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Cited by 694

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Thalamic Abnormalities in Schizophrenia Visualized Through Magnetic Resonance Image Averaging

Andreasen, Nancy C., Arndt, Stephan, Swayze, Victor, Cizadlo, Ted, Flaum, Michael, O'Leary, Daniel, Ehrhardt, James C., Yuh, William T. C.·1994·Science
DOI 10.1126/science.7939669
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Abstract

Schizophrenia is a complex illness characterized by multiple types of symptoms involving many aspects of cognition and emotion. Most efforts to identify its underlying neural substrates have focused on a strategy that relates a single symptom to a single brain region. An alternative hypothesis, that the variety of symptoms could be explained by a lesion in midline neural circuits mediating attention and information processing, is explored. Magnetic resonance images from patients and controls were transformed with a "bounding box" to produce an "average schizophrenic brain" and an "average normal brain." After image subtraction of the two averages, the areas of difference were displayed as an effect size map. Specific regional abnormalities were observed in the thalamus and adjacent white matter. An abnormality in the thalamus and related circuitry explains the diverse symptoms of schizophrenia parsimoniously because they could all result from a defect in filtering or gating sensory input, which is one of the primary functions of the thalamus in the human brain.

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Cited by

Metadata

Authors
Andreasen, N. C., Arndt, S., Swayze, V., Cizadlo, T., Flaum, M., O'Leary, D., Ehrhardt, J. C., & Yuh, W. T. C.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1994-10-14
Volume
266
Issue
5183
Pages
294-298
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.7939669
OpenAlex
W2155752633
Cited by
694
References
2
FWCI
33.96
Type
journal article
Language
en
Open access
closed

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