Experimental transmission of Bartonella henselae by the cat flea
Open accessAbstract
Bartonella henselae is an emerging bacterial pathogen, causing cat scratch disease and bacillary angiomatosis. Cats bacteremic with B. henselae constitute a large reservoir from which humans become infected. Prevention of human infection depends on elucidation of the natural history and means of feline infection. We studied 47 cattery cats in a private home for 12 months to determine the longitudinal prevalence of B. henselae bacteremia, the prevalence of B. henselae in the fleas infesting these cats, and whether B. henselae is transmitted experimentally to cats via fleas. Vector-mediated transmission of B.henselae isolates was evaluated by removing fleas from the naturally bacteremic, flea-infested cattery cats and transferring these fleas to specific-pathogen-free (SPF) kittens housed in a controlled, arthropod-free University Animal Facility. B. henselae bacteremia was detected in 89% of the 47 naturally infected cattery cats. A total of 132 fleas were removed from cats whose blood was simultaneously cultured during different seasons and were tested individually for the presence of B. henselae DNA by PCR. B. henselae DNA was detected in 34% of 132 fleas, with seasonal variation, but without an association between the presence or the level of bacteremia in the corresponding cat. Cat fleas removed from bacteremic cattery cats transmitted B. henselae to five SPF kittens in two separate experiments; however, control SPF kittens housed with highly bacteremic kittens in the absence of fleas did not become infected. These data demonstrate that the cat flea readily transmits B. henselae to cats. Control of feline infestation with this arthropod vector may provide an important strategy for the prevention of infection of both humans and cats.
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Infection of cats by bites of infected fleas has been experimentally demonstrated, although it is not considered a primary route of transmission.
“Infection of cats by bites of infected fleas has been experimentally demonstrated, although not considered a primary route of transmission [30,44,45].”
From Fleas infesting pets in the era of emerging extra-intestinal nematodes (2013) · cites this paper as [44]
Human infection by flea-borne Bartonella spp. generally occurs via scratches of infected cats, while flea bites do not seem to play a key role in the epidemiology of human bartonellosis.
“The human infection by flea-borne Bartonella spp. generally occurs via scratches of infected cats, whilst flea bites do not seem to play a key role in the epidemiology of human bartonellosis.”
From Fleas infesting pets in the era of emerging extra-intestinal nematodes (2013) · cites this paper as [44]
Fleas of pets are capable of harboring Bartonella spp. and it seems plausible that Ctenocephalides felis transmits Bartonella henselae actively.
“Fleas of pets are capable of harboring Bartonella spp. and it seems plausible that C. felis transmits B. henselae actively.”
From Fleas infesting pets in the era of emerging extra-intestinal nematodes (2013) · cites this paper as [44]
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- Authors
- Chomel, B. B., Kasten, R. W., Floyd-Hawkins, K., Chi, B., Yamamoto, K., Roberts-Wilson, J., Gurfield, A. N., Abbott, R. C., Pedersen, N. C., & Koehler, J. E.
- Affiliations
- University of California, Davis (US)
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 1996-08
- Volume
- 34
- Issue
- 8
- Pages
- 1952-1956
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- PMC
- PMC229161
- OpenAlex
- W2118874922
- Cited by
- 617
- References
- 30
- Citations by year
- 2026: 12 · 2025: 9 · 2024: 24 · 2023: 19 · 2022: 20 · 2021: 21 · 2020: 23 · 2019: 19 · 2018: 22 · 2017: 18 · 2016: 16 · 2015: 22 · 2014: 12 · 2013: 24 · 2012: 34
- FWCI
- 15.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Microbiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r29ai036075-05)
- National Institute of Allergy and Infectious Diseases (R29 AI36075)
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Bartonella species infections research
- Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacillus and Francisella bacterial research
- Keywords
- Bartonella henselae, Ctenocephalides felis, cat scratch disease, bacillary angiomatosis, flea infestation, seasonal variation, experimental transmission, zoonotic transmission
- MeSH terms
- Adult, Animals, Cat Diseases, Cat-Scratch Disease, Cats, Ectoparasitic Infestations, Siphonaptera, Humans, Insect Vectors, Longitudinal Studies, Male, Skin, Prevalence, Bacteremia
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