Rat Indwelling Urinary Catheter Model of Candida albicans Biofilm Infection

Nett, Jeniel E.; Brooks, Erin G.; Cabezas-Olcoz, Jonathan; Sanchez, Hiram; Zarnowski, Robert; Marchillo, Karen; Andes, David R.

doi:10.1128/iai.02284-14

Cited by 58Antifungal resistance and susceptibilityUrinary Tract Infections ManagementBacterial biofilms and quorum sensing

Rat Indwelling Urinary Catheter Model of Candida albicans Biofilm Infection

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Nett, Jeniel E., Brooks, Erin G., Cabezas-Olcoz, Jonathan, Sanchez, Hiram, Zarnowski, Robert, Marchillo, Karen, Andes, David R.·2014·Infection and Immunity

DOI 10.1128/iai.02284-14PMC PMC4249295

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Abstract

Indwelling urinary catheters are commonly used in the management of hospitalized patients. Candida can adhere to the device surface and propagate as a biofilm. These Candida biofilm communities differ from free-floating Candida , exhibiting high tolerance to antifungal therapy. The significance of catheter-associated candiduria is often unclear, and treatment may be problematic considering the biofilm drug-resistant phenotype. Here we describe a rodent model for the study of urinary catheter-associated Candida albicans biofilm infection that mimics this common process in patients. In the setting of a functioning, indwelling urinary catheter in a rat, Candida proliferated as a biofilm on the device surface. Characteristic biofilm architecture was observed, including adherent, filamentous cells embedded in an extracellular matrix. Similar to what occurs in human patients, animals with this infection developed candiduria and pyuria. Infection progressed to cystitis, and a biofilmlike covering was observed over the bladder surface. Furthermore, large numbers of C. albicans cells were dispersed into the urine from either the catheter or bladder wall biofilm over the infection period. We successfully utilized the model to test the efficacy of antifungals, analyze transcriptional patterns, and examine the phenotype of a genetic mutant. The model should be useful for future investigations involving the pathogenesis, diagnosis, therapy, prevention, and drug resistance of Candida biofilms in the urinary tract.

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Biofilm architectures in rat and rabbit central venous and indwelling urinary catheter models and in rat denture stomatitis models include numerous yeast cells in the basal region, and hyphae and extracellular matrix extending throughout the biofilm.
“Biofilm architectures in rat and rabbit central venous and indwelling urinary catheter models and in rat denture stomatitis models also include numerous yeast cells in the basal region, and hyphae and extracellular matrix extending throughout the biofilm (5, 84, 131, 134, 166, 173, 199).”
From Candida albicans Biofilms and Human Disease (2015) · cites this paper as [131]

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Rat Indwelling Urinary Catheter Model of Candida albicans
Nett, J. E., Brooks, E. G., Cabezas‐Olcoz, J., Sánchez, H., Żarnowski, R., Marchillo, K., & Andes, D. R. (2014)
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Authors: Nett, J. E., Brooks, E. G., Cabezas-Olcoz, J., Sanchez, H., Zarnowski, R., Marchillo, K., & Andes, D. R.
Affiliations: University of Wisconsin–Madison (US)
Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA
ORCID: Nett, Jeniel E.
Brooks, Erin G.
Andes, David R.
Venue: Infection and Immunity
Publisher: American Society for Microbiology
Published: 2014-12
Volume: 82
Issue: 12
Pages: 4931-4940
ISSN: 0019-9567 (ISSN-L)
1098-5522
DOI: 10.1128/iai.02284-14
PMC: PMC4249295
OpenAlex: W2161017048
Cited by: 58
References: 70
Citations by year: 2026: 3 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 17 · 2018: 5 · 2017: 10 · 2016: 4 · 2015: 3
FWCI: 3.97
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Infection and Immunity (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (T32HL007899)
National Institute of Allergy and Infectious Diseases (K08AI108727, R01AI073289)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Epidemiology › Urinary Tract Infections Management
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Keywords: Candida albicans, biofilm, indwelling urinary catheter, rat model, antifungal resistance, cystitis, pyuria, extracellular matrix, antifungal susceptibility testing, gene expression profiling
MeSH terms: Animals, Candida albicans, Candidiasis, Catheters, Indwelling, Cystitis, Disease Models, Animal, Female, Pyuria, Rats, Sprague-Dawley, Biofilms, Urinary Catheters

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Rat Indwelling Urinary Catheter Model of Candida albicans Biofilm Infection

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