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Living Tissue Formed in Vitro and Accepted as Skin-Equivalent Tissue of Full Thickness
Abstract
Living skin-equivalent grafts consisting of fibroblasts cast in collagen lattices and seeded with epidermal cells were successfully grafted onto the donors of the cells. The grafts were vascularized, did not evoke a homograft reaction, inhibited wound contraction, filled the wound space, and persisted.
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Lutolf, M. P., & Hubbell, J. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1055 · Cited by 4,551
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Grinnell, F. (2003) · Trends in Cell Biology · doi:10.1016/s0962-8924(03)00057-6 · Cited by 819
Tissue Engineering and Regenerative Medicine: History, Progress, and Challenges
Berthiaume, F., Maguire, T. J., & Yarmush, M. L. (2011) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-061010-114257 · Cited by 734
Fibroblasts and myofibroblasts in wound healing: Force generation and measurement
Li, B., & Wang, J. H.-C. (2011) · Journal of Tissue Viability · doi:10.1016/j.jtv.2009.11.004 · Cited by 594
Fibroblast heterogeneity: more than skin deep
Sorrell, J. M., & Caplan, A. I. (2004) · Journal of Cell Science · doi:10.1242/jcs.01005 · Cited by 553
Iron Oxide Nanoparticles for Magnetically-Guided and Magnetically-Responsive Drug Delivery
Estelrich, J., Escribano, E., Queralt, J., & Busquets, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16048070 · Cited by 532
The Reconstitution of Living Skin
Bell, E., Sher, S., Hull, B., Merrill, C., Rosen, S., Chamson, A., Asselineau, D., Dubertret, L., Lapiere, C., Neveux, Y., et al. (1983) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12539993 · Cited by 504
Self-citationSun, W., Starly, B., Daly, A. C., Burdick, J. A., Groll, J., Skeldon, G., Shu, W., Sakai, Y., Shinohara, M., Nishikawa, M., et al. (2020) · Biofabrication · doi:10.1088/1758-5090/ab5158 · Cited by 426
Skin-on-a-chip model simulating inflammation, edema and drug-based treatment
Wufuer, M., Lee, G., Hur, W., Jeon, B., Kim, B. J., Choi, T. H., & Lee, S. (2016) · Scientific Reports · doi:10.1038/srep37471 · Cited by 356
Organ-on-a-chip platforms: a convergence of advanced materials, cells, and microscale technologies
Ahadian, S., Civitarese, R., Bannerman, D., Mohammadi, M. H., Lu, R., Wang, E., Davenport‐Huyer, L., Lai, B., Zhang, B., Zhao, Y., et al. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201700506 · Cited by 315
Collagen—emerging collagen based therapies hit the patient
Abou Neel, E. A., Bozec, L., Knowles, J. C., Syed, O., Mudera, V., Day, R., & Hyun, J. K. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.08.010 · Cited by 296
Dermal Matrices and Bioengineered Skin Substitutes: A Critical Review of Current Options
Debels, H., Hamdi, M., Abberton, K., & Morrison, W. (2015) · Plastic and Reconstructive Surgery Global Open · doi:10.1097/gox.0000000000000219 · Cited by 227
Human Epidermis Reconstructed by Culture: Is It “Normal”?
Asselineau, D., Bernard, B. A., Bailly, C., Darmon, M., & Pruniéras, M. (1986) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12284237 · Cited by 192
Ma, L., Gao, C., Mao, Z., Zhou, J., & Shen, J. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2003.09.092 · Cited by 176
Takezawa, T., Ozaki, K., Nitani, A., Takabayashi, C., & Shimo-Oka, T. (2004) · Cell Transplantation · doi:10.3727/000000004783983882 · Cited by 165
Unger, C., Kramer, N., Walzl, A., Scherzer, M., Hengstschläger, M., & Dolznig, H. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.10.015 · Cited by 158
Stem cells and tissue engineering: past, present, and future
POLAK, J. M., & BISHOP, A. E. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1346.001 · Cited by 155
Reijnders, C. M. A., van Lier, A., Roffel, S., Kramer, D., Scheper, R. J., & Gibbs, S. (2015) · Tissue Engineering Part A · doi:10.1089/ten.tea.2015.0139 · Cited by 147
“23 23–26 The epidermal cells undergo several morphological and biochemical changes leading to the following structural layers: the basal layer, spinous layer, granular layer, and cornified layer.”
Andreadis, S. T., Hamoen, K. E., Yarmush, M. L., & Morgan, J. R. (2001) · The FASEB Journal · doi:10.1096/fsb2fj000324com · Cited by 147
El Ghalbzouri, A., Commandeur, S., Rietveld, M. H., Mulder, A. A., & Willemze, R. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.09.002 · Cited by 121
Skin organoids: a new human model for developmental and translational research
Lee, J., & Koehler, K. R. (2021) · Experimental Dermatology · doi:10.1111/exd.14292 · Cited by 85
Modeling human HSV infection via a vascularized immune-competent skin-on-chip platform
Sun, S., Jin, L., Zheng, Y., & Zhu, J. (2022) · Nature Communications · doi:10.1038/s41467-022-33114-1 · Cited by 78
Reconstruction of renal glomerular tissue using collagen vitrigel scaffold
Wang, P.-C., & Takezawa, T. (2005) · Journal of Bioscience and Bioengineering · doi:10.1263/jbb.99.529 · Cited by 59
Human reconstructed skin xenografts on mice to model skin physiology
Salgado, G., Ng, Y. Z., Koh, L. F., Goh, C. S. M., & Common, J. E. (2017) · Differentiation · doi:10.1016/j.diff.2017.09.004 · Cited by 56
Vascularized 3D Human Skin Models in the Forefront of Dermatological Research
Rimal, R., Muduli, S., Desai, P., Marquez, A. B., Möller, M., Platzman, I., Spatz, J., & Singh, S. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202303351 · Cited by 46
Single-cell transcriptomics of human-skin-equivalent organoids
Stabell, A. R., Lee, G. E., Jia, Y., Wong, K. N., Wang, S., Ling, J., Nguyen, S. D., Sen, G. L., Nie, Q., & Atwood, S. X. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112511 · Cited by 30
Diabetic Foot Ulcers: Evaluation and Management
Maderal, A. D., Vivas, A. C., Zwick, T. G., & Kirsner, R. S. (2012) · Hospital Practice · doi:10.3810/hp.2012.08.994 · Cited by 15
Falanga, V., & Faria, K. (2007) · Principles of Tissue Engineering · doi:10.1016/b978-012370615-7/50081-0 · Cited by 13
Diversity of human skin three-dimensional organotypic cultures
Jia, Y. Y., & Atwood, S. X. (2024) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2024.102275 · Cited by 12
Metadata
- Authors
- Bell, E., Ehrlich, H. P., Buttle, D. J., & Nakatsuji, T.
- Venue
- Science
- Published
- 1981-03-06
- Volume
- 211
- Issue
- 4486
- Pages
- 1052-1054
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1992104579
- Cited by
- 1,052
- References
- 0
- FWCI
- 13.50
- Type
- journal article
- Language
- en
- Open access
- closed
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