Anterior hypothalamic vasopressin regulates pair-bonding and drug-induced aggression in a monogamous rodent
Open accessAbstract
After pair-bonding, male prairie voles (Microtus ochrogaster) display aggression toward novel females but not toward their female partner. Here we show that this selective aggression in pair-bonded male prairie voles is associated with increased release of vasopressin (AVP) in the anterior hypothalamus (AH). Pharmacological activation of AVP-V1a receptors (V1aR) in the AH induced selective aggression in sexually naive males, whereas V1aR blockade diminished selective aggression in pair-bonded males. Pair-bonded males also showed an increased density in V1aR binding in the AH compared to their sexually naive counterparts and overexpression of V1aR in the AH, by viral vector-mediated gene transfer, facilitated aggression toward novel females. These data demonstrate that AH-AVP is both necessary and sufficient in the regulation of selective aggression associated with pair-bonding. In the second part of this study, we examined the effects of amphetamine (AMPH) exposure on female-directed aggression and revealed the potential role of AH-AVP underlying this behavior. Repeated AMPH administration in sexually naive male prairie voles enhanced V1aR expression in the AH and induced aggression toward a familiar or unfamiliar female. In addition, this AMPH-induced aggression was blocked by intra-AH administration of a V1aR antagonist. Together, our data reveal a socioneurobiological mechanism, highlighting a critical role of AH-AVP in the regulation of aggression induced by pair-bonding or drug experience in socially monogamous male prairie voles.
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AVPR1a density in the AH is increased in pair-bonded male voles over sexually naïve males, and viral-mediated overexpression of AVPR1a in this region increases mate guarding.
“AVPR1a density in the AH is increased in pair-bonded male voles over sexually naïve males, and viral-mediated overexpression of AVPR1a in this region increases mate guarding.”
From The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives (2023) · cites this paper as [154]
AVP has been associated with territorial aggression in other species, and activity at AVPR1as in the anterior hypothalamus specifically promotes mate guarding in prairie voles.
“AVP has been associated with territorial aggression in other species, and activity at AVPR1as in the anterior hypothalamus (AH) specifically promotes mate guarding in prairie voles [154].”
From The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives (2023) · cites this paper as [154]
Sexually naïve male prairie voles exhibit relatively low levels of aggression directed at strangers, but following two weeks of cohabitation, mate guarding emerges.
“Sexually naïve male prairie voles exhibit relatively low levels of aggression directed at strangers, but following two weeks of cohabitation, mate guarding emerges.”
From The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives (2023) · cites this paper as [154]
Pair-bonded male prairie voles develop selective aggression towards strangers following pair bond formation.
“To prevent their partner from mating with another male and to prevent another female from threatening an existing bond, pair-bonded males will develop selective aggression towards strangers following pair bond formation (Figure 2e).”
From The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives (2023) · cites this paper as [154]
Vasopressin is also produced in the suprachiasmatic nucleus, which regulates circadian rhythms, and in the accessory nuclei/nucleus circularis region, a likely source of vasopressin regulating aggression and competitive communication.
“AVP is also produced in other hypothalamic nuclei such as the suprachiasmatic nucleus, well known for regulating circadian rhythms (42), and the accessory nuclei/nucleus circularis region, a likely source of AVP regulating aggression and competitive communication (43).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [43]
Vasopressin also plays a role in aggression in prairie voles and Syrian hamsters, sometimes in a sex-specific manner.
“AVP also plays a role in aggression in prairie voles and Syrian hamsters, sometimes in a sex-specific manner.”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [43]
Pharmacological studies revealed that vasopressin in the anterior hypothalamus facilitates intermale aggression both in prairie voles and hamsters, while the opposite effect was found in female hamsters.
“For example, pharmacological studies revealed that AVP in the anterior hypothalamus facilitates intermale aggression both in prairie voles and hamsters (16,43,116), while the opposite effect was found in female hamsters (117).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [43]
V1aR signaling in the ventral pallidum and lateral septum promote partner preferences, while pair bond-induced aggression is mediated by V1aR in the lateral hypothalamus.
“V1aR signaling in the ventral pallidum and LS promote partner preferences (149), while pair bond-induced aggression is mediated by V1aR in the lateral hypothalamus (43,150).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [43]
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- Authors
- Gobrogge, K. L., Liu, Y., Young, L. J., & Wang, Z.
- Affiliations
- Florida State University (US)
- Emory University (US)
- Corresponding author
- Wang, Zuoxin
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-11-10
- Volume
- 106
- Issue
- 45
- Pages
- 19144-19149
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2776424
- OpenAlex
- W2069625275
- Cited by
- 178
- References
- 56
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 4 · 2023: 10 · 2022: 6 · 2021: 10 · 2020: 10 · 2019: 9 · 2018: 15 · 2017: 17 · 2016: 12 · 2015: 14 · 2014: 17 · 2013: 14 · 2012: 14
- FWCI
- 12.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (MHF31-79600, DAR01-19627, MHR01-58616, DAK02-23048)
- U.S. Public Health Service (DAK02-23048, DAR01-19627, MHR01-58616, MHF31-79600)
- National Institute of Mental Health (MH-64692, K02MH064692, R29MH056897, MH 56897, R01MH056897)
- National Institute of Neurological Disorders and Stroke (T-32-NS-07437, T32NS007437)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- vasopressin, anterior hypothalamus, pair bonding, Microtus ochrogaster, V1a receptor, amphetamine, social monogamy, V1a receptor antagonist
- MeSH terms
- Aggression, Amphetamine, Analysis of Variance, Animals, Autoradiography, Arvicolinae, Enzyme-Linked Immunosorbent Assay, Female, Anterior Hypothalamic Nucleus, Male, Pair Bond, Sexual Behavior, Animal, Vasopressins, Antidiuretic Hormone Receptor Antagonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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