cited by 81 · see citing works
Self-citationMa, T., Zhang, Q., Cai, Y., You, Y., Rubenstein, J. L. R., & Yang, Z. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr296 · Cited by 79 · see citing works
Rubin, A. N., & Kessaris, N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077339 · Cited by 69 · see citing works
Craig, M. T., & McBain, C. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.10.002 · Cited by 56 · see citing works
Cai, Y., Zhang, Q., Wang, C., Zhang, Y., Ma, T., Zhou, X., Tian, M., Rubenstein, J. L. R., & Yang, Z. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23186 · Cited by 53 · see citing works
Decoding the transcriptional basis for GABAergic interneuron diversity in the mouse neocortex
Anastasiades, P. G., & Butt, S. J. B. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07904.x · Cited by 26 · see citing works
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A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation
Yao, Z., van Velthoven, C. T. J., Nguyen, T. N., Goldy, J., Sedeno-Cortes, A. E., Baftizadeh, F., Bertagnolli, D., Casper, T., Chiang, M., Crichton, K., et al. (2021) · Cell · doi:10.1016/j.cell.2021.04.021 · Cited by 1,065 · see citing works
Development and Functional Diversification of Cortical Interneurons
Lim, L., Mi, D., Llorca, A., & Marín, O. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.009 · Cited by 714 · see citing works
Diversity of Interneurons in the Dorsal Striatum Revealed by Single-Cell RNA Sequencing and PatchSeq
Muñoz-Manchado, A. B., Bengtsson Gonzales, C., Zeisel, A., Munguba, H., Bekkouche, B., Skene, N. G., Lönnerberg, P., Ryge, J., Harris, K. D., Linnarsson, S., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.053 · Cited by 229 · see citing works
GABAergic Restriction of Network Dynamics Regulates Interneuron Survival in the Developing Cortex
Duan, Z. R. S., Che, A., Chu, P., Modol, L., Bollmann, Y., Babij, R., Fetcho, R. N., Otsuka, T., Fuccillo, M. V., Liston, C., et al. (2020) · Neuron · doi:10.1016/j.neuron.2019.10.008 · Cited by 102 · see citing works
Astrocyte-secreted neurocan controls inhibitory synapse formation and function
Irala, D., Wang, S., Sakers, K., Nagendren, L., Severino, F. P. U., Bindu, D. S., Savage, J. T., & Eroğlu, Ç. (2024) · Neuron · doi:10.1016/j.neuron.2024.03.007 · Cited by 93 · see citing works
Chartrand, T., Dalley, R., Close, J., Goriounova, N. A., Lee, B. R., Mann, R., Miller, J. A., Molnar, G., Mukora, A., Alfiler, L., et al. (2023) · Science · doi:10.1126/science.adf0805 · Cited by 88 · see citing works
Wester, J. C., Mahadevan, V., Rhodes, C. T., Calvigioni, D., Venkatesh, S., Maric, D., Hunt, S., Yuan, X. Q., Zhang, Y., Petros, T. J., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.036 · Cited by 66 · see citing works
Sleep down state-active ID2/Nkx2.1 interneurons in the neocortex
Valero, M., Viney, T. J., Machold, R. P., Mederos, S., Zutshi, I., Schuman, B., Senzai, Y., Rudy, B., & Buzsáki, G. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00797-6 · Cited by 64 · see citing works
Identification of visual cortex cell types and species differences using single-cell RNA sequencing
Wei, J.-R., Hao, Z.-Z., Xu, C., Huang, M., Tang, L., Xu, N., Liu, R., Shen, Y., Teichmann, S. A., Miao, Z., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34590-1 · Cited by 55 · see citing works
GABAergic System Dysfunction and Challenges in Schizophrenia Research
Jahangir, M., Zhou, J., Lang, B., & Wang, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.663854 · Cited by 52 · see citing works
Mining the jewels of the cortex’s crowning mystery
Ibrahim, L. A., Schuman, B., Bandler, R. C., Rudy, B., & Fishell, G. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.04.005 · Cited by 48 · see citing works
Winterer, J., Lukacsovich, D., Que, L., Sartori, A. M., Luo, W., & Földy, C. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14549 · Cited by 40 · see citing works
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Fisher, J., Verhagen, M. G., Long, Z., Moissidis, M., Yan, Y., He, C., Wang, J., Micoli, E., Alastruey, C. M., Moors, R., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.11.013 · Cited by 36 · see citing works
Regulation of the E/I-balance by the neural matrisome
Mueller-Buehl, C., Wegrzyn, D., Bauch, J., & Faissner, A. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1102334 · Cited by 32 · see citing works
Generating neural diversity through spatial and temporal patterning
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Decoding gene networks controlling hypothalamic and prethalamic neuron development
Kim, D. W., Duncan, L. H., Xu, Z., Chang, M., Sejer, S., Terrillion, C. E., Kanold, P. O., Place, E., & Blackshaw, S. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115858 · Cited by 21 · see citing works
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Asgarian, Z., Magno, L., Ktena, N., Harris, K. D., & Kessaris, N. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.09.008 · Cited by 24 · see citing works
Being superficial: a developmental viewpoint on cortical layer 1 wiring
Genescu, I., & Garel, S. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.10.003 · Cited by 21 · see citing works
Zimmer‐Bensch, G. (2018) · Brain Research · doi:10.1016/j.brainres.2018.09.001 · Cited by 21 · see citing works
Serotonergic regulation of bipolar cell survival in the developing cerebral cortex
Wong, F. K., Selten, M. M., Rosés-Novella, C., Sreenivasan, V., Pallas‐Bazarra, N., Serafeimidou‐Pouliou, E., Hanusz-Godoy, A., Oozeer, F., Edwards, R. H., & Marín, Ó. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111037 · Cited by 19 · see citing works
Limoni, G., Murthy, S. S., Jabaudon, D., Dayer, A. G., & Niquille, M. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108644 · Cited by 21 · see citing works
Self-citationGenescu, I., Aníbal-Martínez, M., Kouskoff, V., Chenouard, N., Mailhes‐Hamon, C., Cartonnet, H., Lokmane, L., Rijli, F. M., López‐Bendito, G., Gambino, F., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110667 · Cited by 19 · see citing works
A ‘Marginal’ tale: the development of the neocortical layer 1
Gesuita, L., & Karayannis, T. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.09.002 · Cited by 17 · see citing works
Iannone, A. F., & García, N. V. D. M. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.04.005 · Cited by 17 · see citing works
Li, J., Zheng, S., Dong, Y., Xu, H., Zhu, Y.-Y., Weng, J., Sun, D., Wang, S.-C., Xiao, L., & Jiang, Y. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.08.021 · Cited by 14 · see citing works
Shi, Y., Cui, H. F., Li, X., Chen, L., Zhang, C., Zhao, X., Li, X., Shao, Q., Sun, Q., Yan, K., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112782 · Cited by 18 · see citing works
Reichard, J., Wolff, P., Xie, S., Zuo, K., Fullio, C. L., Du, J., Graff, S., Linde, J., Yildiz, C. B., Pitschelatow, G., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62114-0 · Cited by 13 · see citing works
Alzu’bi, A., & Clowry, G. J. (2020) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2020.00061 · Cited by 12 · see citing works
Venkataramanappa, S., Saaber, F., Abe, P., Schütz, D., Kumar, P. A., & Stumm, R. K. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111157 · Cited by 14 · see citing works
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Iannone, A. F., Akgül, G., Zhang, R., Wacks, S., Hussein, N., Macias, C. G., Donatelle, A., Bauriedel, J. M. J., Wright, C., Abramov, D., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114531 · Cited by 9 · see citing works
Harrach, M. A., Yochum, M., Ruffini, G., Bartoloméi, F., Wendling, F., & Benquet, P. (2024) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2024.108934 · Cited by 7 · see citing works
Chang, C.-C., Kuo, H., Chen, S., Lu, K.-M., Fong, W. L., Wu, H.-L., Saito, T., & Liu, F.-C. (2020) · The Journal of Comparative Neurology · doi:10.1002/cne.24900 · Cited by 7 · see citing works
Application of Lineage Tracing in Central Nervous System Development and Regeneration
Li, H., Zhuang, Y., Zhang, B., Xu, X., & Liu, B. (2023) · Molecular Biotechnology · doi:10.1007/s12033-023-00769-0 · Cited by 6 · see citing works
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Ozsvár, A., Sieburg, M. C., Sietam, M. D., Hou, W., & Capogna, M. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1254460 · Cited by 5 · see citing works
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Vighagen, R., Gesuita, L., Damilou, A., Cavaccini, A., Banterle, L., Steenhuis, V., & Karayannis, T. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.02.470902 · Cited by 1 · see citing works
Markopoulos, F., Chéreau, R., Brandalise, F., Chippalkatti, V., Prados, J., Dayer, A. G., & Holtmaat, A. J. D. G. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.30.651595 · Cited by 1 · see citing works
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Yáñez, F., Messore, F., Qi, G., Dehghani, N., Meyer, H., Feldmeyer, D., Sakmann, B. J., & Oberlaender, M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.05.709819
Assembling layer 1 of the neocortex : roles of Cajal-Retzius cells
Genescu, I. (2020) · theses.fr (ABES) · doi:10.70675/3fe1b21cz5c6bz4150z94e6zd77163aba0ad
Ontogeny of the enteric nervous system
Boismoreau, F. (2020) · doi:10.70675/b24ef52fz17c8z48e3za3afz5cc386550b86
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Riva, M. (2021) · theses.fr (ABES) · doi:10.70675/b321eca5ze455z480bzb6d4z43505d8c9faf
Gene expression mapping of conserved GABAergic interneuron markers in developing zebrafish
Zhu, B., & Baraban, S. C. (2026) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2026.1849805
Tangential migration in the telencephalon
Boutsen, A., Close, R., Bonafina, A., & Nguyen, L. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-24078-2.00003-6
- Authors
- Niquille, M., Limoni, G., Markopoulos, F., Cadilhac, C., Prados, J., Holtmaat, A., & Dayer, A.
- Affiliations
- University of Geneva (CH)
- Corresponding author
- Dayer, Alexandre
- ORCID
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2018-03-20
- Volume
- 7
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC5860868
- OpenAlex
- W2793456087
- Cited by
- 55
- References
- 50
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 8 · 2022: 9 · 2021: 10 · 2020: 9 · 2019: 4 · 2018: 3
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (acceptedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Synapsy 51NF40-158776; 31003A_153448 and CRSII3_154453, Synapsy 51NF40-158776 and 31003A_155896/1)
- International Foundation for Research in Paraplegia (Chair Alain Rossier)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- neurogliaform cells, cortical interneurons, preoptic area, 5-HT3 receptor, interneuron subtypes, Prox1, NR2F2, reelin, VIP
- MeSH terms
- Reelin Protein, Action Potentials, Animals, Cerebral Cortex, Interneurons, Mice, Inbred C57BL, Mice, Transgenic, Nerve Tissue Proteins, Preoptic Area, Transcription Factors, Gene Expression, Homeodomain Proteins, Microscopy, Confocal, Cell Lineage, Receptors, Serotonin, 5-HT3, Green Fluorescent Proteins
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