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β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis
Open accessAbstract
Objectives Pathologic fibroblast activation drives fibrosis of the skin and internal organs in patients with systemic sclerosis (SSc). β-catenin is an integral part of adherens junctions and a central component of canonical Wnt signaling. Here, the authors addressed the role of β-catenin in fibroblasts for the development of SSc dermal fibrosis.Methods Nuclear accumulation of β-catenin in fibroblasts was assessed by triple staining for β-catenin, prolyl-4-hydroxylase-β and 4',6-diamidino-2-phenylindole (DAPI). The expression of Wnt proteins in the skin was analysed by real-time PCR and immunohistochemistry. Mice with fibroblast-specific stabilisation or fibroblast-specific depletion were used to evaluate the role of β-catenin in fibrosis.Results The auhors found significantly increased nuclear levels of β-catenin in fibroblasts in SSc skin compared to fibroblasts in the skin of healthy individuals. The accumulation of β-catenin resulted from increased expression of Wnt-1 and Wnt-10b in SSc. The authors further showed that the nuclear accumulation of β-catenin has direct implications for the development of fibrosis: Mice with fibroblast-specific stabilisation of β-catenin rapidly developed fibrosis within 2 weeks with dermal thickening, accumulation of collagen and differentiation of resting fibroblasts into myofibroblasts. By contrast, fibroblast-specific deletion of β-catenin significantly reduced bleomycin-induced dermal fibrosis.Conclusions The present study findings identify β-catenin as a key player of fibroblast activation and tissue fibrosis in SSc. Although further translational studies are necessary to test the efficacy and tolerability of β-catenin/Wnt inhibition in SSc, the present findings may have clinical implications, because selective inhibitors of β-catenin/Wnt signaling have recently entered clinical trials.
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“TGFβ signaling via p38 MAPK lowers dickkopf-1 (DKK1) expression (62), which is an inhibitor of canonical Wnt signaling via β-catenin. In skin and fibroblasts of SSc patients, decreased DKK1 expression is observed (62), together with increased β-catenin accumulation (63), and increased expression of Wnt signaling-related genes (62, 64).”
From Unraveling SSc Pathophysiology; The Myofibroblast (2018) · cites this paper as [63]
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Cites
Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
MacDonald, B. T., Tamai, K., & He, X. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.016 · Cited by 5,583
Cellular and molecular mechanisms of fibrosis
Wynn, T. (2008) · The Journal of Pathology · doi:10.1002/path.2277 · Cited by 4,495
Woessner, J. F. (1961) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(61)90291-0 · Cited by 3,849
Wnt signalling in stem cells and cancer
Reya, T., & Clevers, H. (2005) · Nature · doi:10.1038/nature03319 · Cited by 3,666
Gabrielli, A., Avvedimento, E. V., & Krieg, T. M. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0806188 · Cited by 1,420
Criteria for the classification of early systemic sclerosis.
LeRoy, E. C., & Medsger, T. A. (2001) · PubMed · Cited by 1,384
Towards an integrated view of Wnt signaling in development
van Amerongen, R., & Nusse, R. (2009) · Development · doi:10.1242/dev.033910 · Cited by 1,213
Intestinal polyposis in mice with a dominant stable mutation of the β‐catenin gene
Harada, N., Tamai, Y., Ishikawa, T., Sauer, B., Takaku, K., Oshima, M., & Taketo, M. M. (1999) · The EMBO Journal · doi:10.1093/emboj/18.21.5931 · Cited by 1,212
Self-citationAberrant Wnt/β-Catenin Pathway Activation in Idiopathic Pulmonary Fibrosis
Chilosi, M., Poletti, V., Zamò, A., Lestani, M., Montagna, L., Piccoli, P., Pedron, S., Bertaso, M., Scarpa, A., Murer, B., et al. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64282-4 · Cited by 708
Mechanisms of Anabolic Therapies for Osteoporosis
CANALIS, E. M., Giustina, A., & Bilezikian, J. P. (2007) · New England Journal of Medicine · doi:10.1056/nejmra067395 · Cited by 675
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Distler, J. H. W., Györfi, A., Ramanujam, M., Whitfield, M. L., Königshoff, M., & Lafyatis, R. (2019) · Nature Reviews Rheumatology · doi:10.1038/s41584-019-0322-7 · Cited by 674
Self-citationSignaling in Fibrosis: TGF-β, WNT, and YAP/TAZ Converge
Piersma, B., Bank, R. A., & Boersema, M. (2015) · Frontiers in Medicine · doi:10.3389/fmed.2015.00059 · Cited by 465
TGF-β-Induced Endothelial-Mesenchymal Transition in Fibrotic Diseases
Pardali, E., Sánchez‐Duffhues, G., Gomez‐Puerto, M. C., & ten Dijke, P. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102157 · Cited by 368
Wnt signaling pathway: A comprehensive review
Hayat, R., Manzoor, M., & Hussain, A. (2022) · Cell Biology International · doi:10.1002/cbin.11797 · Cited by 379
Regeneration of Dermis: Scarring and Cells Involved
Rippa, A. L., Kalabusheva, E. P., & Vorotelyak, E. A. (2019) · Cells · doi:10.3390/cells8060607 · Cited by 319
YAP/TAZ Signaling as a Molecular Link between Fibrosis and Cancer
Noguchi, S. F., Saito, A., & Nagase, T. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113674 · Cited by 295
Endothelial to Mesenchymal Transition (EndoMT) in the Pathogenesis of Human Fibrotic Diseases
Piera-Velázquez, S., Mendoza, F. A., & Jiménez, S. A. (2016) · Journal of Clinical Medicine · doi:10.3390/jcm5040045 · Cited by 287
Targeting TGF-β signaling for the treatment of fibrosis
Györfi, A., Matei, A., & Distler, J. H. W. (2018) · Matrix Biology · doi:10.1016/j.matbio.2017.12.016 · Cited by 283
Self-citationRegenerative Scar-Free Skin Wound Healing
Monavarian, M., Kader, S. I., Moeinzadeh, S., & Jabbari, E. (2019) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2018.0350 · Cited by 297
Exon 3 mutations of CTNNB1 drive tumorigenesis: a review
Gao, C., Wang, Y., Broaddus, R. R., Sun, L., Xue, F., & Zhang, W. (2017) · Oncotarget · doi:10.18632/oncotarget.23695 · Cited by 227
Kramann, R., DiRocco, D. P., & Humphreys, B. D. (2013) · The Journal of Pathology · doi:10.1002/path.4253 · Cited by 215
The GSK-3 Family as Therapeutic Target for Myocardial Diseases
Lal, H., Ahmad, F., Woodgett, J. R., & Force, T. L. (2014) · Circulation Research · doi:10.1161/circresaha.116.303613 · Cited by 211
Xiang, F.-L., Fang, M., & Yutzey, K. E. (2017) · Nature Communications · doi:10.1038/s41467-017-00840-w · Cited by 201
Dees, C., Schlottmann, I., Funke, R., Distler, A., Palumbo‐Zerr, K., Zerr, P., Lin, N., Beyer, C., Distler, O., Schett, G. A., et al. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-203194 · Cited by 209
Self-citationTGF-β and WNT signaling pathways in cardiac fibrosis: non-coding RNAs come into focus
Yousefi, F., Shabaninejad, Z., Vakili, S., Derakhshan, M., Movahedpour, A., Dabiri, H., Ghasemi, Y., Mahjoubin‐Tehran, M., Nikoozadeh, A., Savardashtaki, A., et al. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00555-4 · Cited by 201
The WNT signaling pathways in wound healing and fibrosis
Burgy, O., & Königshoff, M. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.03.017 · Cited by 175
Wehner, D., Tsarouchas, T. M., Michael, A., Haase, C., Weidinger, G., Reimer, M. M., Becker, T., & Becker, C. G. (2017) · Nature Communications · doi:10.1038/s41467-017-00143-0 · Cited by 175
Wnt4/β−Catenin Signaling in Medullary Kidney Myofibroblasts
DiRocco, D. P., Kobayashi, A., Taketo, M. M., McMahon, A. P., & Humphreys, B. D. (2013) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012050512 · Cited by 173
Self-citationHedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis
Horn, A., Palumbo, K., Cordazzo, C., Dees, C., Akhmetshina, A., Tomčík, M., Zerr, P., Avouac, J., Gusinde, J., Zwerina, J., et al. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34444 · Cited by 162
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Rosenbloom, J., Macarak, E. J., Piera-Velázquez, S., & Jiménez, S. A. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7113-8_1 · Cited by 160
Entanglement of GSK-3β, β-catenin and TGF-β1 signaling network to regulate myocardial fibrosis
Guo, Y., Gupte, M., Umbarkar, P., Singh, A. P., Sui, J. Y., Force, T. L., & Lal, H. (2017) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2017.07.011 · Cited by 160
Loss of Yap/Taz in cardiac fibroblasts attenuates adverse remodelling and improves cardiac function
Mia, M. M., Cibi, D. M., Ghani, S. A. B. A., Singh, A., Tee, N., Viswanathan, S., Bogireddi, H., Cook, S. A., Mao, J., & Singh, M. K. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab205 · Cited by 157
Giornale italiano di Dermatologia e Venereologia
Ribero, S., Quaglino, P., Sanlorenzo, M., Osella‐Abate, S., Marenco, F., Fierro, M. T., & Bernengo, M. G. (2012) · Institutional Research Information System University of Turin (University of Turin) · Cited by 155
Unraveling SSc Pathophysiology; The Myofibroblast
van Caam, A., Vonk, M., van den Hoogen, F., van Lent, P., & van der Kraan, P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02452 · Cited by 153
Autophagy: controlling cell fate in rheumatic diseases
Rockel, J. S., & Kapoor, M. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.92 · Cited by 151
Vitamin D receptor regulates TGF-β signalling in systemic sclerosis
Zerr, P., Vollath, S., Palumbo‐Zerr, K., Tomčík, M., Huang, J., Distler, A., Beyer, C., Dees, C., Gela, K., Distler, O., et al. (2014) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-204378 · Cited by 151
Self-citationCancer-associated fibroblasts: how do they contribute to metastasis?
Kwa, M. Q., Herum, K. M., & Brakebusch, C. (2019) · Clinical & Experimental Metastasis · doi:10.1007/s10585-019-09959-0 · Cited by 150
TGF-β–induced epigenetic deregulation of SOCS3 facilitates STAT3 signaling to promote fibrosis
Dees, C., Pötter, S., Zhang, Y., Bergmann, C., Zhou, X., Luber, M., Wohlfahrt, T., Karouzakis, E., Ramming, A., Gelse, K., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci122462 · Cited by 157
Self-citationRognoni, E., Gomez, C., Pisco, A. O., Rawlins, E. L., Simons, B. D., Watt, F. M., & Driskell, R. R. (2016) · Development · doi:10.1242/dev.131797 · Cited by 137
Paracrine Wnt1 Drives Interstitial Fibrosis without Inflammation by Tubulointerstitial Cross-Talk
Maarouf, O. H., Aravamudhan, A., Rangarajan, D., Kusaba, T., Zhang, V., Welborn, J., Gauvin, D., Hou, X., Kramann, R., & Humphreys, B. D. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014121188 · Cited by 133
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Mosa, M. H., Michels, B. E., Menche, C., Nicolas, A. M., Darvishi, T., Greten, F. R., & Farin, H. F. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-0263 · Cited by 136
Beyer, C., Zenzmaier, C., Palumbo‐Zerr, K., Mancuso, R., Distler, A., Dees, C., Zerr, P., Huang, J., Maier, C., Pachowsky, M. L., et al. (2014) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-204508 · Cited by 132
Self-citationJiménez, S. A. (2013) · ISRN Rheumatology · doi:10.1155/2013/835948 · Cited by 130
Wegner, K. A., Keikhosravi, A., Eliceiri, K. W., & Vezina, C. M. (2017) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155417718541 · Cited by 126
Lichtenberger, B. M., Mastrogiannaki, M., & Watt, F. M. (2016) · Nature Communications · doi:10.1038/ncomms10537 · Cited by 115
Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases
Shi, J., Chi, S., Xue, J., Yang, J., Li, F., & Liu, X. (2016) · Journal of Immunology Research · doi:10.1155/2016/9392132 · Cited by 122
Blockade of canonical Wnt signalling ameliorates experimental dermal fibrosis
Beyer, C., Reichert, H., Akan, H., Mallano, T., Schramm, A., Dees, C., Palumbo‐Zerr, K., Lin, N., Distler, A., Gelse, K., et al. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-202544 · Cited by 117
Self-citationHamburg‐Shields, E., DiNuoscio, G., Mullin, N. K., Lafyatis, R., & Atit, R. P. (2014) · The Journal of Pathology · doi:10.1002/path.4481 · Cited by 121
Cellular and molecular mechanisms in fibrosis
Dees, C., Chakraborty, D., & Distler, J. H. W. (2020) · Experimental Dermatology · doi:10.1111/exd.14193 · Cited by 115
Self-citationJiménez, S. A., & Piera-Velázquez, S. (2016) · Matrix Biology · doi:10.1016/j.matbio.2016.01.012 · Cited by 110
Maier, C., Ramming, A., Bergmann, C., Weinkam, R., Kittan, N. A., Schett, G. A., Distler, J. H. W., & Beyer, C. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-210189 · Cited by 107
Self-citationVersican in inflammation and tissue remodeling: The impact on lung disorders
Andersson-Sjoland, A., Hallgren, O., Rolandsson, S., Weitoft, M., Tykesson, E., Larsson-Callerfelt, A.-K., Rydell-Tormanen, K., Bjermer, L., Malmstrom, A., Karlsson, J. C., et al. (2015) · Glycobiology · doi:10.1093/glycob/cwu120 · Cited by 98
The therapeutic potential of targeting the endothelial-to-mesenchymal transition
Man, S., Sánchez‐Duffhues, G., ten Dijke, P., & Baker, D. A. (2018) · Angiogenesis · doi:10.1007/s10456-018-9639-0 · Cited by 99
Svegliati, S., Marrone, G., Pezone, A., Spadoni, T., Grieco, A., Moroncini, G., Grieco, D., Vinciguerra, M., Agnese, S., Jüngel, A., et al. (2014) · Science Signaling · doi:10.1126/scisignal.2004592 · Cited by 100
Self-citationAkcora, B. Ö., Storm, G., & Bansal, R. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.12.001 · Cited by 99
Mastrogiannaki, M., Lichtenberger, B. M., Reimer, A. S., Collins, C. A., Driskell, R. R., & Watt, F. M. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.01.036 · Cited by 100
Heat shock protein 90 (Hsp90) inhibition targets canonical TGF-β signalling to prevent fibrosis
Tomčík, M., Zerr, P., Pitkowski, J., Palumbo‐Zerr, K., Avouac, J., Distler, O., Bečvář, R., Šenolt, L., Schett, G. A., & Distler, J. H. W. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-203095 · Cited by 101
Self-citationInactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signalling
Distler, A., Deloch, L., Huang, J., Dees, C., Lin, N., Palumbo‐Zerr, K., Beyer, C., Weidemann, A., Distler, O., Schett, G. A., et al. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-202275 · Cited by 91
Self-citationS100A4 amplifies TGF-β-induced fibroblast activation in systemic sclerosis
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Irrera, N., Arcoraci, V., Mannino, F., Vermiglio, G., Pallio, G., Minutoli, L., Bagnato, G., Anastasi, G., Mazzon, E., Bramanti, P., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00506 · Cited by 74
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Griffin, M., Huber, J., Fahy, E. J., Quarto, N., & Longaker, M. T. (2021) · Medicinal Research Reviews · doi:10.1002/med.21853 · Cited by 68
Wu, M., Pedroza, M., Lafyatis, R., George, A., Mayes, M. D., Assassi, S., Tan, F. K., Brenner, M. B., & Agarwal, S. K. (2013) · Arthritis & Rheumatology · doi:10.1002/art.38275 · Cited by 68
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Self-citationCanonical Wnt signaling in systemic sclerosis
Bergmann, C., & Distler, J. H. W. (2016) · Laboratory Investigation · doi:10.1038/labinvest.2015.154 · Cited by 69
Self-citationZhang, Y., Dees, C., Beyer, C., Lin, N.-Y., Distler, A., Zerr, P., Palumbo, K., Susok, L., Kreuter, A., Distler, O., et al. (2015) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-204256 · Cited by 64
Self-citationEnzo, M. V., Rastrelli, M., Rossi, C. R., Hladnik, U., & Segat, D. (2015) · Molecular and Cellular Therapies · doi:10.1186/s40591-015-0038-2 · Cited by 68
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Madan, B., Patel, M. B., Zhang, J., Bunte, R. M., Rudemiller, N. P., Griffiths, R., Virshup, D. M., & Crowley, S. D. (2016) · Kidney International · doi:10.1016/j.kint.2016.01.017 · Cited by 56
Lafyatis, R., Mantero, J. C., Gordon, J., Kishore, N., Carns, M., Dittrich, H., Spiera, R., Simms, R. W., & Varga, J. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.06.032 · Cited by 59
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Györfi, A., Matei, A., Fuchs, M., Liang, C., Rigau, A. R., Hong, X., Zhu, H., Luber, M., Bergmann, C., Dees, C., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20201916 · Cited by 56
Self-citationLiang, R., Šumová, B., Cordazzo, C., Mallano, T., Zhang, Y., Wohlfahrt, T., Dees, C., Ramming, A., Krasowska, D., Michalska-Jakubus, M. M., et al. (2016) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-209698 · Cited by 51
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Wong, V., You, F., Januszyk, M., Gurtner, G. C., & Kuang, A. A. (2014) · Annals of Plastic Surgery · doi:10.1097/sap.0b013e31826956f6 · Cited by 49
Gillespie, J., Ross, R. L., Corinaldesi, C., Esteves, F., Derrett‐Smith, E. C., McDermott, M., Doody, G. M., Denton, C. P., Emery, P., & Galdo, F. D. (2018) · Arthritis & Rheumatology · doi:10.1002/art.40437 · Cited by 50
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Palumbo‐Zerr, K., Soare, A., Zerr, P., Liebl, A., Mancuso, R., Tomčík, M., Šumová, B., Dees, C., Chen, C., Wohlfahrt, T., et al. (2016) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2015-208470 · Cited by 47
Self-citationZhang, M., Haughey, M., Wang, N.-Y., Blease, K., Kapoun, A. M., Couto, S., Belka, I., Hoey, T., Groza, M., Hartke, J., et al. (2020) · PLOS ONE · doi:10.1371/journal.pone.0229445 · Cited by 48
Self-citationLi, F., Dai, L., & Niu, J. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29391 · Cited by 47
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Taiyab, A., Korol, A. S., Deschamps, P. A., & West‐Mays, J. A. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-20162 · Cited by 46
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Dufour, A. M., Borowczyk, J., Alvarez, M., Truchetet, M., Modarressi, A., Brembilla, N. C., & Chizzolini, C. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.05.026 · Cited by 45
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Metadata
- Authors
- Beyer, C., Schramm, A., Akhmetshina, A., Dees, C., Kireva, T., Gelse, K., Sonnylal, S., de Crombrugghe, B., Taketo, M. M., Distler, O., Schett, G., & Distler, J. H. W.
- Affiliations
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- The University of Texas MD Anderson Cancer Center (US)
- Kyoto University (JP)
- University of Zurich (CH)
- Corresponding author
- Distler, Jörg H W
- ORCID
- Venue
- Annals of the Rheumatic Diseases
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 71
- Issue
- 5
- Pages
- 761-767
- ISSN
- 0003-4967 (ISSN-L)
- PMC
- PMC3951949
- OpenAlex
- W2106544674
- Cited by
- 203
- References
- 35
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 12 · 2023: 12 · 2022: 10 · 2021: 15 · 2020: 12 · 2019: 11 · 2018: 13 · 2017: 23 · 2016: 26 · 2015: 13 · 2014: 14 · 2013: 16 · 2012: 12
- FWCI
- 12.71
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- Locations
- Annals of the Rheumatic Diseases (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- OPUS FAU (Kooperativer Bibliotheksverbund Berlin-Brandenburg (KOBV), on behalf of the Universitätsbibliothek Erlangen-Nürnberg) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- National Institutes of Health (5p50ar054144-05)
- Japan Society for the Promotion of Science (21229005)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (P50-AR-054144)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Sclerosis and Related Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Rheumatology › Dupuytren's Contracture and Treatments
- Keywords
- β-catenin, Wnt signaling, systemic sclerosis, skin fibrosis, fibroblast activation, Wnt1, myofibroblast differentiation, bleomycin-induced fibrosis, Wnt inhibitors
- MeSH terms
- Adult, Aged, Cell Nucleus, Female, Fibroblasts, Fibrosis, Humans, Male, Middle Aged, Scleroderma, Systemic, Skin, Wnt Proteins, beta Catenin, Young Adult, Wnt Signaling Pathway
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