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Cited by 1,188

The DOI matches its Crossref record.

Association of the APC Tumor Suppressor Protein with Catenins

Su, Li-Kuo, Vogelstein, Bert, Kinzler, Kenneth W.·1993·Science
DOI 10.1126/science.8259519
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Abstract

Mutations of APC appear to initiate sporadic and inherited forms of human colorectal cancer. Although these mutations have been well characterized, little is known about the function of the APC gene product. Two cellular proteins that associate with APC were identified by nucleotide sequence analysis and peptide mapping as the E-cadherin-associated proteins α- and β-catenin. A 27-residue fragment of APC containing a 15-amino acid repeat was sufficient for the interaction with the catenins. These results suggest an important link between tumor initiation and cell adhesion.

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Metadata

Authors
Su, L.-K., Vogelstein, B., & Kinzler, K. W.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1993-12-10
Volume
262
Issue
5140
Pages
1734-1737
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.8259519
OpenAlex
W1967243795
Cited by
1,188
References
0
FWCI
31.85
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.